SLC31A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC31A1
Entrez Gene ID	1317
Full Name	solute carrier family 31 member 1
Synonyms	COPT1,CTR1
General protein information	Preferred Names solute carrier family 31 member 1 Names high affinity copper uptake protein 1 copper transport 1 homolog copper transporter 1 solute carrier family 31 (copper transporter), member 1 solute carrier family 31 (copper transporters), member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q32
Summary	The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011].
Disorder MIM:	603085

mRNA and Protein(s)

mRNA	Protein	Name
NM_001859.4	NP_001850.1	high affinity copper uptake protein 1
NM_001859.3	NP_001850.1	high affinity copper uptake protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC31A1	XP_538800.1
	SLC31A1	XP_001103110.1
Mus musculus (house mouse)	Slc31a1	NP_780299.2
Drosophila melanogaster (fruit fly)	Ctr1A	NP_001245552.1
Gallus gallus (chicken)	SLC31A1	XP_004945826.1
Danio rerio (zebrafish)	slc31a1	NP_991280.1
Homo sapiens (human)	SLC31A1	NP_001850.1
Rattus norvegicus (Norway rat)	Slc31a1	NP_598284.1
Pan troglodytes (chimpanzee)	SLC31A1	XP_520197.2
Bos taurus (cattle)	SLC31A1	NP_001093851.1

Gene Ontology
Bibliography

Related articles in PubMed

Copper-finger protein of Sp1: the molecular basis of copper sensing.
Yuan S, Chen S, Xi Z, Liu Y
Metallomics : integrated biometal science9(8)1169-1175(2017 Aug)

Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma.
Gaudelot K, Gibier JB, Pottier N, H?mon B, Van Seuningen I, Glowacki F, Leroy X, Cauffiez C, Gnemmi V, Aubert S, Perrais M
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317707372(2017 Jul)

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
Logeman BL, Wood LK, Lee J, Thiele DJ
The Journal of biological chemistry292(27)11531-11546(2017 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This result indicates that the formation of copper-finger protein of Sp1 is the molecular basis of copper sensing for the transcriptional regulation of hCtr1 in mammalian cells.
Title: Copper-finger protein of Sp1: the molecular basis of copper sensing.

we assessed the role of miR-21 in mediating renal cell carcinoma chemoresistance and further showed that miR-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 platinum influx transporter expression
Title: Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma.

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2
Title: Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.

Study showed that NEAT1 could function as a competing endogenous lncRNA in lung cancer, mediating CTR1 by sponging hsa-mir-98-5p.
Title: NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells.

It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A, ATP7B), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.
Title: Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells.

The following SLC31A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC31A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22796	NM_001859.4 Latest version!	Homo sapiens solute carrier family 31 member 1 (SLC31A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22796	NM_001859.3	Homo sapiens solute carrier family 31 member 1 (SLC31A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC31A1 ( NM_001859.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001850.1 Homo sapiens solute carrier family 31 member 1 (SLC31A1), mRNA.

Price & Availability↑

CloneID	OHu22796
Clone ID Related Accession (Same CDS sequence)	NM_001859.4 , NM_001859.3
Accession Version	NM_001859.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	high affinity copper uptake protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL449305.4, AL831843.1 and BC013611.1. On Nov 23, 2018 this sequence version replaced NM_001859.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL831843.1, SRR1803615.266015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374212.5/ ENSP00000363329.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCATT CCCACCATAT GGGGATGAGC TATATGGACT CCAACAGTAC CATGCAACCT 
TCTCACCATC ACCCAACCAC TTCAGCCTCA CACTCCCATG GTGGAGGAGA CAGCAGCATG 
ATGATGATGC CTATGACCTT CTACTTTGGC TTTAAGAATG TGGAACTACT GTTTTCCGGT 
TTGGTGATCA ATACAGCTGG AGAAATGGCT GGAGCTTTTG TGGCAGTGTT TTTACTAGCA 
ATGTTCTATG AAGGACTCAA GATAGCCCGA GAGAGCCTGC TGCGTAAGTC ACAAGTCAGC 
ATTCGCTACA ATTCCATGCC TGTCCCAGGA CCAAATGGAA CCATCCTTAT GGAGACACAC 
AAAACTGTTG GGCAACAGAT GCTGAGCTTT CCTCACCTCC TGCAAACAGT GCTGCACATC 
ATCCAGGTGG TCATAAGCTA CTTCCTCATG CTCATCTTCA TGACCTACAA CGGGTACCTC 
TGCATTGCAG TAGCAGCAGG GGCCGGTACA GGATACTTCC TCTTCAGCTG GAAGAAGGCA 
GTGGTAGTGG ATATCACAGA GCATTGCCAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001850.1
CDS	171..743
Translation	MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

Target ORF information:

RefSeq Version	NM_001859.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 31 member 1 (SLC31A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001859.4

ORF Insert Sequence:

ATGGATCATT CCCACCATAT GGGGATGAGC TATATGGACT CCAACAGTAC CATGCAACCT 
TCTCACCATC ACCCAACCAC TTCAGCCTCA CACTCCCATG GTGGAGGAGA CAGCAGCATG 
ATGATGATGC CTATGACCTT CTACTTTGGC TTTAAGAATG TGGAACTACT GTTTTCCGGT 
TTGGTGATCA ATACAGCTGG AGAAATGGCT GGAGCTTTTG TGGCAGTGTT TTTACTAGCA 
ATGTTCTATG AAGGACTCAA GATAGCCCGA GAGAGCCTGC TGCGTAAGTC ACAAGTCAGC 
ATTCGCTACA ATTCCATGCC TGTCCCAGGA CCAAATGGAA CCATCCTTAT GGAGACACAC 
AAAACTGTTG GGCAACAGAT GCTGAGCTTT CCTCACCTCC TGCAAACAGT GCTGCACATC 
ATCCAGGTGG TCATAAGCTA CTTCCTCATG CTCATCTTCA TGACCTACAA CGGGTACCTC 
TGCATTGCAG TAGCAGCAGG GGCCGGTACA GGATACTTCC TCTTCAGCTG GAAGAAGGCA 
GTGGTAGTGG ATATCACAGA GCATTGCCAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC31A1 ( NM_001859.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001850.1 Homo sapiens solute carrier family 31 member 1 (SLC31A1), mRNA.

Price & Availability↑

CloneID	OHu22796
Clone ID Related Accession (Same CDS sequence)	NM_001859.4 , NM_001859.3
Accession Version	NM_001859.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	high affinity copper uptake protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL449305.4, AL831843.1 and BC013611.1. On Sep 25, 2008 this sequence version replaced NM_001859.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL831843.1, SRR1803615.266015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCATT CCCACCATAT GGGGATGAGC TATATGGACT CCAACAGTAC CATGCAACCT 
TCTCACCATC ACCCAACCAC TTCAGCCTCA CACTCCCATG GTGGAGGAGA CAGCAGCATG 
ATGATGATGC CTATGACCTT CTACTTTGGC TTTAAGAATG TGGAACTACT GTTTTCCGGT 
TTGGTGATCA ATACAGCTGG AGAAATGGCT GGAGCTTTTG TGGCAGTGTT TTTACTAGCA 
ATGTTCTATG AAGGACTCAA GATAGCCCGA GAGAGCCTGC TGCGTAAGTC ACAAGTCAGC 
ATTCGCTACA ATTCCATGCC TGTCCCAGGA CCAAATGGAA CCATCCTTAT GGAGACACAC 
AAAACTGTTG GGCAACAGAT GCTGAGCTTT CCTCACCTCC TGCAAACAGT GCTGCACATC 
ATCCAGGTGG TCATAAGCTA CTTCCTCATG CTCATCTTCA TGACCTACAA CGGGTACCTC 
TGCATTGCAG TAGCAGCAGG GGCCGGTACA GGATACTTCC TCTTCAGCTG GAAGAAGGCA 
GTGGTAGTGG ATATCACAGA GCATTGCCAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001850.1
CDS	187..759
Translation	MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

Target ORF information:

RefSeq Version	NM_001859.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 31 member 1 (SLC31A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001859.3

ORF Insert Sequence:

ATGGATCATT CCCACCATAT GGGGATGAGC TATATGGACT CCAACAGTAC CATGCAACCT 
TCTCACCATC ACCCAACCAC TTCAGCCTCA CACTCCCATG GTGGAGGAGA CAGCAGCATG 
ATGATGATGC CTATGACCTT CTACTTTGGC TTTAAGAATG TGGAACTACT GTTTTCCGGT 
TTGGTGATCA ATACAGCTGG AGAAATGGCT GGAGCTTTTG TGGCAGTGTT TTTACTAGCA 
ATGTTCTATG AAGGACTCAA GATAGCCCGA GAGAGCCTGC TGCGTAAGTC ACAAGTCAGC 
ATTCGCTACA ATTCCATGCC TGTCCCAGGA CCAAATGGAA CCATCCTTAT GGAGACACAC 
AAAACTGTTG GGCAACAGAT GCTGAGCTTT CCTCACCTCC TGCAAACAGT GCTGCACATC 
ATCCAGGTGG TCATAAGCTA CTTCCTCATG CTCATCTTCA TGACCTACAA CGGGTACCTC 
TGCATTGCAG TAGCAGCAGG GGCCGGTACA GGATACTTCC TCTTCAGCTG GAAGAAGGCA 
GTGGTAGTGG ATATCACAGA GCATTGCCAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Copper-finger protein of Sp1: the molecular basis of copper sensing.
Metallomics : integrated biometal science9(8)1169-1175(2017 Aug)
Yuan S,Chen S,Xi Z,Liu Y

Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317707372(2017 Jul)
Gaudelot K,Gibier JB,Pottier N,H?mon B,Van Seuningen I,Glowacki F,Leroy X,Cauffiez C,Gnemmi V,Aubert S,Perrais M

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
The Journal of biological chemistry292(27)11531-11546(2017 07)
Logeman BL,Wood LK,Lee J,Thiele DJ

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SLC31A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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