CST1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CST1
Entrez Gene ID	1469
Full Name	cystatin SN
General protein information	Preferred Names cystatin SN Names cystatin-SN cystain-SA-I cystatin 1 cystatin SA-I cysteine proteinase inhibitor, type 2 family salivary cystatin-SA-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p11.21
Summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008].
Disorder MIM:	123855

mRNA and Protein(s)

mRNA	Protein	Name
NM_001898.2	NP_001889.2	cystatin-SN precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CST4	XP_514553.1
Pan troglodytes (chimpanzee)	CST1	XP_003953739.1
Homo sapiens (human)	CST1	NP_001889.2
Pan troglodytes (chimpanzee)	CST2	XP_001147822.3

Gene Ontology
Bibliography

Related articles in PubMed

Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis.
Ndika J, Airaksinen L, Suojalehto H, Karisola P, Fyhrquist N, Puustinen A, Alenius H
The Journal of allergy and clinical immunology140(5)1288-1298(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis
Title: Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis.

These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence.
Title: Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation.

interactions of human family 1 & 2 cystatins with cathepsin L1
Title: Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes.

In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer.
Title: Identification of cystatin SN as a novel biomarker for pancreatic cancer.

high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs.
Title: Expression of Cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients.

The following CST1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CST1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu09592	NM_001898.2 Latest version!	Homo sapiens cystatin SN (CST1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CST1 ( NM_001898.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001889.2 Homo sapiens cystatin SN (CST1), mRNA.

Price & Availability↑

CloneID	OHu09592
Clone ID Related Accession (Same CDS sequence)	NM_001898.2
Accession Version	NM_001898.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	cystatin-SN precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC021225.2. On Apr 2, 2002 this sequence version replaced NM_001898.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021225.2, CB957799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGT ATCTGAGTAC CCTGCTGCTC CTGCTGGCCA CCCTAGCTGT GGCCCTGGCC 
TGGAGCCCCA AGGAGGAGGA TAGGATAATC CCGGGTGGCA TCTATAACGC AGACCTCAAT 
GATGAGTGGG TACAGCGTGC CCTTCACTTC GCCATCAGCG AGTATAACAA GGCCACCAAA 
GATGACTACT ACAGACGTCC GCTGCGGGTA CTAAGAGCCA GGCAACAGAC CGTTGGGGGG 
GTGAATTACT TCTTCGACGT AGAGGTGGGC CGCACCATAT GTACCAAGTC CCAGCCCAAC 
TTGGACACCT GTGCCTTCCA TGAACAGCCA GAACTGCAGA AGAAACAGTT GTGCTCTTTC 
GAGATCTACG AAGTTCCCTG GGAGAACAGA AGGTCCCTGG TGAAATCCAG GTGTCAAGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001889.2
CDS	72..497
Translation	MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES

Target ORF information:

RefSeq Version	NM_001898.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin SN (CST1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001898.2

ORF Insert Sequence:

ATGGCCCAGT ATCTGAGTAC CCTGCTGCTC CTGCTGGCCA CCCTAGCTGT GGCCCTGGCC 
TGGAGCCCCA AGGAGGAGGA TAGGATAATC CCGGGTGGCA TCTATAACGC AGACCTCAAT 
GATGAGTGGG TACAGCGTGC CCTTCACTTC GCCATCAGCG AGTATAACAA GGCCACCAAA 
GATGACTACT ACAGACGTCC GCTGCGGGTA CTAAGAGCCA GGCAACAGAC CGTTGGGGGG 
GTGAATTACT TCTTCGACGT AGAGGTGGGC CGCACCATAT GTACCAAGTC CCAGCCCAAC 
TTGGACACCT GTGCCTTCCA TGAACAGCCA GAACTGCAGA AGAAACAGTT GTGCTCTTTC 
GAGATCTACG AAGTTCCCTG GGAGAACAGA AGGTCCCTGG TGAAATCCAG GTGTCAAGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis.
The Journal of allergy and clinical immunology140(5)1288-1298(2017 Nov)
Ndika J,Airaksinen L,Suojalehto H,Karisola P,Fyhrquist N,Puustinen A,Alenius H

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

CST1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報