PPP1R1C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPP1R1C
Entrez Gene ID	151242
Full Name	protein phosphatase 1 regulatory inhibitor subunit 1C
Synonyms	IPP5
General protein information	Preferred Names protein phosphatase 1 regulatory inhibitor subunit 1C Names protein phosphatase 1 regulatory subunit 1C PP1 inhibitor protein 5 inhibitor-5 of protein phosphatase 1 protein phosphatase 1 regulatory subunit 1A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.3-q32.1
Summary	Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010].
Disorder MIM:	613240

mRNA and Protein(s)

mRNA	Protein	Name
NM_001261424.1	NP_001248353.1	protein phosphatase 1 regulatory subunit 1C isoform 1
NM_001080545.2	NP_001074014.1	protein phosphatase 1 regulatory subunit 1C isoform 2
XM_017003451.1	XP_016858940.1	protein phosphatase 1 regulatory subunit 1C isoform X1
NM_001261425.2	NP_001248354.1	protein phosphatase 1 regulatory subunit 1C isoform 2
NM_001261425.1	NP_001248354.1	protein phosphatase 1 regulatory subunit 1C isoform 2
NM_001261424.2	NP_001248353.1	protein phosphatase 1 regulatory subunit 1C isoform 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	ppp1r1c	NP_001002538.1
Bos taurus (cattle)	PPP1R1C	NP_001178281.1
Mus musculus (house mouse)	Ppp1r1c	NP_766008.2
Rattus norvegicus (Norway rat)	Ppp1r1c	NP_001102670.1
Xenopus tropicalis (tropical clawed frog)	ppp1r1c	NP_001165134.1
	PPP1R1C	XP_001101383.1
Gallus gallus (chicken)	PPP1R1C	XP_004942745.1
Homo sapiens (human)	PPP1R1C	NP_001248353.1
Pan troglodytes (chimpanzee)	PPP1R1C	XP_003309401.1
Canis lupus familiaris (dog)	PPP1R1C	XP_005640435.1

Gene Ontology
Bibliography

Related articles in PubMed

Sensitization of cervical carcinoma cells to paclitaxel by an IPP5 active mutant.
Zeng QY, Huang Y, Zeng LJ, Huang M, Huang YQ, Zhu QF
Asian Pacific journal of cancer prevention : APJCP15(19)8337-43(2014)

8-60hIPP5(m)-induced G2/M cell cycle arrest involves activation of ATM/p53/p21(cip1/waf1) pathways and delayed cyclin B1 nuclear translocation.
Zeng QY, Zeng LJ, Huang Y, Huang YQ, Zhu QF, Liao ZH
Asian Pacific journal of cancer prevention : APJCP15(9)4101-7(2014)

IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest.
Zeng Q, Huang Y, Zeng L, Huang Y, Cai D, Zhang H
Cancer genetics205(9)442-52(2012 Sep)

Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the underlying mechanisms involved.
Zeng Q, Huang Y, Zeng L, Lan X, Huang Y, He S, Zhang H
Biotechnology and applied biochemistry54(4)231-8(2009 Dec)

Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution.
Ceulemans H, Stalmans W, Bollen M
BioEssays : news and reviews in molecular, cellular and developmental biology24(4)371-81(2002 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IPP5 mutations are associated with response to paclitaxel in cervical cancer.
Title: Sensitization of cervical carcinoma cells to paclitaxel by an IPP5 active mutant.

The data demonstrate a novel role for 8-60hIPP5(m) in the control of G2/M cell cycle progression, a process that involves the activation of ATM/p53/p21cip1/waf1/Cdc2/ cyclin B1 pathways.
Title: 8-60hIPP5(m)-induced G2/M cell cycle arrest involves activation of ATM/p53/p21(cip1/waf1) pathways and delayed cyclin B1 nuclear translocation.

The effect of IPP5 on tumor growth and the underlying molecular mechanisms were investigated by overexpression of IPP5 in HeLa cells, a human cervical carcinoma cell line.
Title: IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest.

Observational study of gene-disease association. (HuGE Navigator)
Title: Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following PPP1R1C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP1R1C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10313	NM_001261424.2 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10816	NM_001261425.2 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10816	NM_001080545.2 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu89066	XM_017003451.1 Latest version!	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu10816	NM_001261425.1	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10313	NM_001261424.1	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP1R1C ( NM_001261424.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001248353.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10313
Clone ID Related Accession (Same CDS sequence)	NM_001261424.1 , NM_001261424.2
Accession Version	NM_001261424.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-02
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1C isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009962.11, AF494535.1 and AC011291.8. Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF494535.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2159607 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GCTGGGCTTT TGTCGTTCAC AGATCAGGAA AAGAAGACCT 
ACACCAGCAT CACTTGTGAT TCTCAATGAG CATAACCCCC CAGAAATAGA TGACAAGAGG 
GGGCCCAACA CACAAGGGGA ATTACAGAAT GCATCCCCTA AGCAAAGGAA GCAGAGTGTG 
TACACACCAC CCACCATAAA AGGGGTTAAG CATCTGAAAG GCCAGAATGA ATCAGCATTC 
CCTGAAGAAG AAGAAGGCAC CAATGAAAGA GAGGAGCAGC GGGACCATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001248353.1
CDS	288..638
Translation	MEPNSPKKIQFAVPVFQSQIAPEAAEQLGFCRSQIRKRRPTPASLVILNEHNPPEIDDKRGPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH

Target ORF information:

RefSeq Version	NM_001261424.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001261424.1

ORF Insert Sequence:

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GCTGGGCTTT TGTCGTTCAC AGATCAGGAA AAGAAGACCT 
ACACCAGCAT CACTTGTGAT TCTCAATGAG CATAACCCCC CAGAAATAGA TGACAAGAGG 
GGGCCCAACA CACAAGGGGA ATTACAGAAT GCATCCCCTA AGCAAAGGAA GCAGAGTGTG 
TACACACCAC CCACCATAAA AGGGGTTAAG CATCTGAAAG GCCAGAATGA ATCAGCATTC 
CCTGAAGAAG AAGAAGGCAC CAATGAAAGA GAGGAGCAGC GGGACCATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1C ( NM_001261424.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001248353.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10313
Clone ID Related Accession (Same CDS sequence)	NM_001261424.1 , NM_001261424.2
Accession Version	NM_001261424.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-08
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1C isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009962.11, AF494535.1 and AC011291.8. On Jun 2, 2019 this sequence version replaced NM_001261424.1. Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF494535.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2159607 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GCTGGGCTTT TGTCGTTCAC AGATCAGGAA AAGAAGACCT 
ACACCAGCAT CACTTGTGAT TCTCAATGAG CATAACCCCC CAGAAATAGA TGACAAGAGG 
GGGCCCAACA CACAAGGGGA ATTACAGAAT GCATCCCCTA AGCAAAGGAA GCAGAGTGTG 
TACACACCAC CCACCATAAA AGGGGTTAAG CATCTGAAAG GCCAGAATGA ATCAGCATTC 
CCTGAAGAAG AAGAAGGCAC CAATGAAAGA GAGGAGCAGC GGGACCATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001248353.1
CDS	259..609
Translation	MEPNSPKKIQFAVPVFQSQIAPEAAEQLGFCRSQIRKRRPTPASLVILNEHNPPEIDDKRGPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH

Target ORF information:

RefSeq Version	NM_001261424.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001261424.2

ORF Insert Sequence:

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GCTGGGCTTT TGTCGTTCAC AGATCAGGAA AAGAAGACCT 
ACACCAGCAT CACTTGTGAT TCTCAATGAG CATAACCCCC CAGAAATAGA TGACAAGAGG 
GGGCCCAACA CACAAGGGGA ATTACAGAAT GCATCCCCTA AGCAAAGGAA GCAGAGTGTG 
TACACACCAC CCACCATAAA AGGGGTTAAG CATCTGAAAG GCCAGAATGA ATCAGCATTC 
CCTGAAGAAG AAGAAGGCAC CAATGAAAGA GAGGAGCAGC GGGACCATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1C ( NM_001080545.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001074014.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu10816
Clone ID Related Accession (Same CDS sequence)	NM_001080545.2 , NM_001261425.2 , NM_001261425.1
Accession Version	NM_001080545.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-15
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1C isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009962.11, AC064837.6 and AC011291.8. On May 12, 2012 this sequence version replaced NM_001080545.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and differs in the 3' UTR compared to variant 1. The resulting protein is shorter compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.341185.1, SRR1803612.472059.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2151741 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GATCAGGAAA AGAAGACCTA CACCAGCATC ACTTGTGATT 
CTCAATGAGC ATAACCCCCC AGAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074014.1
CDS	288..617
Translation	MEPNSPKKIQFAVPVFQSQIAPEAAEQIRKRRPTPASLVILNEHNPPEIDDKRGPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH

Target ORF information:

RefSeq Version	NM_001080545.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080545.2

ORF Insert Sequence:

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GATCAGGAAA AGAAGACCTA CACCAGCATC ACTTGTGATT 
CTCAATGAGC ATAACCCCCC AGAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1C ( NM_001261425.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001248354.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10816
Clone ID Related Accession (Same CDS sequence)	NM_001080545.2 , NM_001261425.2 , NM_001261425.1
Accession Version	NM_001261425.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-08
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1C isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009962.11, BX647581.1, AK129898.1 and AC011291.8. On Jun 2, 2019 this sequence version replaced NM_001261425.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein is shorter compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BX647581.1, AK129898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GATCAGGAAA AGAAGACCTA CACCAGCATC ACTTGTGATT 
CTCAATGAGC ATAACCCCCC AGAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001248354.1
CDS	259..588
Translation	MEPNSPKKIQFAVPVFQSQIAPEAAEQIRKRRPTPASLVILNEHNPPEIDDKRGPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH

Target ORF information:

RefSeq Version	NM_001261425.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001261425.2

ORF Insert Sequence:

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GATCAGGAAA AGAAGACCTA CACCAGCATC ACTTGTGATT 
CTCAATGAGC ATAACCCCCC AGAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1C ( NM_001261425.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001248354.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10816
Clone ID Related Accession (Same CDS sequence)	NM_001080545.2 , NM_001261425.2 , NM_001261425.1
Accession Version	NM_001261425.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-14
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1C isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009962.11, BX647581.1, AK129898.1 and AC011291.8. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein is shorter compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BX647581.1, AK129898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GATCAGGAAA AGAAGACCTA CACCAGCATC ACTTGTGATT 
CTCAATGAGC ATAACCCCCC AGAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001248354.1
CDS	288..617
Translation	MEPNSPKKIQFAVPVFQSQIAPEAAEQIRKRRPTPASLVILNEHNPPEIDDKRGPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH

Target ORF information:

RefSeq Version	NM_001261425.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001261425.1

ORF Insert Sequence:

ATGGAGCCCA ACAGTCCCAA AAAGATACAG TTTGCCGTGC CTGTATTCCA GAGTCAGATT 
GCACCTGAAG CAGCAGAGCA GATCAGGAAA AGAAGACCTA CACCAGCATC ACTTGTGATT 
CTCAATGAGC ATAACCCCCC AGAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP1R1C ( XM_017003451.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858940.1 Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu89066
Clone ID Related Accession (Same CDS sequence)	XM_017003451.1
Accession Version	XM_017003451.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein phosphatase 1 regulatory subunit 1C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTATGTA TGCTATACTC CCTCATTTCA TTGTGTGTTT ATACACACAC ACACACACAC 
ACATTTGCTT TTCCACATAC AGGGATTGTG ACTGAGCAGC AGAAGAGAAA ACGGGCTCTC 
CAAAACAAGT CCTTTCAACA AAAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858940.1
CDS	142..471
Translation	MLCMLYSLISLCVYTHTHTHTFAFPHTGIVTEQQKRKRALQNKSFQQKIDDKRGPNTQGELQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH

Target ORF information:

RefSeq Version	XM_017003451.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 1C (PPP1R1C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017003451.1

ORF Insert Sequence:

ATGCTATGTA TGCTATACTC CCTCATTTCA TTGTGTGTTT ATACACACAC ACACACACAC 
ACATTTGCTT TTCCACATAC AGGGATTGTG ACTGAGCAGC AGAAGAGAAA ACGGGCTCTC 
CAAAACAAGT CCTTTCAACA AAAAATAGAT GACAAGAGGG GGCCCAACAC ACAAGGGGAA 
TTACAGAATG CATCCCCTAA GCAAAGGAAG CAGAGTGTGT ACACACCACC CACCATAAAA 
GGGGTTAAGC ATCTGAAAGG CCAGAATGAA TCAGCATTCC CTGAAGAAGA AGAAGGCACC 
AATGAAAGAG AGGAGCAGCG GGACCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sensitization of cervical carcinoma cells to paclitaxel by an IPP5 active mutant.
Asian Pacific journal of cancer prevention : APJCP15(19)8337-43(2014)
Zeng QY,Huang Y,Zeng LJ,Huang M,Huang YQ,Zhu QF

8-60hIPP5(m)-induced G2/M cell cycle arrest involves activation of ATM/p53/p21(cip1/waf1) pathways and delayed cyclin B1 nuclear translocation.
Asian Pacific journal of cancer prevention : APJCP15(9)4101-7(2014)
Zeng QY,Zeng LJ,Huang Y,Huang YQ,Zhu QF,Liao ZH

IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest.
Cancer genetics205(9)442-52(2012 Sep)
Zeng Q,Huang Y,Zeng L,Huang Y,Cai D,Zhang H

Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the underlying mechanisms involved.
Biotechnology and applied biochemistry54(4)231-8(2009 Dec)
Zeng Q,Huang Y,Zeng L,Lan X,Huang Y,He S,Zhang H

Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution.
BioEssays : news and reviews in molecular, cellular and developmental biology24(4)371-81(2002 Apr)
Ceulemans H,Stalmans W,Bollen M

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PPP1R1C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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