ROMO1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ROMO1
Entrez Gene ID	140823
Full Name	reactive oxygen species modulator 1
Synonyms	C20orf52,MTGM,MTGMP,bA353C18.2
General protein information	Preferred Names reactive oxygen species modulator 1 Names reactive oxygen species modulator 1 PCM19 ROS modulator 1 epididymis tissue protein Li 175 glyrichin mitochondrial targeting GXXXG protein mitochondrial targeting GxxxG motif protein protein MGR2 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.22
Summary	The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080748.3	NP_542786.1	reactive oxygen species modulator 1
NM_080748.2	NP_542786.1	reactive oxygen species modulator 1
XM_017027678.1	XP_016883167.1	reactive oxygen species modulator 1 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ROMO1	XP_534406.2
Mus musculus (house mouse)	Romo1	NP_080222.1
Rattus norvegicus (Norway rat)	Romo1	NP_001182419.1
Xenopus tropicalis (tropical clawed frog)	romo1	NP_001165117.1
Homo sapiens (human)	ROMO1	NP_542786.1
	ROMO1	XP_001100157.2
Rattus norvegicus (Norway rat)	LOC100910944	XP_006235514.1
Gallus gallus (chicken)	ROMO1	NP_001185750.1
Danio rerio (zebrafish)	zgc:73345	NP_957091.1
Drosophila melanogaster (fruit fly)	CG6878	NP_648757.1
Gallus gallus (chicken)	LOC100858376	XP_003642490.1
Pan troglodytes (chimpanzee)	ROMO1	XP_001165516.1
Bos taurus (cattle)	ROMO1	NP_001108000.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012145	XP_320383.2

Gene Ontology
Bibliography

Related articles in PubMed

Serum Romo1 is significantly associated with disease severity in patients with obstructive sleep apnea syndrome.
Ye L, Qian Y, Li Q, Fang S, Yang Z, Tan Y, Gu W
Sleep & breathing = Schlaf & Atmung(2018 Jan)

Reactive oxygen species modulator 1, a novel protein, combined with carcinoembryonic antigen in differentiating malignant from benign pleural effusion.
Chen X, Zhang N, Dong J, Sun G
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(5)1010428317698378(2017 May)

Reactive oxygen species modulator-1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients.
Kim HJ, Jo MJ, Kim BR, Kim JL, Jeong YA, Na YJ, Park SH, Lee SY, Lee DH, Lee HS, Kim BH, Lee SI, Min BW, Yoo YD, Oh SC
PloS one12(5)e0176834(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the diagnostic sensitivity and specificity of serum reactive oxygen species modulator 1 were only 41.38% and 86.21%, respectively, with the cutoff value of 27.22 ng/mL. The sensitivity and specificity of pleural fluid carcinoembryonic antigen were 69.23% and 88.00%, respectively, at the cutoff value of 3.05 ng/mL, while serum carcinoembryonic antigen were 80.77% and 72.00% at the cutoff value of 2.60 ng/mL.
Title: Reactive oxygen species modulator 1, a novel protein, combined with carcinoembryonic antigen in differentiating malignant from benign pleural effusion.

elevated in pleural effusion when lung cancer present
Title: Reactive oxygen species modulator 1 (Romo1) as a novel diagnostic marker for lung cancer-related malignant effusion.

Increased Romo1 expression was found to be associated with high lymph node ratio. Cancer invasiveness appeared to be a key reason for the poor survival related to highly expressed Romo1
Title: Reactive oxygen species modulator-1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients.

The rs6060566 polymorphism of the Romo-1 gene was found to be an independent risk factor for DR in Caucasians with T2DM.
Title: The rs6060566 of the reactive oxygen species modulator 1 (Romo-1) gene affects Romo-1 expression and the development of diabetic retinopathy in Caucasians with type 2 diabetes.

High ROMO1 expression is associated with Fanconi anemia.
Title: ROMO1 regulates RedOx states and serves as an inducer of NF-?B-driven EMT factors in Fanconi anemia.

The following ROMO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ROMO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23995	NM_080748.3 Latest version!	Homo sapiens reactive oxygen species modulator 1 (ROMO1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23995	XM_017027678.1 Latest version!	Homo sapiens reactive oxygen species modulator 1 (ROMO1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23995	NM_080748.2	Homo sapiens reactive oxygen species modulator 1 (ROMO1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ROMO1 ( NM_080748.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_542786.1 Homo sapiens reactive oxygen species modulator 1 (ROMO1), mRNA.

Price & Availability↑

CloneID	OHu23995
Clone ID Related Accession (Same CDS sequence)	NM_080748.3 , NM_080748.2 , XM_017027678.1
Accession Version	NM_080748.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	reactive oxygen species modulator 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC105281.1 and AK000548.1. On Nov 22, 2018 this sequence version replaced NM_080748.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK000548.1, BU851902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 16842742; reported by MitoCarta MANE Ensembl match :: ENST00000374077.8/ ENSP00000363190.3 Protein has antimicrobial activity :: PMID: 22083756 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGTGG CCGTGGGTCC CTACGGACAG TCCCAGCCAA GCTGCTTCGA CCGTGTCAAA 
ATGGGCTTCG TGATGGGTTG CGCCGTGGGC ATGGCGGCCG GGGCGCTCTT CGGCACCTTT 
TCCTGTCTCA GGATCGGAAT GCGGGGTCGA GAGCTGATGG GCGGCATTGG GAAAACCATG 
ATGCAGAGTG GCGGCACCTT TGGCACATTC ATGGCCATTG GGATGGGCAT CCGATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542786.1
CDS	53..292
Translation	MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC

Target ORF information:

RefSeq Version	NM_080748.3
Organism	Homo sapiens(human)
Definition	Homo sapiens reactive oxygen species modulator 1 (ROMO1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080748.3

ORF Insert Sequence:

ATGCCGGTGG CCGTGGGTCC CTACGGACAG TCCCAGCCAA GCTGCTTCGA CCGTGTCAAA 
ATGGGCTTCG TGATGGGTTG CGCCGTGGGC ATGGCGGCCG GGGCGCTCTT CGGCACCTTT 
TCCTGTCTCA GGATCGGAAT GCGGGGTCGA GAGCTGATGG GCGGCATTGG GAAAACCATG 
ATGCAGAGTG GCGGCACCTT TGGCACATTC ATGGCCATTG GGATGGGCAT CCGATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ROMO1 ( NM_080748.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_542786.1 Homo sapiens reactive oxygen species modulator 1 (ROMO1), mRNA.

Price & Availability↑

CloneID	OHu23995
Clone ID Related Accession (Same CDS sequence)	NM_080748.3 , NM_080748.2 , XM_017027678.1
Accession Version	NM_080748.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	reactive oxygen species modulator 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM353595.1, BC105281.1 and AK000548.1. On Sep 30, 2006 this sequence version replaced NM_080748.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279834.8460.1, CB110111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 16842742; reported by MitoCarta Protein has antimicrobial activity :: PMID: 22083756 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGGTGG CCGTGGGTCC CTACGGACAG TCCCAGCCAA GCTGCTTCGA CCGTGTCAAA 
ATGGGCTTCG TGATGGGTTG CGCCGTGGGC ATGGCGGCCG GGGCGCTCTT CGGCACCTTT 
TCCTGTCTCA GGATCGGAAT GCGGGGTCGA GAGCTGATGG GCGGCATTGG GAAAACCATG 
ATGCAGAGTG GCGGCACCTT TGGCACATTC ATGGCCATTG GGATGGGCAT CCGATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542786.1
CDS	148..387
Translation	MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC

Target ORF information:

RefSeq Version	NM_080748.2
Organism	Homo sapiens(human)
Definition	Homo sapiens reactive oxygen species modulator 1 (ROMO1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080748.2

ORF Insert Sequence:

ATGCCGGTGG CCGTGGGTCC CTACGGACAG TCCCAGCCAA GCTGCTTCGA CCGTGTCAAA 
ATGGGCTTCG TGATGGGTTG CGCCGTGGGC ATGGCGGCCG GGGCGCTCTT CGGCACCTTT 
TCCTGTCTCA GGATCGGAAT GCGGGGTCGA GAGCTGATGG GCGGCATTGG GAAAACCATG 
ATGCAGAGTG GCGGCACCTT TGGCACATTC ATGGCCATTG GGATGGGCAT CCGATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ROMO1 ( XM_017027678.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883167.1 Homo sapiens reactive oxygen species modulator 1 (ROMO1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu23995
Clone ID Related Accession (Same CDS sequence)	NM_080748.3 , NM_080748.2 , XM_017027678.1
Accession Version	XM_017027678.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	reactive oxygen species modulator 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGTGG CCGTGGGTCC CTACGGACAG TCCCAGCCAA GCTGCTTCGA CCGTGTCAAA 
ATGGGCTTCG TGATGGGTTG CGCCGTGGGC ATGGCGGCCG GGGCGCTCTT CGGCACCTTT 
TCCTGTCTCA GGATCGGAAT GCGGGGTCGA GAGCTGATGG GCGGCATTGG GAAAACCATG 
ATGCAGAGTG GCGGCACCTT TGGCACATTC ATGGCCATTG GGATGGGCAT CCGATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883167.1
CDS	143..382
Translation	MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC

Target ORF information:

RefSeq Version	XM_017027678.1
Organism	Homo sapiens(human)
Definition	Homo sapiens reactive oxygen species modulator 1 (ROMO1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027678.1

ORF Insert Sequence:

ATGCCGGTGG CCGTGGGTCC CTACGGACAG TCCCAGCCAA GCTGCTTCGA CCGTGTCAAA 
ATGGGCTTCG TGATGGGTTG CGCCGTGGGC ATGGCGGCCG GGGCGCTCTT CGGCACCTTT 
TCCTGTCTCA GGATCGGAAT GCGGGGTCGA GAGCTGATGG GCGGCATTGG GAAAACCATG 
ATGCAGAGTG GCGGCACCTT TGGCACATTC ATGGCCATTG GGATGGGCAT CCGATGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum Romo1 is significantly associated with disease severity in patients with obstructive sleep apnea syndrome.
Sleep & breathing = Schlaf & Atmung(2018 Jan)
Ye L,Qian Y,Li Q,Fang S,Yang Z,Tan Y,Gu W

Reactive oxygen species modulator 1, a novel protein, combined with carcinoembryonic antigen in differentiating malignant from benign pleural effusion.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(5)1010428317698378(2017 May)
Chen X,Zhang N,Dong J,Sun G

Reactive oxygen species modulator-1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients.
PloS one12(5)e0176834(2017)
Kim HJ,Jo MJ,Kim BR,Kim JL,Jeong YA,Na YJ,Park SH,Lee SY,Lee DH,Lee HS,Kim BH,Lee SI,Min BW,Yoo YD,Oh SC

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ROMO1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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