SLC38A8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC38A8
Entrez Gene ID	146167
Full Name	solute carrier family 38 member 8
Synonyms	FVH2
General protein information	Preferred Names solute carrier family 38 member 8 Names putative sodium-coupled neutral amino acid transporter 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q23.3
Summary	This gene encodes a putative sodium-dependent amino-acid/proton antiporter. The protein has eleven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. The protein is a member of the SLC38 sodium-coupled neutral amino acid transporter family of proteins. Mutations in this gene result in foveal hypoplasia with or without optic nerve misrouting and/or anterior segment dysgenesis. [provided by RefSeq, May 2014].
Disorder MIM:	615585
Disorder Html:	Foveal hypoplasia 2, with or without optic nerve misrouting and/or anterior segment dysgenesis, 609218 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011522872.1	XP_011521174.1	putative sodium-coupled neutral amino acid transporter 8 isoform X1
NM_001080442.2	NP_001073911.1	putative sodium-coupled neutral amino acid transporter 8
XM_017022946.1	XP_016878435.1	putative sodium-coupled neutral amino acid transporter 8 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC38A8	XP_003315260.1
Canis lupus familiaris (dog)	SLC38A8	XP_005620941.1
Gallus gallus (chicken)	SLC38A8	XP_003641956.1
Xenopus tropicalis (tropical clawed frog)	slc38a8	NP_001037900.1
Danio rerio (zebrafish)	LOC795255	XP_005168973.1
Danio rerio (zebrafish)	LOC100004247	NP_001138287.1
Rattus norvegicus (Norway rat)	Slc38a8	NP_001178938.1
Mus musculus (house mouse)	Slc38a8	NP_001009950.1
Homo sapiens (human)	SLC38A8	NP_001073911.1
Bos taurus (cattle)	SLC38A8	NP_001179423.1

Gene Ontology
Bibliography

Related articles in PubMed

Isolated foveal hypoplasia with secondary nystagmus and low vision is associated with a homozygous SLC38A8 mutation.
Perez Y, Gradstein L, Flusser H, Markus B, Cohen I, Langer Y, Marcus M, Lifshitz T, Kadir R, Birk OS
European journal of human genetics : EJHG22(5)703-6(2014 May)

Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism.
Poulter JA, Al-Araimi M, Conte I, van Genderen MM, Sheridan E, Carr IM, Parry DA, Shires M, Carrella S, Bradbury J, Khan K, Lakeman P, Sergouniotis PI, Webster AR, Moore AT, Pal B, Mohamed MD, Venkataramana A, Ramprasad V, Shetty R, Saktivel M, Kumaramanickavel G, Tan A, Mackey DA, Hewitt AW, Banfi S, Ali M, Inglehearn CF, Toomes C
American journal of human genetics93(6)1143-50(2013 Dec)

Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study.
Liao SY, Lin X, Christiani DC
Environmental health : a global access science source12101(2013 Dec)

Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
Adams LA, White SW, Marsh JA, Lye SJ, Connor KL, Maganga R, Ayonrinde OT, Olynyk JK, Mori TA, Beilin LJ, Palmer LJ, Hamdorf JM, Pennell CE
Hepatology (Baltimore, Md.)57(2)590-600(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Isolated foveal hypoplasia with secondary nystagmus and low vision is associated with a homozygous SLC38A8 mutation.
Title: Isolated foveal hypoplasia with secondary nystagmus and low vision is associated with a homozygous SLC38A8 mutation.

Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism.
Title: Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism.

Study found that SNP rs9931086 in the SLC38A8 gene and genes CTLA-4, HDAC, and PPAR-alpha, which are involved in inflammatory processes, may modify the effects of occupational exposure on lung function.
Title: Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following SLC38A8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC38A8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27760	NM_001080442.2 Latest version!	Homo sapiens solute carrier family 38 member 8 (SLC38A8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu27760	XM_011522872.1 Latest version!	Homo sapiens solute carrier family 38, member 8 (SLC38A8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu27760	XM_017022946.1 Latest version!	Homo sapiens solute carrier family 38 member 8 (SLC38A8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC38A8 ( NM_001080442.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001073911.1 Homo sapiens solute carrier family 38 member 8 (SLC38A8), mRNA.

Price & Availability↑

CloneID	OHu27760
Clone ID Related Accession (Same CDS sequence)	XM_011522872.1 , NM_001080442.2 , XM_017022946.1
Accession Version	NM_001080442.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	putative sodium-coupled neutral amino acid transporter 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC040169.7. This sequence is a reference standard in the RefSeqGene project. On May 30, 2014 this sequence version replaced NM_001080442.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGAGGGAC AGACCCCAGG AAGCAGGGGC CTTCCAGAAA AGCCTCACCC TGCCACGGCT 
GCTGCCACTC TGTCCTCGAT GGGCGCTGTC TTCATCCTCA TGAAGTCCGC GCTGGGAGCT 
GGCCTGCTCA ACTTCCCCTG GGCCTTCTCC AAAGCGGGCG GAGTGGTCCC TGCCTTCCTG 
GTGGAGCTGG TCTCGTTGGT CTTCCTGATC AGCGGGCTGG TCATCCTGGG CTATGCTGCT 
GCTGTCAGTG GCCAGGCCAC CTACCAGGGT GTGGTCAGGG GGCTGTGTGG CCCTGCCATT 
GGGAAGCTGT GTGAGGCCTG CTTCCTCCTC AACCTGCTCA TGATCTCCGT GGCCTTCCTC 
AGGGTGATCG GGGACCAGCT GGAGAAGCTG TGTGACTCCC TCCTGTCTGG CACCCCGCCC 
GCCCCGCAGC CGTGGTACGC AGACCAGCGC TTCACCCTGC CCCTGCTCTC CGTGCTGGTC 
ATCCTGCCCC TGTCTGCCCC GCGGGAGATC GCCTTCCAGA AATACACAAG CATCCTAGGC 
ACTCTGGCTG CCTGTTACCT GGCCCTGGTC ATCACCGTGC AGTACTACCT CTGGCCCCAG 
GGCCTCGTGC GTGAGTCCCA TCCTTCACTG AGCCCTGCCT CCTGGACCTC TGTGTTCAGT 
GTCTTCCCCA CCATCTGCTT CGGGTTTCAG TGTCACGAAG CTGCCGTCTC CATCTACTGC 
AGCATGCGCA AACGGAGCCT CTCCCACTGG GCCCTGGTGT CTGTGCTGTC CTTGCTGGCC 
TGCTGCCTCA TCTATTCACT GACGGGGGTT TATGGCTTCC TGACTTTTGG GACAGAAGTT 
TCTGCTGACG TCTTGATGTC CTACCCAGGC AATGATATGG TCATCATTGT GGCCCGGGTC 
CTTTTTGCTG TCTCCATCGT AACTGTCTAC CCCATCGTGC TCTTCCTGGG GAGGTCAGTG 
ATGCAGGACT TCTGGAGGAG GAGCTGCTTG GGGGGATGGG GGCCCAGCGC CCTGGCCGAC 
CCCTCAGGGC TGTGGGTCCG GATGCCGCTG ACCATCCTGT GGGTCACCGT GACGCTCGCC 
ATGGCGCTGT TTATGCCTGA CCTCAGCGAG ATCGTCAGCA TCATCGGAGG CATCAGTTCC 
TTCTTCATCT TCATCTTCCC AGGTTTGTGC CTCATCTGTG CAATGGGTGT CGAGCCTATA 
GGACCAAGAG TCAAGTGCTG CCTGGAGGTC TGGGGAGTGG TCTCTGTGCT GGTCGGCACC 
TTCATCTTTG GGCAGAGCAC GGCGGCAGCG GTCTGGGAGA TGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073911.1
CDS	1..1308
Translation	MEGQTPGSRGLPEKPHPATAAATLSSMGAVFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAVSGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPAPQPWYADQRFTLPLLSVLVILPLSAPREIAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRESHPSLSPASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACCLIYSLTGVYGFLTFGTEVSADVLMSYPGNDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWVRMPLTILWVTVTLAMALFMPDLSEIVSIIGGISSFFIFIFPGLCLICAMGVEPIGPRVKCCLEVWGVVSVLVGTFIFGQSTAAAVWEMF

Target ORF information:

RefSeq Version	NM_001080442.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 38 member 8 (SLC38A8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080442.2

ORF Insert Sequence:

ATGGAGGGAC AGACCCCAGG AAGCAGGGGC CTTCCAGAAA AGCCTCACCC TGCCACGGCT 
GCTGCCACTC TGTCCTCGAT GGGCGCTGTC TTCATCCTCA TGAAGTCCGC GCTGGGAGCT 
GGCCTGCTCA ACTTCCCCTG GGCCTTCTCC AAAGCGGGCG GAGTGGTCCC TGCCTTCCTG 
GTGGAGCTGG TCTCGTTGGT CTTCCTGATC AGCGGGCTGG TCATCCTGGG CTATGCTGCT 
GCTGTCAGTG GCCAGGCCAC CTACCAGGGT GTGGTCAGGG GGCTGTGTGG CCCTGCCATT 
GGGAAGCTGT GTGAGGCCTG CTTCCTCCTC AACCTGCTCA TGATCTCCGT GGCCTTCCTC 
AGGGTGATCG GGGACCAGCT GGAGAAGCTG TGTGACTCCC TCCTGTCTGG CACCCCGCCC 
GCCCCGCAGC CGTGGTACGC AGACCAGCGC TTCACCCTGC CCCTGCTCTC CGTGCTGGTC 
ATCCTGCCCC TGTCTGCCCC GCGGGAGATC GCCTTCCAGA AATACACAAG CATCCTAGGC 
ACTCTGGCTG CCTGTTACCT GGCCCTGGTC ATCACCGTGC AGTACTACCT CTGGCCCCAG 
GGCCTCGTGC GTGAGTCCCA TCCTTCACTG AGCCCTGCCT CCTGGACCTC TGTGTTCAGT 
GTCTTCCCCA CCATCTGCTT CGGGTTTCAG TGTCACGAAG CTGCCGTCTC CATCTACTGC 
AGCATGCGCA AACGGAGCCT CTCCCACTGG GCCCTGGTGT CTGTGCTGTC CTTGCTGGCC 
TGCTGCCTCA TCTATTCACT GACGGGGGTT TATGGCTTCC TGACTTTTGG GACAGAAGTT 
TCTGCTGACG TCTTGATGTC CTACCCAGGC AATGATATGG TCATCATTGT GGCCCGGGTC 
CTTTTTGCTG TCTCCATCGT AACTGTCTAC CCCATCGTGC TCTTCCTGGG GAGGTCAGTG 
ATGCAGGACT TCTGGAGGAG GAGCTGCTTG GGGGGATGGG GGCCCAGCGC CCTGGCCGAC 
CCCTCAGGGC TGTGGGTCCG GATGCCGCTG ACCATCCTGT GGGTCACCGT GACGCTCGCC 
ATGGCGCTGT TTATGCCTGA CCTCAGCGAG ATCGTCAGCA TCATCGGAGG CATCAGTTCC 
TTCTTCATCT TCATCTTCCC AGGTTTGTGC CTCATCTGTG CAATGGGTGT CGAGCCTATA 
GGACCAAGAG TCAAGTGCTG CCTGGAGGTC TGGGGAGTGG TCTCTGTGCT GGTCGGCACC 
TTCATCTTTG GGCAGAGCAC GGCGGCAGCG GTCTGGGAGA TGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC38A8 ( XM_011522872.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521174.1 Homo sapiens solute carrier family 38, member 8 (SLC38A8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu27760
Clone ID Related Accession (Same CDS sequence)	XM_011522872.1 , NM_001080442.2 , XM_017022946.1
Accession Version	XM_011522872.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	putative sodium-coupled neutral amino acid transporter 8 isoform X1
Comment

ATGGAGGGAC AGACCCCAGG AAGCAGGGGC CTTCCAGAAA AGCCTCACCC TGCCACGGCT 
GCTGCCACTC TGTCCTCGAT GGGCGCTGTC TTCATCCTCA TGAAGTCCGC GCTGGGAGCT 
GGCCTGCTCA ACTTCCCCTG GGCCTTCTCC AAAGCGGGCG GAGTGGTCCC TGCCTTCCTG 
GTGGAGCTGG TCTCGTTGGT CTTCCTGATC AGCGGGCTGG TCATCCTGGG CTATGCTGCT 
GCTGTCAGTG GCCAGGCCAC CTACCAGGGT GTGGTCAGGG GGCTGTGTGG CCCTGCCATT 
GGGAAGCTGT GTGAGGCCTG CTTCCTCCTC AACCTGCTCA TGATCTCCGT GGCCTTCCTC 
AGGGTGATCG GGGACCAGCT GGAGAAGCTG TGTGACTCCC TCCTGTCTGG CACCCCGCCC 
GCCCCGCAGC CGTGGTACGC AGACCAGCGC TTCACCCTGC CCCTGCTCTC CGTGCTGGTC 
ATCCTGCCCC TGTCTGCCCC GCGGGAGATC GCCTTCCAGA AATACACAAG CATCCTAGGC 
ACTCTGGCTG CCTGTTACCT GGCCCTGGTC ATCACCGTGC AGTACTACCT CTGGCCCCAG 
GGCCTCGTGC GTGAGTCCCA TCCTTCACTG AGCCCTGCCT CCTGGACCTC TGTGTTCAGT 
GTCTTCCCCA CCATCTGCTT CGGGTTTCAG TGTCACGAAG CTGCCGTCTC CATCTACTGC 
AGCATGCGCA AACGGAGCCT CTCCCACTGG GCCCTGGTGT CTGTGCTGTC CTTGCTGGCC 
TGCTGCCTCA TCTATTCACT GACGGGGGTT TATGGCTTCC TGACTTTTGG GACAGAAGTT 
TCTGCTGACG TCTTGATGTC CTACCCAGGC AATGATATGG TCATCATTGT GGCCCGGGTC 
CTTTTTGCTG TCTCCATCGT AACTGTCTAC CCCATCGTGC TCTTCCTGGG GAGGTCAGTG 
ATGCAGGACT TCTGGAGGAG GAGCTGCTTG GGGGGATGGG GGCCCAGCGC CCTGGCCGAC 
CCCTCAGGGC TGTGGGTCCG GATGCCGCTG ACCATCCTGT GGGTCACCGT GACGCTCGCC 
ATGGCGCTGT TTATGCCTGA CCTCAGCGAG ATCGTCAGCA TCATCGGAGG CATCAGTTCC 
TTCTTCATCT TCATCTTCCC AGGTTTGTGC CTCATCTGTG CAATGGGTGT CGAGCCTATA 
GGACCAAGAG TCAAGTGCTG CCTGGAGGTC TGGGGAGTGG TCTCTGTGCT GGTCGGCACC 
TTCATCTTTG GGCAGAGCAC GGCGGCAGCG GTCTGGGAGA TGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011521174.1

Translation

MEGQTPGSRGLPEKPHPATAAATLSSMGAVFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAVSGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPAPQPWYADQRFTLPLLSVLVILPLSAPREIAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRESHPSLSPASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACCLIYSLTGVYGFLTFGTEVSADVLMSYPGNDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWVRMPLTILWVTVTLAMALFMPDLSEIVSIIGGISSFFIFIFPGLCLICAMGVEPIGPRVKCCLEVWGVVSVLVGTFIFGQSTAAAVWEMF

Target ORF information:

RefSeq Version	XM_011522872.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens solute carrier family 38, member 8 (SLC38A8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522872.1

ORF Insert Sequence:

ATGGAGGGAC AGACCCCAGG AAGCAGGGGC CTTCCAGAAA AGCCTCACCC TGCCACGGCT 
GCTGCCACTC TGTCCTCGAT GGGCGCTGTC TTCATCCTCA TGAAGTCCGC GCTGGGAGCT 
GGCCTGCTCA ACTTCCCCTG GGCCTTCTCC AAAGCGGGCG GAGTGGTCCC TGCCTTCCTG 
GTGGAGCTGG TCTCGTTGGT CTTCCTGATC AGCGGGCTGG TCATCCTGGG CTATGCTGCT 
GCTGTCAGTG GCCAGGCCAC CTACCAGGGT GTGGTCAGGG GGCTGTGTGG CCCTGCCATT 
GGGAAGCTGT GTGAGGCCTG CTTCCTCCTC AACCTGCTCA TGATCTCCGT GGCCTTCCTC 
AGGGTGATCG GGGACCAGCT GGAGAAGCTG TGTGACTCCC TCCTGTCTGG CACCCCGCCC 
GCCCCGCAGC CGTGGTACGC AGACCAGCGC TTCACCCTGC CCCTGCTCTC CGTGCTGGTC 
ATCCTGCCCC TGTCTGCCCC GCGGGAGATC GCCTTCCAGA AATACACAAG CATCCTAGGC 
ACTCTGGCTG CCTGTTACCT GGCCCTGGTC ATCACCGTGC AGTACTACCT CTGGCCCCAG 
GGCCTCGTGC GTGAGTCCCA TCCTTCACTG AGCCCTGCCT CCTGGACCTC TGTGTTCAGT 
GTCTTCCCCA CCATCTGCTT CGGGTTTCAG TGTCACGAAG CTGCCGTCTC CATCTACTGC 
AGCATGCGCA AACGGAGCCT CTCCCACTGG GCCCTGGTGT CTGTGCTGTC CTTGCTGGCC 
TGCTGCCTCA TCTATTCACT GACGGGGGTT TATGGCTTCC TGACTTTTGG GACAGAAGTT 
TCTGCTGACG TCTTGATGTC CTACCCAGGC AATGATATGG TCATCATTGT GGCCCGGGTC 
CTTTTTGCTG TCTCCATCGT AACTGTCTAC CCCATCGTGC TCTTCCTGGG GAGGTCAGTG 
ATGCAGGACT TCTGGAGGAG GAGCTGCTTG GGGGGATGGG GGCCCAGCGC CCTGGCCGAC 
CCCTCAGGGC TGTGGGTCCG GATGCCGCTG ACCATCCTGT GGGTCACCGT GACGCTCGCC 
ATGGCGCTGT TTATGCCTGA CCTCAGCGAG ATCGTCAGCA TCATCGGAGG CATCAGTTCC 
TTCTTCATCT TCATCTTCCC AGGTTTGTGC CTCATCTGTG CAATGGGTGT CGAGCCTATA 
GGACCAAGAG TCAAGTGCTG CCTGGAGGTC TGGGGAGTGG TCTCTGTGCT GGTCGGCACC 
TTCATCTTTG GGCAGAGCAC GGCGGCAGCG GTCTGGGAGA TGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC38A8 ( XM_017022946.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016878435.1 Homo sapiens solute carrier family 38 member 8 (SLC38A8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu27760
Clone ID Related Accession (Same CDS sequence)	XM_011522872.1 , NM_001080442.2 , XM_017022946.1
Accession Version	XM_017022946.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1308bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	putative sodium-coupled neutral amino acid transporter 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGGAC AGACCCCAGG AAGCAGGGGC CTTCCAGAAA AGCCTCACCC TGCCACGGCT 
GCTGCCACTC TGTCCTCGAT GGGCGCTGTC TTCATCCTCA TGAAGTCCGC GCTGGGAGCT 
GGCCTGCTCA ACTTCCCCTG GGCCTTCTCC AAAGCGGGCG GAGTGGTCCC TGCCTTCCTG 
GTGGAGCTGG TCTCGTTGGT CTTCCTGATC AGCGGGCTGG TCATCCTGGG CTATGCTGCT 
GCTGTCAGTG GCCAGGCCAC CTACCAGGGT GTGGTCAGGG GGCTGTGTGG CCCTGCCATT 
GGGAAGCTGT GTGAGGCCTG CTTCCTCCTC AACCTGCTCA TGATCTCCGT GGCCTTCCTC 
AGGGTGATCG GGGACCAGCT GGAGAAGCTG TGTGACTCCC TCCTGTCTGG CACCCCGCCC 
GCCCCGCAGC CGTGGTACGC AGACCAGCGC TTCACCCTGC CCCTGCTCTC CGTGCTGGTC 
ATCCTGCCCC TGTCTGCCCC GCGGGAGATC GCCTTCCAGA AATACACAAG CATCCTAGGC 
ACTCTGGCTG CCTGTTACCT GGCCCTGGTC ATCACCGTGC AGTACTACCT CTGGCCCCAG 
GGCCTCGTGC GTGAGTCCCA TCCTTCACTG AGCCCTGCCT CCTGGACCTC TGTGTTCAGT 
GTCTTCCCCA CCATCTGCTT CGGGTTTCAG TGTCACGAAG CTGCCGTCTC CATCTACTGC 
AGCATGCGCA AACGGAGCCT CTCCCACTGG GCCCTGGTGT CTGTGCTGTC CTTGCTGGCC 
TGCTGCCTCA TCTATTCACT GACGGGGGTT TATGGCTTCC TGACTTTTGG GACAGAAGTT 
TCTGCTGACG TCTTGATGTC CTACCCAGGC AATGATATGG TCATCATTGT GGCCCGGGTC 
CTTTTTGCTG TCTCCATCGT AACTGTCTAC CCCATCGTGC TCTTCCTGGG GAGGTCAGTG 
ATGCAGGACT TCTGGAGGAG GAGCTGCTTG GGGGGATGGG GGCCCAGCGC CCTGGCCGAC 
CCCTCAGGGC TGTGGGTCCG GATGCCGCTG ACCATCCTGT GGGTCACCGT GACGCTCGCC 
ATGGCGCTGT TTATGCCTGA CCTCAGCGAG ATCGTCAGCA TCATCGGAGG CATCAGTTCC 
TTCTTCATCT TCATCTTCCC AGGTTTGTGC CTCATCTGTG CAATGGGTGT CGAGCCTATA 
GGACCAAGAG TCAAGTGCTG CCTGGAGGTC TGGGGAGTGG TCTCTGTGCT GGTCGGCACC 
TTCATCTTTG GGCAGAGCAC GGCGGCAGCG GTCTGGGAGA TGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016878435.1
CDS	466..1773
Translation	MEGQTPGSRGLPEKPHPATAAATLSSMGAVFILMKSALGAGLLNFPWAFSKAGGVVPAFLVELVSLVFLISGLVILGYAAAVSGQATYQGVVRGLCGPAIGKLCEACFLLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPAPQPWYADQRFTLPLLSVLVILPLSAPREIAFQKYTSILGTLAACYLALVITVQYYLWPQGLVRESHPSLSPASWTSVFSVFPTICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACCLIYSLTGVYGFLTFGTEVSADVLMSYPGNDMVIIVARVLFAVSIVTVYPIVLFLGRSVMQDFWRRSCLGGWGPSALADPSGLWVRMPLTILWVTVTLAMALFMPDLSEIVSIIGGISSFFIFIFPGLCLICAMGVEPIGPRVKCCLEVWGVVSVLVGTFIFGQSTAAAVWEMF

Target ORF information:

RefSeq Version	XM_017022946.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 38 member 8 (SLC38A8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022946.1

ORF Insert Sequence:

ATGGAGGGAC AGACCCCAGG AAGCAGGGGC CTTCCAGAAA AGCCTCACCC TGCCACGGCT 
GCTGCCACTC TGTCCTCGAT GGGCGCTGTC TTCATCCTCA TGAAGTCCGC GCTGGGAGCT 
GGCCTGCTCA ACTTCCCCTG GGCCTTCTCC AAAGCGGGCG GAGTGGTCCC TGCCTTCCTG 
GTGGAGCTGG TCTCGTTGGT CTTCCTGATC AGCGGGCTGG TCATCCTGGG CTATGCTGCT 
GCTGTCAGTG GCCAGGCCAC CTACCAGGGT GTGGTCAGGG GGCTGTGTGG CCCTGCCATT 
GGGAAGCTGT GTGAGGCCTG CTTCCTCCTC AACCTGCTCA TGATCTCCGT GGCCTTCCTC 
AGGGTGATCG GGGACCAGCT GGAGAAGCTG TGTGACTCCC TCCTGTCTGG CACCCCGCCC 
GCCCCGCAGC CGTGGTACGC AGACCAGCGC TTCACCCTGC CCCTGCTCTC CGTGCTGGTC 
ATCCTGCCCC TGTCTGCCCC GCGGGAGATC GCCTTCCAGA AATACACAAG CATCCTAGGC 
ACTCTGGCTG CCTGTTACCT GGCCCTGGTC ATCACCGTGC AGTACTACCT CTGGCCCCAG 
GGCCTCGTGC GTGAGTCCCA TCCTTCACTG AGCCCTGCCT CCTGGACCTC TGTGTTCAGT 
GTCTTCCCCA CCATCTGCTT CGGGTTTCAG TGTCACGAAG CTGCCGTCTC CATCTACTGC 
AGCATGCGCA AACGGAGCCT CTCCCACTGG GCCCTGGTGT CTGTGCTGTC CTTGCTGGCC 
TGCTGCCTCA TCTATTCACT GACGGGGGTT TATGGCTTCC TGACTTTTGG GACAGAAGTT 
TCTGCTGACG TCTTGATGTC CTACCCAGGC AATGATATGG TCATCATTGT GGCCCGGGTC 
CTTTTTGCTG TCTCCATCGT AACTGTCTAC CCCATCGTGC TCTTCCTGGG GAGGTCAGTG 
ATGCAGGACT TCTGGAGGAG GAGCTGCTTG GGGGGATGGG GGCCCAGCGC CCTGGCCGAC 
CCCTCAGGGC TGTGGGTCCG GATGCCGCTG ACCATCCTGT GGGTCACCGT GACGCTCGCC 
ATGGCGCTGT TTATGCCTGA CCTCAGCGAG ATCGTCAGCA TCATCGGAGG CATCAGTTCC 
TTCTTCATCT TCATCTTCCC AGGTTTGTGC CTCATCTGTG CAATGGGTGT CGAGCCTATA 
GGACCAAGAG TCAAGTGCTG CCTGGAGGTC TGGGGAGTGG TCTCTGTGCT GGTCGGCACC 
TTCATCTTTG GGCAGAGCAC GGCGGCAGCG GTCTGGGAGA TGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Isolated foveal hypoplasia with secondary nystagmus and low vision is associated with a homozygous SLC38A8 mutation.
European journal of human genetics : EJHG22(5)703-6(2014 May)
Perez Y,Gradstein L,Flusser H,Markus B,Cohen I,Langer Y,Marcus M,Lifshitz T,Kadir R,Birk OS

Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism.
American journal of human genetics93(6)1143-50(2013 Dec)
Poulter JA,Al-Araimi M,Conte I,van Genderen MM,Sheridan E,Carr IM,Parry DA,Shires M,Carrella S,Bradbury J,Khan K,Lakeman P,Sergouniotis PI,Webster AR,Moore AT,Pal B,Mohamed MD,Venkataramana A,Ramprasad V,Shetty R,Saktivel M,Kumaramanickavel G,Tan A,Mackey DA,Hewitt AW,Banfi S,Ali M,Inglehearn CF,Toomes C

Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study.
Environmental health : a global access science source12101(2013 Dec)
Liao SY,Lin X,Christiani DC

Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.)57(2)590-600(2013 Feb)
Adams LA,White SW,Marsh JA,Lye SJ,Connor KL,Maganga R,Ayonrinde OT,Olynyk JK,Mori TA,Beilin LJ,Palmer LJ,Hamdorf JM,Pennell CE

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SLC38A8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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