ASB6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ASB6
Entrez Gene ID	140459
Full Name	ankyrin repeat and SOCS box containing 6
General protein information	Preferred Names ankyrin repeat and SOCS box containing 6 Names ankyrin repeat and SOCS box protein 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q34.11
Summary	The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011].
Disorder MIM:	615051

mRNA and Protein(s)

mRNA	Protein	Name
NM_017873.3	NP_060343.1	ankyrin repeat and SOCS box protein 6 isoform 1
NM_177999.2	NP_821066.1	ankyrin repeat and SOCS box protein 6 isoform 2
NM_017873.4	NP_060343.1	ankyrin repeat and SOCS box protein 6 isoform 1
NM_001202403.1	NP_001189332.1	ankyrin repeat and SOCS box protein 6 isoform 3
NM_177999.3	NP_821066.1	ankyrin repeat and SOCS box protein 6 isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ASB6	NP_001192590.1
Gallus gallus (chicken)	ASB6	NP_001025859.1
	ASB6	XP_001107816.1
Danio rerio (zebrafish)	asb6	NP_001018412.1
Rattus norvegicus (Norway rat)	Asb6	NP_001011963.1
Xenopus tropicalis (tropical clawed frog)	asb6	NP_001016375.1
Homo sapiens (human)	ASB6	NP_060343.1
Pan troglodytes (chimpanzee)	ASB6	XP_001163675.1
Canis lupus familiaris (dog)	ASB6	XP_548420.2
Mus musculus (house mouse)	Asb6	NP_579924.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Girard A, Sachidanandam R, Hannon GJ, Carmell MA
Nature442(7099)199-202(2006 Jul)

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
Kohroki J, Nishiyama T, Nakamura T, Masuho Y
FEBS letters579(30)6796-802(2005 Dec)

Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.
Wilcox A, Katsanakis KD, Bheda F, Pillay TS
The Journal of biological chemistry279(37)38881-8(2004 Sep)

The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ
Trends in biochemical sciences27(5)235-41(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ASB6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASB6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12305	NM_001202403.1 Latest version!	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu12524	NM_177999.3 Latest version!	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu12878	NM_017873.4 Latest version!	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
View Old Accession Versions >>
OHu12878	NM_017873.3	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu12524	NM_177999.2	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ASB6 ( NM_001202403.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001189332.1 Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu12305
Clone ID Related Accession (Same CDS sequence)	NM_001202403.1
Accession Version	NM_001202403.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 6 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA953275.1, AK225618.1, AK000555.1, AL590369.18 and AL390135.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK225618.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGATCCACGA GAGTAGCCCC 
TTGGACCTGG CCAGCGAGGA GCCTGAGCGC CTGCCCTGCC TGCAGCGCCT CCTGGACCTT 
GGAGCTGATG TCAATGCCGC TGACAAGCAT GGGGCAGACG TCAAGGCCAC CACCAAAGAT 
GGGGACACAG TGTTCACCTG CATCATCTTC CTGCTTGGTG AGACCGTGGG AGGGGACAAA 
GAGGAGGCCC AGATGATCAA CCGCTTCTGC TTCCAAGTCA CACGGCTGCT GCTGGCACAC 
GGGGCCGACC CCAGCGAGTG CCCAGCCCAC GAGTCCCTCA CCCACATCTG CCTGAAGAGC 
TTTAAACTGC ACTTCCCTCT CCTGCGCTTC CTCCTGGAGT CCGGAGCCGC CTACAACTGC 
TCCCTGCACG GTGCGTCCTG CTGGTCTGGC TTTCACATCA TCTTTGAGAG GCTCTGTTCC 
CACCCAGGCT GCACGGAAGA CGAGAGCCAT GCGGACCTCC TGCGCAAAGC TGAGACTGTC 
CTGGATCTCA TGGTGACCAA CTCTCAGAAA CTCCAGCTGC CCGAAAACTT CGATATCCAC 
CCTGTGGGCA GCCTGGCGGA AAAGATCCAG GCCCTCCACT TCTCCTTGAG GCAGCTGGAG 
AGCTATCCCC CGCCCCTCAA GCACCTGTGC CGTGTGGCCA TCCGGCTCTA CCTTCAGCCG 
TGGCCTGTGG ATGTGAAGGT CAAAGCCCTG CCTCTGCCCG ACAGGCTGAA GTGGTACCTC 
CTTAGCGAGC ACAGTGGCTC CGTGGAAGAT GACATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001189332.1
CDS	171..1349
Translation	MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI

Target ORF information:

RefSeq Version	NM_001202403.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001202403.1

ORF Insert Sequence:

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGATCCACGA GAGTAGCCCC 
TTGGACCTGG CCAGCGAGGA GCCTGAGCGC CTGCCCTGCC TGCAGCGCCT CCTGGACCTT 
GGAGCTGATG TCAATGCCGC TGACAAGCAT GGGGCAGACG TCAAGGCCAC CACCAAAGAT 
GGGGACACAG TGTTCACCTG CATCATCTTC CTGCTTGGTG AGACCGTGGG AGGGGACAAA 
GAGGAGGCCC AGATGATCAA CCGCTTCTGC TTCCAAGTCA CACGGCTGCT GCTGGCACAC 
GGGGCCGACC CCAGCGAGTG CCCAGCCCAC GAGTCCCTCA CCCACATCTG CCTGAAGAGC 
TTTAAACTGC ACTTCCCTCT CCTGCGCTTC CTCCTGGAGT CCGGAGCCGC CTACAACTGC 
TCCCTGCACG GTGCGTCCTG CTGGTCTGGC TTTCACATCA TCTTTGAGAG GCTCTGTTCC 
CACCCAGGCT GCACGGAAGA CGAGAGCCAT GCGGACCTCC TGCGCAAAGC TGAGACTGTC 
CTGGATCTCA TGGTGACCAA CTCTCAGAAA CTCCAGCTGC CCGAAAACTT CGATATCCAC 
CCTGTGGGCA GCCTGGCGGA AAAGATCCAG GCCCTCCACT TCTCCTTGAG GCAGCTGGAG 
AGCTATCCCC CGCCCCTCAA GCACCTGTGC CGTGTGGCCA TCCGGCTCTA CCTTCAGCCG 
TGGCCTGTGG ATGTGAAGGT CAAAGCCCTG CCTCTGCCCG ACAGGCTGAA GTGGTACCTC 
CTTAGCGAGC ACAGTGGCTC CGTGGAAGAT GACATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASB6 ( NM_177999.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_821066.1 Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12524
Clone ID Related Accession (Same CDS sequence)	NM_177999.2 , NM_177999.3
Accession Version	NM_177999.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA953275.1, BC001719.1, AK000555.1, AL590369.18 and AL390135.1. On Jan 28, 2011 this sequence version replaced NM_177999.1. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a unique C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC001719.1, BI199939.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGGAAAAACT GCTCTGCTCC 
ATGCTCTGGC CAGCAGCGAC GGGGTGCAGA TCCACAATAC TGAGAACATT CGTCTCTTAC 
TGGAAGGAGG GGCAGACGTC AAGGCCACCA CCAAAGATGG GGACACAGTG TTCACCTGCA 
TCATCTTCCT GCTTGGTGAG ACCGTGGGAG GGGACAAAGA GGAGGCCCAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_821066.1
CDS	171..764
Translation	MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPASSSCLVRPWEGTKRRPR

Target ORF information:

RefSeq Version	NM_177999.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177999.2

ORF Insert Sequence:

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGGAAAAACT GCTCTGCTCC 
ATGCTCTGGC CAGCAGCGAC GGGGTGCAGA TCCACAATAC TGAGAACATT CGTCTCTTAC 
TGGAAGGAGG GGCAGACGTC AAGGCCACCA CCAAAGATGG GGACACAGTG TTCACCTGCA 
TCATCTTCCT GCTTGGTGAG ACCGTGGGAG GGGACAAAGA GGAGGCCCAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASB6 ( NM_177999.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_821066.1 Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12524
Clone ID Related Accession (Same CDS sequence)	NM_177999.2 , NM_177999.3
Accession Version	NM_177999.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590369.18. On May 31, 2019 this sequence version replaced NM_177999.2. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a unique C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC001719.1, BI199939.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGGAAAAACT GCTCTGCTCC 
ATGCTCTGGC CAGCAGCGAC GGGGTGCAGA TCCACAATAC TGAGAACATT CGTCTCTTAC 
TGGAAGGAGG GGCAGACGTC AAGGCCACCA CCAAAGATGG GGACACAGTG TTCACCTGCA 
TCATCTTCCT GCTTGGTGAG ACCGTGGGAG GGGACAAAGA GGAGGCCCAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_821066.1
CDS	153..746
Translation	MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPASSSCLVRPWEGTKRRPR

Target ORF information:

RefSeq Version	NM_177999.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177999.3

ORF Insert Sequence:

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGGAAAAACT GCTCTGCTCC 
ATGCTCTGGC CAGCAGCGAC GGGGTGCAGA TCCACAATAC TGAGAACATT CGTCTCTTAC 
TGGAAGGAGG GGCAGACGTC AAGGCCACCA CCAAAGATGG GGACACAGTG TTCACCTGCA 
TCATCTTCCT GCTTGGTGAG ACCGTGGGAG GGGACAAAGA GGAGGCCCAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASB6 ( NM_017873.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060343.1 Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12878
Clone ID Related Accession (Same CDS sequence)	NM_017873.3 , NM_017873.4
Accession Version	NM_017873.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA953275.1, AK000555.1, AL590369.18 and AL390135.1. On Jan 28, 2011 this sequence version replaced NM_017873.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.22872.1, SRR1803611.183085.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGATCCACGA GAGTAGCCCC 
TTGGACCTGG CCAGCGAGGA GCCTGAGCGC CTGCCCTGCC TGCAGCGCCT CCTGGACCTT 
GGAGCTGATG TCAATGCCGC TGACAAGCAT GGAAAAACTG CTCTGCTCCA TGCTCTGGCC 
AGCAGCGACG GGGTGCAGAT CCACAATACT GAGAACATTC GTCTCTTACT GGAAGGAGGG 
GCAGACGTCA AGGCCACCAC CAAAGATGGG GACACAGTGT TCACCTGCAT CATCTTCCTG 
CTTGGTGAGA CCGTGGGAGG GGACAAAGAG GAGGCCCAGA TGATCAACCG CTTCTGCTTC 
CAAGTCACAC GGCTGCTGCT GGCACACGGG GCCGACCCCA GCGAGTGCCC AGCCCACGAG 
TCCCTCACCC ACATCTGCCT GAAGAGCTTT AAACTGCACT TCCCTCTCCT GCGCTTCCTC 
CTGGAGTCCG GAGCCGCCTA CAACTGCTCC CTGCACGGTG CGTCCTGCTG GTCTGGCTTT 
CACATCATCT TTGAGAGGCT CTGTTCCCAC CCAGGCTGCA CGGAAGACGA GAGCCATGCG 
GACCTCCTGC GCAAAGCTGA GACTGTCCTG GATCTCATGG TGACCAACTC TCAGAAACTC 
CAGCTGCCCG AAAACTTCGA TATCCACCCT GTGGGCAGCC TGGCGGAAAA GATCCAGGCC 
CTCCACTTCT CCTTGAGGCA GCTGGAGAGC TATCCCCCGC CCCTCAAGCA CCTGTGCCGT 
GTGGCCATCC GGCTCTACCT TCAGCCGTGG CCTGTGGATG TGAAGGTCAA AGCCCTGCCT 
CTGCCCGACA GGCTGAAGTG GTACCTCCTT AGCGAGCACA GTGGCTCCGT GGAAGATGAC 
ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060343.1
CDS	171..1436
Translation	MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI

Target ORF information:

RefSeq Version	NM_017873.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017873.3

ORF Insert Sequence:

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGATCCACGA GAGTAGCCCC 
TTGGACCTGG CCAGCGAGGA GCCTGAGCGC CTGCCCTGCC TGCAGCGCCT CCTGGACCTT 
GGAGCTGATG TCAATGCCGC TGACAAGCAT GGAAAAACTG CTCTGCTCCA TGCTCTGGCC 
AGCAGCGACG GGGTGCAGAT CCACAATACT GAGAACATTC GTCTCTTACT GGAAGGAGGG 
GCAGACGTCA AGGCCACCAC CAAAGATGGG GACACAGTGT TCACCTGCAT CATCTTCCTG 
CTTGGTGAGA CCGTGGGAGG GGACAAAGAG GAGGCCCAGA TGATCAACCG CTTCTGCTTC 
CAAGTCACAC GGCTGCTGCT GGCACACGGG GCCGACCCCA GCGAGTGCCC AGCCCACGAG 
TCCCTCACCC ACATCTGCCT GAAGAGCTTT AAACTGCACT TCCCTCTCCT GCGCTTCCTC 
CTGGAGTCCG GAGCCGCCTA CAACTGCTCC CTGCACGGTG CGTCCTGCTG GTCTGGCTTT 
CACATCATCT TTGAGAGGCT CTGTTCCCAC CCAGGCTGCA CGGAAGACGA GAGCCATGCG 
GACCTCCTGC GCAAAGCTGA GACTGTCCTG GATCTCATGG TGACCAACTC TCAGAAACTC 
CAGCTGCCCG AAAACTTCGA TATCCACCCT GTGGGCAGCC TGGCGGAAAA GATCCAGGCC 
CTCCACTTCT CCTTGAGGCA GCTGGAGAGC TATCCCCCGC CCCTCAAGCA CCTGTGCCGT 
GTGGCCATCC GGCTCTACCT TCAGCCGTGG CCTGTGGATG TGAAGGTCAA AGCCCTGCCT 
CTGCCCGACA GGCTGAAGTG GTACCTCCTT AGCGAGCACA GTGGCTCCGT GGAAGATGAC 
ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASB6 ( NM_017873.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060343.1 Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 1, mRNA.

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CloneID	OHu12878
Clone ID Related Accession (Same CDS sequence)	NM_017873.3 , NM_017873.4
Accession Version	NM_017873.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	ankyrin repeat and SOCS box protein 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590369.18. On Nov 23, 2018 this sequence version replaced NM_017873.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.254876.1, SRR1803617.22872.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000277458.5/ ENSP00000277458.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGATCCACGA GAGTAGCCCC 
TTGGACCTGG CCAGCGAGGA GCCTGAGCGC CTGCCCTGCC TGCAGCGCCT CCTGGACCTT 
GGAGCTGATG TCAATGCCGC TGACAAGCAT GGAAAAACTG CTCTGCTCCA TGCTCTGGCC 
AGCAGCGACG GGGTGCAGAT CCACAATACT GAGAACATTC GTCTCTTACT GGAAGGAGGG 
GCAGACGTCA AGGCCACCAC CAAAGATGGG GACACAGTGT TCACCTGCAT CATCTTCCTG 
CTTGGTGAGA CCGTGGGAGG GGACAAAGAG GAGGCCCAGA TGATCAACCG CTTCTGCTTC 
CAAGTCACAC GGCTGCTGCT GGCACACGGG GCCGACCCCA GCGAGTGCCC AGCCCACGAG 
TCCCTCACCC ACATCTGCCT GAAGAGCTTT AAACTGCACT TCCCTCTCCT GCGCTTCCTC 
CTGGAGTCCG GAGCCGCCTA CAACTGCTCC CTGCACGGTG CGTCCTGCTG GTCTGGCTTT 
CACATCATCT TTGAGAGGCT CTGTTCCCAC CCAGGCTGCA CGGAAGACGA GAGCCATGCG 
GACCTCCTGC GCAAAGCTGA GACTGTCCTG GATCTCATGG TGACCAACTC TCAGAAACTC 
CAGCTGCCCG AAAACTTCGA TATCCACCCT GTGGGCAGCC TGGCGGAAAA GATCCAGGCC 
CTCCACTTCT CCTTGAGGCA GCTGGAGAGC TATCCCCCGC CCCTCAAGCA CCTGTGCCGT 
GTGGCCATCC GGCTCTACCT TCAGCCGTGG CCTGTGGATG TGAAGGTCAA AGCCCTGCCT 
CTGCCCGACA GGCTGAAGTG GTACCTCCTT AGCGAGCACA GTGGCTCCGT GGAAGATGAC 
ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060343.1
CDS	153..1418
Translation	MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDDI

Target ORF information:

RefSeq Version	NM_017873.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017873.4

ORF Insert Sequence:

ATGCCGTTCC TGCACGGCTT CCGGAGGATC ATCTTCGAGT ACCAGCCGCT GGTGGATGCG 
ATTCTGGGCT CCCTGGGGAT CCAGGACCCC GAGCGGCAGG AGTCTCTGGA CCGGCCCAGT 
TATGTCGCCA GCGAGGAGAG CCGAATCCTT GTTCTCACTG AGCTGCTGGA GAGGAAAGCC 
CACTCTCCCT TTTACCAGGA AGGCGTGAGC AACGCCCTGC TCAAGATGGC TGAGCTGGGG 
CTGACGCGGG CGGCCGACGT TCTCTTGCGG CATGGGGCCA ATCTCAACTT TGAAGACCCA 
GTCACCTACT ACACGGCCTT GCACATCGCC GTCCTGCGGA ACCAGCCGGA CATGGTGGAG 
CTGCTGGTGC ATCACGGGGC CGACGTTAAT CGGAGGGACC GGATCCACGA GAGTAGCCCC 
TTGGACCTGG CCAGCGAGGA GCCTGAGCGC CTGCCCTGCC TGCAGCGCCT CCTGGACCTT 
GGAGCTGATG TCAATGCCGC TGACAAGCAT GGAAAAACTG CTCTGCTCCA TGCTCTGGCC 
AGCAGCGACG GGGTGCAGAT CCACAATACT GAGAACATTC GTCTCTTACT GGAAGGAGGG 
GCAGACGTCA AGGCCACCAC CAAAGATGGG GACACAGTGT TCACCTGCAT CATCTTCCTG 
CTTGGTGAGA CCGTGGGAGG GGACAAAGAG GAGGCCCAGA TGATCAACCG CTTCTGCTTC 
CAAGTCACAC GGCTGCTGCT GGCACACGGG GCCGACCCCA GCGAGTGCCC AGCCCACGAG 
TCCCTCACCC ACATCTGCCT GAAGAGCTTT AAACTGCACT TCCCTCTCCT GCGCTTCCTC 
CTGGAGTCCG GAGCCGCCTA CAACTGCTCC CTGCACGGTG CGTCCTGCTG GTCTGGCTTT 
CACATCATCT TTGAGAGGCT CTGTTCCCAC CCAGGCTGCA CGGAAGACGA GAGCCATGCG 
GACCTCCTGC GCAAAGCTGA GACTGTCCTG GATCTCATGG TGACCAACTC TCAGAAACTC 
CAGCTGCCCG AAAACTTCGA TATCCACCCT GTGGGCAGCC TGGCGGAAAA GATCCAGGCC 
CTCCACTTCT CCTTGAGGCA GCTGGAGAGC TATCCCCCGC CCCTCAAGCA CCTGTGCCGT 
GTGGCCATCC GGCTCTACCT TCAGCCGTGG CCTGTGGATG TGAAGGTCAA AGCCCTGCCT 
CTGCCCGACA GGCTGAAGTG GTACCTCCTT AGCGAGCACA GTGGCTCCGT GGAAGATGAC 
ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Nature442(7099)199-202(2006 Jul)
Girard A,Sachidanandam R,Hannon GJ,Carmell MA

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
FEBS letters579(30)6796-802(2005 Dec)
Kohroki J,Nishiyama T,Nakamura T,Masuho Y

Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.
The Journal of biological chemistry279(37)38881-8(2004 Sep)
Wilcox A,Katsanakis KD,Bheda F,Pillay TS

The SOCS box: a tale of destruction and degradation.
Trends in biochemical sciences27(5)235-41(2002 May)
Kile BT,Schulman BA,Alexander WS,Nicola NA,Martin HM,Hilton DJ

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ASB6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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