NLRP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NLRP4
Entrez Gene ID	147945
Full Name	NLR family pyrin domain containing 4
Synonyms	CLR19.5,CT58,NALP4,PAN2,PYPAF4,RNH2
General protein information	Preferred Names NLR family pyrin domain containing 4 Names NACHT, LRR and PYD domains-containing protein 4 NACHT, leucine rich repeat and PYD containing 4 PAAD and NACHT-containing protein 2 PYRIN and NACHT-containing protein 2 PYRIN-containing APAF1-like protein 4 cancer/testis antigen 58 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4 ribonuclease inhibitor 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.43
Summary	The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016].
Disorder MIM:	609645

mRNA and Protein(s)

mRNA	Protein	Name
NM_134444.5	NP_604393.2	NACHT, LRR and PYD domains-containing protein 4
XM_017026345.1	XP_016881834.1	NACHT, LRR and PYD domains-containing protein 4 isoform X2
NM_134444.4	NP_604393.2	NACHT, LRR and PYD domains-containing protein 4
XM_017026344.1	XP_016881833.1	NACHT, LRR and PYD domains-containing protein 4 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NLRP4	NP_604393.2
	NLRP4	XP_001090438.1
Mus musculus (house mouse)	Nlrp4e	NP_001004194.2
Mus musculus (house mouse)	Nlrp4c	NP_113566.2
Rattus norvegicus (Norway rat)	Nlrp4	NP_001165635.1
Pan troglodytes (chimpanzee)	NLRP4	XP_524404.4

Gene Ontology
Bibliography

Related articles in PubMed

NLRP4 is an essential negative regulator of fructose-induced cardiac injury in vitro and in vivo.
Lian YG, Zhao HY, Wang SJ, Xu QL, Xia XJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie91590-601(2017 Jul)

The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation.
Nozawa T, Aikawa C, Minowa-Nozawa A, Nakagawa I
Autophagy13(11)1841-1854(2017)

USP38 Inhibits Type I Interferon Signaling by Editing TBK1?Ubiquitination through NLRP4 Signalosome.
Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, Qin Y, Wang RF, Cui J
Molecular cell64(2)267-281(2016 Oct)

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF
Nature immunology13(4)387-95(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin domain fold.
Title: Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization.

Findings suggest that NLR family pyrin domain containing 2 (NLRP2P) is a processed pseudogene that regulates NF-kappaB RelA/p65 activity and thus represents the newest member of the POP family, pyrin-only protein 4 (POP4; NLRP4).
Title: The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-?B, pyrin-only protein 4.

Structural and functional analysis of the NLRP4 pyrin domain.
Title: Structural and functional analysis of the NLRP4 pyrin domain.

Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation.
Title: NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.

NLRP4 is recruited to and accumulates in bacteria-containing phagosomes and transiently dissociates from beclin1 following group A streptococcus infection, thereby controlling the autophagic flux crucial for cell-autonomous antibacterial resistance.
Title: NLRP4 negatively regulates autophagic processes through an association with beclin1.

The following NLRP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NLRP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31714	NM_134444.5 Latest version!	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
OHu88242	XM_017026344.1 Latest version!	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu88243	XM_017026345.1 Latest version!	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OHu31714	NM_134444.4	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NLRP4 ( NM_134444.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_604393.2 Homo sapiens NLR family pyrin domain containing 4 (NLRP4), mRNA.

Price & Availability↑

CloneID	OHu31714
Clone ID Related Accession (Same CDS sequence)	NM_134444.5 , NM_134444.4
Accession Version	NM_134444.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2985bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012310.5, AK315003.1, AF479747.1, BE302040.1 and BU632773.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_134444.4. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK315003.1, BC050326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301295.11/ ENSP00000301295.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGCTG GTAAATTGTC ACCTCTCACC CATTGATTGT 
GAAGTCCTTG CTGGCCTTCT AACCAACAAC AAGAAGCTGA CGTATCTGAA TGTATCCTGC 
AACCAGTTAG ACACAGGCGT GCCCCTTTTG TGTGAAGCCC TGTGCAGCCC AGACACGGTC 
CTGGTATACC TGATGTTGGC TTTCTGCCAC CTCAGCGAGC AGTGCTGCGA ATACATCTCT 
GAAATGCTTC TGCGTAACAA GAGCGTGCGC TATCTAGACC TCAGTGCCAA TGTCCTGAAG 
GACGAAGGAC TGAAAACTCT CTGCGAGGCC TTGAAACATC CGGACTGCTG CCTGGATTCA 
CTGTGTTTGG TAAAATGTTT TATCACTGCT GCTGGCTGTG AAGACCTCGC CTCTGCTCTC 
ATCAGCAATC AAAACCTGAA GATTCTGCAA ATTGGGTGCA ATGAAATCGG AGATGTGGGT 
GTGCAGCTGT TGTGTCGGGC TCTGACGCAT ACGGATTGCC GCTTAGAGAT TCTTGGGTTG 
GAAGAATGTG GGTTAACGAG CACCTGCTGT AAGGATCTCG CGTCTGTTCT CACCTGCAGT 
AAGACCCTGC AGCAGCTCAA CCTGACCTTG AACACCTTGG ACCACACAGG GGTGGTTGTA 
CTCTGTGAGG CCCTGAGACA CCCAGAGTGT GCCCTGCAGG TGCTCGGGCT GAGAAAAACT 
GATTTTGATG AGGAAACCCA GGCACTTCTG ACGGCTGAGG AAGAGAGAAA TCCTAACCTG 
ACCATCACAG ACGACTGTGA CACAATCACA AGGGTAGAGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_604393.2
CDS	461..3445
Translation	MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITRVEI

Target ORF information:

RefSeq Version	NM_134444.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134444.5

ORF Insert Sequence:

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGCTG GTAAATTGTC ACCTCTCACC CATTGATTGT 
GAAGTCCTTG CTGGCCTTCT AACCAACAAC AAGAAGCTGA CGTATCTGAA TGTATCCTGC 
AACCAGTTAG ACACAGGCGT GCCCCTTTTG TGTGAAGCCC TGTGCAGCCC AGACACGGTC 
CTGGTATACC TGATGTTGGC TTTCTGCCAC CTCAGCGAGC AGTGCTGCGA ATACATCTCT 
GAAATGCTTC TGCGTAACAA GAGCGTGCGC TATCTAGACC TCAGTGCCAA TGTCCTGAAG 
GACGAAGGAC TGAAAACTCT CTGCGAGGCC TTGAAACATC CGGACTGCTG CCTGGATTCA 
CTGTGTTTGG TAAAATGTTT TATCACTGCT GCTGGCTGTG AAGACCTCGC CTCTGCTCTC 
ATCAGCAATC AAAACCTGAA GATTCTGCAA ATTGGGTGCA ATGAAATCGG AGATGTGGGT 
GTGCAGCTGT TGTGTCGGGC TCTGACGCAT ACGGATTGCC GCTTAGAGAT TCTTGGGTTG 
GAAGAATGTG GGTTAACGAG CACCTGCTGT AAGGATCTCG CGTCTGTTCT CACCTGCAGT 
AAGACCCTGC AGCAGCTCAA CCTGACCTTG AACACCTTGG ACCACACAGG GGTGGTTGTA 
CTCTGTGAGG CCCTGAGACA CCCAGAGTGT GCCCTGCAGG TGCTCGGGCT GAGAAAAACT 
GATTTTGATG AGGAAACCCA GGCACTTCTG ACGGCTGAGG AAGAGAGAAA TCCTAACCTG 
ACCATCACAG ACGACTGTGA CACAATCACA AGGGTAGAGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP4 ( NM_134444.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_604393.2 Homo sapiens NLR family pyrin domain containing 4 (NLRP4), mRNA.

Price & Availability↑

CloneID	OHu31714
Clone ID Related Accession (Same CDS sequence)	NM_134444.5 , NM_134444.4
Accession Version	NM_134444.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2985bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315003.1, AC012310.5, AF479747.1, BE302040.1 and BU632773.1. This sequence is a reference standard in the RefSeqGene project. On Jul 10, 2008 this sequence version replaced NM_134444.3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK315003.1, BC050326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGCTG GTAAATTGTC ACCTCTCACC CATTGATTGT 
GAAGTCCTTG CTGGCCTTCT AACCAACAAC AAGAAGCTGA CGTATCTGAA TGTATCCTGC 
AACCAGTTAG ACACAGGCGT GCCCCTTTTG TGTGAAGCCC TGTGCAGCCC AGACACGGTC 
CTGGTATACC TGATGTTGGC TTTCTGCCAC CTCAGCGAGC AGTGCTGCGA ATACATCTCT 
GAAATGCTTC TGCGTAACAA GAGCGTGCGC TATCTAGACC TCAGTGCCAA TGTCCTGAAG 
GACGAAGGAC TGAAAACTCT CTGCGAGGCC TTGAAACATC CGGACTGCTG CCTGGATTCA 
CTGTGTTTGG TAAAATGTTT TATCACTGCT GCTGGCTGTG AAGACCTCGC CTCTGCTCTC 
ATCAGCAATC AAAACCTGAA GATTCTGCAA ATTGGGTGCA ATGAAATCGG AGATGTGGGT 
GTGCAGCTGT TGTGTCGGGC TCTGACGCAT ACGGATTGCC GCTTAGAGAT TCTTGGGTTG 
GAAGAATGTG GGTTAACGAG CACCTGCTGT AAGGATCTCG CGTCTGTTCT CACCTGCAGT 
AAGACCCTGC AGCAGCTCAA CCTGACCTTG AACACCTTGG ACCACACAGG GGTGGTTGTA 
CTCTGTGAGG CCCTGAGACA CCCAGAGTGT GCCCTGCAGG TGCTCGGGCT GAGAAAAACT 
GATTTTGATG AGGAAACCCA GGCACTTCTG ACGGCTGAGG AAGAGAGAAA TCCTAACCTG 
ACCATCACAG ACGACTGTGA CACAATCACA AGGGTAGAGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_604393.2
CDS	423..3407
Translation	MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITRVEI

Target ORF information:

RefSeq Version	NM_134444.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134444.4

ORF Insert Sequence:

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGCTG GTAAATTGTC ACCTCTCACC CATTGATTGT 
GAAGTCCTTG CTGGCCTTCT AACCAACAAC AAGAAGCTGA CGTATCTGAA TGTATCCTGC 
AACCAGTTAG ACACAGGCGT GCCCCTTTTG TGTGAAGCCC TGTGCAGCCC AGACACGGTC 
CTGGTATACC TGATGTTGGC TTTCTGCCAC CTCAGCGAGC AGTGCTGCGA ATACATCTCT 
GAAATGCTTC TGCGTAACAA GAGCGTGCGC TATCTAGACC TCAGTGCCAA TGTCCTGAAG 
GACGAAGGAC TGAAAACTCT CTGCGAGGCC TTGAAACATC CGGACTGCTG CCTGGATTCA 
CTGTGTTTGG TAAAATGTTT TATCACTGCT GCTGGCTGTG AAGACCTCGC CTCTGCTCTC 
ATCAGCAATC AAAACCTGAA GATTCTGCAA ATTGGGTGCA ATGAAATCGG AGATGTGGGT 
GTGCAGCTGT TGTGTCGGGC TCTGACGCAT ACGGATTGCC GCTTAGAGAT TCTTGGGTTG 
GAAGAATGTG GGTTAACGAG CACCTGCTGT AAGGATCTCG CGTCTGTTCT CACCTGCAGT 
AAGACCCTGC AGCAGCTCAA CCTGACCTTG AACACCTTGG ACCACACAGG GGTGGTTGTA 
CTCTGTGAGG CCCTGAGACA CCCAGAGTGT GCCCTGCAGG TGCTCGGGCT GAGAAAAACT 
GATTTTGATG AGGAAACCCA GGCACTTCTG ACGGCTGAGG AAGAGAGAAA TCCTAACCTG 
ACCATCACAG ACGACTGTGA CACAATCACA AGGGTAGAGA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP4 ( XM_017026344.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881833.1 Homo sapiens NLR family pyrin domain containing 4 (NLRP4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88242
Clone ID Related Accession (Same CDS sequence)	XM_017026344.1
Accession Version	XM_017026344.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2817bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGTTG GCTTTCTGCC ACCTCAGCGA GCAGTGCTGC 
GAATACATCT CTGAAATGCT TCTGCGTAAC AAGAGCGTGC GCTATCTAGA CCTCAGTGCC 
AATGTCCTGA AGGACGAAGG ACTGAAAACT CTCTGCGAGG CCTTGAAACA TCCGGACTGC 
TGCCTGGATT CACTGTGTTT GGTAAAATGT TTTATCACTG CTGCTGGCTG TGAAGACCTC 
GCCTCTGCTC TCATCAGCAA TCAAAACCTG AAGATTCTGC AAATTGGGTG CAATGAAATC 
GGAGATGTGG GTGTGCAGCT GTTGTGTCGG GCTCTGACGC ATACGGATTG CCGCTTAGAG 
ATTCTTGGGT TGGAAGAATG TGGGTTAACG AGCACCTGCT GTAAGGATCT CGCGTCTGTT 
CTCACCTGCA GTAAGACCCT GCAGCAGCTC AACCTGACCT TGAACACCTT GGACCACACA 
GGGGTGGTTG TACTCTGTGA GGCCCTGAGA CACCCAGAGT GTGCCCTGCA GGTGCTCGGG 
CTGAGAAAAA CTGATTTTGA TGAGGAAACC CAGGCACTTC TGACGGCTGA GGAAGAGAGA 
AATCCTAACC TGACCATCAC AGACGACTGT GACACAATCA CAAGGGTAGA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881833.1
CDS	66..2882
Translation	MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITRVEI

Target ORF information:

RefSeq Version	XM_017026344.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026344.1

ORF Insert Sequence:

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGTTG GCTTTCTGCC ACCTCAGCGA GCAGTGCTGC 
GAATACATCT CTGAAATGCT TCTGCGTAAC AAGAGCGTGC GCTATCTAGA CCTCAGTGCC 
AATGTCCTGA AGGACGAAGG ACTGAAAACT CTCTGCGAGG CCTTGAAACA TCCGGACTGC 
TGCCTGGATT CACTGTGTTT GGTAAAATGT TTTATCACTG CTGCTGGCTG TGAAGACCTC 
GCCTCTGCTC TCATCAGCAA TCAAAACCTG AAGATTCTGC AAATTGGGTG CAATGAAATC 
GGAGATGTGG GTGTGCAGCT GTTGTGTCGG GCTCTGACGC ATACGGATTG CCGCTTAGAG 
ATTCTTGGGT TGGAAGAATG TGGGTTAACG AGCACCTGCT GTAAGGATCT CGCGTCTGTT 
CTCACCTGCA GTAAGACCCT GCAGCAGCTC AACCTGACCT TGAACACCTT GGACCACACA 
GGGGTGGTTG TACTCTGTGA GGCCCTGAGA CACCCAGAGT GTGCCCTGCA GGTGCTCGGG 
CTGAGAAAAA CTGATTTTGA TGAGGAAACC CAGGCACTTC TGACGGCTGA GGAAGAGAGA 
AATCCTAACC TGACCATCAC AGACGACTGT GACACAATCA CAAGGGTAGA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NLRP4 ( XM_017026345.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881834.1 Homo sapiens NLR family pyrin domain containing 4 (NLRP4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu88243
Clone ID Related Accession (Same CDS sequence)	XM_017026345.1
Accession Version	XM_017026345.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2814bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NACHT, LRR and PYD domains-containing protein 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGCTG GTAAATTGTC ACCTCTCACC CATTGATTGT 
GAAGTCCTTG CTGGCCTTCT AACCAACAAC AAGAAGCTGA CGTATCTGAA TGTATCCTGC 
AACCAGTTAG ACACAGGCGT GCCCCTTTTG TGTGAAGCCC TGTGCAGCCC AGACACGGTC 
CTGGTATACC TGATGTTGGC TTTCTGCCAC CTCAGCGAGC AGTGCTGCGA ATACATCTCT 
GAAATGCTTC TGCGTAACAA GAGCGTGCGC TATCTAGACC TCAGTGCCAA TGTCCTGAAG 
GACGAAGGAC TGAAAACTCT CTGCGAGGCC TTGAAACATC CGGACTGCTG CCTGGATTCA 
CTGTGGTTGG AAGAATGTGG GTTAACGAGC ACCTGCTGTA AGGATCTCGC GTCTGTTCTC 
ACCTGCAGTA AGACCCTGCA GCAGCTCAAC CTGACCTTGA ACACCTTGGA CCACACAGGG 
GTGGTTGTAC TCTGTGAGGC CCTGAGACAC CCAGAGTGTG CCCTGCAGGT GCTCGGGCTG 
AGAAAAACTG ATTTTGATGA GGAAACCCAG GCACTTCTGA CGGCTGAGGA AGAGAGAAAT 
CCTAACCTGA CCATCACAGA CGACTGTGAC ACAATCACAA GGGTAGAGAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881834.1
CDS	66..2879
Translation	MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLWLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITRVEI

Target ORF information:

RefSeq Version	XM_017026345.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NLR family pyrin domain containing 4 (NLRP4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026345.1

ORF Insert Sequence:

ATGGCAGCCT CTTTCTTCTC TGATTTTGGT CTTATGTGGT ATCTGGAGGA GCTCAAAAAG 
GAGGAGTTCA GGAAATTTAA AGAACATCTC AAGCAAATGA CTTTGCAGCT TGAACTCAAG 
CAGATTCCCT GGACTGAGGT CAAAAAAGCA TCCCGGGAAG AACTTGCAAA CCTCTTGATC 
AAGCACTATG AAGAACAACA AGCTTGGAAC ATAACCTTAA GAATCTTTCA AAAGATGGAT 
AGAAAGGATC TCTGCATGAA GGTCATGAGG GAGAGAACAG GATACACAAA GACCTATCAA 
GCTCACGCAA AGCAGAAATT CAGCCGCTTA TGGTCCAGCA AGTCTGTCAC TGAGATTCAC 
CTATACTTTG AGGAGGAAGT CAAGCAAGAA GAATGTGACC ATTTGGACCG CCTTTTTGCT 
CCCAAGGAAG CTGGGAAACA GCCACGTACA GTGATCATTC AAGGACCACA AGGAATTGGA 
AAAACGACAC TCCTGATGAA GCTGATGATG GCCTGGTCGG ACAACAAGAT CTTTCGGGAT 
AGGTTCCTGT ACACGTTCTA TTTCTGCTGC AGAGAACTGA GGGAGTTGCC GCCAACGAGT 
TTGGCTGACT TGATTTCCAG AGAGTGGCCT GACCCCGCTG CTCCTATAAC AGAGATCGTG 
TCTCAACCGG AGAGACTCTT GTTCGTCATC GACAGCTTCG AAGAGCTGCA GGGCGGCTTG 
AACGAACCCG ATTCGGATCT GTGTGGTGAC TTGATGGAGA AACGGCCGGT GCAGGTGCTT 
CTGAGCAGTT TGCTGAGGAA GAAGATGCTC CCGGAGGCCT CCCTGCTCAT CGCTATCAAA 
CCCGTGTGCC CGAAGGAGCT CCGGGATCAG GTGACGATCT CAGAAATCTA CCAGCCCCGG 
GGATTCAACG AGAGTGATAG GTTAGTGTAT TTCTGCTGTT TCTTCAAAGA CCCGAAAAGA 
GCCATGGAAG CCTTCAATCT TGTAAGAGAA AGTGAACAGC TGTTTTCCAT ATGCCAAATC 
CCGCTCCTCT GCTGGATCCT GTGTACCAGT CTGAAGCAAG AGATGCAGAA AGGAAAAGAC 
CTGGCCCTGA CCTGCCAGAG CACTACCTCT GTGTACTCCT CTTTCGTCTT TAACCTGTTC 
ACACCTGAGG GTGCCGAGGG CCCGACTCCG CAAACCCAGC ACCAGCTGAA GGCCCTGTGC 
TCCCTGGCTG CAGAGGGTAT GTGGACAGAC ACATTTGAGT TTTGTGAAGA CGACCTCCGG 
AGAAATGGGG TTGTTGACGC TGACATCCCT GCGCTGCTGG GCACCAAGAT ACTTCTGAAG 
TACGGGGAGC GTGAGAGCTC CTACGTGTTC CTCCACGTGT GTATCCAGGA GTTCTGTGCC 
GCCTTGTTCT ATTTGCTCAA GAGCCACCTT GATCATCCTC ACCCAGCTGT GAGATGTGTA 
CAGGAATTGC TAGTTGCCAA TTTTGAAAAA GCAAGGAGAG CACATTGGAT TTTTTTGGGG 
TGTTTTCTAA CTGGCCTTTT AAATAAAAAG GAACAAGAAA AACTGGATGC GTTTTTTGGC 
TTCCAACTGT CCCAAGAGAT AAAGCAGCAA ATTCACCAGT GCCTGAAGAG CTTAGGGGAG 
CGTGGCAATC CTCAGGGACA GGTGGATTCC TTGGCGATAT TTTACTGTCT CTTTGAAATG 
CAGGATCCTG CCTTTGTGAA GCAGGCAGTG AACCTCCTCC AAGAAGCTAA CTTTCATATT 
ATTGACAACG TGGACTTGGT GGTTTCTGCC TACTGCTTAA AATACTGCTC CAGCTTGAGG 
AAACTCTGTT TTTCCGTTCA AAATGTCTTT AAGAAAGAGG ATGAACACAG CTCTACGTCG 
GATTACAGCC TCATCTGTTG GCATCACATC TGCTCTGTGC TCACCACCAG CGGGCACCTC 
AGAGAGCTCC AGGTGCAGGA CAGCACCCTC AGCGAGTCGA CCTTTGTGAC CTGGTGTAAC 
CAGCTGAGGC ATCCCAGCTG TCGCCTTCAG AAGCTTGGAA TAAATAACGT TTCCTTTTCT 
GGCCAGAGTG TTCTGCTCTT TGAGGTGCTC TTTTATCAGC CAGACTTGAA ATACCTGAGC 
TTCACCCTCA CGAAACTCTC TCGTGATGAC ATCAGGTCCC TCTGTGATGC CTTGAACTAC 
CCAGCAGGCA ACGTCAAAGA GCTAGCGCTG GTAAATTGTC ACCTCTCACC CATTGATTGT 
GAAGTCCTTG CTGGCCTTCT AACCAACAAC AAGAAGCTGA CGTATCTGAA TGTATCCTGC 
AACCAGTTAG ACACAGGCGT GCCCCTTTTG TGTGAAGCCC TGTGCAGCCC AGACACGGTC 
CTGGTATACC TGATGTTGGC TTTCTGCCAC CTCAGCGAGC AGTGCTGCGA ATACATCTCT 
GAAATGCTTC TGCGTAACAA GAGCGTGCGC TATCTAGACC TCAGTGCCAA TGTCCTGAAG 
GACGAAGGAC TGAAAACTCT CTGCGAGGCC TTGAAACATC CGGACTGCTG CCTGGATTCA 
CTGTGGTTGG AAGAATGTGG GTTAACGAGC ACCTGCTGTA AGGATCTCGC GTCTGTTCTC 
ACCTGCAGTA AGACCCTGCA GCAGCTCAAC CTGACCTTGA ACACCTTGGA CCACACAGGG 
GTGGTTGTAC TCTGTGAGGC CCTGAGACAC CCAGAGTGTG CCCTGCAGGT GCTCGGGCTG 
AGAAAAACTG ATTTTGATGA GGAAACCCAG GCACTTCTGA CGGCTGAGGA AGAGAGAAAT 
CCTAACCTGA CCATCACAGA CGACTGTGAC ACAATCACAA GGGTAGAGAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NLRP4 is an essential negative regulator of fructose-induced cardiac injury in vitro and in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie91590-601(2017 Jul)
Lian YG,Zhao HY,Wang SJ,Xu QL,Xia XJ

The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation.
Autophagy13(11)1841-1854(2017)
Nozawa T,Aikawa C,Minowa-Nozawa A,Nakagawa I

USP38 Inhibits Type I Interferon Signaling by Editing TBK1?Ubiquitination through NLRP4 Signalosome.
Molecular cell64(2)267-281(2016 Oct)
Lin M,Zhao Z,Yang Z,Meng Q,Tan P,Xie W,Qin Y,Wang RF,Cui J

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
Nature immunology13(4)387-95(2012 Mar)
Cui J,Li Y,Zhu L,Liu D,Songyang Z,Wang HY,Wang RF

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NLRP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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