COMP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COMP
Entrez Gene ID	1311
Full Name	cartilage oligomeric matrix protein
Synonyms	EDM1,EPD1,MED,PSACH,THBS5,TSP5
General protein information	Preferred Names cartilage oligomeric matrix protein Names cartilage oligomeric matrix protein cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) pseudoachondroplasia (epiphyseal dysplasia 1, multiple) thrombospondin-5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016].
Disorder MIM:	600310
Disorder Html:	Pseudoachondroplasia, 177170 (3); Epiphyseal dysplasia, multiple, 1, 132400 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000095.2	NP_000086.2	cartilage oligomeric matrix protein precursor
NM_000095.3	NP_000086.2	cartilage oligomeric matrix protein precursor

Pathways from BioSystems

Homologies

	COMP	XP_001115565.1
Canis lupus familiaris (dog)	COMP	XP_533869.2
Gallus gallus (chicken)	COMP	XP_418238.2
Homo sapiens (human)	COMP	NP_000086.2
Danio rerio (zebrafish)	im:7154332	XP_002663752.3
Rattus norvegicus (Norway rat)	Comp	NP_036966.1
Drosophila melanogaster (fruit fly)	Tsp	NP_523495.2
Xenopus tropicalis (tropical clawed frog)	comp	XP_002940251.2
Pan troglodytes (chimpanzee)	COMP	NP_001092035.1
Bos taurus (cattle)	COMP	NP_001159989.1
Mus musculus (house mouse)	Comp	NP_057894.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002157	XP_308033.5

Gene Ontology
Bibliography

Related articles in PubMed

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.
Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Br?khus A, Fladby T, Selb?k G, Hosseinpanah F, Azizi F, Koh JM, Tang NLS, Daneshpour MS, Mayordomo JI, Welt C, Braund PS, Samani NJ, Kiemeney LA, Lohmander LS, Christiansen C, Andreassen OA, , Magnusson O, Masson G, Kong A, Jonsdottir I, Gudbjartsson D, Sulem P, Jonsson H, Loughlin J, Ingvarsson T, Thorsteinsdottir U, Stefansson K
Nature genetics49(5)801-805(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement.
Title: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

COMT Val158Met polymorphism may influence responses to dextromethorphan (30 mg/d) by decreasing depressive symptoms in BD patients.
Title: The COMT Val158Met Polymorphism Is Associated With Response to Add-on Dextromethorphan Treatment in Bipolar Disorder.

Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.
Title: Running decreases knee intra-articular cytokine and cartilage oligomeric matrix concentrations: a pilot study.

The current study expanded the mutation spectrum of the COMP gene, and contributes to the understanding of phenotype/genotype of COMPassociated diseases.
Title: Identification of two novel mutations in the COMP gene in six families with pseudoachondroplasia.

The expression of COMP in circulation reflects the severity of rheumatoid arthritis.
Title: [THE COMPARATIVE ANALYSIS OF LEVEL OF OLIGOMERIC MATRIX PROTEIN OF CARTILAGE IN BLOOD SERUM OF PATIENTS WITH DISEASES OF MUSCULO-SKELETAL SYSTEM].

The following COMP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19189	NM_000095.3 Latest version!	Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu19189	NM_000095.2	Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COMP ( NM_000095.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000086.2 Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA.

Price & Availability↑

CloneID	OHu19189
Clone ID Related Accession (Same CDS sequence)	NM_000095.2 , NM_000095.3
Accession Version	NM_000095.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	cartilage oligomeric matrix protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU120397.1, BC033676.1 and L32137.1. This sequence is a reference standard in the RefSeqGene project. On Dec 19, 2003 this sequence version replaced NM_000095.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223216.1, SRR1660809.75424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTCCCCG ACACCGCCTG CGTTCTTCTG CTCACCCTGG CTGCCCTCGG CGCGTCCGGA 
CAGGGCCAGA GCCCGTTGGG CTCAGACCTG GGCCCGCAGA TGCTTCGGGA ACTGCAGGAA 
ACCAACGCGG CGCTGCAGGA CGTGCGGGAG CTGCTGCGGC AGCAGGTCAG GGAGATCACG 
TTCCTGAAAA ACACGGTGAT GGAGTGTGAC GCGTGCGGGA TGCAGCAGTC AGTACGCACC 
GGCCTACCCA GCGTGCGGCC CCTGCTCCAC TGCGCGCCCG GCTTCTGCTT CCCCGGCGTG 
GCCTGCATCC AGACGGAGAG CGGCGCGCGC TGCGGCCCCT GCCCCGCGGG CTTCACGGGC 
AACGGCTCGC ACTGCACCGA CGTCAACGAG TGCAACGCCC ACCCCTGCTT CCCCCGAGTC 
CGCTGTATCA ACACCAGCCC GGGGTTCCGC TGCGAGGCTT GCCCGCCGGG GTACAGCGGC 
CCCACCCACC AGGGCGTGGG GCTGGCTTTC GCCAAGGCCA ACAAGCAGGT TTGCACGGAC 
ATCAACGAGT GTGAGACCGG GCAACATAAC TGCGTCCCCA ACTCCGTGTG CATCAACACC 
CGGGGCTCCT TCCAGTGCGG CCCGTGCCAG CCCGGCTTCG TGGGCGACCA GGCGTCCGGC 
TGCCAGCGGC GCGCACAGCG CTTCTGCCCC GACGGCTCGC CCAGCGAGTG CCACGAGCAT 
GCAGACTGCG TCCTAGAGCG CGATGGCTCG CGGTCGTGCG TGTGTGCCGT TGGCTGGGCC 
GGCAACGGGA TCCTCTGTGG TCGCGACACT GACCTAGACG GCTTCCCGGA CGAGAAGCTG 
CGCTGCCCGG AGCGCCAGTG CCGTAAGGAC AACTGCGTGA CTGTGCCCAA CTCAGGGCAG 
GAGGATGTGG ACCGCGATGG CATCGGAGAC GCCTGCGATC CGGATGCCGA CGGGGACGGG 
GTCCCCAATG AAAAGGACAA CTGCCCGCTG GTGCGGAACC CAGACCAGCG CAACACGGAC 
GAGGACAAGT GGGGCGATGC GTGCGACAAC TGCCGGTCCC AGAAGAACGA CGACCAAAAG 
GACACAGACC AGGACGGCCG GGGCGATGCG TGCGACGACG ACATCGACGG CGACCGGATC 
CGCAACCAGG CCGACAACTG CCCTAGGGTA CCCAACTCAG ACCAGAAGGA CAGTGATGGC 
GATGGTATAG GGGATGCCTG TGACAACTGT CCCCAGAAGA GCAACCCGGA TCAGGCGGAT 
GTGGACCACG ACTTTGTGGG AGATGCTTGT GACAGCGATC AAGACCAGGA TGGAGACGGA 
CATCAGGACT CTCGGGACAA CTGTCCCACG GTGCCTAACA GTGCCCAGGA GGACTCAGAC 
CACGATGGCC AGGGTGATGC CTGCGACGAC GACGACGACA ATGACGGAGT CCCTGACAGT 
CGGGACAACT GCCGCCTGGT GCCTAACCCC GGCCAGGAGG ACGCGGACAG GGACGGCGTG 
GGCGACGTGT GCCAGGACGA CTTTGATGCA GACAAGGTGG TAGACAAGAT CGACGTGTGT 
CCGGAGAACG CTGAAGTCAC GCTCACCGAC TTCAGGGCCT TCCAGACAGT CGTGCTGGAC 
CCGGAGGGTG ACGCGCAGAT TGACCCCAAC TGGGTGGTGC TCAACCAGGG AAGGGAGATC 
GTGCAGACAA TGAACAGCGA CCCAGGCCTG GCTGTGGGTT ACACTGCCTT CAATGGCGTG 
GACTTCGAGG GCACGTTCCA TGTGAACACG GTCACGGATG ACGACTATGC GGGCTTCATC 
TTTGGCTACC AGGACAGCTC CAGCTTCTAC GTGGTCATGT GGAAGCAGAT GGAGCAAACG 
TATTGGCAGG CGAACCCCTT CCGTGCTGTG GCCGAGCCTG GCATCCAACT CAAGGCTGTG 
AAGTCTTCCA CAGGCCCCGG GGAACAGCTG CGGAACGCTC TGTGGCATAC AGGAGACACA 
GAGTCCCAGG TGCGGCTGCT GTGGAAGGAC CCGCGAAACG TGGGTTGGAA GGACAAGAAG 
TCCTATCGTT GGTTCCTGCA GCACCGGCCC CAAGTGGGCT ACATCAGGGT GCGATTCTAT 
GAGGGCCCTG AGCTGGTGGC CGACAGCAAC GTGGTCTTGG ACACAACCAT GCGGGGTGGC 
CGCCTGGGGG TCTTCTGCTT CTCCCAGGAG AACATCATCT GGGCCAACCT GCGTTACCGC 
TGCAATGACA CCATCCCAGA GGACTATGAG ACCCATCAGC TGCGGCAAGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000086.2
CDS	37..2310
Translation	MVPDTACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTGNGSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSRSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA

Target ORF information:

RefSeq Version	NM_000095.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000095.2

ORF Insert Sequence:

ATGGTCCCCG ACACCGCCTG CGTTCTTCTG CTCACCCTGG CTGCCCTCGG CGCGTCCGGA 
CAGGGCCAGA GCCCGTTGGG CTCAGACCTG GGCCCGCAGA TGCTTCGGGA ACTGCAGGAA 
ACCAACGCGG CGCTGCAGGA CGTGCGGGAG CTGCTGCGGC AGCAGGTCAG GGAGATCACG 
TTCCTGAAAA ACACGGTGAT GGAGTGTGAC GCGTGCGGGA TGCAGCAGTC AGTACGCACC 
GGCCTACCCA GCGTGCGGCC CCTGCTCCAC TGCGCGCCCG GCTTCTGCTT CCCCGGCGTG 
GCCTGCATCC AGACGGAGAG CGGCGCGCGC TGCGGCCCCT GCCCCGCGGG CTTCACGGGC 
AACGGCTCGC ACTGCACCGA CGTCAACGAG TGCAACGCCC ACCCCTGCTT CCCCCGAGTC 
CGCTGTATCA ACACCAGCCC GGGGTTCCGC TGCGAGGCTT GCCCGCCGGG GTACAGCGGC 
CCCACCCACC AGGGCGTGGG GCTGGCTTTC GCCAAGGCCA ACAAGCAGGT TTGCACGGAC 
ATCAACGAGT GTGAGACCGG GCAACATAAC TGCGTCCCCA ACTCCGTGTG CATCAACACC 
CGGGGCTCCT TCCAGTGCGG CCCGTGCCAG CCCGGCTTCG TGGGCGACCA GGCGTCCGGC 
TGCCAGCGGC GCGCACAGCG CTTCTGCCCC GACGGCTCGC CCAGCGAGTG CCACGAGCAT 
GCAGACTGCG TCCTAGAGCG CGATGGCTCG CGGTCGTGCG TGTGTGCCGT TGGCTGGGCC 
GGCAACGGGA TCCTCTGTGG TCGCGACACT GACCTAGACG GCTTCCCGGA CGAGAAGCTG 
CGCTGCCCGG AGCGCCAGTG CCGTAAGGAC AACTGCGTGA CTGTGCCCAA CTCAGGGCAG 
GAGGATGTGG ACCGCGATGG CATCGGAGAC GCCTGCGATC CGGATGCCGA CGGGGACGGG 
GTCCCCAATG AAAAGGACAA CTGCCCGCTG GTGCGGAACC CAGACCAGCG CAACACGGAC 
GAGGACAAGT GGGGCGATGC GTGCGACAAC TGCCGGTCCC AGAAGAACGA CGACCAAAAG 
GACACAGACC AGGACGGCCG GGGCGATGCG TGCGACGACG ACATCGACGG CGACCGGATC 
CGCAACCAGG CCGACAACTG CCCTAGGGTA CCCAACTCAG ACCAGAAGGA CAGTGATGGC 
GATGGTATAG GGGATGCCTG TGACAACTGT CCCCAGAAGA GCAACCCGGA TCAGGCGGAT 
GTGGACCACG ACTTTGTGGG AGATGCTTGT GACAGCGATC AAGACCAGGA TGGAGACGGA 
CATCAGGACT CTCGGGACAA CTGTCCCACG GTGCCTAACA GTGCCCAGGA GGACTCAGAC 
CACGATGGCC AGGGTGATGC CTGCGACGAC GACGACGACA ATGACGGAGT CCCTGACAGT 
CGGGACAACT GCCGCCTGGT GCCTAACCCC GGCCAGGAGG ACGCGGACAG GGACGGCGTG 
GGCGACGTGT GCCAGGACGA CTTTGATGCA GACAAGGTGG TAGACAAGAT CGACGTGTGT 
CCGGAGAACG CTGAAGTCAC GCTCACCGAC TTCAGGGCCT TCCAGACAGT CGTGCTGGAC 
CCGGAGGGTG ACGCGCAGAT TGACCCCAAC TGGGTGGTGC TCAACCAGGG AAGGGAGATC 
GTGCAGACAA TGAACAGCGA CCCAGGCCTG GCTGTGGGTT ACACTGCCTT CAATGGCGTG 
GACTTCGAGG GCACGTTCCA TGTGAACACG GTCACGGATG ACGACTATGC GGGCTTCATC 
TTTGGCTACC AGGACAGCTC CAGCTTCTAC GTGGTCATGT GGAAGCAGAT GGAGCAAACG 
TATTGGCAGG CGAACCCCTT CCGTGCTGTG GCCGAGCCTG GCATCCAACT CAAGGCTGTG 
AAGTCTTCCA CAGGCCCCGG GGAACAGCTG CGGAACGCTC TGTGGCATAC AGGAGACACA 
GAGTCCCAGG TGCGGCTGCT GTGGAAGGAC CCGCGAAACG TGGGTTGGAA GGACAAGAAG 
TCCTATCGTT GGTTCCTGCA GCACCGGCCC CAAGTGGGCT ACATCAGGGT GCGATTCTAT 
GAGGGCCCTG AGCTGGTGGC CGACAGCAAC GTGGTCTTGG ACACAACCAT GCGGGGTGGC 
CGCCTGGGGG TCTTCTGCTT CTCCCAGGAG AACATCATCT GGGCCAACCT GCGTTACCGC 
TGCAATGACA CCATCCCAGA GGACTATGAG ACCCATCAGC TGCGGCAAGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMP ( NM_000095.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000086.2 Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA.

Price & Availability↑

CloneID	OHu19189
Clone ID Related Accession (Same CDS sequence)	NM_000095.2 , NM_000095.3
Accession Version	NM_000095.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	cartilage oligomeric matrix protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU120397.1, BC033676.1 and L32137.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000095.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223216.1, SRR1660809.75424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222271.7/ ENSP00000222271.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTCCCCG ACACCGCCTG CGTTCTTCTG CTCACCCTGG CTGCCCTCGG CGCGTCCGGA 
CAGGGCCAGA GCCCGTTGGG CTCAGACCTG GGCCCGCAGA TGCTTCGGGA ACTGCAGGAA 
ACCAACGCGG CGCTGCAGGA CGTGCGGGAG CTGCTGCGGC AGCAGGTCAG GGAGATCACG 
TTCCTGAAAA ACACGGTGAT GGAGTGTGAC GCGTGCGGGA TGCAGCAGTC AGTACGCACC 
GGCCTACCCA GCGTGCGGCC CCTGCTCCAC TGCGCGCCCG GCTTCTGCTT CCCCGGCGTG 
GCCTGCATCC AGACGGAGAG CGGCGCGCGC TGCGGCCCCT GCCCCGCGGG CTTCACGGGC 
AACGGCTCGC ACTGCACCGA CGTCAACGAG TGCAACGCCC ACCCCTGCTT CCCCCGAGTC 
CGCTGTATCA ACACCAGCCC GGGGTTCCGC TGCGAGGCTT GCCCGCCGGG GTACAGCGGC 
CCCACCCACC AGGGCGTGGG GCTGGCTTTC GCCAAGGCCA ACAAGCAGGT TTGCACGGAC 
ATCAACGAGT GTGAGACCGG GCAACATAAC TGCGTCCCCA ACTCCGTGTG CATCAACACC 
CGGGGCTCCT TCCAGTGCGG CCCGTGCCAG CCCGGCTTCG TGGGCGACCA GGCGTCCGGC 
TGCCAGCGGC GCGCACAGCG CTTCTGCCCC GACGGCTCGC CCAGCGAGTG CCACGAGCAT 
GCAGACTGCG TCCTAGAGCG CGATGGCTCG CGGTCGTGCG TGTGTGCCGT TGGCTGGGCC 
GGCAACGGGA TCCTCTGTGG TCGCGACACT GACCTAGACG GCTTCCCGGA CGAGAAGCTG 
CGCTGCCCGG AGCGCCAGTG CCGTAAGGAC AACTGCGTGA CTGTGCCCAA CTCAGGGCAG 
GAGGATGTGG ACCGCGATGG CATCGGAGAC GCCTGCGATC CGGATGCCGA CGGGGACGGG 
GTCCCCAATG AAAAGGACAA CTGCCCGCTG GTGCGGAACC CAGACCAGCG CAACACGGAC 
GAGGACAAGT GGGGCGATGC GTGCGACAAC TGCCGGTCCC AGAAGAACGA CGACCAAAAG 
GACACAGACC AGGACGGCCG GGGCGATGCG TGCGACGACG ACATCGACGG CGACCGGATC 
CGCAACCAGG CCGACAACTG CCCTAGGGTA CCCAACTCAG ACCAGAAGGA CAGTGATGGC 
GATGGTATAG GGGATGCCTG TGACAACTGT CCCCAGAAGA GCAACCCGGA TCAGGCGGAT 
GTGGACCACG ACTTTGTGGG AGATGCTTGT GACAGCGATC AAGACCAGGA TGGAGACGGA 
CATCAGGACT CTCGGGACAA CTGTCCCACG GTGCCTAACA GTGCCCAGGA GGACTCAGAC 
CACGATGGCC AGGGTGATGC CTGCGACGAC GACGACGACA ATGACGGAGT CCCTGACAGT 
CGGGACAACT GCCGCCTGGT GCCTAACCCC GGCCAGGAGG ACGCGGACAG GGACGGCGTG 
GGCGACGTGT GCCAGGACGA CTTTGATGCA GACAAGGTGG TAGACAAGAT CGACGTGTGT 
CCGGAGAACG CTGAAGTCAC GCTCACCGAC TTCAGGGCCT TCCAGACAGT CGTGCTGGAC 
CCGGAGGGTG ACGCGCAGAT TGACCCCAAC TGGGTGGTGC TCAACCAGGG AAGGGAGATC 
GTGCAGACAA TGAACAGCGA CCCAGGCCTG GCTGTGGGTT ACACTGCCTT CAATGGCGTG 
GACTTCGAGG GCACGTTCCA TGTGAACACG GTCACGGATG ACGACTATGC GGGCTTCATC 
TTTGGCTACC AGGACAGCTC CAGCTTCTAC GTGGTCATGT GGAAGCAGAT GGAGCAAACG 
TATTGGCAGG CGAACCCCTT CCGTGCTGTG GCCGAGCCTG GCATCCAACT CAAGGCTGTG 
AAGTCTTCCA CAGGCCCCGG GGAACAGCTG CGGAACGCTC TGTGGCATAC AGGAGACACA 
GAGTCCCAGG TGCGGCTGCT GTGGAAGGAC CCGCGAAACG TGGGTTGGAA GGACAAGAAG 
TCCTATCGTT GGTTCCTGCA GCACCGGCCC CAAGTGGGCT ACATCAGGGT GCGATTCTAT 
GAGGGCCCTG AGCTGGTGGC CGACAGCAAC GTGGTCTTGG ACACAACCAT GCGGGGTGGC 
CGCCTGGGGG TCTTCTGCTT CTCCCAGGAG AACATCATCT GGGCCAACCT GCGTTACCGC 
TGCAATGACA CCATCCCAGA GGACTATGAG ACCCATCAGC TGCGGCAAGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000086.2
CDS	37..2310
Translation	MVPDTACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTGNGSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSRSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA

Target ORF information:

RefSeq Version	NM_000095.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000095.3

ORF Insert Sequence:

ATGGTCCCCG ACACCGCCTG CGTTCTTCTG CTCACCCTGG CTGCCCTCGG CGCGTCCGGA 
CAGGGCCAGA GCCCGTTGGG CTCAGACCTG GGCCCGCAGA TGCTTCGGGA ACTGCAGGAA 
ACCAACGCGG CGCTGCAGGA CGTGCGGGAG CTGCTGCGGC AGCAGGTCAG GGAGATCACG 
TTCCTGAAAA ACACGGTGAT GGAGTGTGAC GCGTGCGGGA TGCAGCAGTC AGTACGCACC 
GGCCTACCCA GCGTGCGGCC CCTGCTCCAC TGCGCGCCCG GCTTCTGCTT CCCCGGCGTG 
GCCTGCATCC AGACGGAGAG CGGCGCGCGC TGCGGCCCCT GCCCCGCGGG CTTCACGGGC 
AACGGCTCGC ACTGCACCGA CGTCAACGAG TGCAACGCCC ACCCCTGCTT CCCCCGAGTC 
CGCTGTATCA ACACCAGCCC GGGGTTCCGC TGCGAGGCTT GCCCGCCGGG GTACAGCGGC 
CCCACCCACC AGGGCGTGGG GCTGGCTTTC GCCAAGGCCA ACAAGCAGGT TTGCACGGAC 
ATCAACGAGT GTGAGACCGG GCAACATAAC TGCGTCCCCA ACTCCGTGTG CATCAACACC 
CGGGGCTCCT TCCAGTGCGG CCCGTGCCAG CCCGGCTTCG TGGGCGACCA GGCGTCCGGC 
TGCCAGCGGC GCGCACAGCG CTTCTGCCCC GACGGCTCGC CCAGCGAGTG CCACGAGCAT 
GCAGACTGCG TCCTAGAGCG CGATGGCTCG CGGTCGTGCG TGTGTGCCGT TGGCTGGGCC 
GGCAACGGGA TCCTCTGTGG TCGCGACACT GACCTAGACG GCTTCCCGGA CGAGAAGCTG 
CGCTGCCCGG AGCGCCAGTG CCGTAAGGAC AACTGCGTGA CTGTGCCCAA CTCAGGGCAG 
GAGGATGTGG ACCGCGATGG CATCGGAGAC GCCTGCGATC CGGATGCCGA CGGGGACGGG 
GTCCCCAATG AAAAGGACAA CTGCCCGCTG GTGCGGAACC CAGACCAGCG CAACACGGAC 
GAGGACAAGT GGGGCGATGC GTGCGACAAC TGCCGGTCCC AGAAGAACGA CGACCAAAAG 
GACACAGACC AGGACGGCCG GGGCGATGCG TGCGACGACG ACATCGACGG CGACCGGATC 
CGCAACCAGG CCGACAACTG CCCTAGGGTA CCCAACTCAG ACCAGAAGGA CAGTGATGGC 
GATGGTATAG GGGATGCCTG TGACAACTGT CCCCAGAAGA GCAACCCGGA TCAGGCGGAT 
GTGGACCACG ACTTTGTGGG AGATGCTTGT GACAGCGATC AAGACCAGGA TGGAGACGGA 
CATCAGGACT CTCGGGACAA CTGTCCCACG GTGCCTAACA GTGCCCAGGA GGACTCAGAC 
CACGATGGCC AGGGTGATGC CTGCGACGAC GACGACGACA ATGACGGAGT CCCTGACAGT 
CGGGACAACT GCCGCCTGGT GCCTAACCCC GGCCAGGAGG ACGCGGACAG GGACGGCGTG 
GGCGACGTGT GCCAGGACGA CTTTGATGCA GACAAGGTGG TAGACAAGAT CGACGTGTGT 
CCGGAGAACG CTGAAGTCAC GCTCACCGAC TTCAGGGCCT TCCAGACAGT CGTGCTGGAC 
CCGGAGGGTG ACGCGCAGAT TGACCCCAAC TGGGTGGTGC TCAACCAGGG AAGGGAGATC 
GTGCAGACAA TGAACAGCGA CCCAGGCCTG GCTGTGGGTT ACACTGCCTT CAATGGCGTG 
GACTTCGAGG GCACGTTCCA TGTGAACACG GTCACGGATG ACGACTATGC GGGCTTCATC 
TTTGGCTACC AGGACAGCTC CAGCTTCTAC GTGGTCATGT GGAAGCAGAT GGAGCAAACG 
TATTGGCAGG CGAACCCCTT CCGTGCTGTG GCCGAGCCTG GCATCCAACT CAAGGCTGTG 
AAGTCTTCCA CAGGCCCCGG GGAACAGCTG CGGAACGCTC TGTGGCATAC AGGAGACACA 
GAGTCCCAGG TGCGGCTGCT GTGGAAGGAC CCGCGAAACG TGGGTTGGAA GGACAAGAAG 
TCCTATCGTT GGTTCCTGCA GCACCGGCCC CAAGTGGGCT ACATCAGGGT GCGATTCTAT 
GAGGGCCCTG AGCTGGTGGC CGACAGCAAC GTGGTCTTGG ACACAACCAT GCGGGGTGGC 
CGCCTGGGGG TCTTCTGCTT CTCCCAGGAG AACATCATCT GGGCCAACCT GCGTTACCGC 
TGCAATGACA CCATCCCAGA GGACTATGAG ACCCATCAGC TGCGGCAAGC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.
Nature genetics49(5)801-805(2017 May)
Styrkarsdottir U,Helgason H,Sigurdsson A,Norddahl GL,Agustsdottir AB,Reynard LN,Villalvilla A,Halldorsson GH,Jonasdottir A,Magnusdottir A,Oddson A,Sulem G,Zink F,Sveinbjornsson G,Helgason A,Johannsdottir HS,Helgadottir A,Stefansson H,Gretarsdottir S,Rafnar T,Almdahl IS,Br?khus A,Fladby T,Selb?k G,Hosseinpanah F,Azizi F,Koh JM,Tang NLS,Daneshpour MS,Mayordomo JI,Welt C,Braund PS,Samani NJ,Kiemeney LA,Lohmander LS,Christiansen C,Andreassen OA,,Magnusson O,Masson G,Kong A,Jonsdottir I,Gudbjartsson D,Sulem P,Jonsson H,Loughlin J,Ingvarsson T,Thorsteinsdottir U,Stefansson K

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COMP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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