EFNA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EFNA3
Entrez Gene ID	1944
Full Name	ephrin A3
Synonyms	EFL2,EPLG3,Ehk1-L,LERK3
General protein information	Preferred Names ephrin A3 Names ephrin-A3 EFL-2 EHK1 ligand LERK-3 eph-related receptor tyrosine kinase ligand 3 ligand of eph-related kinase 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008].
Disorder MIM:	601381

mRNA and Protein(s)

mRNA	Protein	Name
NM_004952.5	NP_004943.1	ephrin-A3 precursor
NM_004952.4	NP_004943.1	ephrin-A3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Efna3	NP_034238.1
Canis lupus familiaris (dog)	EFNA3	XP_003639199.1
Bos taurus (cattle)	EFNA3	NP_001098899.1
Rattus norvegicus (Norway rat)	Efna3	XP_574979.4
Pan troglodytes (chimpanzee)	EFNA3	XP_003308464.1
	EFNA3	XP_001115043.1
Homo sapiens (human)	EFNA3	NP_004943.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation.
Nakashima S, Jinnin M, Kanemaru H, Kajihara I, Igata T, Okamoto S, Tazaki Y, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Amoh Y, Masuzawa M, Ihn H
European journal of dermatology : EJD27(5)464-471(2017 Oct)

Dissecting the roles of Ephrin-A3 in malignant peripheral nerve sheath tumor by TALENs.
Wang Z, Liu Z, Liu B, Liu G, Wu S
Oncology reports34(1)391-8(2015 Jul)

Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.
Li Y, Liu DX, Li MY, Qin XX, Fang WG, Zhao WD, Chen YH
Anatomical record (Hoboken, N.J. : 2007)297(10)1908-18(2014 Oct)

Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.
Lai WB, Wang BJ, Hu MK, Hsu WM, Her GM, Liao YF
Molecular neurobiology49(2)1055-68(2014 Apr)

Ephrin-As, Eph receptors and integrin ?3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.
Makarov A, Ylivinkka I, Nyman TA, Hyyti?inen M, Keski-Oja J
Cell biology international37(10)1080-8(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that EFNA3 serves as a tumor suppressor in malignant peripheral nerve sheath tumor cells and it may play a critical role in the FAK signaling and VEGF-associated tumor angiogenesis pathway.
Title: Dissecting the roles of Ephrin-A3 in malignant peripheral nerve sheath tumor by TALENs.

The present study provides evidence that microglia upregulates endothelial ephrin-A3 and ephrin-A4 to facilitate in vitro angiogenesis of brain endothelial cells, which is mediated by microglia-released TNF-alpha.
Title: Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.

The interaction between ephrin-As, Eph receptors and integrin alpha3 is plausibly important for the crosstalk between Eph and integrin signalling pathways at the membrane protrusions and in the migration of brain cancer cells.
Title: Ephrin-As, Eph receptors and integrin ?3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.

EphA3 mutants with constitutively-released kinase domains efficiently support shedding, even when their kinase is disabled. Our data suggest that this phosphorylation-activated conformational switch of EphA3 directly controls ADAM-mediated shedding.
Title: Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.

The following EFNA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EFNA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31770	NM_004952.5 Latest version!	Homo sapiens ephrin A3 (EFNA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu31770	NM_004952.4	Homo sapiens ephrin A3 (EFNA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EFNA3 ( NM_004952.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004943.1 Homo sapiens ephrin A3 (EFNA3), mRNA.

Price & Availability↑

CloneID	OHu31770
Clone ID Related Accession (Same CDS sequence)	NM_004952.5 , NM_004952.4
Accession Version	NM_004952.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	ephrin-A3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL691442.32. On Nov 22, 2018 this sequence version replaced NM_004952.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.438053.1, SRR3476690.820847.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368408.4/ ENSP00000357393.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG CTCCGCTGCT GCTGCTGCTG CTGCTCGTGC CCGTGCCGCT GCTGCCGCTG 
CTGGCCCAAG GGCCCGGAGG GGCGCTGGGA AACCGGCATG CGGTGTACTG GAACAGCTCC 
AACCAGCACC TGCGGCGAGA GGGCTACACC GTGCAGGTGA ACGTGAACGA CTATCTGGAT 
ATTTACTGCC CGCACTACAA CAGCTCGGGG GTGGGCCCCG GGGCGGGACC GGGGCCCGGA 
GGCGGGGCAG AGCAGTACGT GCTGTACATG GTGAGCCGCA ACGGCTACCG CACCTGCAAC 
GCCAGCCAGG GCTTCAAGCG CTGGGAGTGC AACCGGCCGC ACGCCCCGCA CAGCCCCATC 
AAGTTCTCGG AGAAGTTCCA GCGCTACAGC GCCTTCTCTC TGGGCTACGA GTTCCACGCC 
GGCCACGAGT ACTACTACAT CTCCACGCCC ACTCACAACC TGCACTGGAA GTGTCTGAGG 
ATGAAGGTGT TCGTCTGCTG CGCCTCCACA TCGCACTCCG GGGAGAAGCC GGTCCCCACT 
CTCCCCCAGT TCACCATGGG CCCCAATGTG AAGATCAACG TGCTGGAAGA CTTTGAGGGA 
GAGAACCCTC AGGTGCCCAA GCTTGAGAAG AGCATCAGCG GGACCAGCCC CAAACGGGAA 
CACCTGCCCC TGGCCGTGGG CATCGCCTTC TTCCTCATGA CGTTCTTGGC CTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004943.1
CDS	106..822
Translation	MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS

Target ORF information:

RefSeq Version	NM_004952.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ephrin A3 (EFNA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004952.5

ORF Insert Sequence:

ATGGCGGCGG CTCCGCTGCT GCTGCTGCTG CTGCTCGTGC CCGTGCCGCT GCTGCCGCTG 
CTGGCCCAAG GGCCCGGAGG GGCGCTGGGA AACCGGCATG CGGTGTACTG GAACAGCTCC 
AACCAGCACC TGCGGCGAGA GGGCTACACC GTGCAGGTGA ACGTGAACGA CTATCTGGAT 
ATTTACTGCC CGCACTACAA CAGCTCGGGG GTGGGCCCCG GGGCGGGACC GGGGCCCGGA 
GGCGGGGCAG AGCAGTACGT GCTGTACATG GTGAGCCGCA ACGGCTACCG CACCTGCAAC 
GCCAGCCAGG GCTTCAAGCG CTGGGAGTGC AACCGGCCGC ACGCCCCGCA CAGCCCCATC 
AAGTTCTCGG AGAAGTTCCA GCGCTACAGC GCCTTCTCTC TGGGCTACGA GTTCCACGCC 
GGCCACGAGT ACTACTACAT CTCCACGCCC ACTCACAACC TGCACTGGAA GTGTCTGAGG 
ATGAAGGTGT TCGTCTGCTG CGCCTCCACA TCGCACTCCG GGGAGAAGCC GGTCCCCACT 
CTCCCCCAGT TCACCATGGG CCCCAATGTG AAGATCAACG TGCTGGAAGA CTTTGAGGGA 
GAGAACCCTC AGGTGCCCAA GCTTGAGAAG AGCATCAGCG GGACCAGCCC CAAACGGGAA 
CACCTGCCCC TGGCCGTGGG CATCGCCTTC TTCCTCATGA CGTTCTTGGC CTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EFNA3 ( NM_004952.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004943.1 Homo sapiens ephrin A3 (EFNA3), mRNA.

Price & Availability↑

CloneID	OHu31770
Clone ID Related Accession (Same CDS sequence)	NM_004952.5 , NM_004952.4
Accession Version	NM_004952.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ephrin-A3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL691442.32. On Aug 16, 2007 this sequence version replaced NM_004952.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110406.1, AL533153.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CTCCGCTGCT GCTGCTGCTG CTGCTCGTGC CCGTGCCGCT GCTGCCGCTG 
CTGGCCCAAG GGCCCGGAGG GGCGCTGGGA AACCGGCATG CGGTGTACTG GAACAGCTCC 
AACCAGCACC TGCGGCGAGA GGGCTACACC GTGCAGGTGA ACGTGAACGA CTATCTGGAT 
ATTTACTGCC CGCACTACAA CAGCTCGGGG GTGGGCCCCG GGGCGGGACC GGGGCCCGGA 
GGCGGGGCAG AGCAGTACGT GCTGTACATG GTGAGCCGCA ACGGCTACCG CACCTGCAAC 
GCCAGCCAGG GCTTCAAGCG CTGGGAGTGC AACCGGCCGC ACGCCCCGCA CAGCCCCATC 
AAGTTCTCGG AGAAGTTCCA GCGCTACAGC GCCTTCTCTC TGGGCTACGA GTTCCACGCC 
GGCCACGAGT ACTACTACAT CTCCACGCCC ACTCACAACC TGCACTGGAA GTGTCTGAGG 
ATGAAGGTGT TCGTCTGCTG CGCCTCCACA TCGCACTCCG GGGAGAAGCC GGTCCCCACT 
CTCCCCCAGT TCACCATGGG CCCCAATGTG AAGATCAACG TGCTGGAAGA CTTTGAGGGA 
GAGAACCCTC AGGTGCCCAA GCTTGAGAAG AGCATCAGCG GGACCAGCCC CAAACGGGAA 
CACCTGCCCC TGGCCGTGGG CATCGCCTTC TTCCTCATGA CGTTCTTGGC CTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004943.1
CDS	71..787
Translation	MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS

Target ORF information:

RefSeq Version	NM_004952.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ephrin A3 (EFNA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004952.4

ORF Insert Sequence:

ATGGCGGCGG CTCCGCTGCT GCTGCTGCTG CTGCTCGTGC CCGTGCCGCT GCTGCCGCTG 
CTGGCCCAAG GGCCCGGAGG GGCGCTGGGA AACCGGCATG CGGTGTACTG GAACAGCTCC 
AACCAGCACC TGCGGCGAGA GGGCTACACC GTGCAGGTGA ACGTGAACGA CTATCTGGAT 
ATTTACTGCC CGCACTACAA CAGCTCGGGG GTGGGCCCCG GGGCGGGACC GGGGCCCGGA 
GGCGGGGCAG AGCAGTACGT GCTGTACATG GTGAGCCGCA ACGGCTACCG CACCTGCAAC 
GCCAGCCAGG GCTTCAAGCG CTGGGAGTGC AACCGGCCGC ACGCCCCGCA CAGCCCCATC 
AAGTTCTCGG AGAAGTTCCA GCGCTACAGC GCCTTCTCTC TGGGCTACGA GTTCCACGCC 
GGCCACGAGT ACTACTACAT CTCCACGCCC ACTCACAACC TGCACTGGAA GTGTCTGAGG 
ATGAAGGTGT TCGTCTGCTG CGCCTCCACA TCGCACTCCG GGGAGAAGCC GGTCCCCACT 
CTCCCCCAGT TCACCATGGG CCCCAATGTG AAGATCAACG TGCTGGAAGA CTTTGAGGGA 
GAGAACCCTC AGGTGCCCAA GCTTGAGAAG AGCATCAGCG GGACCAGCCC CAAACGGGAA 
CACCTGCCCC TGGCCGTGGG CATCGCCTTC TTCCTCATGA CGTTCTTGGC CTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation.
European journal of dermatology : EJD27(5)464-471(2017 Oct)
Nakashima S,Jinnin M,Kanemaru H,Kajihara I,Igata T,Okamoto S,Tazaki Y,Harada M,Masuguchi S,Fukushima S,Masuzawa M,Amoh Y,Masuzawa M,Ihn H

Dissecting the roles of Ephrin-A3 in malignant peripheral nerve sheath tumor by TALENs.
Oncology reports34(1)391-8(2015 Jul)
Wang Z,Liu Z,Liu B,Liu G,Wu S

Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.
Anatomical record (Hoboken, N.J. : 2007)297(10)1908-18(2014 Oct)
Li Y,Liu DX,Li MY,Qin XX,Fang WG,Zhao WD,Chen YH

Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.
Molecular neurobiology49(2)1055-68(2014 Apr)
Lai WB,Wang BJ,Hu MK,Hsu WM,Her GM,Liao YF

Ephrin-As, Eph receptors and integrin ?3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.
Cell biology international37(10)1080-8(2013 Oct)
Makarov A,Ylivinkka I,Nyman TA,Hyyti?inen M,Keski-Oja J

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EFNA3 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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