ASPRV1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ASPRV1
Entrez Gene ID	151516
Full Name	aspartic peptidase retroviral like 1
Synonyms	MUNO,SASP,SASPase,Taps
General protein information	Preferred Names aspartic peptidase retroviral like 1 Names retroviral-like aspartic protease 1 TPA-inducible aspartic proteinase-like protein skin aspartic protease skin-specific retroviral-like aspartic protease
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.3
Summary	Filaggrin is a structural protein that is crucial for in the development and maintenance of the skin barrier. This gene encodes a retroviral-like protease involved in profilaggrin-to-filaggrin processing. Expression is found primarily in the epidermis and inner root sheath of hair follicles. [provided by RefSeq, May 2017]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	611765

mRNA and Protein(s)

mRNA	Protein	Name
NM_152792.2	NP_690005.2	retroviral-like aspartic protease 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ASPRV1	XP_003586694.1
Homo sapiens (human)	ASPRV1	NP_690005.2
Pan troglodytes (chimpanzee)	ASPRV1	XP_525777.1
	ASPRV1	XP_001098191.1
Mus musculus (house mouse)	Asprv1	NP_080690.2

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin.
Sandilands A, Brown SJ, Goh CS, Pohler E, Wilson NJ, Campbell LE, Miyamoto K, Kubo A, Irvine AD, Thawer-Esmail F, Munro CS, McLean WH, Kudoh J, Amagai M, Matsui T
The Journal of investigative dermatology132(5)1507-10(2012 May)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing.
Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M
EMBO molecular medicine3(6)320-33(2011 Jun)

A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin.
Rhiemeier V, Breitenbach U, Richter KH, Gebhardt C, Vogt I, Hartenstein B, F?rstenberger G, Mauch C, Hess J, Angel P
The American journal of pathology168(4)1354-64(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results failed to find an association between ASPRV1 gene mutations and atopic eczema or clinically dry skin in the European populations studied
Title: Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin.

SASPase activity is indispensable for processing profilaggrin and maintaining the texture and hydration of the stratum corneum.
Title: SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing.

Taps expression is negatively associated with dedifferentiation and malignant progression in squamous cell carcinomas of the skin.
Title: A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin.

Identification and characterization of a new member of the aspartic proteases family, a unique epidermal retroviral-like protease, Skin ASpartic Protease.
Title: Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis.

The following ASPRV1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASPRV1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29140	NM_152792.2 Latest version!	Homo sapiens aspartic peptidase retroviral like 1 (ASPRV1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ASPRV1 ( NM_152792.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_690005.2 Homo sapiens aspartic peptidase retroviral like 1 (ASPRV1), mRNA.

Price & Availability↑

CloneID	OHu29140
Clone ID Related Accession (Same CDS sequence)	NM_152792.2
Accession Version	NM_152792.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	retroviral-like aspartic protease 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK055994.1, AC079811.6, AK057813.1 and BC031997.1. This sequence is a reference standard in the RefSeqGene project. On Jun 5, 2008 this sequence version replaced NM_152792.1. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGAGCC CAGGGGCCAG CCTAGGCATC AAAAAGGCTC TGCAGAGTGA ACAGGCCACA 
GCACTGCCTG CCTCTGCCCC AGCAGTCAGC CAGCCGACCG CGCCTGCTCC CTCCTGCTTG 
CCCAAGGCCG GGCAAGTCAT CCCCACTCTG CTTCGAGAGG CCCCGTTTTC CAGCGTGATT 
GCGCCGACAC TGCTCTGTGG GTTTCTCTTC TTGGCGTGGG TTGCTGCTGA GGTTCCAGAG 
GAGAGCAGCA GGATGGCCGG GAGCGGAGCC AGGAGTGAGG AAGGCCGCCG GCAGCATGCC 
TTCGTCCCGG AACCTTTTGA TGGGGCCAAT GTCGTCCCAA ACCTCTGGCT GCACAGCTTT 
GAAGTCATCA ATGACCTCAA CCATTGGGAC CATATCACCA AGCTAAGGTT CCTGAAAGAG 
TCCCTCAGAG GAGAGGCCCT GGGTGTCTAC AATAGGCTCA GTCCCCAGGA CCAGGGAGAC 
TATGGGACTG TGAAAGAGGC CCTCCTGAAG GCCTTTGGGG TCCCTGGGGC TGCCCCCAGC 
CACCTGCCCA AAGAGATCGT CTTTGCCAAC AGCATGGGTA AGGGCTACTA TCTCAAGGGG 
AAGATTGGCA AAGTGCCCGT GAGGTTCCTG GTGGACTCTG GGGCCCAGGT CTCTGTGGTC 
CACCCAAACT TGTGGGAGGA GGTCACTGAT GGCGATCTGG ACACCCTGCA GCCCTTTGAG 
AATGTGGTAA AGGTGGCCAA TGGTGCTGAA ATGAAGATCC TGGGTGTCTG GGATACAGCG 
GTGTCCCTAG GCAAGCTGAA GCTGAAGGCA CAGTTCCTAG TGGCCAATGC GAGTGCCGAG 
GAAGCCATCA TTGGCACTGA TGTGCTCCAG GACCACAATG CTATCCTGGA CTTTGAGCAC 
CGCACATGCA CCCTGAAAGG GAAGAAGTTT CGCCTTCTGC CTGTGGGAGG GTCCCTGGAA 
GATGAGTTTG ACCTGGAGCT CATAGAGGAG GACCCCTCCT CAGAAGAAGG GCGGCAGGAG 
CTATCCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690005.2
CDS	578..1609
Translation	MGSPGASLGIKKALQSEQATALPASAPAVSQPTAPAPSCLPKAGQVIPTLLREAPFSSVIAPTLLCGFLFLAWVAAEVPEESSRMAGSGARSEEGRRQHAFVPEPFDGANVVPNLWLHSFEVINDLNHWDHITKLRFLKESLRGEALGVYNRLSPQDQGDYGTVKEALLKAFGVPGAAPSHLPKEIVFANSMGKGYYLKGKIGKVPVRFLVDSGAQVSVVHPNLWEEVTDGDLDTLQPFENVVKVANGAEMKILGVWDTAVSLGKLKLKAQFLVANASAEEAIIGTDVLQDHNAILDFEHRTCTLKGKKFRLLPVGGSLEDEFDLELIEEDPSSEEGRQELSH

Target ORF information:

RefSeq Version	NM_152792.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aspartic peptidase retroviral like 1 (ASPRV1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152792.2

ORF Insert Sequence:

ATGGGGAGCC CAGGGGCCAG CCTAGGCATC AAAAAGGCTC TGCAGAGTGA ACAGGCCACA 
GCACTGCCTG CCTCTGCCCC AGCAGTCAGC CAGCCGACCG CGCCTGCTCC CTCCTGCTTG 
CCCAAGGCCG GGCAAGTCAT CCCCACTCTG CTTCGAGAGG CCCCGTTTTC CAGCGTGATT 
GCGCCGACAC TGCTCTGTGG GTTTCTCTTC TTGGCGTGGG TTGCTGCTGA GGTTCCAGAG 
GAGAGCAGCA GGATGGCCGG GAGCGGAGCC AGGAGTGAGG AAGGCCGCCG GCAGCATGCC 
TTCGTCCCGG AACCTTTTGA TGGGGCCAAT GTCGTCCCAA ACCTCTGGCT GCACAGCTTT 
GAAGTCATCA ATGACCTCAA CCATTGGGAC CATATCACCA AGCTAAGGTT CCTGAAAGAG 
TCCCTCAGAG GAGAGGCCCT GGGTGTCTAC AATAGGCTCA GTCCCCAGGA CCAGGGAGAC 
TATGGGACTG TGAAAGAGGC CCTCCTGAAG GCCTTTGGGG TCCCTGGGGC TGCCCCCAGC 
CACCTGCCCA AAGAGATCGT CTTTGCCAAC AGCATGGGTA AGGGCTACTA TCTCAAGGGG 
AAGATTGGCA AAGTGCCCGT GAGGTTCCTG GTGGACTCTG GGGCCCAGGT CTCTGTGGTC 
CACCCAAACT TGTGGGAGGA GGTCACTGAT GGCGATCTGG ACACCCTGCA GCCCTTTGAG 
AATGTGGTAA AGGTGGCCAA TGGTGCTGAA ATGAAGATCC TGGGTGTCTG GGATACAGCG 
GTGTCCCTAG GCAAGCTGAA GCTGAAGGCA CAGTTCCTAG TGGCCAATGC GAGTGCCGAG 
GAAGCCATCA TTGGCACTGA TGTGCTCCAG GACCACAATG CTATCCTGGA CTTTGAGCAC 
CGCACATGCA CCCTGAAAGG GAAGAAGTTT CGCCTTCTGC CTGTGGGAGG GTCCCTGGAA 
GATGAGTTTG ACCTGGAGCT CATAGAGGAG GACCCCTCCT CAGAAGAAGG GCGGCAGGAG 
CTATCCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin.
The Journal of investigative dermatology132(5)1507-10(2012 May)
Sandilands A,Brown SJ,Goh CS,Pohler E,Wilson NJ,Campbell LE,Miyamoto K,Kubo A,Irvine AD,Thawer-Esmail F,Munro CS,McLean WH,Kudoh J,Amagai M,Matsui T

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing.
EMBO molecular medicine3(6)320-33(2011 Jun)
Matsui T,Miyamoto K,Kubo A,Kawasaki H,Ebihara T,Hata K,Tanahashi S,Ichinose S,Imoto I,Inazawa J,Kudoh J,Amagai M

A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin.
The American journal of pathology168(4)1354-64(2006 Apr)
Rhiemeier V,Breitenbach U,Richter KH,Gebhardt C,Vogt I,Hartenstein B,F?rstenberger G,Mauch C,Hess J,Angel P

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ASPRV1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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