COX6A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX6A1
Entrez Gene ID	1337
Full Name	cytochrome c oxidase subunit 6A1
Synonyms	CMTRID,COX6A,COX6AL
General protein information	Preferred Names cytochrome c oxidase subunit 6A1 Names cytochrome c oxidase subunit 6A1, mitochondrial COX VIa-L cytochrome C oxidase subunit VIa homolog cytochrome c oxidase polypeptide VIa-liver cytochrome c oxidase subunit VIA-liver cytochrome c oxidase subunit VIa polypeptide 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q24.31\|12q24.2
Summary	Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008].
Disorder MIM:	602072
Disorder Html:	Charcot-Marie-Tooth disease, recessive intermediate D, 616039 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004373.4	NP_004364.2	cytochrome c oxidase subunit 6A1, mitochondrial
NM_004373.3	NP_004364.2	cytochrome c oxidase subunit 6A1, mitochondrial

Pathways from BioSystems

Homologies

	LOC696956	XP_002808040.1
Mus musculus (house mouse)	Cox6a1	NP_031774.1
Rattus norvegicus (Norway rat)	Cox6a1	NP_036946.1
Canis lupus familiaris (dog)	LOC477508	XP_534704.3
Gallus gallus (chicken)	COX6A1	NP_001264438.1
Danio rerio (zebrafish)	cox6a1	NP_001005592.1
Xenopus tropicalis (tropical clawed frog)	cox6a1	NP_001016543.1
Homo sapiens (human)	COX6A1	NP_004364.2
Pan troglodytes (chimpanzee)	LOC100616508	XP_003339284.1
Drosophila melanogaster (fruit fly)	levy	NP_611805.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000851	XP_316821.4

Gene Ontology
Bibliography

Related articles in PubMed

Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
Boczonadi V, Giunta M, Lane M, Tulinius M, Schara U, Horvath R
The international journal of biochemistry & cell biology6332-40(2015 Jun)

A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.
Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K
American journal of human genetics95(3)294-300(2014 Sep)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.
Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J
The Biochemical journal428(3)363-74(2010 May)

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
Lazarou M, Smith SM, Thorburn DR, Ryan MT, McKenzie M
The FEBS journal276(22)6701-13(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle
Title: Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.

Mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.
Title: A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 6a
Title: Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.

Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates.
Title: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.

The following COX6A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55939	NM_004373.4 Latest version!	Homo sapiens cytochrome c oxidase subunit 6A1 (COX6A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55939	NM_004373.3	Homo sapiens cytochrome c oxidase subunit 6A1 (COX6A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX6A1 ( NM_004373.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004364.2 Homo sapiens cytochrome c oxidase subunit 6A1 (COX6A1), mRNA.

Price & Availability↑

CloneID	OHu55939
Clone ID Related Accession (Same CDS sequence)	NM_004373.4 , NM_004373.3
Accession Version	NM_004373.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6A1, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312009.1 and BC107861.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004373.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV716665.1, SRR1163657.341458.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000229379.3/ ENSP00000229379.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT 
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG 
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG 
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT 
CCACTTCCAA CTGGCTACGA AGATGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004364.2
CDS	15..344
Translation	MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLKSHHGEHERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE

Target ORF information:

RefSeq Version	NM_004373.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6A1 (COX6A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004373.4

ORF Insert Sequence:

ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT 
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG 
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG 
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT 
CCACTTCCAA CTGGCTACGA AGATGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX6A1 ( NM_004373.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004364.2 Homo sapiens cytochrome c oxidase subunit 6A1 (COX6A1), mRNA.

Price & Availability↑

CloneID	OHu55939
Clone ID Related Accession (Same CDS sequence)	NM_004373.4 , NM_004373.3
Accession Version	NM_004373.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6A1, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312009.1, BC107861.1 and BP378295.1. This sequence is a reference standard in the RefSeqGene project. On Dec 31, 2011 this sequence version replaced NM_004373.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.106352.1, SRR1163657.528814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT 
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG 
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG 
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT 
CCACTTCCAA CTGGCTACGA AGATGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004364.2
CDS	38..367
Translation	MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLKSHHGEHERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE

Target ORF information:

RefSeq Version	NM_004373.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6A1 (COX6A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004373.3

ORF Insert Sequence:

ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT 
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG 
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG 
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT 
CCACTTCCAA CTGGCTACGA AGATGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
The international journal of biochemistry & cell biology6332-40(2015 Jun)
Boczonadi V,Giunta M,Lane M,Tulinius M,Schara U,Horvath R

A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.
American journal of human genetics95(3)294-300(2014 Sep)
Tamiya G,Makino S,Hayashi M,Abe A,Numakura C,Ueki M,Tanaka A,Ito C,Toshimori K,Ogawa N,Terashima T,Maegawa H,Yanagisawa D,Tooyama I,Tada M,Onodera O,Hayasaka K

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.
The Biochemical journal428(3)363-74(2010 May)
Fornuskova D,Stiburek L,Wenchich L,Vinsova K,Hansikova H,Zeman J

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
The FEBS journal276(22)6701-13(2009 Nov)
Lazarou M,Smith SM,Thorburn DR,Ryan MT,McKenzie M

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

COX6A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報