GDF7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GDF7
Entrez Gene ID	151449
Full Name	growth differentiation factor 7
Synonyms	BMP12
General protein information	Preferred Names growth differentiation factor 7 Names growth/differentiation factor 7 GDF-7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p24.1
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016].
Disorder MIM:	604651

mRNA and Protein(s)

mRNA	Protein	Name
NM_182828.4	NP_878248.2	growth/differentiation factor 7 preproprotein
NM_182828.3	NP_878248.2	growth/differentiation factor 7 preproprotein

Pathways from BioSystems

Homologies

	GDF7	XP_001096970.1
Gallus gallus (chicken)	GDF7	XP_003641114.2
Bos taurus (cattle)	GDF7	NP_001193030.1
Homo sapiens (human)	GDF7	NP_878248.2
Pan troglodytes (chimpanzee)	GDF7	XP_003308955.1
Mus musculus (house mouse)	Gdf7	NP_038555.1
Rattus norvegicus (Norway rat)	Gdf7	NP_001163821.1
Danio rerio (zebrafish)	gdf7	XP_694563.2
Xenopus tropicalis (tropical clawed frog)	LOC100496775	XP_002934530.1

Gene Ontology
Bibliography

Related articles in PubMed

Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.
Zarychta-Wi?niewska W, Burdzinska A, Kulesza A, Gala K, Kaleta B, Zielniok K, Siennicka K, Sabat M, Paczek L
BMC cell biology18(1)13(2017 Feb)

The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.
Becker J, May A, Gerges C, Anders M, Schmidt C, Veits L, Noder T, Mayershofer R, Kreuser N, Manner H, Venerito M, Hofer JH, Lyros O, Ahlbrand CJ, Arras M, Hofer S, Heinrichs SK, Weise K, Hess T, B?hmer AC, Kosiol N, Kiesslich R, Izbicki JR, H?lscher AH, Bollschweiler E, Malfertheiner P, Lang H, Moehler M, Lorenz D, Ott K, Schmidt T, N?then MM, Hackelsberger A, Schumacher B, Pech O, Vashist Y, Vieth M, Weism?ller J, Knapp M, Neuhaus H, R?sch T, Ell C, Gockel I, Schumacher J
Cancer medicine5(5)888-91(2016 05)

Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.
Gelberman RH, Shen H, Kormpakis I, Rothrauff B, Yang G, Tuan RS, Xia Y, Sakiyama-Elbert S, Silva MJ, Thomopoulos S
Journal of orthopaedic research : official publication of the Orthopaedic Research Society34(4)630-40(2016 Apr)

Local rhBMP-12 on an Absorbable Collagen Sponge as an Adjuvant Therapy for Rotator Cuff Repair - A Phase 1, Randomized, Standard of Care Control, Multicenter Study: Safety and Feasibility.
Greiner S, Ide J, Van Noort A, Mochizuki Y, Ochi H, Marraffino S, Sridharan S, Rudicel S, Itoi E
The American journal of sports medicine43(8)1994-2004(2015 Aug)

Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, Watson P, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J
Gastroenterology148(2)367-78(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BMP-12 activates tenogenic pathway in human adipose stem cells.
Title: Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.

The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.
Title: The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.

closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development
Title: Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.

BMP12 induces tenogenic differentiation of adipose-derived stromal cells via the Smad1/5/8 pathway.
Title: BMP12 induces tenogenic differentiation of adipose-derived stromal cells.

studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers
Title: Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.

The following GDF7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30270	NM_182828.4 Latest version!	Homo sapiens growth differentiation factor 7 (GDF7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu30270	NM_182828.3	Homo sapiens growth differentiation factor 7 (GDF7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GDF7 ( NM_182828.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_878248.2 Homo sapiens growth differentiation factor 7 (GDF7), mRNA.

Price & Availability↑

CloneID	OHu30270
Clone ID Related Accession (Same CDS sequence)	NM_182828.4 , NM_182828.3
Accession Version	NM_182828.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	growth/differentiation factor 7 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF522369.1, AB158468.1, AC012065.8 and BQ182131.1. On Nov 23, 2018 this sequence version replaced NM_182828.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF522369.1, AB158468.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000272224.5/ ENSP00000272224.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC 
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA 
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG 
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC 
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC 
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG 
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC 
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC 
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG 
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT 
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC 
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG 
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT 
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA 
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG 
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG 
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC 
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG 
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC 
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG 
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC 
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG 
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_878248.2
CDS	97..1449
Translation	MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPVRSPGGGGGGGGGGRTLAQAAGAAAVPAAAVPRARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAGAAAVSASGHGRADTITGFTDQATQDESAAETGQSFLFDVSSLNDADEVVGAELRVLRRGSPESGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAEPLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIRAQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR

Target ORF information:

RefSeq Version	NM_182828.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 7 (GDF7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182828.4

ORF Insert Sequence:

ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC 
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA 
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG 
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC 
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC 
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG 
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC 
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC 
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG 
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT 
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC 
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG 
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT 
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA 
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG 
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG 
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC 
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG 
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC 
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG 
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC 
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG 
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GDF7 ( NM_182828.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_878248.2 Homo sapiens growth differentiation factor 7 (GDF7), mRNA.

Price & Availability↑

CloneID	OHu30270
Clone ID Related Accession (Same CDS sequence)	NM_182828.4 , NM_182828.3
Accession Version	NM_182828.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-03
Organism	Homo sapiens(human)
Product	growth/differentiation factor 7 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF522369.1, AB158468.1, AC012065.8 and BQ182131.1. On May 13, 2016 this sequence version replaced NM_182828.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF522369.1, AB158468.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC 
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA 
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG 
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC 
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC 
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG 
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC 
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC 
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG 
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT 
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC 
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG 
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT 
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA 
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG 
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG 
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC 
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG 
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC 
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG 
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC 
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG 
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_878248.2
CDS	577..1929
Translation	MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPVRSPGGGGGGGGGGRTLAQAAGAAAVPAAAVPRARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAGAAAVSASGHGRADTITGFTDQATQDESAAETGQSFLFDVSSLNDADEVVGAELRVLRRGSPESGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAEPLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIRAQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR

Target ORF information:

RefSeq Version	NM_182828.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth differentiation factor 7 (GDF7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182828.3

ORF Insert Sequence:

ATGGACCTGA GCGCCGCCGC CGCGCTGTGC CTTTGGCTGC TGAGCGCCTG CCGCCCCCGC 
GACGGGCTGG AAGCGGCCGC CGTGCTGCGA GCGGCGGGGG CTGGGCCGGT CCGGAGCCCA 
GGGGGCGGCG GCGGCGGCGG CGGCGGCGGG CGGACTCTTG CCCAGGCTGC GGGCGCCGCG 
GCTGTCCCGG CCGCCGCGGT TCCCCGGGCC CGCGCCGCGC GCCGCGCCGC GGGCTCCGGC 
TTCAGGAACG GCTCGGTGGT GCCGCACCAC TTCATGATGT CGCTTTACCG GAGCCTGGCC 
GGGAGGGCTC CGGCCGGGGC AGCCGCTGTC TCCGCCTCGG GCCATGGTCG CGCGGACACG 
ATCACCGGCT TCACAGACCA GGCGACCCAA GACGAATCGG CAGCCGAAAC AGGCCAGAGC 
TTCCTGTTCG ACGTGTCCAG CCTTAACGAC GCAGACGAGG TGGTGGGTGC CGAGCTGCGC 
GTGCTGCGCC GGGGATCTCC AGAGTCGGGC CCAGGCAGCT GGACTTCTCC GCCGTTGCTG 
CTGCTGTCCA CGTGCCCGGG CGCCGCCCGA GCGCCACGCC TGCTGTACTC GCGGGCAGCT 
GAGCCCCTAG TCGGTCAGCG CTGGGAGGCG TTCGACGTGG CGGACGCCAT GAGGCGCCAC 
CGTCGTGAAC CGCGCCCCCC CCGCGCGTTC TGCCTCTTGC TGCGCGCAGT GGCAGGCCCG 
GTGCCGAGCC CGTTGGCACT GCGGCGGCTG GGCTTCGGCT GGCCGGGCGG AGGGGGCTCT 
GCGGCAGAGG AGCGCGCGGT GCTAGTCGTC TCCTCCCGCA CGCAGAGGAA AGAGAGCTTA 
TTCCGGGAGA TCCGCGCCCA GGCCCGCGCG CTCGGGGCCG CTCTGGCCTC AGAGCCGCTG 
CCCGACCCAG GAACCGGCAC CGCGTCGCCA AGGGCAGTCA TTGGCGGCCG CAGACGGAGG 
AGGACGGCGT TGGCCGGGAC GCGGACAGCG CAGGGCAGCG GCGGGGGCGC GGGCCGGGGC 
CACGGGCGCA GGGGCCGGAG CCGCTGCAGC CGCAAGCCGT TGCACGTGGA CTTCAAGGAG 
CTCGGCTGGG ACGACTGGAT CATCGCGCCG CTGGACTACG AGGCGTACCA CTGCGAGGGC 
CTTTGCGACT TCCCTTTGCG TTCGCACCTC GAGCCCACCA ACCATGCCAT CATTCAGACG 
CTGCTCAACT CCATGGCACC AGACGCGGCG CCGGCCTCCT GCTGTGTGCC AGCGCGCCTC 
AGCCCCATCA GCATCCTCTA CATCGACGCC GCCAACAACG TTGTCTACAA GCAATACGAG 
GACATGGTGG TGGAGGCCTG CGGCTGCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.
BMC cell biology18(1)13(2017 Feb)
Zarychta-Wi?niewska W,Burdzinska A,Kulesza A,Gala K,Kaleta B,Zielniok K,Siennicka K,Sabat M,Paczek L

The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.
Cancer medicine5(5)888-91(2016 05)
Becker J,May A,Gerges C,Anders M,Schmidt C,Veits L,Noder T,Mayershofer R,Kreuser N,Manner H,Venerito M,Hofer JH,Lyros O,Ahlbrand CJ,Arras M,Hofer S,Heinrichs SK,Weise K,Hess T,B?hmer AC,Kosiol N,Kiesslich R,Izbicki JR,H?lscher AH,Bollschweiler E,Malfertheiner P,Lang H,Moehler M,Lorenz D,Ott K,Schmidt T,N?then MM,Hackelsberger A,Schumacher B,Pech O,Vashist Y,Vieth M,Weism?ller J,Knapp M,Neuhaus H,R?sch T,Ell C,Gockel I,Schumacher J

Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society34(4)630-40(2016 Apr)
Gelberman RH,Shen H,Kormpakis I,Rothrauff B,Yang G,Tuan RS,Xia Y,Sakiyama-Elbert S,Silva MJ,Thomopoulos S

Local rhBMP-12 on an Absorbable Collagen Sponge as an Adjuvant Therapy for Rotator Cuff Repair - A Phase 1, Randomized, Standard of Care Control, Multicenter Study: Safety and Feasibility.
The American journal of sports medicine43(8)1994-2004(2015 Aug)
Greiner S,Ide J,Van Noort A,Mochizuki Y,Ochi H,Marraffino S,Sridharan S,Rudicel S,Itoi E

Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
Gastroenterology148(2)367-78(2015 Feb)
Palles C,Chegwidden L,Li X,Findlay JM,Farnham G,Castro Giner F,Peppelenbosch MP,Kovac M,Adams CL,Prenen H,Briggs S,Harrison R,Sanders S,MacDonald D,Haigh C,Tucker A,Love S,Nanji M,deCaestecker J,Ferry D,Rathbone B,Hapeshi J,Barr H,Moayyedi P,Watson P,Zietek B,Maroo N,Gay L,Underwood T,Boulter L,McMurtry H,Monk D,Patel P,Ragunath K,Al Dulaimi D,Murray I,Koss K,Veitch A,Trudgill N,Nwokolo C,Rembacken B,Atherfold P,Green E,Ang Y,Kuipers EJ,Chow W,Paterson S,Kadri S,Beales I,Grimley C,Mullins P,Beckett C,Farrant M,Dixon A,Kelly S,Johnson M,Wajed S,Dhar A,Sawyer E,Roylance R,Onstad L,Gammon MD,Corley DA,Shaheen NJ,Bird NC,Hardie LJ,Reid BJ,Ye W,Liu G,Romero Y,Bernstein L,Wu AH,Casson AG,Fitzgerald R,Whiteman DC,Risch HA,Levine DM,Vaughan TL,Verhaar AP,van den Brande J,Toxopeus EL,Spaander MC,Wijnhoven BP,van der Laan LJ,Krishnadath K,Wijmenga C,Trynka G,McManus R,Reynolds JV,O'Sullivan J,MacMathuna P,McGarrigle SA,Kelleher D,Vermeire S,Cleynen I,Bisschops R,Tomlinson I,Jankowski J

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GDF7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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