UCMA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UCMA
Entrez Gene ID	221044
Full Name	upper zone of growth plate and cartilage matrix associated
Synonyms	C10orf49,GRP,GRP/UCMA
General protein information	Preferred Names upper zone of growth plate and cartilage matrix associated Names unique cartilage matrix-associated protein Gla-rich protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p13
Summary	This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001303119.2	NP_001290048.1	unique cartilage matrix-associated protein isoform 3 precursor
NM_145314.3	NP_660357.2	unique cartilage matrix-associated protein isoform 1 preproprotein
NM_001303118.1	NP_001290047.1	unique cartilage matrix-associated protein isoform 2 precursor
NM_001303119.1	NP_001290048.1	unique cartilage matrix-associated protein isoform 3 precursor
NM_145314.2	NP_660357.2	unique cartilage matrix-associated protein isoform 1 preproprotein
NM_001303118.2	NP_001290047.1	unique cartilage matrix-associated protein isoform 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	UCMA	XP_535186.2
Danio rerio (zebrafish)	ucmab	NP_998099.1
Homo sapiens (human)	UCMA	NP_660357.2
	LOC698795	XP_001087282.2
Mus musculus (house mouse)	Ucma	NP_001107030.1
Bos taurus (cattle)	UCMA	NP_001193155.1
Xenopus tropicalis (tropical clawed frog)	ucma	NP_001016485.1
Pan troglodytes (chimpanzee)	UCMA	XP_001140953.1
Rattus norvegicus (Norway rat)	Ucma	NP_001099591.1

Gene Ontology
Bibliography

Related articles in PubMed

Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein).
Viegas CSB, Santos L, Macedo AL, Matos AA, Silva AP, Neves PL, Staes A, Gevaert K, Morais R, Vermeer C, Schurgers L, Simes DC
Arteriosclerosis, thrombosis, and vascular biology(2018 Jan)

Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.
Viegas CSB, Costa RM, Santos L, Videira PA, Silva Z, Ara?jo N, Macedo AL, Matos AP, Vermeer C, Simes DC
PloS one12(5)e0177829(2017)

Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis.
Cavaco S, Viegas CS, Rafael MS, Ramos A, Magalh?es J, Blanco FJ, Vermeer C, Simes DC
Cellular and molecular life sciences : CMLS73(5)1051-65(2016 Mar)

Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and ?-carboxylation status.
Rafael MS, Cavaco S, Viegas CS, Santos S, Ramos A, Willems BA, Herfs M, Theuwissen E, Vermeer C, Simes DC
Molecular nutrition & food research58(8)1636-46(2014 Aug)

Exon resequencing of the gene encoding UCma/GRP reveals a common carboxy-terminal 138Thr > Ser polymorphism.
Osman A, Uhlin F, Fr?nlund E, Fernstr?m A, Magnusson P
Clinical laboratory59(11-12)1397-401(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GRP might act as a novel molecular mediator linking inflammation and calcification events
Title: Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.

The study demonstrates the involvement of GRP in the two major molecular processes affecting osteoarthritis: mineralization and inflammation of articular tissue.
Title: Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis.

Data suggest that novel splice variants of GRP are expressed in cartilage and other tissues (i.e. GRP-F5, GRP-F6); GRP-F1 is predominant splice variant expressed in adult tissues particularly in cartilage of patients with osteoarthritis.
Title: Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and ?-carboxylation status.

full exon resequencing of DNA samples from 17 chronic kidney disease patients (stage 5) and 121 healthy controls in a Swsedish population; the 138Thr > Ser polymorphism seems to be the only non-synonymous SNP found in the UCMA gene in a Swedish population
Title: Exon resequencing of the gene encoding UCma/GRP reveals a common carboxy-terminal 138Thr > Ser polymorphism.

Gla-rich protein (GRP) is a new vitamin K-dependent protein that can bind calcium through Gla residues.
Title: Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates.

The following UCMA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UCMA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu77988	NM_145314.3 Latest version!	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu77989	NM_001303118.2 Latest version!	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu77990	NM_001303119.2 Latest version!	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu77990	NM_001303119.1	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu77988	NM_145314.2	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu77989	NM_001303118.1	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UCMA ( NM_145314.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_660357.2 Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu77988
Clone ID Related Accession (Same CDS sequence)	NM_145314.3 , NM_145314.2
Accession Version	NM_145314.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	unique cartilage matrix-associated protein isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138764.21, BC018068.1 and AA628504.1. On Nov 22, 2018 this sequence version replaced NM_145314.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC018068.1, BG709040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMN03267763 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378681.8/ ENSP00000367952.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGATGCAA AACAGAAGAT TTTCATGCAG GAATCAGATG CCTCGAATTT CCTCAAGAGG 
CGCGGCAAGC GGTCCCCCAA GTCCAGAGAT GAGGTCAATG TGGAAAACAG GCAGAAGCTT 
CGGGTTGATG AGCTGCGGAG AGAATATTAC GAGGAACAAA GGAATGAATT TGAGAACTTC 
GTGGAGGAAC AAAACGATGA GCAGGAAGAG AGGAGCCGGG AGGCTGTGGA GCAGTGGCGC 
CAGTGGCACT ATGACGGCCT GCACCCATCC TATCTCTACA ACCGCCACCA CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660357.2
CDS	117..533
Translation	MTWRQAVLLSCFSAVVLLSMLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT

Target ORF information:

RefSeq Version	NM_145314.3
Organism	Homo sapiens(human)
Definition	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145314.3

ORF Insert Sequence:

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGATGCAA AACAGAAGAT TTTCATGCAG GAATCAGATG CCTCGAATTT CCTCAAGAGG 
CGCGGCAAGC GGTCCCCCAA GTCCAGAGAT GAGGTCAATG TGGAAAACAG GCAGAAGCTT 
CGGGTTGATG AGCTGCGGAG AGAATATTAC GAGGAACAAA GGAATGAATT TGAGAACTTC 
GTGGAGGAAC AAAACGATGA GCAGGAAGAG AGGAGCCGGG AGGCTGTGGA GCAGTGGCGC 
CAGTGGCACT ATGACGGCCT GCACCCATCC TATCTCTACA ACCGCCACCA CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCMA ( NM_145314.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_660357.2 Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu77988
Clone ID Related Accession (Same CDS sequence)	NM_145314.3 , NM_145314.2
Accession Version	NM_145314.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	unique cartilage matrix-associated protein isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC018068.1, AL138764.21 and AA628504.1. On Dec 17, 2014 this sequence version replaced NM_145314.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC018068.1, BG709040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMN03267763 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGATGCAA AACAGAAGAT TTTCATGCAG GAATCAGATG CCTCGAATTT CCTCAAGAGG 
CGCGGCAAGC GGTCCCCCAA GTCCAGAGAT GAGGTCAATG TGGAAAACAG GCAGAAGCTT 
CGGGTTGATG AGCTGCGGAG AGAATATTAC GAGGAACAAA GGAATGAATT TGAGAACTTC 
GTGGAGGAAC AAAACGATGA GCAGGAAGAG AGGAGCCGGG AGGCTGTGGA GCAGTGGCGC 
CAGTGGCACT ATGACGGCCT GCACCCATCC TATCTCTACA ACCGCCACCA CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660357.2
CDS	71..487
Translation	MTWRQAVLLSCFSAVVLLSMLREGTSVSVGTMQMAGEEASEDAKQKIFMQESDASNFLKRRGKRSPKSRDEVNVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT

Target ORF information:

RefSeq Version	NM_145314.2
Organism	Homo sapiens(human)
Definition	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145314.2

ORF Insert Sequence:

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGATGCAA AACAGAAGAT TTTCATGCAG GAATCAGATG CCTCGAATTT CCTCAAGAGG 
CGCGGCAAGC GGTCCCCCAA GTCCAGAGAT GAGGTCAATG TGGAAAACAG GCAGAAGCTT 
CGGGTTGATG AGCTGCGGAG AGAATATTAC GAGGAACAAA GGAATGAATT TGAGAACTTC 
GTGGAGGAAC AAAACGATGA GCAGGAAGAG AGGAGCCGGG AGGCTGTGGA GCAGTGGCGC 
CAGTGGCACT ATGACGGCCT GCACCCATCC TATCTCTACA ACCGCCACCA CACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCMA ( NM_001303118.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290047.1 Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu77989
Clone ID Related Accession (Same CDS sequence)	NM_001303118.1 , NM_001303118.2
Accession Version	NM_001303118.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-12
Organism	Homo sapiens(human)
Product	unique cartilage matrix-associated protein isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC018068.1, JX169864.1 and AA628504.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: JX169864.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465420 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGTGGAAA ACAGGCAGAA GCTTCGGGTT GATGAGCTGC GGAGAGAATA TTACGAGGAA 
CAAAGGAATG AATTTGAGAA CTTCGTGGAG GAACAAAACG ATGAGCAGGA AGAGAGGAGC 
CGGGAGGCTG TGGAGCAGTG GCGCCAGTGG CACTATGACG GCCTGCACCC ATCCTATCTC 
TACAACCGCC ACCACACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290047.1
CDS	71..391
Translation	MTWRQAVLLSCFSAVVLLSMLREGTSVSVGTMQMAGEEASEVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT

Target ORF information:

RefSeq Version	NM_001303118.1
Organism	Homo sapiens(human)
Definition	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303118.1

ORF Insert Sequence:

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGTGGAAA ACAGGCAGAA GCTTCGGGTT GATGAGCTGC GGAGAGAATA TTACGAGGAA 
CAAAGGAATG AATTTGAGAA CTTCGTGGAG GAACAAAACG ATGAGCAGGA AGAGAGGAGC 
CGGGAGGCTG TGGAGCAGTG GCGCCAGTGG CACTATGACG GCCTGCACCC ATCCTATCTC 
TACAACCGCC ACCACACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCMA ( NM_001303118.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290047.1 Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu77989
Clone ID Related Accession (Same CDS sequence)	NM_001303118.1 , NM_001303118.2
Accession Version	NM_001303118.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	unique cartilage matrix-associated protein isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138764.21, BC018068.1, JX169864.1 and AA628504.1. On May 31, 2019 this sequence version replaced NM_001303118.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: JX169864.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465420 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGTGGAAA ACAGGCAGAA GCTTCGGGTT GATGAGCTGC GGAGAGAATA TTACGAGGAA 
CAAAGGAATG AATTTGAGAA CTTCGTGGAG GAACAAAACG ATGAGCAGGA AGAGAGGAGC 
CGGGAGGCTG TGGAGCAGTG GCGCCAGTGG CACTATGACG GCCTGCACCC ATCCTATCTC 
TACAACCGCC ACCACACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290047.1
CDS	117..437
Translation	MTWRQAVLLSCFSAVVLLSMLREGTSVSVGTMQMAGEEASEVENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT

Target ORF information:

RefSeq Version	NM_001303118.2
Organism	Homo sapiens(human)
Definition	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303118.2

ORF Insert Sequence:

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
CTGAGAGAGG GAACCAGTGT ATCTGTGGGC ACCATGCAGA TGGCGGGAGA AGAGGCGAGT 
GAAGTGGAAA ACAGGCAGAA GCTTCGGGTT GATGAGCTGC GGAGAGAATA TTACGAGGAA 
CAAAGGAATG AATTTGAGAA CTTCGTGGAG GAACAAAACG ATGAGCAGGA AGAGAGGAGC 
CGGGAGGCTG TGGAGCAGTG GCGCCAGTGG CACTATGACG GCCTGCACCC ATCCTATCTC 
TACAACCGCC ACCACACCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCMA ( NM_001303119.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290048.1 Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu77990
Clone ID Related Accession (Same CDS sequence)	NM_001303119.2 , NM_001303119.1
Accession Version	NM_001303119.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	unique cartilage matrix-associated protein isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL138764.21, BC018068.1, JX169865.1 and AA628504.1. On May 31, 2019 this sequence version replaced NM_001303119.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: JX169865.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA2151741 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
GAAAACAGGC AGAAGCTTCG GGTTGATGAG CTGCGGAGAG AATATTACGA GGAACAAAGG 
AATGAATTTG AGAACTTCGT GGAGGAACAA AACGATGAGC AGGAAGAGAG GAGCCGGGAG 
GCTGTGGAGC AGTGGCGCCA GTGGCACTAT GACGGCCTGC ACCCATCCTA TCTCTACAAC 
CGCCACCACA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290048.1
CDS	117..371
Translation	MTWRQAVLLSCFSAVVLLSMENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT

Target ORF information:

RefSeq Version	NM_001303119.2
Organism	Homo sapiens(human)
Definition	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303119.2

ORF Insert Sequence:

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
GAAAACAGGC AGAAGCTTCG GGTTGATGAG CTGCGGAGAG AATATTACGA GGAACAAAGG 
AATGAATTTG AGAACTTCGT GGAGGAACAA AACGATGAGC AGGAAGAGAG GAGCCGGGAG 
GCTGTGGAGC AGTGGCGCCA GTGGCACTAT GACGGCCTGC ACCCATCCTA TCTCTACAAC 
CGCCACCACA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCMA ( NM_001303119.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290048.1 Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu77990
Clone ID Related Accession (Same CDS sequence)	NM_001303119.2 , NM_001303119.1
Accession Version	NM_001303119.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 255bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-12
Organism	Homo sapiens(human)
Product	unique cartilage matrix-associated protein isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC018068.1, JX169865.1 and AA628504.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: JX169865.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA2151741 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
GAAAACAGGC AGAAGCTTCG GGTTGATGAG CTGCGGAGAG AATATTACGA GGAACAAAGG 
AATGAATTTG AGAACTTCGT GGAGGAACAA AACGATGAGC AGGAAGAGAG GAGCCGGGAG 
GCTGTGGAGC AGTGGCGCCA GTGGCACTAT GACGGCCTGC ACCCATCCTA TCTCTACAAC 
CGCCACCACA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290048.1
CDS	71..325
Translation	MTWRQAVLLSCFSAVVLLSMENRQKLRVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYNRHHT

Target ORF information:

RefSeq Version	NM_001303119.1
Organism	Homo sapiens(human)
Definition	Homo sapiens upper zone of growth plate and cartilage matrix associated (UCMA), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303119.1

ORF Insert Sequence:

ATGACTTGGA GACAGGCCGT CCTGCTGTCT TGCTTCTCCG CCGTGGTGCT CCTGTCTATG 
GAAAACAGGC AGAAGCTTCG GGTTGATGAG CTGCGGAGAG AATATTACGA GGAACAAAGG 
AATGAATTTG AGAACTTCGT GGAGGAACAA AACGATGAGC AGGAAGAGAG GAGCCGGGAG 
GCTGTGGAGC AGTGGCGCCA GTGGCACTAT GACGGCCTGC ACCCATCCTA TCTCTACAAC 
CGCCACCACA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein).
Arteriosclerosis, thrombosis, and vascular biology(2018 Jan)
Viegas CSB,Santos L,Macedo AL,Matos AA,Silva AP,Neves PL,Staes A,Gevaert K,Morais R,Vermeer C,Schurgers L,Simes DC

Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.
PloS one12(5)e0177829(2017)
Viegas CSB,Costa RM,Santos L,Videira PA,Silva Z,Ara?jo N,Macedo AL,Matos AP,Vermeer C,Simes DC

Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis.
Cellular and molecular life sciences : CMLS73(5)1051-65(2016 Mar)
Cavaco S,Viegas CS,Rafael MS,Ramos A,Magalh?es J,Blanco FJ,Vermeer C,Simes DC

Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and ?-carboxylation status.
Molecular nutrition & food research58(8)1636-46(2014 Aug)
Rafael MS,Cavaco S,Viegas CS,Santos S,Ramos A,Willems BA,Herfs M,Theuwissen E,Vermeer C,Simes DC

Exon resequencing of the gene encoding UCma/GRP reveals a common carboxy-terminal 138Thr > Ser polymorphism.
Clinical laboratory59(11-12)1397-401(2013)
Osman A,Uhlin F,Fr?nlund E,Fernstr?m A,Magnusson P

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UCMA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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