KCTD11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCTD11
Entrez Gene ID	147040
Full Name	potassium channel tetramerization domain containing 11
Synonyms	C17orf36,KCASH1,REN,REN/KCTD11
General protein information	Preferred Names potassium channel tetramerization domain containing 11 Names BTB/POZ domain-containing protein KCTD11 RING-type E3 ubiquitin transferase KCTD11 RING-type E3 ubiquitin transferase subunit KCTD11 potassium channel tetramerisation domain containing 11 potassium channel tetramerization domain-containing protein 11 retinoic acid, EGF, NGF induced gene protein retinoic acid, EGF, NGF induced gene/potassium channel tetramerization domain containing 11
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Disorder MIM:	609848

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002914.2	NP_001002914.1	BTB/POZ domain-containing protein KCTD11 s
NM_001363642.1	NP_001350571.1	BTB/POZ domain-containing protein KCTD11 l

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCTD11	XP_005620034.1
Homo sapiens (human)	KCTD11	NP_001002914.1
Bos taurus (cattle)	KCTD11	NP_001030498.2
Mus musculus (house mouse)	Kctd11	NP_694783.1
Rattus norvegicus (Norway rat)	Kctd11	NP_001102301.1
Pan troglodytes (chimpanzee)	KCTD11	XP_523831.1
	KCTD11	XP_001107578.1

Gene Ontology
Bibliography

Related articles in PubMed

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L, Ciccarelli L
FEBS letters590(11)1663-71(2016 Jun)

KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma.
Zazzeroni F, Nicosia D, Tessitore A, Gallo R, Verzella D, Fischietti M, Vecchiotti D, Ventura L, Capece D, Gulino A, Alesse E
BioMed research international2014380398(2014)

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.
De Smaele E, Di Marcotullio L, Moretti M, Pelloni M, Occhione MA, Infante P, Cucchi D, Greco A, Pietrosanti L, Todorovic J, Coni S, Canettieri G, Ferretti E, Bei R, Maroder M, Screpanti I, Gulino A
Neoplasia (New York, N.Y.)13(4)374-85(2011 Apr)

Molecular organization of the cullin E3 ligase adaptor KCTD11.
Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazz? D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone EM
Biochimie93(4)715-24(2011 Apr)

The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors.
Mancarelli MM, Zazzeroni F, Ciccocioppo L, Capece D, Po A, Murgo S, Di Camillo R, Rinaldi C, Ferretti E, Gulino A, Alesse E
Molecular cancer9172(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our study demonstrates and supports that KCTD11, as well as negatively regulated downstream effectors belonging to Hh signaling, plays a role in prostate cancer pathogenesis.
Title: KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma.

the protein is expressed in two alternative variants: a short previously characterized form (sKCTD11) composed by 232 amino acids and a longer variant (lKCTD11) which contains an N-terminal extension of 39 residues.
Title: Molecular organization of the cullin E3 ligase adaptor KCTD11.

findings identify KCTD11 as a widely down-regulated gene in human cancers, and provide a basis to understand how its expression might be deregulated in tumor cells
Title: The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors.

Results identify REN(KCTD11) as a suppressor of Hedgehog signaling and suggest that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog pathway in medulloblastoma.
Title: REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.

The following KCTD11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCTD11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30833	NM_001002914.2 Latest version!	Homo sapiens potassium channel tetramerization domain containing 11 (KCTD11), transcript variant 1a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu106766	NM_001363642.1 Latest version!	Homo sapiens potassium channel tetramerization domain containing 11 (KCTD11), transcript variant 1b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCTD11 ( NM_001002914.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002914.1 Homo sapiens potassium channel tetramerization domain containing 11 (KCTD11), transcript variant 1a, mRNA.

Price & Availability↑

CloneID	OHu30833
Clone ID Related Accession (Same CDS sequence)	NM_001002914.2
Accession Version	NM_001002914.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD11 s
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC103744.1, AY646650.1 and BC019929.1. On May 1, 2007 this sequence version replaced NM_001002914.1. COMPLETENESS: complete on the 3' end.

ATGCTGGGGG CCATGTTTAG GGCCGGCACC CCCATGCCCC CCAACCTCAA TTCCCAAGGA 
GGCGGCCACT ACTTCATCGA CCGGGATGGC AAGGCCTTCC GGCACATCCT CAATTTCCTG 
AGGCTGGGCC GCCTGGACCT GCCCCGTGGG TACGGAGAGA CAGCGCTGCT CAGGGCAGAG 
GCTGACTTCT ACCAGATCCG GCCCCTCCTG GACGCGCTGC GGGAACTGGA GGCCTCTCAG 
GGGACCCCTG CACCCACAGC TGCCCTGCTC CACGCAGATG TAGATGTCAG CCCCCGCCTG 
GTGCACTTCT CTGCTCGCCG GGGACCCCAT CACTATGAGC TGAGCTCCGT CCAGGTGGAC 
ACCTTCCGAG CCAACCTTTT CTGCACCGAC TCTGAGTGTC TAGGTGCTTT GCGGGCCCGA 
TTTGGTGTGG CCAGTGGGGA TAGGGCAGAG GGGAGCCCAC ATTTTCATCT GGAGTGGGCC 
CCCCGCCCCG TGGAACTCCC CGAGGTGGAG TATGGGAGAC TGGGGCTGCA GCCGCTGTGG 
ACTGGGGGGC CAGGAGAGCG GCGGGAGGTG GTGGGCACCC CAAGCTTCCT GGAGGAGGTG 
CTGCGGGTGG CTCTCGAGCA CGGCTTCCGA CTAGACTCTG TCTTCCCCGA CCCCGAAGAC 
CTGCTCAACT CCAGGTCTCT GCGCTTTGTC CGGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002914.1
CDS	1055..1753
Translation	MLGAMFRAGTPMPPNLNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAPTAALLHADVDVSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDSECLGALRARFGVASGDRAEGSPHFHLEWAPRPVELPEVEYGRLGLQPLWTGGPGERREVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH

Target ORF information:

RefSeq Version	NM_001002914.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 11 (KCTD11), transcript variant 1a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002914.2

ORF Insert Sequence:

ATGCTGGGGG CCATGTTTAG GGCCGGCACC CCCATGCCCC CCAACCTCAA TTCCCAAGGA 
GGCGGCCACT ACTTCATCGA CCGGGATGGC AAGGCCTTCC GGCACATCCT CAATTTCCTG 
AGGCTGGGCC GCCTGGACCT GCCCCGTGGG TACGGAGAGA CAGCGCTGCT CAGGGCAGAG 
GCTGACTTCT ACCAGATCCG GCCCCTCCTG GACGCGCTGC GGGAACTGGA GGCCTCTCAG 
GGGACCCCTG CACCCACAGC TGCCCTGCTC CACGCAGATG TAGATGTCAG CCCCCGCCTG 
GTGCACTTCT CTGCTCGCCG GGGACCCCAT CACTATGAGC TGAGCTCCGT CCAGGTGGAC 
ACCTTCCGAG CCAACCTTTT CTGCACCGAC TCTGAGTGTC TAGGTGCTTT GCGGGCCCGA 
TTTGGTGTGG CCAGTGGGGA TAGGGCAGAG GGGAGCCCAC ATTTTCATCT GGAGTGGGCC 
CCCCGCCCCG TGGAACTCCC CGAGGTGGAG TATGGGAGAC TGGGGCTGCA GCCGCTGTGG 
ACTGGGGGGC CAGGAGAGCG GCGGGAGGTG GTGGGCACCC CAAGCTTCCT GGAGGAGGTG 
CTGCGGGTGG CTCTCGAGCA CGGCTTCCGA CTAGACTCTG TCTTCCCCGA CCCCGAAGAC 
CTGCTCAACT CCAGGTCTCT GCGCTTTGTC CGGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCTD11 ( NM_001363642.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350571.1 Homo sapiens potassium channel tetramerization domain containing 11 (KCTD11), transcript variant 1b, mRNA.

Price & Availability↑

CloneID	OHu106766
Clone ID Related Accession (Same CDS sequence)	NM_001363642.1
Accession Version	NM_001363642.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	BTB/POZ domain-containing protein KCTD11 l
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC026954.14. Transcript Variant: This variant (1b) initiates translation at an upstream AUU alternate start codon and encodes an isoform (l) with a longer N-terminus compared to isoform s. This isoform is suggested by experimental data in PMID:21237243. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 21237243 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATTTCTCCTC CTCCTGTGCC CTCTTCGCCC CCCTCCTTTG GGGGCCCCGT GACCCTGAAT 
GTGGGGGGCA CACTATATTC CACCACTTTG GAGACCCTGA CCCGCTTCCC AGACTCTATG 
CTGGGGGCCA TGTTTAGGGC CGGCACCCCC ATGCCCCCCA ACCTCAATTC CCAAGGAGGC 
GGCCACTACT TCATCGACCG GGATGGCAAG GCCTTCCGGC ACATCCTCAA TTTCCTGAGG 
CTGGGCCGCC TGGACCTGCC CCGTGGGTAC GGAGAGACAG CGCTGCTCAG GGCAGAGGCT 
GACTTCTACC AGATCCGGCC CCTCCTGGAC GCGCTGCGGG AACTGGAGGC CTCTCAGGGG 
ACCCCTGCAC CCACAGCTGC CCTGCTCCAC GCAGATGTAG ATGTCAGCCC CCGCCTGGTG 
CACTTCTCTG CTCGCCGGGG ACCCCATCAC TATGAGCTGA GCTCCGTCCA GGTGGACACC 
TTCCGAGCCA ACCTTTTCTG CACCGACTCT GAGTGTCTAG GTGCTTTGCG GGCCCGATTT 
GGTGTGGCCA GTGGGGATAG GGCAGAGGGG AGCCCACATT TTCATCTGGA GTGGGCCCCC 
CGCCCCGTGG AACTCCCCGA GGTGGAGTAT GGGAGACTGG GGCTGCAGCC GCTGTGGACT 
GGGGGGCCAG GAGAGCGGCG GGAGGTGGTG GGCACCCCAA GCTTCCTGGA GGAGGTGCTG 
CGGGTGGCTC TCGAGCACGG CTTCCGACTA GACTCTGTCT TCCCCGACCC CGAAGACCTG 
CTCAACTCCA GGTCTCTGCG CTTTGTCCGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350571.1
CDS	665..1480
Translation	ISPPPVPSSPPSFGGPVTLNVGGTLYSTTLETLTRFPDSMLGAMFRAGTPMPPNLNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAPTAALLHADVDVSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDSECLGALRARFGVASGDRAEGSPHFHLEWAPRPVELPEVEYGRLGLQPLWTGGPGERREVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH

Target ORF information:

RefSeq Version	NM_001363642.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium channel tetramerization domain containing 11 (KCTD11), transcript variant 1b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363642.1

ORF Insert Sequence:

ATTTCTCCTC CTCCTGTGCC CTCTTCGCCC CCCTCCTTTG GGGGCCCCGT GACCCTGAAT 
GTGGGGGGCA CACTATATTC CACCACTTTG GAGACCCTGA CCCGCTTCCC AGACTCTATG 
CTGGGGGCCA TGTTTAGGGC CGGCACCCCC ATGCCCCCCA ACCTCAATTC CCAAGGAGGC 
GGCCACTACT TCATCGACCG GGATGGCAAG GCCTTCCGGC ACATCCTCAA TTTCCTGAGG 
CTGGGCCGCC TGGACCTGCC CCGTGGGTAC GGAGAGACAG CGCTGCTCAG GGCAGAGGCT 
GACTTCTACC AGATCCGGCC CCTCCTGGAC GCGCTGCGGG AACTGGAGGC CTCTCAGGGG 
ACCCCTGCAC CCACAGCTGC CCTGCTCCAC GCAGATGTAG ATGTCAGCCC CCGCCTGGTG 
CACTTCTCTG CTCGCCGGGG ACCCCATCAC TATGAGCTGA GCTCCGTCCA GGTGGACACC 
TTCCGAGCCA ACCTTTTCTG CACCGACTCT GAGTGTCTAG GTGCTTTGCG GGCCCGATTT 
GGTGTGGCCA GTGGGGATAG GGCAGAGGGG AGCCCACATT TTCATCTGGA GTGGGCCCCC 
CGCCCCGTGG AACTCCCCGA GGTGGAGTAT GGGAGACTGG GGCTGCAGCC GCTGTGGACT 
GGGGGGCCAG GAGAGCGGCG GGAGGTGGTG GGCACCCCAA GCTTCCTGGA GGAGGTGCTG 
CGGGTGGCTC TCGAGCACGG CTTCCGACTA GACTCTGTCT TCCCCGACCC CGAAGACCTG 
CTCAACTCCA GGTCTCTGCG CTTTGTCCGG CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
FEBS letters590(11)1663-71(2016 Jun)
Smaldone G,Pirone L,Pedone E,Marlovits T,Vitagliano L,Ciccarelli L

KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma.
BioMed research international2014380398(2014)
Zazzeroni F,Nicosia D,Tessitore A,Gallo R,Verzella D,Fischietti M,Vecchiotti D,Ventura L,Capece D,Gulino A,Alesse E

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.
Neoplasia (New York, N.Y.)13(4)374-85(2011 Apr)
De Smaele E,Di Marcotullio L,Moretti M,Pelloni M,Occhione MA,Infante P,Cucchi D,Greco A,Pietrosanti L,Todorovic J,Coni S,Canettieri G,Ferretti E,Bei R,Maroder M,Screpanti I,Gulino A

Molecular organization of the cullin E3 ligase adaptor KCTD11.
Biochimie93(4)715-24(2011 Apr)
Correale S,Pirone L,Di Marcotullio L,De Smaele E,Greco A,Mazz? D,Moretti M,Alterio V,Vitagliano L,Di Gaetano S,Gulino A,Pedone EM

The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors.
Molecular cancer9172(2010 Jun)
Mancarelli MM,Zazzeroni F,Ciccocioppo L,Capece D,Po A,Murgo S,Di Camillo R,Rinaldi C,Ferretti E,Gulino A,Alesse E

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KCTD11 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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