GRK7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GRK7
Entrez Gene ID	131890
Full Name	G protein-coupled receptor kinase 7
Synonyms	GPRK7
General protein information	Preferred Names G protein-coupled receptor kinase 7 Names rhodopsin kinase g protein-coupled receptor kinase GRK7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q23
Summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008].
Disorder MIM:	606987

mRNA and Protein(s)

mRNA	Protein	Name
XM_017005717.1	XP_016861206.1	rhodopsin kinase isoform X1
NM_139209.2	NP_631948.1	rhodopsin kinase GRK7
XM_017005717.2	XP_016861206.1	rhodopsin kinase GRK7 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	GRK7	NP_631948.1
	GRK7	XP_001112570.1
Gallus gallus (chicken)	GRK7	XP_426681.2
Danio rerio (zebrafish)	grk7b	NP_001028262.1
Xenopus tropicalis (tropical clawed frog)	grk7	NP_001120573.1
Canis lupus familiaris (dog)	LOC485693	XP_542813.2
Pan troglodytes (chimpanzee)	GRK7	XP_526333.2
Bos taurus (cattle)	GRK7	NP_776757.1
Danio rerio (zebrafish)	grk7a	NP_001027011.2

Gene Ontology
Bibliography

Related articles in PubMed

A tale of two kinases in rods and cones.
Osawa S, Weiss ER
Advances in experimental medicine and biology723821-7(2012)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.
Torisawa A, Arinobu D, Tachibanaki S, Kawamura S
Photochemistry and photobiology84(4)823-30(2008 Jul-Aug)

Mapping of transcription start sites of human retina expressed genes.
Roni V, Carpio R, Wissinger B
BMC genomics842(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.
Title: A tale of two kinases in rods and cones.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

synthesis of 29 of GRK1 or GRK7 partial peptides that cover the entire sequence of GRK1/GRK7, to see which interacts with recoverin.
Title: Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.

The following GRK7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRK7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29274	NM_139209.2 Latest version!	Homo sapiens G protein-coupled receptor kinase 7 (GRK7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu29274	XM_017005717.2 Latest version!	Homo sapiens G protein-coupled receptor kinase 7 (GRK7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu29274	XM_017005717.1	Homo sapiens G protein-coupled receptor kinase 7 (GRK7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GRK7 ( NM_139209.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_631948.1 Homo sapiens G protein-coupled receptor kinase 7 (GRK7), mRNA.

Price & Availability↑

CloneID	OHu29274
Clone ID Related Accession (Same CDS sequence)	XM_017005717.1 , NM_139209.2 , XM_017005717.2
Accession Version	NM_139209.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Homo sapiens(human)
Product	rhodopsin kinase GRK7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF439409.1. On Sep 7, 2004 this sequence version replaced NM_139209.1. ##Evidence-Data-START## Transcript exon combination :: AF282269.1, AF439409.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142586 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGTGGACA TGGGGGCCCT GGACAACCTG ATCGCCAACA CCGCCTACCT GCAGGCCCGG 
AAGCCCTCGG ACTGCGACAG CAAAGAGCTG CAGCGGCGGC GGCGTAGCCT GGCCCTGCCC 
GGGCTGCAGG GCTGCGCGGA GCTCCGCCAG AAGCTGTCCC TGAACTTCCA CAGCCTGTGT 
GAGCAGCAGC CCATCGGTCG CCGCCTCTTC CGTGACTTCC TAGCCACAGT GCCCACGTTC 
CGCAAGGCGG CAACCTTCCT AGAGGACGTG CAGAACTGGG AGCTGGCCGA GGAGGGACCC 
ACCAAAGACA GCGCGCTGCA GGGGCTGGTG GCCACTTGTG CGAGTGCCCC TGCCCCGGGG 
AACCCGCAAC CCTTCCTCAG CCAGGCCGTG GCCACCAAGT GCCAAGCAGC CACCACTGAG 
GAAGAGCGAG TGGCTGCAGT GACGCTGGCC AAGGCTGAGG CCATGGCTTT CTTGCAAGAG 
CAGCCCTTTA AGGATTTCGT GACCAGCGCC TTCTACGACA AGTTTCTGCA GTGGAAACTC 
TTCGAGATGC AACCAGTGTC AGACAAGTAC TTCACTGAGT TCAGAGTGCT GGGGAAAGGT 
GGTTTTGGGG AGGTATGTGC CGTCCAGGTG AAAAACACTG GGAAGATGTA TGCCTGTAAG 
AAACTGGACA AGAAGCGGCT GAAGAAGAAA GGTGGCGAGA AGATGGCTCT CTTGGAAAAG 
GAAATCTTGG AGAAGGTCAG CAGCCCTTTC ATTGTCTCTC TGGCCTATGC CTTTGAGAGC 
AAGACCCATC TCTGCCTTGT CATGAGCCTG ATGAATGGGG GAGACCTCAA GTTCCACATC 
TACAACGTGG GCACGCGTGG CCTGGACATG AGCCGGGTGA TCTTTTACTC GGCCCAGATA 
GCCTGTGGGA TGCTGCACCT CCATGAACTC GGCATCGTCT ATCGGGACAT GAAGCCTGAG 
AATGTGCTTC TGGATGACCT CGGCAACTGC AGGTTATCTG ACCTGGGGCT GGCCGTGGAG 
ATGAAGGGTG GCAAGCCCAT CACCCAGAGG GCTGGAACCA ATGGTTACAT GGCTCCTGAG 
ATCCTAATGG AAAAGGTAAG TTATTCCTAT CCTGTGGACT GGTTTGCCAT GGGATGCAGC 
ATTTATGAAA TGGTTGCTGG ACGAACACCA TTCAAAGATT ACAAGGAAAA GGTCAGTAAA 
GAGGATCTGA AGCAAAGAAC TCTGCAAGAC GAGGTCAAAT TCCAGCATGA TAACTTCACA 
GAGGAAGCAA AAGATATTTG CAGGCTCTTC TTGGCTAAGA AACCAGAGCA ACGCTTAGGA 
AGCAGAGAAA AGTCTGATGA TCCCAGGAAA CATCATTTCT TTAAAACGAT CAACTTTCCT 
CGCCTGGAAG CTGGCCTAAT TGAACCCCCA TTTGTGCCAG ACCCTTCAGT GGTTTATGCC 
AAAGACATCG CTGAAATTGA TGATTTCTCT GAGGTTCGGG GGGTGGAATT TGATGACAAA 
GATAAGCAGT TCTTCAAAAA CTTTGCGACA GGTGCTGTTC CTATAGCATG GCAGGAAGAA 
ATTATAGAAA CGGGACTGTT TGAGGAACTG AATGACCCCA ACAGACCTAC GGGTTGTGAG 
GAGGGTAATT CATCCAAGTC TGGCGTGTGT TTGTTATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_631948.1
CDS	85..1746
Translation	MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL

Target ORF information:

RefSeq Version	NM_139209.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor kinase 7 (GRK7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139209.2

ORF Insert Sequence:

ATGGTGGACA TGGGGGCCCT GGACAACCTG ATCGCCAACA CCGCCTACCT GCAGGCCCGG 
AAGCCCTCGG ACTGCGACAG CAAAGAGCTG CAGCGGCGGC GGCGTAGCCT GGCCCTGCCC 
GGGCTGCAGG GCTGCGCGGA GCTCCGCCAG AAGCTGTCCC TGAACTTCCA CAGCCTGTGT 
GAGCAGCAGC CCATCGGTCG CCGCCTCTTC CGTGACTTCC TAGCCACAGT GCCCACGTTC 
CGCAAGGCGG CAACCTTCCT AGAGGACGTG CAGAACTGGG AGCTGGCCGA GGAGGGACCC 
ACCAAAGACA GCGCGCTGCA GGGGCTGGTG GCCACTTGTG CGAGTGCCCC TGCCCCGGGG 
AACCCGCAAC CCTTCCTCAG CCAGGCCGTG GCCACCAAGT GCCAAGCAGC CACCACTGAG 
GAAGAGCGAG TGGCTGCAGT GACGCTGGCC AAGGCTGAGG CCATGGCTTT CTTGCAAGAG 
CAGCCCTTTA AGGATTTCGT GACCAGCGCC TTCTACGACA AGTTTCTGCA GTGGAAACTC 
TTCGAGATGC AACCAGTGTC AGACAAGTAC TTCACTGAGT TCAGAGTGCT GGGGAAAGGT 
GGTTTTGGGG AGGTATGTGC CGTCCAGGTG AAAAACACTG GGAAGATGTA TGCCTGTAAG 
AAACTGGACA AGAAGCGGCT GAAGAAGAAA GGTGGCGAGA AGATGGCTCT CTTGGAAAAG 
GAAATCTTGG AGAAGGTCAG CAGCCCTTTC ATTGTCTCTC TGGCCTATGC CTTTGAGAGC 
AAGACCCATC TCTGCCTTGT CATGAGCCTG ATGAATGGGG GAGACCTCAA GTTCCACATC 
TACAACGTGG GCACGCGTGG CCTGGACATG AGCCGGGTGA TCTTTTACTC GGCCCAGATA 
GCCTGTGGGA TGCTGCACCT CCATGAACTC GGCATCGTCT ATCGGGACAT GAAGCCTGAG 
AATGTGCTTC TGGATGACCT CGGCAACTGC AGGTTATCTG ACCTGGGGCT GGCCGTGGAG 
ATGAAGGGTG GCAAGCCCAT CACCCAGAGG GCTGGAACCA ATGGTTACAT GGCTCCTGAG 
ATCCTAATGG AAAAGGTAAG TTATTCCTAT CCTGTGGACT GGTTTGCCAT GGGATGCAGC 
ATTTATGAAA TGGTTGCTGG ACGAACACCA TTCAAAGATT ACAAGGAAAA GGTCAGTAAA 
GAGGATCTGA AGCAAAGAAC TCTGCAAGAC GAGGTCAAAT TCCAGCATGA TAACTTCACA 
GAGGAAGCAA AAGATATTTG CAGGCTCTTC TTGGCTAAGA AACCAGAGCA ACGCTTAGGA 
AGCAGAGAAA AGTCTGATGA TCCCAGGAAA CATCATTTCT TTAAAACGAT CAACTTTCCT 
CGCCTGGAAG CTGGCCTAAT TGAACCCCCA TTTGTGCCAG ACCCTTCAGT GGTTTATGCC 
AAAGACATCG CTGAAATTGA TGATTTCTCT GAGGTTCGGG GGGTGGAATT TGATGACAAA 
GATAAGCAGT TCTTCAAAAA CTTTGCGACA GGTGCTGTTC CTATAGCATG GCAGGAAGAA 
ATTATAGAAA CGGGACTGTT TGAGGAACTG AATGACCCCA ACAGACCTAC GGGTTGTGAG 
GAGGGTAATT CATCCAAGTC TGGCGTGTGT TTGTTATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRK7 ( XM_017005717.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861206.1 Homo sapiens G protein-coupled receptor kinase 7 (GRK7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu29274
Clone ID Related Accession (Same CDS sequence)	XM_017005717.1 , NM_139209.2 , XM_017005717.2
Accession Version	XM_017005717.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	rhodopsin kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGACA TGGGGGCCCT GGACAACCTG ATCGCCAACA CCGCCTACCT GCAGGCCCGG 
AAGCCCTCGG ACTGCGACAG CAAAGAGCTG CAGCGGCGGC GGCGTAGCCT GGCCCTGCCC 
GGGCTGCAGG GCTGCGCGGA GCTCCGCCAG AAGCTGTCCC TGAACTTCCA CAGCCTGTGT 
GAGCAGCAGC CCATCGGTCG CCGCCTCTTC CGTGACTTCC TAGCCACAGT GCCCACGTTC 
CGCAAGGCGG CAACCTTCCT AGAGGACGTG CAGAACTGGG AGCTGGCCGA GGAGGGACCC 
ACCAAAGACA GCGCGCTGCA GGGGCTGGTG GCCACTTGTG CGAGTGCCCC TGCCCCGGGG 
AACCCGCAAC CCTTCCTCAG CCAGGCCGTG GCCACCAAGT GCCAAGCAGC CACCACTGAG 
GAAGAGCGAG TGGCTGCAGT GACGCTGGCC AAGGCTGAGG CCATGGCTTT CTTGCAAGAG 
CAGCCCTTTA AGGATTTCGT GACCAGCGCC TTCTACGACA AGTTTCTGCA GTGGAAACTC 
TTCGAGATGC AACCAGTGTC AGACAAGTAC TTCACTGAGT TCAGAGTGCT GGGGAAAGGT 
GGTTTTGGGG AGGTATGTGC CGTCCAGGTG AAAAACACTG GGAAGATGTA TGCCTGTAAG 
AAACTGGACA AGAAGCGGCT GAAGAAGAAA GGTGGCGAGA AGATGGCTCT CTTGGAAAAG 
GAAATCTTGG AGAAGGTCAG CAGCCCTTTC ATTGTCTCTC TGGCCTATGC CTTTGAGAGC 
AAGACCCATC TCTGCCTTGT CATGAGCCTG ATGAATGGGG GAGACCTCAA GTTCCACATC 
TACAACGTGG GCACGCGTGG CCTGGACATG AGCCGGGTGA TCTTTTACTC GGCCCAGATA 
GCCTGTGGGA TGCTGCACCT CCATGAACTC GGCATCGTCT ATCGGGACAT GAAGCCTGAG 
AATGTGCTTC TGGATGACCT CGGCAACTGC AGGTTATCTG ACCTGGGGCT GGCCGTGGAG 
ATGAAGGGTG GCAAGCCCAT CACCCAGAGG GCTGGAACCA ATGGTTACAT GGCTCCTGAG 
ATCCTAATGG AAAAGGTAAG TTATTCCTAT CCTGTGGACT GGTTTGCCAT GGGATGCAGC 
ATTTATGAAA TGGTTGCTGG ACGAACACCA TTCAAAGATT ACAAGGAAAA GGTCAGTAAA 
GAGGATCTGA AGCAAAGAAC TCTGCAAGAC GAGGTCAAAT TCCAGCATGA TAACTTCACA 
GAGGAAGCAA AAGATATTTG CAGGCTCTTC TTGGCTAAGA AACCAGAGCA ACGCTTAGGA 
AGCAGAGAAA AGTCTGATGA TCCCAGGAAA CATCATTTCT TTAAAACGAT CAACTTTCCT 
CGCCTGGAAG CTGGCCTAAT TGAACCCCCA TTTGTGCCAG ACCCTTCAGT GGTTTATGCC 
AAAGACATCG CTGAAATTGA TGATTTCTCT GAGGTTCGGG GGGTGGAATT TGATGACAAA 
GATAAGCAGT TCTTCAAAAA CTTTGCGACA GGTGCTGTTC CTATAGCATG GCAGGAAGAA 
ATTATAGAAA CGGGACTGTT TGAGGAACTG AATGACCCCA ACAGACCTAC GGGTTGTGAG 
GAGGGTAATT CATCCAAGTC TGGCGTGTGT TTGTTATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861206.1
CDS	2827..4488
Translation	MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL

Target ORF information:

RefSeq Version	XM_017005717.1
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor kinase 7 (GRK7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005717.1

ORF Insert Sequence:

ATGGTGGACA TGGGGGCCCT GGACAACCTG ATCGCCAACA CCGCCTACCT GCAGGCCCGG 
AAGCCCTCGG ACTGCGACAG CAAAGAGCTG CAGCGGCGGC GGCGTAGCCT GGCCCTGCCC 
GGGCTGCAGG GCTGCGCGGA GCTCCGCCAG AAGCTGTCCC TGAACTTCCA CAGCCTGTGT 
GAGCAGCAGC CCATCGGTCG CCGCCTCTTC CGTGACTTCC TAGCCACAGT GCCCACGTTC 
CGCAAGGCGG CAACCTTCCT AGAGGACGTG CAGAACTGGG AGCTGGCCGA GGAGGGACCC 
ACCAAAGACA GCGCGCTGCA GGGGCTGGTG GCCACTTGTG CGAGTGCCCC TGCCCCGGGG 
AACCCGCAAC CCTTCCTCAG CCAGGCCGTG GCCACCAAGT GCCAAGCAGC CACCACTGAG 
GAAGAGCGAG TGGCTGCAGT GACGCTGGCC AAGGCTGAGG CCATGGCTTT CTTGCAAGAG 
CAGCCCTTTA AGGATTTCGT GACCAGCGCC TTCTACGACA AGTTTCTGCA GTGGAAACTC 
TTCGAGATGC AACCAGTGTC AGACAAGTAC TTCACTGAGT TCAGAGTGCT GGGGAAAGGT 
GGTTTTGGGG AGGTATGTGC CGTCCAGGTG AAAAACACTG GGAAGATGTA TGCCTGTAAG 
AAACTGGACA AGAAGCGGCT GAAGAAGAAA GGTGGCGAGA AGATGGCTCT CTTGGAAAAG 
GAAATCTTGG AGAAGGTCAG CAGCCCTTTC ATTGTCTCTC TGGCCTATGC CTTTGAGAGC 
AAGACCCATC TCTGCCTTGT CATGAGCCTG ATGAATGGGG GAGACCTCAA GTTCCACATC 
TACAACGTGG GCACGCGTGG CCTGGACATG AGCCGGGTGA TCTTTTACTC GGCCCAGATA 
GCCTGTGGGA TGCTGCACCT CCATGAACTC GGCATCGTCT ATCGGGACAT GAAGCCTGAG 
AATGTGCTTC TGGATGACCT CGGCAACTGC AGGTTATCTG ACCTGGGGCT GGCCGTGGAG 
ATGAAGGGTG GCAAGCCCAT CACCCAGAGG GCTGGAACCA ATGGTTACAT GGCTCCTGAG 
ATCCTAATGG AAAAGGTAAG TTATTCCTAT CCTGTGGACT GGTTTGCCAT GGGATGCAGC 
ATTTATGAAA TGGTTGCTGG ACGAACACCA TTCAAAGATT ACAAGGAAAA GGTCAGTAAA 
GAGGATCTGA AGCAAAGAAC TCTGCAAGAC GAGGTCAAAT TCCAGCATGA TAACTTCACA 
GAGGAAGCAA AAGATATTTG CAGGCTCTTC TTGGCTAAGA AACCAGAGCA ACGCTTAGGA 
AGCAGAGAAA AGTCTGATGA TCCCAGGAAA CATCATTTCT TTAAAACGAT CAACTTTCCT 
CGCCTGGAAG CTGGCCTAAT TGAACCCCCA TTTGTGCCAG ACCCTTCAGT GGTTTATGCC 
AAAGACATCG CTGAAATTGA TGATTTCTCT GAGGTTCGGG GGGTGGAATT TGATGACAAA 
GATAAGCAGT TCTTCAAAAA CTTTGCGACA GGTGCTGTTC CTATAGCATG GCAGGAAGAA 
ATTATAGAAA CGGGACTGTT TGAGGAACTG AATGACCCCA ACAGACCTAC GGGTTGTGAG 
GAGGGTAATT CATCCAAGTC TGGCGTGTGT TTGTTATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GRK7 ( XM_017005717.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861206.1 Homo sapiens G protein-coupled receptor kinase 7 (GRK7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu29274
Clone ID Related Accession (Same CDS sequence)	XM_017005717.1 , NM_139209.2 , XM_017005717.2
Accession Version	XM_017005717.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rhodopsin kinase GRK7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017005717.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGACA TGGGGGCCCT GGACAACCTG ATCGCCAACA CCGCCTACCT GCAGGCCCGG 
AAGCCCTCGG ACTGCGACAG CAAAGAGCTG CAGCGGCGGC GGCGTAGCCT GGCCCTGCCC 
GGGCTGCAGG GCTGCGCGGA GCTCCGCCAG AAGCTGTCCC TGAACTTCCA CAGCCTGTGT 
GAGCAGCAGC CCATCGGTCG CCGCCTCTTC CGTGACTTCC TAGCCACAGT GCCCACGTTC 
CGCAAGGCGG CAACCTTCCT AGAGGACGTG CAGAACTGGG AGCTGGCCGA GGAGGGACCC 
ACCAAAGACA GCGCGCTGCA GGGGCTGGTG GCCACTTGTG CGAGTGCCCC TGCCCCGGGG 
AACCCGCAAC CCTTCCTCAG CCAGGCCGTG GCCACCAAGT GCCAAGCAGC CACCACTGAG 
GAAGAGCGAG TGGCTGCAGT GACGCTGGCC AAGGCTGAGG CCATGGCTTT CTTGCAAGAG 
CAGCCCTTTA AGGATTTCGT GACCAGCGCC TTCTACGACA AGTTTCTGCA GTGGAAACTC 
TTCGAGATGC AACCAGTGTC AGACAAGTAC TTCACTGAGT TCAGAGTGCT GGGGAAAGGT 
GGTTTTGGGG AGGTATGTGC CGTCCAGGTG AAAAACACTG GGAAGATGTA TGCCTGTAAG 
AAACTGGACA AGAAGCGGCT GAAGAAGAAA GGTGGCGAGA AGATGGCTCT CTTGGAAAAG 
GAAATCTTGG AGAAGGTCAG CAGCCCTTTC ATTGTCTCTC TGGCCTATGC CTTTGAGAGC 
AAGACCCATC TCTGCCTTGT CATGAGCCTG ATGAATGGGG GAGACCTCAA GTTCCACATC 
TACAACGTGG GCACGCGTGG CCTGGACATG AGCCGGGTGA TCTTTTACTC GGCCCAGATA 
GCCTGTGGGA TGCTGCACCT CCATGAACTC GGCATCGTCT ATCGGGACAT GAAGCCTGAG 
AATGTGCTTC TGGATGACCT CGGCAACTGC AGGTTATCTG ACCTGGGGCT GGCCGTGGAG 
ATGAAGGGTG GCAAGCCCAT CACCCAGAGG GCTGGAACCA ATGGTTACAT GGCTCCTGAG 
ATCCTAATGG AAAAGGTAAG TTATTCCTAT CCTGTGGACT GGTTTGCCAT GGGATGCAGC 
ATTTATGAAA TGGTTGCTGG ACGAACACCA TTCAAAGATT ACAAGGAAAA GGTCAGTAAA 
GAGGATCTGA AGCAAAGAAC TCTGCAAGAC GAGGTCAAAT TCCAGCATGA TAACTTCACA 
GAGGAAGCAA AAGATATTTG CAGGCTCTTC TTGGCTAAGA AACCAGAGCA ACGCTTAGGA 
AGCAGAGAAA AGTCTGATGA TCCCAGGAAA CATCATTTCT TTAAAACGAT CAACTTTCCT 
CGCCTGGAAG CTGGCCTAAT TGAACCCCCA TTTGTGCCAG ACCCTTCAGT GGTTTATGCC 
AAAGACATCG CTGAAATTGA TGATTTCTCT GAGGTTCGGG GGGTGGAATT TGATGACAAA 
GATAAGCAGT TCTTCAAAAA CTTTGCGACA GGTGCTGTTC CTATAGCATG GCAGGAAGAA 
ATTATAGAAA CGGGACTGTT TGAGGAACTG AATGACCCCA ACAGACCTAC GGGTTGTGAG 
GAGGGTAATT CATCCAAGTC TGGCGTGTGT TTGTTATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861206.1
CDS	2830..4491
Translation	MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL

Target ORF information:

RefSeq Version	XM_017005717.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor kinase 7 (GRK7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017005717.2

ORF Insert Sequence:

ATGGTGGACA TGGGGGCCCT GGACAACCTG ATCGCCAACA CCGCCTACCT GCAGGCCCGG 
AAGCCCTCGG ACTGCGACAG CAAAGAGCTG CAGCGGCGGC GGCGTAGCCT GGCCCTGCCC 
GGGCTGCAGG GCTGCGCGGA GCTCCGCCAG AAGCTGTCCC TGAACTTCCA CAGCCTGTGT 
GAGCAGCAGC CCATCGGTCG CCGCCTCTTC CGTGACTTCC TAGCCACAGT GCCCACGTTC 
CGCAAGGCGG CAACCTTCCT AGAGGACGTG CAGAACTGGG AGCTGGCCGA GGAGGGACCC 
ACCAAAGACA GCGCGCTGCA GGGGCTGGTG GCCACTTGTG CGAGTGCCCC TGCCCCGGGG 
AACCCGCAAC CCTTCCTCAG CCAGGCCGTG GCCACCAAGT GCCAAGCAGC CACCACTGAG 
GAAGAGCGAG TGGCTGCAGT GACGCTGGCC AAGGCTGAGG CCATGGCTTT CTTGCAAGAG 
CAGCCCTTTA AGGATTTCGT GACCAGCGCC TTCTACGACA AGTTTCTGCA GTGGAAACTC 
TTCGAGATGC AACCAGTGTC AGACAAGTAC TTCACTGAGT TCAGAGTGCT GGGGAAAGGT 
GGTTTTGGGG AGGTATGTGC CGTCCAGGTG AAAAACACTG GGAAGATGTA TGCCTGTAAG 
AAACTGGACA AGAAGCGGCT GAAGAAGAAA GGTGGCGAGA AGATGGCTCT CTTGGAAAAG 
GAAATCTTGG AGAAGGTCAG CAGCCCTTTC ATTGTCTCTC TGGCCTATGC CTTTGAGAGC 
AAGACCCATC TCTGCCTTGT CATGAGCCTG ATGAATGGGG GAGACCTCAA GTTCCACATC 
TACAACGTGG GCACGCGTGG CCTGGACATG AGCCGGGTGA TCTTTTACTC GGCCCAGATA 
GCCTGTGGGA TGCTGCACCT CCATGAACTC GGCATCGTCT ATCGGGACAT GAAGCCTGAG 
AATGTGCTTC TGGATGACCT CGGCAACTGC AGGTTATCTG ACCTGGGGCT GGCCGTGGAG 
ATGAAGGGTG GCAAGCCCAT CACCCAGAGG GCTGGAACCA ATGGTTACAT GGCTCCTGAG 
ATCCTAATGG AAAAGGTAAG TTATTCCTAT CCTGTGGACT GGTTTGCCAT GGGATGCAGC 
ATTTATGAAA TGGTTGCTGG ACGAACACCA TTCAAAGATT ACAAGGAAAA GGTCAGTAAA 
GAGGATCTGA AGCAAAGAAC TCTGCAAGAC GAGGTCAAAT TCCAGCATGA TAACTTCACA 
GAGGAAGCAA AAGATATTTG CAGGCTCTTC TTGGCTAAGA AACCAGAGCA ACGCTTAGGA 
AGCAGAGAAA AGTCTGATGA TCCCAGGAAA CATCATTTCT TTAAAACGAT CAACTTTCCT 
CGCCTGGAAG CTGGCCTAAT TGAACCCCCA TTTGTGCCAG ACCCTTCAGT GGTTTATGCC 
AAAGACATCG CTGAAATTGA TGATTTCTCT GAGGTTCGGG GGGTGGAATT TGATGACAAA 
GATAAGCAGT TCTTCAAAAA CTTTGCGACA GGTGCTGTTC CTATAGCATG GCAGGAAGAA 
ATTATAGAAA CGGGACTGTT TGAGGAACTG AATGACCCCA ACAGACCTAC GGGTTGTGAG 
GAGGGTAATT CATCCAAGTC TGGCGTGTGT TTGTTATTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A tale of two kinases in rods and cones.
Advances in experimental medicine and biology723821-7(2012)
Osawa S,Weiss ER

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.
Photochemistry and photobiology84(4)823-30(2008 Jul-Aug)
Torisawa A,Arinobu D,Tachibanaki S,Kawamura S

Mapping of transcription start sites of human retina expressed genes.
BMC genomics842(2007 Feb)
Roni V,Carpio R,Wissinger B

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GRK7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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