CS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CS
Entrez Gene ID	1431
Full Name	citrate synthase
General protein information	Preferred Names citrate synthase Names citrate synthase, mitochondrial citrate (Si)-synthase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.3
Summary	The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008].
Disorder MIM:	118950

mRNA and Protein(s)

mRNA	Protein	Name
NM_004077.2	NP_004068.2	citrate synthase, mitochondrial precursor
NM_004077.3	NP_004068.2	citrate synthase, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CS	XP_001153202.1
Bos taurus (cattle)	CS	NP_001038186.1
Rattus norvegicus (Norway rat)	Cs	NP_570111.1
Danio rerio (zebrafish)	LOC100536541	XP_003201261.1
Drosophila melanogaster (fruit fly)	kdn	NP_572319.2
Arabidopsis thaliana (thale cress)	ATCS	NP_850415.1
Oryza sativa (rice)	Os11g0538900	NP_001068031.1
Gallus gallus (chicken)	CS	XP_003644004.2
	LOC709604	XP_001098147.2
Canis lupus familiaris (dog)	CS	XP_531634.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012048	XP_320478.4
Saccharomyces cerevisiae (baker's yeast)	CIT2	NP_009931.1
Mus musculus (house mouse)	Cs	NP_080720.1
Caenorhabditis elegans (roundworm)	cts-1	NP_499264.1
Xenopus tropicalis (tropical clawed frog)	cs	NP_001017313.1
Homo sapiens (human)	CS	NP_004068.2
Danio rerio (zebrafish)	cs	NP_955892.1
Oryza sativa (rice)	Os02g0194100	NP_001046175.1

Gene Ontology
Bibliography

Related articles in PubMed

Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.
Ma?ecki J, Jakobsson ME, Ho AYY, Moen A, Rustan AC, Falnes P?
The Journal of biological chemistry292(43)17950-17962(2017 10)

Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.
Rhein VF, Carroll J, Ding S, Fearnley IM, Walker JE
FEBS letters591(12)1641-1652(2017 Jun)

Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis.
Cai Q, Zhao M, Liu X, Wang X, Nie Y, Li P, Liu T, Ge R, Han F
Biochemical and biophysical research communications485(2)388-394(2017 04)

SIRT3 deacetylated and increased citrate synthase activity in PD model.
Cui XX, Li X, Dong SY, Guo YJ, Liu T, Wu YC
Biochemical and biophysical research communications484(4)767-773(2017 03)

G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers.
Zeng Y, Lv Y, Tao L, Ma J, Zhang H, Xu H, Xiao B, Shi Q, Ma K, Chen L
Oncotarget7(46)74526-74536(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

METTL12 methylates CS on Lys-395, which is localized in the CS active site. Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate.
Title: Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.

Data suggest that METTL12, localized in mitochondrial matrix, modifies/methylates Lys368 of citrate synthase in external surface region close to its catalytic site; addition/removal of methylation has no effect on citrate synthase activity; Lys368 occurs in highly conserved sequence of amino acid residues of citrate synthase. (METTL12 = methyltransferase-like protein 12)
Title: Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.

Data suggest that downregulation of citrate synthase (CS) expression in 293T cells leads to low level of ATP production, excessive superoxide formation and cell apoptosis, which implies a possible mechanism for hearing loss in A/J mice.
Title: Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis.

Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities.
Title: SIRT3 deacetylated and increased citrate synthase activity in PD model.

mir-122 and its targets G6PC3, ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers.
Title: G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers.

The following CS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25632	NM_004077.3 Latest version!	Homo sapiens citrate synthase (CS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu25632	NM_004077.2	Homo sapiens citrate synthase (CS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CS ( NM_004077.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004068.2 Homo sapiens citrate synthase (CS), mRNA.

Price & Availability↑

CloneID	OHu25632
Clone ID Related Accession (Same CDS sequence)	NM_004077.2 , NM_004077.3
Accession Version	NM_004077.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1401bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	citrate synthase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB990178.1, AK074956.1, BC000105.1 and BX640838.1. On Nov 14, 2003 this sequence version replaced NM_004077.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.253162.1, SRR1803612.255702.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTTAC TTACTGCGGC CGCCCGGCTC TTGGGAACCA AGAATGCATC TTGTCTTGTT 
CTTGCAGCCC GGCATGCCAG TGCTTCCTCC ACGAATTTGA AAGACATATT GGCTGACCTG 
ATACCTAAGG AGCAGGCCAG AATTAAGACT TTCAGGCAGC AACATGGCAA GACGGTGGTG 
GGCCAAATCA CTGTGGACAT GATGTATGGT GGCATGAGAG GCATGAAGGG ATTGGTCTAT 
GAAACATCAG TTCTTGATCC TGATGAGGGC ATCCGTTTCC GAGGCTTTAG TATCCCTGAA 
TGCCAGAAAC TGCTACCCAA GGCTAAGGGT GGGGAAGAAC CCCTGCCTGA GGGCTTATTT 
TGGCTGCTGG TAACTGGACA TATCCCAACA GAGGAACAGG TATCTTGGCT CTCAAAAGAG 
TGGGCAAAGA GGGCAGCTCT GCCTTCCCAT GTGGTCACCA TGCTGGACAA CTTTCCCACC 
AATCTACACC CCATGTCTCA GCTCAGTGCA GCTGTTACAG CCCTCAACAG TGAAAGTAAC 
TTTGCCCGAG CATATGCACA GGGTATCAGC CGAACCAAGT ACTGGGAGTT GATTTATGAA 
GACTCTATGG ATCTAATCGC AAAGCTACCT TGTGTTGCAG CAAAGATCTA CCGAAATCTC 
TACAGAGAAG GCAGCGGTAT TGGGGCCATT GACTCTAACC TGGACTGGTC TCACAATTTC 
ACCAACATGT TAGGCTATAC TGATCATCAG TTCACTGAGC TCACGCGCCT GTACCTCACC 
ATCCACAGTG ACCATGAGGG TGGCAATGTA AGTGCCCATA CCAGCCATTT GGTGGGCAGT 
GCCCTTTCCG ACCCTTACCT GTCCTTTGCA GCAGCCATGA ACGGGCTGGC AGGGCCTCTC 
CATGGACTGG CAAATCAGGA AGTGCTTGTC TGGCTAACAC AGCTGCAGAA GGAAGTTGGC 
AAAGATGTGT CAGATGAGAA GTTACGAGAC TACATCTGGA ACACACTCAA CTCAGGACGG 
GTTGTTCCAG GCTATGGCCA TGCAGTACTA AGGAAGACTG ATCCGCGATA TACCTGTCAG 
CGAGAGTTTG CTCTGAAACA CCTGCCTAAT GACCCCATGT TTAAGTTGGT TGCTCAGCTG 
TACAAGATTG TGCCCAATGT CCTCTTAGAG CAGGGTAAAG CCAAGAATCC TTGGCCCAAT 
GTAGATGCTC ACAGTGGGGT GCTGCTCCAG TATTATGGCA TGACGGAGAT GAATTACTAC 
ACGGTCCTGT TTGGGGTGTC ACGAGCATTG GGTGTACTGG CACAGCTCAT CTGGAGCCGA 
GCCTTAGGCT TCCCTCTAGA AAGGCCCAAG TCCATGAGCA CAGAGGGTCT GATGAAGTTT 
GTGGACTCTA AGTCAGGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004068.2
CDS	191..1591
Translation	MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

Target ORF information:

RefSeq Version	NM_004077.2
Organism	Homo sapiens(human)
Definition	Homo sapiens citrate synthase (CS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004077.2

ORF Insert Sequence:

ATGGCTTTAC TTACTGCGGC CGCCCGGCTC TTGGGAACCA AGAATGCATC TTGTCTTGTT 
CTTGCAGCCC GGCATGCCAG TGCTTCCTCC ACGAATTTGA AAGACATATT GGCTGACCTG 
ATACCTAAGG AGCAGGCCAG AATTAAGACT TTCAGGCAGC AACATGGCAA GACGGTGGTG 
GGCCAAATCA CTGTGGACAT GATGTATGGT GGCATGAGAG GCATGAAGGG ATTGGTCTAT 
GAAACATCAG TTCTTGATCC TGATGAGGGC ATCCGTTTCC GAGGCTTTAG TATCCCTGAA 
TGCCAGAAAC TGCTACCCAA GGCTAAGGGT GGGGAAGAAC CCCTGCCTGA GGGCTTATTT 
TGGCTGCTGG TAACTGGACA TATCCCAACA GAGGAACAGG TATCTTGGCT CTCAAAAGAG 
TGGGCAAAGA GGGCAGCTCT GCCTTCCCAT GTGGTCACCA TGCTGGACAA CTTTCCCACC 
AATCTACACC CCATGTCTCA GCTCAGTGCA GCTGTTACAG CCCTCAACAG TGAAAGTAAC 
TTTGCCCGAG CATATGCACA GGGTATCAGC CGAACCAAGT ACTGGGAGTT GATTTATGAA 
GACTCTATGG ATCTAATCGC AAAGCTACCT TGTGTTGCAG CAAAGATCTA CCGAAATCTC 
TACAGAGAAG GCAGCGGTAT TGGGGCCATT GACTCTAACC TGGACTGGTC TCACAATTTC 
ACCAACATGT TAGGCTATAC TGATCATCAG TTCACTGAGC TCACGCGCCT GTACCTCACC 
ATCCACAGTG ACCATGAGGG TGGCAATGTA AGTGCCCATA CCAGCCATTT GGTGGGCAGT 
GCCCTTTCCG ACCCTTACCT GTCCTTTGCA GCAGCCATGA ACGGGCTGGC AGGGCCTCTC 
CATGGACTGG CAAATCAGGA AGTGCTTGTC TGGCTAACAC AGCTGCAGAA GGAAGTTGGC 
AAAGATGTGT CAGATGAGAA GTTACGAGAC TACATCTGGA ACACACTCAA CTCAGGACGG 
GTTGTTCCAG GCTATGGCCA TGCAGTACTA AGGAAGACTG ATCCGCGATA TACCTGTCAG 
CGAGAGTTTG CTCTGAAACA CCTGCCTAAT GACCCCATGT TTAAGTTGGT TGCTCAGCTG 
TACAAGATTG TGCCCAATGT CCTCTTAGAG CAGGGTAAAG CCAAGAATCC TTGGCCCAAT 
GTAGATGCTC ACAGTGGGGT GCTGCTCCAG TATTATGGCA TGACGGAGAT GAATTACTAC 
ACGGTCCTGT TTGGGGTGTC ACGAGCATTG GGTGTACTGG CACAGCTCAT CTGGAGCCGA 
GCCTTAGGCT TCCCTCTAGA AAGGCCCAAG TCCATGAGCA CAGAGGGTCT GATGAAGTTT 
GTGGACTCTA AGTCAGGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CS ( NM_004077.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004068.2 Homo sapiens citrate synthase (CS), mRNA.

Price & Availability↑

CloneID	OHu25632
Clone ID Related Accession (Same CDS sequence)	NM_004077.2 , NM_004077.3
Accession Version	NM_004077.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1401bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	citrate synthase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB990178.1, AK074956.1 and BC000105.1. On Nov 23, 2018 this sequence version replaced NM_004077.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.938381.1, SRR1660805.242950.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000351328.8/ ENSP00000342056.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTTAC TTACTGCGGC CGCCCGGCTC TTGGGAACCA AGAATGCATC TTGTCTTGTT 
CTTGCAGCCC GGCATGCCAG TGCTTCCTCC ACGAATTTGA AAGACATATT GGCTGACCTG 
ATACCTAAGG AGCAGGCCAG AATTAAGACT TTCAGGCAGC AACATGGCAA GACGGTGGTG 
GGCCAAATCA CTGTGGACAT GATGTATGGT GGCATGAGAG GCATGAAGGG ATTGGTCTAT 
GAAACATCAG TTCTTGATCC TGATGAGGGC ATCCGTTTCC GAGGCTTTAG TATCCCTGAA 
TGCCAGAAAC TGCTACCCAA GGCTAAGGGT GGGGAAGAAC CCCTGCCTGA GGGCTTATTT 
TGGCTGCTGG TAACTGGACA TATCCCAACA GAGGAACAGG TATCTTGGCT CTCAAAAGAG 
TGGGCAAAGA GGGCAGCTCT GCCTTCCCAT GTGGTCACCA TGCTGGACAA CTTTCCCACC 
AATCTACACC CCATGTCTCA GCTCAGTGCA GCTGTTACAG CCCTCAACAG TGAAAGTAAC 
TTTGCCCGAG CATATGCACA GGGTATCAGC CGAACCAAGT ACTGGGAGTT GATTTATGAA 
GACTCTATGG ATCTAATCGC AAAGCTACCT TGTGTTGCAG CAAAGATCTA CCGAAATCTC 
TACAGAGAAG GCAGCGGTAT TGGGGCCATT GACTCTAACC TGGACTGGTC TCACAATTTC 
ACCAACATGT TAGGCTATAC TGATCATCAG TTCACTGAGC TCACGCGCCT GTACCTCACC 
ATCCACAGTG ACCATGAGGG TGGCAATGTA AGTGCCCATA CCAGCCATTT GGTGGGCAGT 
GCCCTTTCCG ACCCTTACCT GTCCTTTGCA GCAGCCATGA ACGGGCTGGC AGGGCCTCTC 
CATGGACTGG CAAATCAGGA AGTGCTTGTC TGGCTAACAC AGCTGCAGAA GGAAGTTGGC 
AAAGATGTGT CAGATGAGAA GTTACGAGAC TACATCTGGA ACACACTCAA CTCAGGACGG 
GTTGTTCCAG GCTATGGCCA TGCAGTACTA AGGAAGACTG ATCCGCGATA TACCTGTCAG 
CGAGAGTTTG CTCTGAAACA CCTGCCTAAT GACCCCATGT TTAAGTTGGT TGCTCAGCTG 
TACAAGATTG TGCCCAATGT CCTCTTAGAG CAGGGTAAAG CCAAGAATCC TTGGCCCAAT 
GTAGATGCTC ACAGTGGGGT GCTGCTCCAG TATTATGGCA TGACGGAGAT GAATTACTAC 
ACGGTCCTGT TTGGGGTGTC ACGAGCATTG GGTGTACTGG CACAGCTCAT CTGGAGCCGA 
GCCTTAGGCT TCCCTCTAGA AAGGCCCAAG TCCATGAGCA CAGAGGGTCT GATGAAGTTT 
GTGGACTCTA AGTCAGGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004068.2
CDS	130..1530
Translation	MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

Target ORF information:

RefSeq Version	NM_004077.3
Organism	Homo sapiens(human)
Definition	Homo sapiens citrate synthase (CS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004077.3

ORF Insert Sequence:

ATGGCTTTAC TTACTGCGGC CGCCCGGCTC TTGGGAACCA AGAATGCATC TTGTCTTGTT 
CTTGCAGCCC GGCATGCCAG TGCTTCCTCC ACGAATTTGA AAGACATATT GGCTGACCTG 
ATACCTAAGG AGCAGGCCAG AATTAAGACT TTCAGGCAGC AACATGGCAA GACGGTGGTG 
GGCCAAATCA CTGTGGACAT GATGTATGGT GGCATGAGAG GCATGAAGGG ATTGGTCTAT 
GAAACATCAG TTCTTGATCC TGATGAGGGC ATCCGTTTCC GAGGCTTTAG TATCCCTGAA 
TGCCAGAAAC TGCTACCCAA GGCTAAGGGT GGGGAAGAAC CCCTGCCTGA GGGCTTATTT 
TGGCTGCTGG TAACTGGACA TATCCCAACA GAGGAACAGG TATCTTGGCT CTCAAAAGAG 
TGGGCAAAGA GGGCAGCTCT GCCTTCCCAT GTGGTCACCA TGCTGGACAA CTTTCCCACC 
AATCTACACC CCATGTCTCA GCTCAGTGCA GCTGTTACAG CCCTCAACAG TGAAAGTAAC 
TTTGCCCGAG CATATGCACA GGGTATCAGC CGAACCAAGT ACTGGGAGTT GATTTATGAA 
GACTCTATGG ATCTAATCGC AAAGCTACCT TGTGTTGCAG CAAAGATCTA CCGAAATCTC 
TACAGAGAAG GCAGCGGTAT TGGGGCCATT GACTCTAACC TGGACTGGTC TCACAATTTC 
ACCAACATGT TAGGCTATAC TGATCATCAG TTCACTGAGC TCACGCGCCT GTACCTCACC 
ATCCACAGTG ACCATGAGGG TGGCAATGTA AGTGCCCATA CCAGCCATTT GGTGGGCAGT 
GCCCTTTCCG ACCCTTACCT GTCCTTTGCA GCAGCCATGA ACGGGCTGGC AGGGCCTCTC 
CATGGACTGG CAAATCAGGA AGTGCTTGTC TGGCTAACAC AGCTGCAGAA GGAAGTTGGC 
AAAGATGTGT CAGATGAGAA GTTACGAGAC TACATCTGGA ACACACTCAA CTCAGGACGG 
GTTGTTCCAG GCTATGGCCA TGCAGTACTA AGGAAGACTG ATCCGCGATA TACCTGTCAG 
CGAGAGTTTG CTCTGAAACA CCTGCCTAAT GACCCCATGT TTAAGTTGGT TGCTCAGCTG 
TACAAGATTG TGCCCAATGT CCTCTTAGAG CAGGGTAAAG CCAAGAATCC TTGGCCCAAT 
GTAGATGCTC ACAGTGGGGT GCTGCTCCAG TATTATGGCA TGACGGAGAT GAATTACTAC 
ACGGTCCTGT TTGGGGTGTC ACGAGCATTG GGTGTACTGG CACAGCTCAT CTGGAGCCGA 
GCCTTAGGCT TCCCTCTAGA AAGGCCCAAG TCCATGAGCA CAGAGGGTCT GATGAAGTTT 
GTGGACTCTA AGTCAGGGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation.
The Journal of biological chemistry292(43)17950-17962(2017 10)
Ma?ecki J,Jakobsson ME,Ho AYY,Moen A,Rustan AC,Falnes P?

Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.
FEBS letters591(12)1641-1652(2017 Jun)
Rhein VF,Carroll J,Ding S,Fearnley IM,Walker JE

Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis.
Biochemical and biophysical research communications485(2)388-394(2017 04)
Cai Q,Zhao M,Liu X,Wang X,Nie Y,Li P,Liu T,Ge R,Han F

SIRT3 deacetylated and increased citrate synthase activity in PD model.
Biochemical and biophysical research communications484(4)767-773(2017 03)
Cui XX,Li X,Dong SY,Guo YJ,Liu T,Wu YC

G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers.
Oncotarget7(46)74526-74536(2016 10)
Zeng Y,Lv Y,Tao L,Ma J,Zhang H,Xu H,Xiao B,Shi Q,Ma K,Chen L

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CS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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