CORT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CORT
Entrez Gene ID	1325
Full Name	cortistatin
Synonyms	CST-14,CST-17,CST-29
General protein information	Preferred Names cortistatin Names cortistatin cortistatin-14 cortistatin-17 cortistatin-29 prepro-cortistatin preprocortistatin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.22
Summary	This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010].
Disorder MIM:	602784

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302.5	NP_001293.3	cortistatin preproprotein
NM_001302.4	NP_001293.3	cortistatin preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CORT	NP_001293.3
Pan troglodytes (chimpanzee)	CORT	NP_001191822.1
Bos taurus (cattle)	CORT	NP_001191825.1
Mus musculus (house mouse)	Cort	NP_031771.1
Rattus norvegicus (Norway rat)	Cort	NP_036967.1

Gene Ontology
Bibliography

Related articles in PubMed

Circulating levels of cortistatin are correlated with metabolic parameters in patients with newly diagnosed type 2 diabetes mellitus.
Chen W, Fu Y, Yin X, Liu Y
Peptides9486-90(2017 Aug)

The plasma levels of CST and BCKDK in patients with sepsis.
Zhang B, Sun GZ, Zhu ML, Li Y, Sun DJ, Zhang B, Bai XP
Peptides8680-84(2016 Dec)

Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.
Duran-Prado M, Morell M, Delgado-Maroto V, Casta?o JP, Aneiros-Fernandez J, de Lecea L, Culler MD, Hernandez-Cortes P, O'Valle F, Delgado M
Circulation research112(11)1444-55(2013 May)

Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fern?ndez-Aranda F, Guitart M, Mart?n-Santos R, Mench?n JM, Navin?s R, Soria V, Torrens M, Urretavizcaya M, Vall?s V, Gratac?s M, Estivill X
Journal of psychiatric research44(14)971-8(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

There is a relationship between plamsa CST and BCKDK in sepsis patients.
Title: The plasma levels of CST and BCKDK in patients with sepsis.

Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation.
Title: Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.

The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed.
Title: Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

The following CORT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CORT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08513	NM_001302.5 Latest version!	Homo sapiens cortistatin (CORT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu08513	NM_001302.4	Homo sapiens cortistatin (CORT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CORT ( NM_001302.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001293.3 Homo sapiens cortistatin (CORT), mRNA.

Price & Availability↑

CloneID	OHu08513
Clone ID Related Accession (Same CDS sequence)	NM_001302.5 , NM_001302.4
Accession Version	NM_001302.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	cortistatin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358561.1, BC119724.1, BC040034.1 and BF590359.1. On Jun 2, 2019 this sequence version replaced NM_001302.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040034.1, BI756063.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:11011067) RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA 
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC 
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA 
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC 
TTCTCCTCCT GCAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001293.3
CDS	194..511
Translation	MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK

Target ORF information:

RefSeq Version	NM_001302.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cortistatin (CORT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302.5

ORF Insert Sequence:

ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA 
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC 
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA 
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC 
TTCTCCTCCT GCAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CORT ( NM_001302.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001293.3 Homo sapiens cortistatin (CORT), mRNA.

Price & Availability↑

CloneID	OHu08513
Clone ID Related Accession (Same CDS sequence)	NM_001302.5 , NM_001302.4
Accession Version	NM_001302.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	cortistatin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358561.1, BC119724.1, BC040034.1, BF590359.1 and AL354956.13. On Nov 11, 2010 this sequence version replaced NM_001302.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358561.1, AF013252.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:11011067) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA 
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC 
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA 
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC 
TTCTCCTCCT GCAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001293.3
CDS	506..823
Translation	MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK

Target ORF information:

RefSeq Version	NM_001302.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cortistatin (CORT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302.4

ORF Insert Sequence:

ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA 
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC 
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA 
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC 
TTCTCCTCCT GCAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circulating levels of cortistatin are correlated with metabolic parameters in patients with newly diagnosed type 2 diabetes mellitus.
Peptides9486-90(2017 Aug)
Chen W,Fu Y,Yin X,Liu Y

The plasma levels of CST and BCKDK in patients with sepsis.
Peptides8680-84(2016 Dec)
Zhang B,Sun GZ,Zhu ML,Li Y,Sun DJ,Zhang B,Bai XP

Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.
Circulation research112(11)1444-55(2013 May)
Duran-Prado M,Morell M,Delgado-Maroto V,Casta?o JP,Aneiros-Fernandez J,de Lecea L,Culler MD,Hernandez-Cortes P,O'Valle F,Delgado M

Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Journal of psychiatric research44(14)971-8(2010 Oct)
Saus E,Brunet A,Armengol L,Alonso P,Crespo JM,Fern?ndez-Aranda F,Guitart M,Mart?n-Santos R,Mench?n JM,Navin?s R,Soria V,Torrens M,Urretavizcaya M,Vall?s V,Gratac?s M,Estivill X

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CORT cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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