The following PDE12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDE12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu30697 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_177966.6 , NM_177966.7 | |
| Accession Version | NM_177966.7 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1830bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-01 | |
| Organism | Homo sapiens(human) | |
| Product | 2',5'-phosphodiesterase 12 isoform 1 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092418.3, AL831824.1 and U79276.1. On Nov 23, 2018 this sequence version replaced NM_177966.6. Transcript Variant: This variant (1) represents the predominant transcript and encodes the canonical protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.131458.1, SRR1803613.242445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311180.9/ ENSP00000309142.7 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_808881.3 |
| CDS | 107..1936 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_177966.7 |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu30697 | |
| Clone ID Related Accession (Same CDS sequence) | NM_177966.6 , NM_177966.7 | |
| Accession Version | NM_177966.6 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1830bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-02 | |
| Organism | Homo sapiens(human) | |
| Product | 2',5'-phosphodiesterase 12 isoform 1 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092418.3, AL831824.1 and U79276.1. On Apr 7, 2016 this sequence version replaced NM_177966.5. Transcript Variant: This variant (1) represents the predominant transcript and encodes the canonical protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.242445.1, SRR1803612.182283.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_808881.3 |
| CDS | 134..1963 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_177966.6 |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu77764 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001322176.2 , NM_001322176.1 | |
| Accession Version | NM_001322176.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-30 | |
| Organism | Homo sapiens(human) | |
| Product | 2',5'-phosphodiesterase 12 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092418.3, BM713922.1 and AC114480.2. On May 31, 2019 this sequence version replaced NM_001322176.1. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1. Isoform 2 may lack phospodiesterase or deadenylase activty. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.171102.1, SRR1660809.261059.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001309105.1 |
| CDS | 107..1663 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001322176.2 |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu77764 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001322176.2 , NM_001322176.1 | |
| Accession Version | NM_001322176.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-06-30 | |
| Organism | Homo sapiens(human) | |
| Product | 2',5'-phosphodiesterase 12 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092418.3, BM713922.1 and AC114480.2. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1. Isoform 2 may lack phospodiesterase or deadenylase activty. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.261059.1, SRR1803611.171102.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001309105.1 |
| CDS | 134..1690 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001322176.1 |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu100347 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001322177.1 , NM_001322177.2 | |
| Accession Version | NM_001322177.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-24 | |
| Organism | Homo sapiens(human) | |
| Product | 2',5'-phosphodiesterase 12 isoform 3 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092418.3, BC034978.2 and U79276.1. Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a shorter protein (isoform 3) with a distinct C-terminus, compared to isoform 1. Isoform 3 may lack phospodiesterase or deadenylase activty. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.154.1, SRR1660809.164275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001309106.1 |
| CDS | 134..1552 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001322177.1 |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu100347 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001322177.1 , NM_001322177.2 | |
| Accession Version | NM_001322177.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-30 | |
| Organism | Homo sapiens(human) | |
| Product | 2',5'-phosphodiesterase 12 isoform 3 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092418.3, BC034978.2 and U79276.1. On May 31, 2019 this sequence version replaced NM_001322177.1. Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a shorter protein (isoform 3) with a distinct C-terminus, compared to isoform 1. Isoform 3 may lack phospodiesterase or deadenylase activty. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.154.1, SRR1660809.164275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001309106.1 |
| CDS | 107..1525 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001322177.2 |
1 | ATGTGGAGGC TCCCAGGCGC CCGCGCCGCG CTTCGGGTGA TCCGGACGGC GGTGGAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. |
Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1. |
PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. |
Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover. |
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |
