ACTRT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACTRT1
Entrez Gene ID	139741
Full Name	actin related protein T1
Synonyms	AIP1,ARIP1,ARPT1,HSD27
General protein information	Preferred Names actin related protein T1 Names actin-related protein T1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq25
Summary	This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010].
Disorder MIM:	300487

mRNA and Protein(s)

mRNA	Protein	Name
NM_138289.3	NP_612146.1	actin-related protein T1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ACTRT1	NP_612146.1
Canis lupus familiaris (dog)	ACTRT1	XP_549241.1
Rattus norvegicus (Norway rat)	Actrt1	NP_001013983.1
Mus musculus (house mouse)	Actrt1	NP_082790.1
Bos taurus (cattle)	ACTRT1	XP_002699559.1
Pan troglodytes (chimpanzee)	ACTRT1	XP_529145.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.
Bal E, Park HS, Belaid-Choucair Z, Kayserili H, Naville M, Madrange M, Chiticariu E, Hadj-Rabia S, Cagnard N, Kuonen F, Bachmann D, Huber M, Le Gall C, C?t? F, Hanein S, Rosti R?, Aslanger AD, Waisfisz Q, Bodemer C, Hermine O, Morice-Picard F, Labeille B, Caux F, Mazereeuw-Hautier J, Philip N, Levy N, Taieb A, Avril MF, Headon DJ, Gyapay G, Magnaldo T, Fraitag S, Crollius HR, Vabres P, Hohl D, Munnich A, Smahi A
Nature medicine23(10)1226-1233(2017 Oct)

Image-based genome-wide siRNA screen identifies selective autophagy factors.
Orvedahl A, Sumpter R Jr, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B
Nature480(7375)113-7(2011 Dec)

Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head.
Heid H, Figge U, Winter S, Kuhn C, Zimbelmann R, Franke W
Experimental cell research279(2)177-87(2002 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified mutations in the ACTRT1 gene, which encodes actin-related protein T1 (ARP-T1), in two of the six families with Bazex-Dupre-Christol syndrome (BDCS) that were examined in this study. ARP-T1 was found to directly bind to the GLI1 promoter, thus inhibiting GLI1 expression, and loss of ARP-T1 led to activation of the Hedgehog pathway in individuals with BDCS.
Title: Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.

Describes the discovery of two actin-related proteins as major components in a cytoskeletal, nonmotile structure of bull spermatozoa, suggesting that certain members of this family of proteins may serve functions other than nucleation of actin filaments.
Title: Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head.

The following ACTRT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACTRT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18276	NM_138289.3 Latest version!	Homo sapiens actin related protein T1 (ACTRT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACTRT1 ( NM_138289.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_612146.1 Homo sapiens actin related protein T1 (ACTRT1), mRNA.

Price & Availability↑

CloneID	OHu18276
Clone ID Related Accession (Same CDS sequence)	NM_138289.3
Accession Version	NM_138289.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	actin-related protein T1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB452140.1, BC014597.1 and DB510229.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2009 this sequence version replaced NM_138289.2. ##Evidence-Data-START## Transcript is intronless :: BC014597.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTAATC CACATGCATT AGATGTTCCT GCTGTAATTT TTGACAATGG TTCAGGACTC 
TGCAAAGCAG GCCTGTCTGG AGAGATTGGA CCCCGCCATG TCATCAGCTC CGTCTTGGGA 
CATTGTAAAT TCAATGTGCC TTTAGCAAGA CTTAATCAGA AGTACTTCGT GGGGCAAGAA 
GCCCTGTACA AGTATGAGGC CCTACATTTG CACTACCCCA TTGAGCGTGG ACTGGTAACA 
GGATGGGATG ACATGGAGAA ACTCTGGAAA CATCTCTTTG AGCGGGAGCT TGGAGTAAAA 
CCCAGCCAAC AGCCTGTACT TATGACCGAG CCCTCTTTGA ATCCTAGGGA AATTCGAGAA 
AAGCTAGCAG AAATGATGTT TGAGACCTTC AGTGTGCCTG GTTTCTACCT GTCTAATCAT 
GCGGTGGCAG CGCTCTATGC CTCTGCCTGT GTCACAGGCC TGGTGGTGGA CAGTGGAGAT 
GGGGTCACTT GCACTGTCCC CATCTTTGAG GGTTACTCCC TGCCTCACGC AGTCACCAAA 
CTCTGTATGG CAGGGAGGGA CATCACAGAG CACCTCACCC GGCTCCTCTT TGCTAGCGGG 
TTTAACTTCC CTTGCATACT CAACAAGGCC GTGGTAAATA ACATCAAAGA GAAGTTGTGC 
TACATCGCCT TGGAGCCAGA GAAAGAGCTA CGCAAGAGCC GGGGAGAGGT CCTGGGAGCA 
TACAGACTGC CAGATGGACA TGTCATCCAC TTTGGGGATG AGCTGTACCA AGTGCCCGAG 
GTTCTTTTTG CACCTGACCA GCTGGGCATC CACAGCCCAG GACTCTCAAA AATGGTCTCC 
AGCAGCATCA TGAAGTGTGA CACTGACATC CAGAATAAAC TTTATGCAGA CATTGTACTC 
TCCGGGGGCA CCACTCTCCT CCCTGGGCTG GAGGAAAGGC TCATGAAGGA AGTGGAACAG 
CTGGCTTCCA AAGGTACTCC CATCAAGATC ACAGCTTCTC CTGATAGATG CTTCTCTGCA 
TGGATTGGTG CATCCATCAT GACCTCTATG AGCAGTTTCA AGCAGATGTG GGTCACCTCG 
GCAGACTTCA AGGAGTATGG GACATCTGTG GTTCAAAGAA GGTGCTTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612146.1
CDS	198..1328
Translation	MFNPHALDVPAVIFDNGSGLCKAGLSGEIGPRHVISSVLGHCKFNVPLARLNQKYFVGQEALYKYEALHLHYPIERGLVTGWDDMEKLWKHLFERELGVKPSQQPVLMTEPSLNPREIREKLAEMMFETFSVPGFYLSNHAVAALYASACVTGLVVDSGDGVTCTVPIFEGYSLPHAVTKLCMAGRDITEHLTRLLFASGFNFPCILNKAVVNNIKEKLCYIALEPEKELRKSRGEVLGAYRLPDGHVIHFGDELYQVPEVLFAPDQLGIHSPGLSKMVSSSIMKCDTDIQNKLYADIVLSGGTTLLPGLEERLMKEVEQLASKGTPIKITASPDRCFSAWIGASIMTSMSSFKQMWVTSADFKEYGTSVVQRRCF

Target ORF information:

RefSeq Version	NM_138289.3
Organism	Homo sapiens(human)
Definition	Homo sapiens actin related protein T1 (ACTRT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138289.3

ORF Insert Sequence:

ATGTTTAATC CACATGCATT AGATGTTCCT GCTGTAATTT TTGACAATGG TTCAGGACTC 
TGCAAAGCAG GCCTGTCTGG AGAGATTGGA CCCCGCCATG TCATCAGCTC CGTCTTGGGA 
CATTGTAAAT TCAATGTGCC TTTAGCAAGA CTTAATCAGA AGTACTTCGT GGGGCAAGAA 
GCCCTGTACA AGTATGAGGC CCTACATTTG CACTACCCCA TTGAGCGTGG ACTGGTAACA 
GGATGGGATG ACATGGAGAA ACTCTGGAAA CATCTCTTTG AGCGGGAGCT TGGAGTAAAA 
CCCAGCCAAC AGCCTGTACT TATGACCGAG CCCTCTTTGA ATCCTAGGGA AATTCGAGAA 
AAGCTAGCAG AAATGATGTT TGAGACCTTC AGTGTGCCTG GTTTCTACCT GTCTAATCAT 
GCGGTGGCAG CGCTCTATGC CTCTGCCTGT GTCACAGGCC TGGTGGTGGA CAGTGGAGAT 
GGGGTCACTT GCACTGTCCC CATCTTTGAG GGTTACTCCC TGCCTCACGC AGTCACCAAA 
CTCTGTATGG CAGGGAGGGA CATCACAGAG CACCTCACCC GGCTCCTCTT TGCTAGCGGG 
TTTAACTTCC CTTGCATACT CAACAAGGCC GTGGTAAATA ACATCAAAGA GAAGTTGTGC 
TACATCGCCT TGGAGCCAGA GAAAGAGCTA CGCAAGAGCC GGGGAGAGGT CCTGGGAGCA 
TACAGACTGC CAGATGGACA TGTCATCCAC TTTGGGGATG AGCTGTACCA AGTGCCCGAG 
GTTCTTTTTG CACCTGACCA GCTGGGCATC CACAGCCCAG GACTCTCAAA AATGGTCTCC 
AGCAGCATCA TGAAGTGTGA CACTGACATC CAGAATAAAC TTTATGCAGA CATTGTACTC 
TCCGGGGGCA CCACTCTCCT CCCTGGGCTG GAGGAAAGGC TCATGAAGGA AGTGGAACAG 
CTGGCTTCCA AAGGTACTCC CATCAAGATC ACAGCTTCTC CTGATAGATG CTTCTCTGCA 
TGGATTGGTG CATCCATCAT GACCTCTATG AGCAGTTTCA AGCAGATGTG GGTCACCTCG 
GCAGACTTCA AGGAGTATGG GACATCTGTG GTTCAAAGAA GGTGCTTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.
Nature medicine23(10)1226-1233(2017 Oct)
Bal E,Park HS,Belaid-Choucair Z,Kayserili H,Naville M,Madrange M,Chiticariu E,Hadj-Rabia S,Cagnard N,Kuonen F,Bachmann D,Huber M,Le Gall C,C?t? F,Hanein S,Rosti R?,Aslanger AD,Waisfisz Q,Bodemer C,Hermine O,Morice-Picard F,Labeille B,Caux F,Mazereeuw-Hautier J,Philip N,Levy N,Taieb A,Avril MF,Headon DJ,Gyapay G,Magnaldo T,Fraitag S,Crollius HR,Vabres P,Hohl D,Munnich A,Smahi A

Image-based genome-wide siRNA screen identifies selective autophagy factors.
Nature480(7375)113-7(2011 Dec)
Orvedahl A,Sumpter R Jr,Xiao G,Ng A,Zou Z,Tang Y,Narimatsu M,Gilpin C,Sun Q,Roth M,Forst CV,Wrana JL,Zhang YE,Luby-Phelps K,Xavier RJ,Xie Y,Levine B

Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head.
Experimental cell research279(2)177-87(2002 Oct)
Heid H,Figge U,Winter S,Kuhn C,Zimbelmann R,Franke W

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ACTRT1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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