DEFB129 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFB129
Entrez Gene ID	140881
Full Name	defensin beta 129
Synonyms	C20orf87,DEFB-29,DEFB29,bA530N10.3,hBD-29
General protein information	Preferred Names defensin beta 129 Names beta-defensin 129 beta-defensin 29
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p13
Summary	Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080831.4	NP_543021.1	beta-defensin 129 precursor
NM_080831.3	NP_543021.1	beta-defensin 129 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DEFB129	NP_001073396.1
	DEFB129	XP_001111314.1
Canis lupus familiaris (dog)	DEFB129	XP_003433280.2
Mus musculus (house mouse)	Defb23	NP_001033022.1
Homo sapiens (human)	DEFB129	NP_543021.1
Bos taurus (cattle)	BBD129	XP_005215143.1
Rattus norvegicus (Norway rat)	Defb23	NP_001032607.1

Gene Ontology
Bibliography

Related articles in PubMed

A genome-wide association study identifies potential susceptibility loci for Hirschsprung disease.
Kim JH, Cheong HS, Sul JH, Seo JM, Kim DY, Oh JT, Park KW, Kim HY, Jung SM, Jung K, Cho MJ, Bae JS, Shin HD
PloS one9(10)e110292(2014)

ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
Kao CY, Chen Y, Zhao YH, Wu R
American journal of respiratory cell and molecular biology29(1)71-80(2003 Jul)

Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.
Rodr?guez-Jim?nez FJ, Krause A, Schulz S, Forssmann WG, Conejo-Garcia JR, Schreeb R, Motzkus D
Genomics81(2)175-83(2003 Feb)

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)

The DNA sequence and comparative analysis of human chromosome 20.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J
Nature414(6866)865-71(2001 Dec 20-27)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The protein encoded by this gene is thought to display antimicrobial activity.
Title: Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.

The following DEFB129 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB129 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05844	NM_080831.4 Latest version!	Homo sapiens defensin beta 129 (DEFB129), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu05844	NM_080831.3	Homo sapiens defensin beta 129 (DEFB129), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFB129 ( NM_080831.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_543021.1 Homo sapiens defensin beta 129 (DEFB129), mRNA.

Price & Availability↑

CloneID	OHu05844
Clone ID Related Accession (Same CDS sequence)	NM_080831.4 , NM_080831.3
Accession Version	NM_080831.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	beta-defensin 129 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070359.1, AF525931.1 and AI217663.1. On May 17, 2019 this sequence version replaced NM_080831.3. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.366842.1, GQ891507.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000246105.4/ ENSP00000246105.4 Protein has antimicrobial activity :: PMID: 12620395 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCC TTTTTCCTAT CTTTGCCAGC CTCATGCTAC AGTACCAGGT GAACACAGAA 
TTTATTGGCT TGAGACGCTG TTTAATGGGT TTGGGGAGAT GCAGGGATCA CTGCAATGTG 
GATGAAAAAG AGATACAGAA ATGCAAGATG AAAAAATGTT GTGTTGGACC AAAAGTGGTT 
AAATTGATTA AAAACTACCT GCAATATGGA ACACCAAATG TACTTAATGA AGACGTCCAA 
GAAATGCTAA AACCTGCCAA GAATTCTAGT GCTGTGATAC AAAGAAAACA TATTTTATCT 
GTTCTCCCCC AAATCAAAAG CACTAGCTTT TTTGCTAATA CCAACTTTGT CATCATTCCA 
AATGCCACCC CTATGAACTC TGCCACCATC AGCACTATGA CCCCAGGACA GATCACATAC 
ACTGCTACTT CTACCAAGAG TAACACCAAA GAAAGCAGAG ATTCTGCCAC TGCCTCGCCA 
CCACCAGCAC CACCTCCACC AAACATACTG CCAACACCAT CACTGGAGCT AGAGGAAGCA 
GAAGAGCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543021.1
CDS	32..583
Translation	MKLLFPIFASLMLQYQVNTEFIGLRRCLMGLGRCRDHCNVDEKEIQKCKMKKCCVGPKVVKLIKNYLQYGTPNVLNEDVQEMLKPAKNSSAVIQRKHILSVLPQIKSTSFFANTNFVIIPNATPMNSATISTMTPGQITYTATSTKSNTKESRDSATASPPPAPPPPNILPTPSLELEEAEEQ

Target ORF information:

RefSeq Version	NM_080831.4
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 129 (DEFB129), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080831.4

ORF Insert Sequence:

ATGAAGCTCC TTTTTCCTAT CTTTGCCAGC CTCATGCTAC AGTACCAGGT GAACACAGAA 
TTTATTGGCT TGAGACGCTG TTTAATGGGT TTGGGGAGAT GCAGGGATCA CTGCAATGTG 
GATGAAAAAG AGATACAGAA ATGCAAGATG AAAAAATGTT GTGTTGGACC AAAAGTGGTT 
AAATTGATTA AAAACTACCT GCAATATGGA ACACCAAATG TACTTAATGA AGACGTCCAA 
GAAATGCTAA AACCTGCCAA GAATTCTAGT GCTGTGATAC AAAGAAAACA TATTTTATCT 
GTTCTCCCCC AAATCAAAAG CACTAGCTTT TTTGCTAATA CCAACTTTGT CATCATTCCA 
AATGCCACCC CTATGAACTC TGCCACCATC AGCACTATGA CCCCAGGACA GATCACATAC 
ACTGCTACTT CTACCAAGAG TAACACCAAA GAAAGCAGAG ATTCTGCCAC TGCCTCGCCA 
CCACCAGCAC CACCTCCACC AAACATACTG CCAACACCAT CACTGGAGCT AGAGGAAGCA 
GAAGAGCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFB129 ( NM_080831.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_543021.1 Homo sapiens defensin beta 129 (DEFB129), mRNA.

Price & Availability↑

CloneID	OHu05844
Clone ID Related Accession (Same CDS sequence)	NM_080831.4 , NM_080831.3
Accession Version	NM_080831.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-08
Organism	Homo sapiens(human)
Product	beta-defensin 129 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070359.1, AF525931.1 and AI217663.1. On Nov 30, 2010 this sequence version replaced NM_080831.2. ##Evidence-Data-START## Transcript exon combination :: BC070359.1, AY358186.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12620395 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCC TTTTTCCTAT CTTTGCCAGC CTCATGCTAC AGTACCAGGT GAACACAGAA 
TTTATTGGCT TGAGACGCTG TTTAATGGGT TTGGGGAGAT GCAGGGATCA CTGCAATGTG 
GATGAAAAAG AGATACAGAA ATGCAAGATG AAAAAATGTT GTGTTGGACC AAAAGTGGTT 
AAATTGATTA AAAACTACCT GCAATATGGA ACACCAAATG TACTTAATGA AGACGTCCAA 
GAAATGCTAA AACCTGCCAA GAATTCTAGT GCTGTGATAC AAAGAAAACA TATTTTATCT 
GTTCTCCCCC AAATCAAAAG CACTAGCTTT TTTGCTAATA CCAACTTTGT CATCATTCCA 
AATGCCACCC CTATGAACTC TGCCACCATC AGCACTATGA CCCCAGGACA GATCACATAC 
ACTGCTACTT CTACCAAGAG TAACACCAAA GAAAGCAGAG ATTCTGCCAC TGCCTCGCCA 
CCACCAGCAC CACCTCCACC AAACATACTG CCAACACCAT CACTGGAGCT AGAGGAAGCA 
GAAGAGCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543021.1
CDS	32..583
Translation	MKLLFPIFASLMLQYQVNTEFIGLRRCLMGLGRCRDHCNVDEKEIQKCKMKKCCVGPKVVKLIKNYLQYGTPNVLNEDVQEMLKPAKNSSAVIQRKHILSVLPQIKSTSFFANTNFVIIPNATPMNSATISTMTPGQITYTATSTKSNTKESRDSATASPPPAPPPPNILPTPSLELEEAEEQ

Target ORF information:

RefSeq Version	NM_080831.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin beta 129 (DEFB129), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080831.3

ORF Insert Sequence:

ATGAAGCTCC TTTTTCCTAT CTTTGCCAGC CTCATGCTAC AGTACCAGGT GAACACAGAA 
TTTATTGGCT TGAGACGCTG TTTAATGGGT TTGGGGAGAT GCAGGGATCA CTGCAATGTG 
GATGAAAAAG AGATACAGAA ATGCAAGATG AAAAAATGTT GTGTTGGACC AAAAGTGGTT 
AAATTGATTA AAAACTACCT GCAATATGGA ACACCAAATG TACTTAATGA AGACGTCCAA 
GAAATGCTAA AACCTGCCAA GAATTCTAGT GCTGTGATAC AAAGAAAACA TATTTTATCT 
GTTCTCCCCC AAATCAAAAG CACTAGCTTT TTTGCTAATA CCAACTTTGT CATCATTCCA 
AATGCCACCC CTATGAACTC TGCCACCATC AGCACTATGA CCCCAGGACA GATCACATAC 
ACTGCTACTT CTACCAAGAG TAACACCAAA GAAAGCAGAG ATTCTGCCAC TGCCTCGCCA 
CCACCAGCAC CACCTCCACC AAACATACTG CCAACACCAT CACTGGAGCT AGAGGAAGCA 
GAAGAGCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genome-wide association study identifies potential susceptibility loci for Hirschsprung disease.
PloS one9(10)e110292(2014)
Kim JH,Cheong HS,Sul JH,Seo JM,Kim DY,Oh JT,Park KW,Kim HY,Jung SM,Jung K,Cho MJ,Bae JS,Shin HD

ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
American journal of respiratory cell and molecular biology29(1)71-80(2003 Jul)
Kao CY,Chen Y,Zhao YH,Wu R

Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.
Genomics81(2)175-83(2003 Feb)
Rodr?guez-Jim?nez FJ,Krause A,Schulz S,Forssmann WG,Conejo-Garcia JR,Schreeb R,Motzkus D

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
Proceedings of the National Academy of Sciences of the United States of America99(4)2129-33(2002 Feb)
Schutte BC,Mitros JP,Bartlett JA,Walters JD,Jia HP,Welsh MJ,Casavant TL,McCray PB Jr

The DNA sequence and comparative analysis of human chromosome 20.
Nature414(6866)865-71(2001 Dec 20-27)
Deloukas P,Matthews LH,Ashurst J,Burton J,Gilbert JG,Jones M,Stavrides G,Almeida JP,Babbage AK,Bagguley CL,Bailey J,Barlow KF,Bates KN,Beard LM,Beare DM,Beasley OP,Bird CP,Blakey SE,Bridgeman AM,Brown AJ,Buck D,Burrill W,Butler AP,Carder C,Carter NP,Chapman JC,Clamp M,Clark G,Clark LN,Clark SY,Clee CM,Clegg S,Cobley VE,Collier RE,Connor R,Corby NR,Coulson A,Coville GJ,Deadman R,Dhami P,Dunn M,Ellington AG,Frankland JA,Fraser A,French L,Garner P,Grafham DV,Griffiths C,Griffiths MN,Gwilliam R,Hall RE,Hammond S,Harley JL,Heath PD,Ho S,Holden JL,Howden PJ,Huckle E,Hunt AR,Hunt SE,Jekosch K,Johnson CM,Johnson D,Kay MP,Kimberley AM,King A,Knights A,Laird GK,Lawlor S,Lehvaslaiho MH,Leversha M,Lloyd C,Lloyd DM,Lovell JD,Marsh VL,Martin SL,McConnachie LJ,McLay K,McMurray AA,Milne S,Mistry D,Moore MJ,Mullikin JC,Nickerson T,Oliver K,Parker A,Patel R,Pearce TA,Peck AI,Phillimore BJ,Prathalingam SR,Plumb RW,Ramsay H,Rice CM,Ross MT,Scott CE,Sehra HK,Shownkeen R,Sims S,Skuce CD,Smith ML,Soderlund C,Steward CA,Sulston JE,Swann M,Sycamore N,Taylor R,Tee L,Thomas DW,Thorpe A,Tracey A,Tromans AC,Vaudin M,Wall M,Wallis JM,Whitehead SL,Whittaker P,Willey DL,Williams L,Williams SA,Wilming L,Wray PW,Hubbard T,Durbin RM,Bentley DR,Beck S,Rogers J

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DEFB129 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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