ESCO2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ESCO2
Entrez Gene ID	157570
Full Name	establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms	2410004I17Rik,EFO2,RBS
General protein information	Preferred Names establishment of sister chromatid cohesion N-acetyltransferase 2 Names N-acetyltransferase ESCO2 ECO1 homolog 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p21.1
Summary	This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008].
Disorder MIM:	609353
Disorder Html:	Roberts syndrome, 268300 (3); SC phocomelia syndrome, 269000 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017420.3	NP_001017420.1	N-acetyltransferase ESCO2
XM_011544422.2	XP_011542724.1	N-acetyltransferase ESCO2 isoform X2
XM_011544421.2	XP_011542723.1	N-acetyltransferase ESCO2 isoform X1
NM_001017420.2	NP_001017420.1	N-acetyltransferase ESCO2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ESCO2	XP_528296.2
Canis lupus familiaris (dog)	ESCO2	XP_543224.2
Mus musculus (house mouse)	Esco2	NP_082315.3
Rattus norvegicus (Norway rat)	Esco2	XP_006252234.1
Oryza sativa (rice)	Os04g0498900	NP_001053216.2
Xenopus tropicalis (tropical clawed frog)	esco2	NP_001121462.1
Homo sapiens (human)	ESCO2	NP_001017420.1
Bos taurus (cattle)	ESCO2	NP_001094652.1
Oryza sativa (rice)	Os05g0376300	NP_001055381.1
Gallus gallus (chicken)	ESCO2	XP_420012.3
Danio rerio (zebrafish)	esco2	NP_001003872.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011742	XP_320770.4
Arabidopsis thaliana (thale cress)	CTF7	NP_194868.2

Gene Ontology
Bibliography

Related articles in PubMed

ESCO2 knockdown inhibits cell proliferation and induces apoptosis in human gastric cancer cells.
Chen H, Zhang L, He W, Liu T, Zhao Y, Chen H, Li Y
Biochemical and biophysical research communications(2018 Jan)

Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression.
Alomer RM, da Silva EML, Chen J, Piekarz KM, McDonald K, Sansam CG, Sansam CL, Rankin S
Proceedings of the National Academy of Sciences of the United States of America114(37)9906-9911(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Esco2 is required for double-strand break (DSB) repair, which is consistent with previous studies in Roberts syndrome(RBS) cells.
Title: The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions.

the ESCO2 gene mutation responsible for developmental abnormalities maps to chromosome 8p21.
Title: A child with Roberts syndrome.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

These results demonstrated that the Staf binding site functioned as the basal transcriptional activator of the S phase-specific gene ESCO2, but other mechanisms are required for cell cycle-dependent expression.
Title: Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene.

ESCO2 has an S-phase specific role in the maintenance of genome stability
Title: The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.

The following ESCO2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ESCO2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25405	NM_001017420.3 Latest version!	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu25405	XM_011544421.2 Latest version!	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu76885	XM_011544422.2 Latest version!	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu25405	NM_001017420.2	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ESCO2 ( NM_001017420.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017420.1 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), mRNA.

Price & Availability↑

CloneID	OHu25405
Clone ID Related Accession (Same CDS sequence)	NM_001017420.3 , XM_011544421.2 , NM_001017420.2
Accession Version	NM_001017420.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY882862.1, AF306679.1 and AC104997.4. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001017420.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL832666.1, SRR1803612.162167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305188.13/ ENSP00000306999.8 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GGCAAGTTAT TTGCAACCAA GTACTGCAAC ACCCCTAATT TCCTCGTATA TAATTTTAAT 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017420.1
CDS	71..1876
Translation	MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS

Target ORF information:

RefSeq Version	NM_001017420.3
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017420.3

ORF Insert Sequence:

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GGCAAGTTAT TTGCAACCAA GTACTGCAAC ACCCCTAATT TCCTCGTATA TAATTTTAAT 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESCO2 ( NM_001017420.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017420.1 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), mRNA.

Price & Availability↑

CloneID	OHu25405
Clone ID Related Accession (Same CDS sequence)	NM_001017420.3 , XM_011544421.2 , NM_001017420.2
Accession Version	NM_001017420.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY882862.1 and AF306679.1. This sequence is a reference standard in the RefSeqGene project. On May 11, 2005 this sequence version replaced NM_001017420.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF306679.1, AL832666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GGCAAGTTAT TTGCAACCAA GTACTGCAAC ACCCCTAATT TCCTCGTATA TAATTTTAAT 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017420.1
CDS	84..1889
Translation	MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS

Target ORF information:

RefSeq Version	NM_001017420.2
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017420.2

ORF Insert Sequence:

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GGCAAGTTAT TTGCAACCAA GTACTGCAAC ACCCCTAATT TCCTCGTATA TAATTTTAAT 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESCO2 ( XM_011544421.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542723.1 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu25405
Clone ID Related Accession (Same CDS sequence)	NM_001017420.3 , XM_011544421.2 , NM_001017420.2
Accession Version	XM_011544421.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544421.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GGCAAGTTAT TTGCAACCAA GTACTGCAAC ACCCCTAATT TCCTCGTATA TAATTTTAAT 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542723.1
CDS	137..1942
Translation	MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS

Target ORF information:

RefSeq Version	XM_011544421.2
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544421.2

ORF Insert Sequence:

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GGCAAGTTAT TTGCAACCAA GTACTGCAAC ACCCCTAATT TCCTCGTATA TAATTTTAAT 
AGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ESCO2 ( XM_011544422.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542724.1 Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), transcript variant X3, mRNA.

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CloneID	OHu76885
Clone ID Related Accession (Same CDS sequence)	XM_011544422.2
Accession Version	XM_011544422.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	N-acetyltransferase ESCO2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544422.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GATTGTAGAA GATTAAATAG GTACCAGGAG ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542724.1
CDS	85..1860
Translation	MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDDCRRLNRYQET

Target ORF information:

RefSeq Version	XM_011544422.2
Organism	Homo sapiens(human)
Definition	Homo sapiens establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544422.2

ORF Insert Sequence:

ATGGCAGCTC TTACTCCAAG GAAGAGGAAG CAGGATTCTT TGAAGTGTGA CAGCCTTTTA 
CACTTCACTG AAAATCTGTT TCCATCACCT AATAAAAAGC ACTGTTTTTA TCAAAACAGT 
GATAAAAATG AAGAAAACCT GCATTGCTCT CAACAAGAGC ATTTTGTTTT AAGTGCGCTC 
AAAACAACTG AAATAAATAG ACTGCCATCA GCAAATCAAG GCTCACCATT TAAATCTGCG 
CTCTCCACTG TATCTTTTTA CAACCAAAAT AAGTGGTACC TCAATCCACT GGAGAGAAAG 
CTGATAAAAG AGAGTAGATC TACTTGTCTA AAAACTAATG ATGAAGATAA ATCTTTTCCC 
ATTGTGACAG AAAAAATGCA AGGAAAACCA GTCTGCTCCA AGAAGAACAA CAAAAAACCA 
CAGAAGAGTT TAACTGCTAA GTATCAACCA AAGTATAGAC ACATCAAGCC TGTATCAAGG 
AATTCTAGAA ATTCCAAGCA AAATCGAGTG ATCTATAAGC CAATTGTGGA GAAGGAAAAT 
AATTGTCATT CAGCTGAAAA TAATTCCAAT GCTCCTCGGG TTCTGAGCCA AAAAATAAAA 
CCACAAGTTA CACTCCAGGG TGGAGCAGCA TTTTTTGTTA GAAAAAAATC TTCTCTTAGA 
AAATCGTCCC TGGAAAATGA GCCGTCACTG GGACGCACCC AAAAGAGTAA ATCAGAAGTC 
ATTGAAGATT CTGATGTAGA GACTGTCAGT GAAAAAAAAA CTTTTGCGAC AAGGCAAGTG 
CCAAAGTGCT TGGTCCTAGA AGAGAAATTG AAAATTGGAC TACTGAGTGC AAGCAGTAAA 
AATAAAGAGA AATTAATAAA GGATTCATCA GATGACAGAG TTTCTTCAAA GGAACATAAA 
GTTGATAAAA ATGAGGCTTT TTCTTCAGAG GATTCTCTTG GTGAGAATAA GACAATTTCT 
CCTAAGTCCA CTGTCTATCC AATCTTCAGT GCATCTTCAG TCAATTCAAA AAGATCTTTA 
GGTGAAGAAC AGTTTTCTGT GGGATCTGTC AACTTCATGA AACAGACCAA TATCCAGAAA 
AATACTAATA CCAGAGATAC AAGTAAAAAA ACAAAAGACC AGCTCATCAT CGACGCTGGT 
CAGAAACATT TTGGGGCTAC TGTGTGCAAG TCTTGTGGTA TGATATATAC TGCTTCCAAC 
CCTGAAGATG AAATGCAGCA TGTACAGCAT CACCACAGGT TTCTGGAAGG AATCAAATAT 
GTGGGTTGGA AGAAAGAACG TGTAGTAGCA GAGTTTTGGG ATGGGAAAAT CGTGTTGGTT 
CTGCCACATG ATCCAAGCTT TGCTATCAAA AAGGTAGAAG ATGTCCAAGA ACTTGTTGAT 
AATGAATTGG GCTTCCAGCA AGTTGTTCCT AAATGTCCAA ACAAAATAAA AACTTTTCTT 
TTTATATCTG ATGAAAAGAG AGTAGTTGGG TGTTTAATTG CAGAACCCAT CAAACAGGCA 
TTTCGTGTCC TGTCTGAACC AATTGGTCCA GAATCCCCAA GCTCTACGGA ATGTCCTAGG 
GCTTGGCAAT GTTCAGATGT ACCAGAACCT GCAGTCTGTG GGATAAGTAG AATCTGGGTT 
TTCAGACTGA AGAGAAGAAA GCGCATTGCA AGACGACTGG TTGATACCCT CAGGAATTGC 
TTCATGTTTG GCTGTTTTCT CAGCACTGAT GAAATAGCAT TTTCTGACCC AACACCAGAT 
GATTGTAGAA GATTAAATAG GTACCAGGAG ACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ESCO2 knockdown inhibits cell proliferation and induces apoptosis in human gastric cancer cells.
Biochemical and biophysical research communications(2018 Jan)
Chen H,Zhang L,He W,Liu T,Zhao Y,Chen H,Li Y

Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression.
Proceedings of the National Academy of Sciences of the United States of America114(37)9906-9911(2017 Sep)
Alomer RM,da Silva EML,Chen J,Piekarz KM,McDonald K,Sansam CG,Sansam CL,Rankin S

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ESCO2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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