GSTA5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GSTA5
Entrez Gene ID	221357
Full Name	glutathione S-transferase alpha 5
General protein information	Preferred Names glutathione S-transferase alpha 5 Names glutathione S-transferase A5 GST class-alpha member 5 glutathione S-transferase A5-5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p12.2
Summary	The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008].
Disorder MIM:	607605

mRNA and Protein(s)

mRNA	Protein	Name
NM_153699.1	NP_714543.1	glutathione S-transferase A5

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gm10639	NP_001116132.1
Homo sapiens (human)	GSTA5	NP_714543.1
Mus musculus (house mouse)	Gm3776	NP_001230021.1
Pan troglodytes (chimpanzee)	GSTA5	XP_001153791.1
	LOC709417	XP_001108174.1
Mus musculus (house mouse)	Gsta2	NP_032208.2
Mus musculus (house mouse)	Gsta1	NP_032207.3
Rattus norvegicus (Norway rat)	Gsta5	NP_001010921.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
Moyer AM, Sun Z, Batzler AJ, Li L, Schaid DJ, Yang P, Weinshilboum RM
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology19(3)811-21(2010 Mar)

The human hGSTA5 gene encodes an enzymatically active protein.
Singh SP, Zimniak L, Zimniak P
Biochimica et biophysica acta1800(1)16-22(2010 Jan)

The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.
Morel F, Rauch C, Coles B, Le Ferrec E, Guillouzo A
Pharmacogenetics12(4)277-86(2002 Jun)

Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype.
Coles BF, Anderson KE, Doerge DR, Churchwell MI, Lang NP, Kadlubar FF
Cancer research60(3)573-9(2000 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

We observed suggestive associations between survival and GSTT1 copy number and GSTA5, GSTM4, and ABCC4 single nucleotide polymorphisms
Title: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.

Data show that hGSTA5 can be processed to a mature mRNA which is translation-competent, producing a catalytically active enzyme.
Title: The human hGSTA5 gene encodes an enzymatically active protein.

Observational study of gene-disease association. (HuGE Navigator)
Title: Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.

Observational study of gene-disease association. (HuGE Navigator)
Title: A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

The following GSTA5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSTA5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu07063	NM_153699.1 Latest version!	Homo sapiens glutathione S-transferase alpha 5 (GSTA5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GSTA5 ( NM_153699.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_714543.1 Homo sapiens glutathione S-transferase alpha 5 (GSTA5), mRNA.

Price & Availability↑

CloneID	OHu07063
Clone ID Related Accession (Same CDS sequence)	NM_153699.1
Accession Version	NM_153699.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	glutathione S-transferase A5
Comment	Comment: INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from BK000212.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2144835 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCAGAGA AGCCCAAGCT CCACTACTCC AATGCACGGG GCAGTATGGA GTCCATTCGG 
TGGCTCCTGG CTGCAGCTGG AGTAGAGTTG GAAGAGAAAT TTCTAGAATC TGCAGAAGAT 
TTGGACAAGT TAAGAAATGA TGGGAGTTTG CTGTTCCAGC AAGTACCAAT GGTTGAGATT 
GACGGGATGA AGCTGGTGCA GACCAGAGCC ATTCTTAACT ACATTGCCAG CAAATACAAC 
CTTTATGGGA AAGACATGAA GGAGAGAGCC CTGATTGATA TGTACACAGA AGGTATAGTA 
GATTTGACTG AAATGATCCT TCTTCTGCTC ATATGTCAAC CAGAGGAAAG AGATGCCAAG 
ACTGCCTTGG TCAAAGAGAA AATAAAAAAT CGCTACTTCC CTGCCTTTGA AAAAGTCTTA 
AAGAGCCACA GACAAGACTA CCTTGTTGGC AACAAGCTGA GCTGGGCTGA CATTCACCTG 
GTGGAACTTT TCTACTACGT GGAAGAGCTT GACTCGAGTC TTATCTCCAG CTTCCCTCTG 
CTGAAGGCCC TGAAAACCAG AATCAGCAAC CTGCCCACGG TGAAGAAGTT TCTGCAGCCT 
GGCAGCCAGA GAAAGCCTCC CATGGATGAG AAATCTTTAG AAGAAGCAAG GAAGATTTTC 
AGGTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_714543.1
CDS	71..739
Translation	MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKLRNDGSLLFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYTEGIVDLTEMILLLLICQPEERDAKTALVKEKIKNRYFPAFEKVLKSHRQDYLVGNKLSWADIHLVELFYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSQRKPPMDEKSLEEARKIFRF

Target ORF information:

RefSeq Version	NM_153699.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glutathione S-transferase alpha 5 (GSTA5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153699.1

ORF Insert Sequence:

ATGGCAGAGA AGCCCAAGCT CCACTACTCC AATGCACGGG GCAGTATGGA GTCCATTCGG 
TGGCTCCTGG CTGCAGCTGG AGTAGAGTTG GAAGAGAAAT TTCTAGAATC TGCAGAAGAT 
TTGGACAAGT TAAGAAATGA TGGGAGTTTG CTGTTCCAGC AAGTACCAAT GGTTGAGATT 
GACGGGATGA AGCTGGTGCA GACCAGAGCC ATTCTTAACT ACATTGCCAG CAAATACAAC 
CTTTATGGGA AAGACATGAA GGAGAGAGCC CTGATTGATA TGTACACAGA AGGTATAGTA 
GATTTGACTG AAATGATCCT TCTTCTGCTC ATATGTCAAC CAGAGGAAAG AGATGCCAAG 
ACTGCCTTGG TCAAAGAGAA AATAAAAAAT CGCTACTTCC CTGCCTTTGA AAAAGTCTTA 
AAGAGCCACA GACAAGACTA CCTTGTTGGC AACAAGCTGA GCTGGGCTGA CATTCACCTG 
GTGGAACTTT TCTACTACGT GGAAGAGCTT GACTCGAGTC TTATCTCCAG CTTCCCTCTG 
CTGAAGGCCC TGAAAACCAG AATCAGCAAC CTGCCCACGG TGAAGAAGTT TCTGCAGCCT 
GGCAGCCAGA GAAAGCCTCC CATGGATGAG AAATCTTTAG AAGAAGCAAG GAAGATTTTC 
AGGTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology19(3)811-21(2010 Mar)
Moyer AM,Sun Z,Batzler AJ,Li L,Schaid DJ,Yang P,Weinshilboum RM

The human hGSTA5 gene encodes an enzymatically active protein.
Biochimica et biophysica acta1800(1)16-22(2010 Jan)
Singh SP,Zimniak L,Zimniak P

The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.
Pharmacogenetics12(4)277-86(2002 Jun)
Morel F,Rauch C,Coles B,Le Ferrec E,Guillouzo A

Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype.
Cancer research60(3)573-9(2000 Feb)
Coles BF,Anderson KE,Doerge DR,Churchwell MI,Lang NP,Kadlubar FF

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GSTA5 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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