RDH10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RDH10
Entrez Gene ID	157506
Full Name	retinol dehydrogenase 10
Synonyms	SDR16C4
General protein information	Preferred Names retinol dehydrogenase 10 Names retinol dehydrogenase 10 retinol dehydrogenase 10 (all-trans) short chain dehydrogenase/reductase family 16C member 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.11
Summary	This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011].
Disorder MIM:	607599

mRNA and Protein(s)

mRNA	Protein	Name
NM_172037.5	NP_742034.1	retinol dehydrogenase 10
NM_172037.4	NP_742034.1	retinol dehydrogenase 10

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	RDH10	NP_001186388.1
Xenopus tropicalis (tropical clawed frog)	rdh10	NP_001011091.1
Homo sapiens (human)	RDH10	NP_742034.1
Rattus norvegicus (Norway rat)	Rdh10	NP_852143.1
	RDH10	XP_001084084.1
Mus musculus (house mouse)	Rdh10	NP_598593.1
Canis lupus familiaris (dog)	RDH10	XP_849875.1
Bos taurus (cattle)	RDH10	NP_777159.1
Danio rerio (zebrafish)	rdh10a	NP_001074052.1
Pan troglodytes (chimpanzee)	RDH10	XP_528167.2

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.
Adams MK, Lee SA, Belyaeva OV, Wu L, Kedishvili NY
Chemico-biological interactions27688-94(2017 Oct)

The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-
Belyaeva OV, Adams MK, Wu L, Kedishvili NY
The Journal of biological chemistry292(14)5884-5897(2017 04)

Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.
Kurosaka H, Wang Q, Sandell L, Yamashiro T, Trainor PA
Human molecular genetics26(7)1268-1279(2017 04)

Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.
Obrochta KM, Krois CR, Campos B, Napoli JL
The Journal of biological chemistry290(11)7259-68(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In close proximity to RDH10 gene on human chromosome 8 are located two genes that are phylogenetically related to RDH10. The predicted protein products of these genes, retinol dehydrogenase epidermal 2 (RDHE2, SDR16C5) and retinol dehydrogenase epidermal 2-similar (RDHE2S, SDR16C6), share 59% and 56% sequence similarity with RDH10.
Title: Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.

the bifunctional nature of retinoid oxidoreductase complex provides the RA-based signaling system with robustness by safeguarding appropriate RA concentration despite naturally occurring fluctuations in RDH10 and DHRS3.
Title: The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-

Taken together, our findings demonstrate that RDH10 is essential during the early stages of facial morphogenesis for the formation of a functional nasal airway, and furthermore establish Rdh10 mutant mice as an important model system to study choanal atresia (CA) .
Title: Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.

Insulin inhibits retinoic acid biosynthesis through inhibition of FoxO1-induced Rdh10 gene expression.
Title: Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.

Data indicate that retinaldehyde reductase (DHRS3) requires retinol dehydrogenase 10 (RDH10) for full enzymatic activity and, in turn, activates RDH10.
Title: The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.

The following RDH10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RDH10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22603	NM_172037.5 Latest version!	Homo sapiens retinol dehydrogenase 10 (RDH10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu22603	NM_172037.4	Homo sapiens retinol dehydrogenase 10 (RDH10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RDH10 ( NM_172037.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_742034.1 Homo sapiens retinol dehydrogenase 10 (RDH10), mRNA.

Price & Availability↑

CloneID	OHu22603
Clone ID Related Accession (Same CDS sequence)	NM_172037.5 , NM_172037.4
Accession Version	NM_172037.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	retinol dehydrogenase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD110145.1, AF456765.1, BC067131.1, AC111149.4, BM472905.1, BM804062.1 and BM979260.1. On Nov 22, 2018 this sequence version replaced NM_172037.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC067131.1, SRR1660805.173060.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000240285.10/ ENSP00000240285.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACATCG TGGTGGAGTT CTTCGTGGTC ACTTTCAAAG TGCTCTGGGC GTTCGTGCTG 
GCCGCGGCGC GCTGGCTGGT GCGGCCCAAG GAGAAGAGCG TGGCGGGCCA GGTGTGCCTC 
ATCACCGGCG CCGGCAGCGG CCTGGGCCGC CTCTTCGCGC TGGAGTTCGC CCGGCGTCGG 
GCGCTGCTGG TGCTGTGGGA CATCAACACG CAAAGCAACG AGGAGACGGC TGGCATGGTG 
CGCCACATCT ACCGCGACCT GGAGGCGGCC GACGCCGCTG CGCTGCAAGC TGGGAATGGT 
GAGGAAGAAA TTCTGCCCCA CTGTAACTTG CAGGTTTTTA CCTACACCTG TGACGTGGGG 
AAGAGGGAGA ACGTCTACCT GACGGCTGAA AGAGTCCGCA AGGAGGTTGG CGAAGTCTCA 
GTCCTGGTCA ATAATGCTGG TGTGGTCTCT GGGCATCACC TTCTGGAATG TCCTGATGAG 
CTCATTGAGA GAACCATGAT GGTCAATTGC CATGCACACT TCTGGACCAC TAAGGCTTTT 
CTTCCTACGA TGCTGGAGAT TAATCATGGT CATATTGTGA CAGTTGCAAG TTCCTTGGGA 
TTGTTCAGTA CTGCCGGAGT TGAGGATTAC TGTGCCAGTA AATTTGGAGT TGTGGGTTTT 
CATGAATCCC TGAGCCATGA ACTAAAGGCT GCTGAAAAGG ATGGAATTAA AACAACCTTG 
GTTTGCCCTT ATCTTGTAGA CACTGGCATG TTCAGAGGCT GCCGAATCAG GAAAGAAATT 
GAGCCTTTTC TGCCACCTCT GAAGCCTGAT TACTGTGTGA AGCAGGCCAT GAAGGCCATC 
CTCACTGACC AGCCCATGAT CTGCACTCCC CGCCTCATGT ACATCGTGAC CTTCATGAAG 
AGCATCCTAC CATTTGAAGC AGTTGTGTGC ATGTATCGGT TCCTAGGAGC GGACAAGTGT 
ATGTACCCCT TTATTGCTCA AAGAAAGCAA GCCACAAACA ATAATGAAGC AAAAAATGGA 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742034.1
CDS	689..1714
Translation	MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI

Target ORF information:

RefSeq Version	NM_172037.5
Organism	Homo sapiens(human)
Definition	Homo sapiens retinol dehydrogenase 10 (RDH10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172037.5

ORF Insert Sequence:

ATGAACATCG TGGTGGAGTT CTTCGTGGTC ACTTTCAAAG TGCTCTGGGC GTTCGTGCTG 
GCCGCGGCGC GCTGGCTGGT GCGGCCCAAG GAGAAGAGCG TGGCGGGCCA GGTGTGCCTC 
ATCACCGGCG CCGGCAGCGG CCTGGGCCGC CTCTTCGCGC TGGAGTTCGC CCGGCGTCGG 
GCGCTGCTGG TGCTGTGGGA CATCAACACG CAAAGCAACG AGGAGACGGC TGGCATGGTG 
CGCCACATCT ACCGCGACCT GGAGGCGGCC GACGCCGCTG CGCTGCAAGC TGGGAATGGT 
GAGGAAGAAA TTCTGCCCCA CTGTAACTTG CAGGTTTTTA CCTACACCTG TGACGTGGGG 
AAGAGGGAGA ACGTCTACCT GACGGCTGAA AGAGTCCGCA AGGAGGTTGG CGAAGTCTCA 
GTCCTGGTCA ATAATGCTGG TGTGGTCTCT GGGCATCACC TTCTGGAATG TCCTGATGAG 
CTCATTGAGA GAACCATGAT GGTCAATTGC CATGCACACT TCTGGACCAC TAAGGCTTTT 
CTTCCTACGA TGCTGGAGAT TAATCATGGT CATATTGTGA CAGTTGCAAG TTCCTTGGGA 
TTGTTCAGTA CTGCCGGAGT TGAGGATTAC TGTGCCAGTA AATTTGGAGT TGTGGGTTTT 
CATGAATCCC TGAGCCATGA ACTAAAGGCT GCTGAAAAGG ATGGAATTAA AACAACCTTG 
GTTTGCCCTT ATCTTGTAGA CACTGGCATG TTCAGAGGCT GCCGAATCAG GAAAGAAATT 
GAGCCTTTTC TGCCACCTCT GAAGCCTGAT TACTGTGTGA AGCAGGCCAT GAAGGCCATC 
CTCACTGACC AGCCCATGAT CTGCACTCCC CGCCTCATGT ACATCGTGAC CTTCATGAAG 
AGCATCCTAC CATTTGAAGC AGTTGTGTGC ATGTATCGGT TCCTAGGAGC GGACAAGTGT 
ATGTACCCCT TTATTGCTCA AAGAAAGCAA GCCACAAACA ATAATGAAGC AAAAAATGGA 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RDH10 ( NM_172037.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_742034.1 Homo sapiens retinol dehydrogenase 10 (RDH10), mRNA.

Price & Availability↑

CloneID	OHu22603
Clone ID Related Accession (Same CDS sequence)	NM_172037.5 , NM_172037.4
Accession Version	NM_172037.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	retinol dehydrogenase 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD110145.1, AF456765.1, BC067131.1, AC111149.4, BM472905.1, BM804062.1 and BM979260.1. On Dec 2, 2011 this sequence version replaced NM_172037.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC067131.1, SRR1660805.173060.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAACATCG TGGTGGAGTT CTTCGTGGTC ACTTTCAAAG TGCTCTGGGC GTTCGTGCTG 
GCCGCGGCGC GCTGGCTGGT GCGGCCCAAG GAGAAGAGCG TGGCGGGCCA GGTGTGCCTC 
ATCACCGGCG CCGGCAGCGG CCTGGGCCGC CTCTTCGCGC TGGAGTTCGC CCGGCGTCGG 
GCGCTGCTGG TGCTGTGGGA CATCAACACG CAAAGCAACG AGGAGACGGC TGGCATGGTG 
CGCCACATCT ACCGCGACCT GGAGGCGGCC GACGCCGCTG CGCTGCAAGC TGGGAATGGT 
GAGGAAGAAA TTCTGCCCCA CTGTAACTTG CAGGTTTTTA CCTACACCTG TGACGTGGGG 
AAGAGGGAGA ACGTCTACCT GACGGCTGAA AGAGTCCGCA AGGAGGTTGG CGAAGTCTCA 
GTCCTGGTCA ATAATGCTGG TGTGGTCTCT GGGCATCACC TTCTGGAATG TCCTGATGAG 
CTCATTGAGA GAACCATGAT GGTCAATTGC CATGCACACT TCTGGACCAC TAAGGCTTTT 
CTTCCTACGA TGCTGGAGAT TAATCATGGT CATATTGTGA CAGTTGCAAG TTCCTTGGGA 
TTGTTCAGTA CTGCCGGAGT TGAGGATTAC TGTGCCAGTA AATTTGGAGT TGTGGGTTTT 
CATGAATCCC TGAGCCATGA ACTAAAGGCT GCTGAAAAGG ATGGAATTAA AACAACCTTG 
GTTTGCCCTT ATCTTGTAGA CACTGGCATG TTCAGAGGCT GCCGAATCAG GAAAGAAATT 
GAGCCTTTTC TGCCACCTCT GAAGCCTGAT TACTGTGTGA AGCAGGCCAT GAAGGCCATC 
CTCACTGACC AGCCCATGAT CTGCACTCCC CGCCTCATGT ACATCGTGAC CTTCATGAAG 
AGCATCCTAC CATTTGAAGC AGTTGTGTGC ATGTATCGGT TCCTAGGAGC GGACAAGTGT 
ATGTACCCCT TTATTGCTCA AAGAAAGCAA GCCACAAACA ATAATGAAGC AAAAAATGGA 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742034.1
CDS	689..1714
Translation	MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI

Target ORF information:

RefSeq Version	NM_172037.4
Organism	Homo sapiens(human)
Definition	Homo sapiens retinol dehydrogenase 10 (RDH10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172037.4

ORF Insert Sequence:

ATGAACATCG TGGTGGAGTT CTTCGTGGTC ACTTTCAAAG TGCTCTGGGC GTTCGTGCTG 
GCCGCGGCGC GCTGGCTGGT GCGGCCCAAG GAGAAGAGCG TGGCGGGCCA GGTGTGCCTC 
ATCACCGGCG CCGGCAGCGG CCTGGGCCGC CTCTTCGCGC TGGAGTTCGC CCGGCGTCGG 
GCGCTGCTGG TGCTGTGGGA CATCAACACG CAAAGCAACG AGGAGACGGC TGGCATGGTG 
CGCCACATCT ACCGCGACCT GGAGGCGGCC GACGCCGCTG CGCTGCAAGC TGGGAATGGT 
GAGGAAGAAA TTCTGCCCCA CTGTAACTTG CAGGTTTTTA CCTACACCTG TGACGTGGGG 
AAGAGGGAGA ACGTCTACCT GACGGCTGAA AGAGTCCGCA AGGAGGTTGG CGAAGTCTCA 
GTCCTGGTCA ATAATGCTGG TGTGGTCTCT GGGCATCACC TTCTGGAATG TCCTGATGAG 
CTCATTGAGA GAACCATGAT GGTCAATTGC CATGCACACT TCTGGACCAC TAAGGCTTTT 
CTTCCTACGA TGCTGGAGAT TAATCATGGT CATATTGTGA CAGTTGCAAG TTCCTTGGGA 
TTGTTCAGTA CTGCCGGAGT TGAGGATTAC TGTGCCAGTA AATTTGGAGT TGTGGGTTTT 
CATGAATCCC TGAGCCATGA ACTAAAGGCT GCTGAAAAGG ATGGAATTAA AACAACCTTG 
GTTTGCCCTT ATCTTGTAGA CACTGGCATG TTCAGAGGCT GCCGAATCAG GAAAGAAATT 
GAGCCTTTTC TGCCACCTCT GAAGCCTGAT TACTGTGTGA AGCAGGCCAT GAAGGCCATC 
CTCACTGACC AGCCCATGAT CTGCACTCCC CGCCTCATGT ACATCGTGAC CTTCATGAAG 
AGCATCCTAC CATTTGAAGC AGTTGTGTGC ATGTATCGGT TCCTAGGAGC GGACAAGTGT 
ATGTACCCCT TTATTGCTCA AAGAAAGCAA GCCACAAACA ATAATGAAGC AAAAAATGGA 
ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10.
Chemico-biological interactions27688-94(2017 Oct)
Adams MK,Lee SA,Belyaeva OV,Wu L,Kedishvili NY

The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-
The Journal of biological chemistry292(14)5884-5897(2017 04)
Belyaeva OV,Adams MK,Wu L,Kedishvili NY

Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.
Human molecular genetics26(7)1268-1279(2017 04)
Kurosaka H,Wang Q,Sandell L,Yamashiro T,Trainor PA

Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.
The Journal of biological chemistry290(11)7259-68(2015 Mar)
Obrochta KM,Krois CR,Campos B,Napoli JL

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RDH10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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