CLDN23 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLDN23
Entrez Gene ID	137075
Full Name	claudin 23
Synonyms	CLDNL,hCG1646163
General protein information	Preferred Names claudin 23 Names claudin-23 2310014B08Rik
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010].
Disorder MIM:	609203

mRNA and Protein(s)

mRNA	Protein	Name
NM_194284.3	NP_919260.2	claudin-23
NM_194284.2	NP_919260.2	claudin-23

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLDN23	NP_919260.2
Gallus gallus (chicken)	CLDN23	XP_004941217.1
Danio rerio (zebrafish)	LOC567620	XP_005155637.1
Pan troglodytes (chimpanzee)	CLDN23	XP_528065.2
Xenopus tropicalis (tropical clawed frog)	LOC100490599	XP_004911118.1
Danio rerio (zebrafish)	si:ch211-95j8.2	XP_001337447.2
	CLDN23	XP_001091185.1
Rattus norvegicus (Norway rat)	Cldn23	NP_001028234.1
Bos taurus (cattle)	CLDN23	XP_002698731.1
Mus musculus (house mouse)	Cldn23	NP_082274.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer.
Lu Y, Jing J, Sun L, Gong Y, Chen M, Wang Z, Sun M, Yuan Y
PloS one12(3)e0174476(2017)

Regulation of the expression of claudin 23 by the enhancer of zeste 2 polycomb group protein in colorectal cancer.
Maryan N, Statkiewicz M, Mikula M, Goryca K, Paziewska A, Strza?kowska A, Dabrowska M, Bujko M, Ostrowski J
Molecular medicine reports12(1)728-36(2015 Jul)

Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
Li L, Fridley BL, Kalari K, Niu N, Jenkins G, Batzler A, Abo RP, Schaid D, Wang L
BMC genomics1593(2014 Feb)

Differential expression and prognostic role of selected genes in colorectal cancer patients.
Pitule P, Vycital O, Bruha J, Novak P, Hosek P, Treska V, Hlavata I, Soucek P, Kralickova M, Liska V
Anticancer research33(11)4855-65(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of claudin-11, -23 was remarkably downregulated in gastric cancer.
Title: Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer.

The present study demonstrated an epigenetic link between the activity of the EZH2 methyltransferase at the CLDN23 locus and the expression of CLDN23 in CRC tissue.
Title: Regulation of the expression of claudin 23 by the enhancer of zeste 2 polycomb group protein in colorectal cancer.

Down-regulation of CLDN23 is associated with colorectal cancer.
Title: Differential expression and prognostic role of selected genes in colorectal cancer patients.

Observational study of gene-disease association. (HuGE Navigator)
Title: MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene.

characterization of CLDN23 gene, a candidate tumor suppressor gene implicated in intestinal-type gastric cancer
Title: CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.

The following CLDN23 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLDN23 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29165	NM_194284.3 Latest version!	Homo sapiens claudin 23 (CLDN23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu29165	NM_194284.2	Homo sapiens claudin 23 (CLDN23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLDN23 ( NM_194284.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_919260.2 Homo sapiens claudin 23 (CLDN23), mRNA.

Price & Availability↑

CloneID	OHu29165
Clone ID Related Accession (Same CDS sequence)	NM_194284.3 , NM_194284.2
Accession Version	NM_194284.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	claudin-23
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087269.5, BC125149.1 and BC016047.1. On May 17, 2019 this sequence version replaced NM_194284.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR6380200.29125.21, SRR7346977.1094289.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000519106.2/ ENSP00000428780.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGACGC CGGTGGTGAT GACGCTGGGC ATGGTGTTGG CGCCCTGCGG GCTCCTGCTC 
AACCTGACCG GCACCCTGGC GCCCGGCTGG CGGCTGGTGA AGGGCTTCCT GAACCAGCCA 
GTGGACGTGG AGTTGTACCA GGGCCTGTGG GACATGTGTC GCGAGCAGAG CAGCCGCGAG 
CGCGAGTGCG GCCAGACGGA CCAGTGGGGC TACTTCGAGG CCCAGCCCGT GCTGGTGGCG 
CGGGCACTCA TGGTCACCTC GCTGGCCGCC ACGGTCCTGG GGCTTCTGCT GGCGTCGCTG 
GGCGTGCGCT GCTGGCAGGA CGAGCCCAAC TTCGTGCTGG CAGGGCTCTC GGGCGTCGTG 
CTCTTCGTCG CTGGCCTCCT CGGCCTCATC CCGGTGTCCT GGTACAACCA CTTCTTGGGG 
GACCGCGACG TGCTGCCCGC CCCGGCCAGC CCGGTCACGG TGCAGGTCAG CTACAGCCTG 
GTCCTGGGCT ACCTGGGCAG CTGCCTCCTG CTGCTGGGCG GCTTCTCGCT GGCGCTCAGC 
TTCGCGCCCT GGTGCGACGA GCGTTGTCGC CGCCGCCGCA AGGGACCCTC CGCCGGGCCT 
CGCCGCAGCA GCGTCAGCAC CATCCAAGTG GAGTGGCCCG AGCCCGACCT GGCGCCCGCC 
ATCAAGTACT ACAGCGACGG CCAGCACCGA CCGCCGCCTG CCCAGCACCG CAAGCCCAAG 
CCCAAGCCCA AGGTCGGCTT CCCCATGCCG CGGCCGCGGC CCAAGGCCTA CACCAACTCG 
GTGGACGTCC TCGACGGGGA GGGGTGGGAG TCCCAGGACG CTCCCTCGTG CAGCACCCAC 
CCCTGCGACA GCTCGCTGCC CTGCGACTCC GACCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919260.2
CDS	463..1341
Translation	MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSFAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLAPAIKYYSDGQHRPPPAQHRKPKPKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPSCSTHPCDSSLPCDSDL

Target ORF information:

RefSeq Version	NM_194284.3
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 23 (CLDN23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194284.3

ORF Insert Sequence:

ATGCGGACGC CGGTGGTGAT GACGCTGGGC ATGGTGTTGG CGCCCTGCGG GCTCCTGCTC 
AACCTGACCG GCACCCTGGC GCCCGGCTGG CGGCTGGTGA AGGGCTTCCT GAACCAGCCA 
GTGGACGTGG AGTTGTACCA GGGCCTGTGG GACATGTGTC GCGAGCAGAG CAGCCGCGAG 
CGCGAGTGCG GCCAGACGGA CCAGTGGGGC TACTTCGAGG CCCAGCCCGT GCTGGTGGCG 
CGGGCACTCA TGGTCACCTC GCTGGCCGCC ACGGTCCTGG GGCTTCTGCT GGCGTCGCTG 
GGCGTGCGCT GCTGGCAGGA CGAGCCCAAC TTCGTGCTGG CAGGGCTCTC GGGCGTCGTG 
CTCTTCGTCG CTGGCCTCCT CGGCCTCATC CCGGTGTCCT GGTACAACCA CTTCTTGGGG 
GACCGCGACG TGCTGCCCGC CCCGGCCAGC CCGGTCACGG TGCAGGTCAG CTACAGCCTG 
GTCCTGGGCT ACCTGGGCAG CTGCCTCCTG CTGCTGGGCG GCTTCTCGCT GGCGCTCAGC 
TTCGCGCCCT GGTGCGACGA GCGTTGTCGC CGCCGCCGCA AGGGACCCTC CGCCGGGCCT 
CGCCGCAGCA GCGTCAGCAC CATCCAAGTG GAGTGGCCCG AGCCCGACCT GGCGCCCGCC 
ATCAAGTACT ACAGCGACGG CCAGCACCGA CCGCCGCCTG CCCAGCACCG CAAGCCCAAG 
CCCAAGCCCA AGGTCGGCTT CCCCATGCCG CGGCCGCGGC CCAAGGCCTA CACCAACTCG 
GTGGACGTCC TCGACGGGGA GGGGTGGGAG TCCCAGGACG CTCCCTCGTG CAGCACCCAC 
CCCTGCGACA GCTCGCTGCC CTGCGACTCC GACCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN23 ( NM_194284.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_919260.2 Homo sapiens claudin 23 (CLDN23), mRNA.

Price & Availability↑

CloneID	OHu29165
Clone ID Related Accession (Same CDS sequence)	NM_194284.3 , NM_194284.2
Accession Version	NM_194284.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	claudin-23
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087269.5, BC125149.1 and BC016047.1. On Jan 25, 2007 this sequence version replaced NM_194284.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCGGACGC CGGTGGTGAT GACGCTGGGC ATGGTGTTGG CGCCCTGCGG GCTCCTGCTC 
AACCTGACCG GCACCCTGGC GCCCGGCTGG CGGCTGGTGA AGGGCTTCCT GAACCAGCCA 
GTGGACGTGG AGTTGTACCA GGGCCTGTGG GACATGTGTC GCGAGCAGAG CAGCCGCGAG 
CGCGAGTGCG GCCAGACGGA CCAGTGGGGC TACTTCGAGG CCCAGCCCGT GCTGGTGGCG 
CGGGCACTCA TGGTCACCTC GCTGGCCGCC ACGGTCCTGG GGCTTCTGCT GGCGTCGCTG 
GGCGTGCGCT GCTGGCAGGA CGAGCCCAAC TTCGTGCTGG CAGGGCTCTC GGGCGTCGTG 
CTCTTCGTCG CTGGCCTCCT CGGCCTCATC CCGGTGTCCT GGTACAACCA CTTCTTGGGG 
GACCGCGACG TGCTGCCCGC CCCGGCCAGC CCGGTCACGG TGCAGGTCAG CTACAGCCTG 
GTCCTGGGCT ACCTGGGCAG CTGCCTCCTG CTGCTGGGCG GCTTCTCGCT GGCGCTCAGC 
TTCGCGCCCT GGTGCGACGA GCGTTGTCGC CGCCGCCGCA AGGGACCCTC CGCCGGGCCT 
CGCCGCAGCA GCGTCAGCAC CATCCAAGTG GAGTGGCCCG AGCCCGACCT GGCGCCCGCC 
ATCAAGTACT ACAGCGACGG CCAGCACCGA CCGCCGCCTG CCCAGCACCG CAAGCCCAAG 
CCCAAGCCCA AGGTCGGCTT CCCCATGCCG CGGCCGCGGC CCAAGGCCTA CACCAACTCG 
GTGGACGTCC TCGACGGGGA GGGGTGGGAG TCCCAGGACG CTCCCTCGTG CAGCACCCAC 
CCCTGCGACA GCTCGCTGCC CTGCGACTCC GACCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919260.2
CDS	244..1122
Translation	MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSFAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLAPAIKYYSDGQHRPPPAQHRKPKPKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPSCSTHPCDSSLPCDSDL

Target ORF information:

RefSeq Version	NM_194284.2
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 23 (CLDN23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194284.2

ORF Insert Sequence:

ATGCGGACGC CGGTGGTGAT GACGCTGGGC ATGGTGTTGG CGCCCTGCGG GCTCCTGCTC 
AACCTGACCG GCACCCTGGC GCCCGGCTGG CGGCTGGTGA AGGGCTTCCT GAACCAGCCA 
GTGGACGTGG AGTTGTACCA GGGCCTGTGG GACATGTGTC GCGAGCAGAG CAGCCGCGAG 
CGCGAGTGCG GCCAGACGGA CCAGTGGGGC TACTTCGAGG CCCAGCCCGT GCTGGTGGCG 
CGGGCACTCA TGGTCACCTC GCTGGCCGCC ACGGTCCTGG GGCTTCTGCT GGCGTCGCTG 
GGCGTGCGCT GCTGGCAGGA CGAGCCCAAC TTCGTGCTGG CAGGGCTCTC GGGCGTCGTG 
CTCTTCGTCG CTGGCCTCCT CGGCCTCATC CCGGTGTCCT GGTACAACCA CTTCTTGGGG 
GACCGCGACG TGCTGCCCGC CCCGGCCAGC CCGGTCACGG TGCAGGTCAG CTACAGCCTG 
GTCCTGGGCT ACCTGGGCAG CTGCCTCCTG CTGCTGGGCG GCTTCTCGCT GGCGCTCAGC 
TTCGCGCCCT GGTGCGACGA GCGTTGTCGC CGCCGCCGCA AGGGACCCTC CGCCGGGCCT 
CGCCGCAGCA GCGTCAGCAC CATCCAAGTG GAGTGGCCCG AGCCCGACCT GGCGCCCGCC 
ATCAAGTACT ACAGCGACGG CCAGCACCGA CCGCCGCCTG CCCAGCACCG CAAGCCCAAG 
CCCAAGCCCA AGGTCGGCTT CCCCATGCCG CGGCCGCGGC CCAAGGCCTA CACCAACTCG 
GTGGACGTCC TCGACGGGGA GGGGTGGGAG TCCCAGGACG CTCCCTCGTG CAGCACCCAC 
CCCTGCGACA GCTCGCTGCC CTGCGACTCC GACCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer.
PloS one12(3)e0174476(2017)
Lu Y,Jing J,Sun L,Gong Y,Chen M,Wang Z,Sun M,Yuan Y

Regulation of the expression of claudin 23 by the enhancer of zeste 2 polycomb group protein in colorectal cancer.
Molecular medicine reports12(1)728-36(2015 Jul)
Maryan N,Statkiewicz M,Mikula M,Goryca K,Paziewska A,Strza?kowska A,Dabrowska M,Bujko M,Ostrowski J

Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
BMC genomics1593(2014 Feb)
Li L,Fridley BL,Kalari K,Niu N,Jenkins G,Batzler A,Abo RP,Schaid D,Wang L

Differential expression and prognostic role of selected genes in colorectal cancer patients.
Anticancer research33(11)4855-65(2013 Nov)
Pitule P,Vycital O,Bruha J,Novak P,Hosek P,Treska V,Hlavata I,Soucek P,Kralickova M,Liska V

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CLDN23 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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