CRIP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRIP1
Entrez Gene ID	1396
Full Name	cysteine rich protein 1
Synonyms	CRHP,CRIP,CRP-1,CRP1
General protein information	Preferred Names cysteine rich protein 1 Names cysteine-rich protein 1 cysteine-rich heart protein cysteine-rich intestinal protein cysteine-rich protein 1 (intestinal)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.33
Summary	Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008].
Disorder MIM:	123875

mRNA and Protein(s)

mRNA	Protein	Name
NM_001311.4	NP_001302.1	cysteine-rich protein 1
NM_001311.5	NP_001302.1	cysteine-rich protein 1

Pathways from BioSystems

Homologies

	CRIP1	XP_001086526.2
Canis lupus familiaris (dog)	CRIP1	XP_855531.1
Bos taurus (cattle)	CRIP1	NP_001020520.1
Rattus norvegicus (Norway rat)	Crip1	NP_001128405.1
Caenorhabditis elegans (roundworm)	exc-9	NP_501326.2
Mus musculus (house mouse)	Crip1	NP_031789.1
Gallus gallus (chicken)	CRIP1	XP_004943210.1
Danio rerio (zebrafish)	crip1	NP_001160054.1
Caenorhabditis elegans (roundworm)	valv-1	NP_501187.1
Homo sapiens (human)	CRIP1	NP_001302.1
Xenopus tropicalis (tropical clawed frog)	crip1	NP_001165119.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
Zeller T, Schurmann C, Schramm K, M?ller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T, Schnabel RB, Roden M, Wahl S, Rotter JI, Ojeda F, Carstensen-Kirberg M, Tregouet DA, D?rr M, Meitinger T, Lackner KJ, Wolf P, Felix SB, Landmesser U, Costanzo S, Ziegler A, Liu Y, V?lker U, Palmas W, Prokisch H, Guo X, Herder C, Blankenberg S, Homuth G
Hypertension (Dallas, Tex. : 1979)70(4)743-750(2017 10)

Cysteine-Rich Intestinal Protein 1 Silencing Inhibits Migration and Invasion in Human Colorectal Cancer.
He G, Zou L, Zhou L, Gao P, Qian X, Cui J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(3)897-906(2017)

The Impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) on Thyroid Carcinoma.
Li HG, Zhao LH, Zhang ZH, Liu JZ, Ren K, Li SY, Su ZJ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology43(5)2037-2046(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CRIP1 gene expression was correlated to measures of cardiac hypertrophy in Hypertension patients. Assessment of circulating CRIP1 (cystein-rich protein 1) levels as biomarkers showed a strong association with increased risk for incident stroke.
Title: Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.

The CRIP1 expression level was highest in the highly metastatic colon cancer cell lines and CRIP1 silencing did not significantly affect the percentage of apoptotic SW620 and HT29 cells.
Title: Cysteine-Rich Intestinal Protein 1 Silencing Inhibits Migration and Invasion in Human Colorectal Cancer.

This study provides evidence for a prognostic clinical potential of the combined study of GAL-3 and CRIP-1 in endometrial cancer
Title: Co-expression of galectin-3 and CRIP-1 in endometrial cancer: prognostic value and patient survival.

CRIP1 expression is associated with long-term survival and no metastases in osteosarcoma patients.
Title: CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients.

The following CRIP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRIP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31512	NM_001311.5 Latest version!	Homo sapiens cysteine rich protein 1 (CRIP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31512	NM_001311.4	Homo sapiens cysteine rich protein 1 (CRIP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRIP1 ( NM_001311.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001302.1 Homo sapiens cysteine rich protein 1 (CRIP1), mRNA.

Price & Availability↑

CloneID	OHu31512
Clone ID Related Accession (Same CDS sequence)	NM_001311.4 , NM_001311.5
Accession Version	NM_001311.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 234bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	cysteine-rich protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ128075.1, BU500642.1 and BC002738.2. On May 21, 2008 this sequence version replaced NM_001311.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.299829.1, SRR1163658.398610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAAGT GTCCCAAGTG CAACAAGGAG GTGTACTTCG CCGAGAGGGT GACCTCTCTG 
GGCAAGGACT GGCATCGGCC CTGCCTGAAG TGCGAGAAAT GTGGGAAGAC GCTGACCTCT 
GGGGGCCACG CTGAGCACGA AGGCAAACCC TACTGCAACC ACCCCTGCTA CGCAGCCATG 
TTTGGGCCTA AAGGCTTTGG GCGGGGCGGA GCCGAGAGCC ACACTTTCAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001302.1
CDS	115..348
Translation	MPKCPKCNKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK

Target ORF information:

RefSeq Version	NM_001311.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteine rich protein 1 (CRIP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311.4

ORF Insert Sequence:

ATGCCCAAGT GTCCCAAGTG CAACAAGGAG GTGTACTTCG CCGAGAGGGT GACCTCTCTG 
GGCAAGGACT GGCATCGGCC CTGCCTGAAG TGCGAGAAAT GTGGGAAGAC GCTGACCTCT 
GGGGGCCACG CTGAGCACGA AGGCAAACCC TACTGCAACC ACCCCTGCTA CGCAGCCATG 
TTTGGGCCTA AAGGCTTTGG GCGGGGCGGA GCCGAGAGCC ACACTTTCAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRIP1 ( NM_001311.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001302.1 Homo sapiens cysteine rich protein 1 (CRIP1), mRNA.

Price & Availability↑

CloneID	OHu31512
Clone ID Related Accession (Same CDS sequence)	NM_001311.4 , NM_001311.5
Accession Version	NM_001311.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 234bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	cysteine-rich protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL928654.1, BQ128075.1, BU500642.1 and BC002738.2. On May 17, 2019 this sequence version replaced NM_001311.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.517542.1, SRR1163658.398610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000392531.4/ ENSP00000376315.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCCAAGT GTCCCAAGTG CAACAAGGAG GTGTACTTCG CCGAGAGGGT GACCTCTCTG 
GGCAAGGACT GGCATCGGCC CTGCCTGAAG TGCGAGAAAT GTGGGAAGAC GCTGACCTCT 
GGGGGCCACG CTGAGCACGA AGGCAAACCC TACTGCAACC ACCCCTGCTA CGCAGCCATG 
TTTGGGCCTA AAGGCTTTGG GCGGGGCGGA GCCGAGAGCC ACACTTTCAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001302.1
CDS	149..382
Translation	MPKCPKCNKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK

Target ORF information:

RefSeq Version	NM_001311.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteine rich protein 1 (CRIP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311.5

ORF Insert Sequence:

ATGCCCAAGT GTCCCAAGTG CAACAAGGAG GTGTACTTCG CCGAGAGGGT GACCTCTCTG 
GGCAAGGACT GGCATCGGCC CTGCCTGAAG TGCGAGAAAT GTGGGAAGAC GCTGACCTCT 
GGGGGCCACG CTGAGCACGA AGGCAAACCC TACTGCAACC ACCCCTGCTA CGCAGCCATG 
TTTGGGCCTA AAGGCTTTGG GCGGGGCGGA GCCGAGAGCC ACACTTTCAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
Hypertension (Dallas, Tex. : 1979)70(4)743-750(2017 10)
Zeller T,Schurmann C,Schramm K,M?ller C,Kwon S,Wild PS,Teumer A,Herrington D,Schillert A,Iacoviello L,Kratzer A,Jagodzinski A,Karakas M,Ding J,Neumann JT,Kuulasmaa K,Gieger C,Kacprowski T,Schnabel RB,Roden M,Wahl S,Rotter JI,Ojeda F,Carstensen-Kirberg M,Tregouet DA,D?rr M,Meitinger T,Lackner KJ,Wolf P,Felix SB,Landmesser U,Costanzo S,Ziegler A,Liu Y,V?lker U,Palmas W,Prokisch H,Guo X,Herder C,Blankenberg S,Homuth G

Cysteine-Rich Intestinal Protein 1 Silencing Inhibits Migration and Invasion in Human Colorectal Cancer.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(3)897-906(2017)
He G,Zou L,Zhou L,Gao P,Qian X,Cui J

The Impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) on Thyroid Carcinoma.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology43(5)2037-2046(2017)
Li HG,Zhao LH,Zhang ZH,Liu JZ,Ren K,Li SY,Su ZJ

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CRIP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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