CNGA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CNGA2
Entrez Gene ID	1260
Full Name	cyclic nucleotide gated channel alpha 2
Synonyms	CNCA,CNCA1,CNG2,OCNC1,OCNCALPHA,OCNCa
General protein information	Preferred Names cyclic nucleotide gated channel alpha 2 Names cyclic nucleotide-gated olfactory channel CNG channel alpha-2 cyclic-nucleotide-gated cation channel 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010].
Disorder MIM:	300338

mRNA and Protein(s)

mRNA	Protein	Name
NM_005140.1	NP_005131.1	cyclic nucleotide-gated olfactory channel

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CNGA2	XP_529195.2
Bos taurus (cattle)	CNGA2	NP_001001139.1
Danio rerio (zebrafish)	cnga5	NP_001038211.1
Rattus norvegicus (Norway rat)	Cnga2	NP_037060.1
Xenopus tropicalis (tropical clawed frog)	cnga2	XP_002939246.1
	LOC704486	XP_001092844.2
Homo sapiens (human)	CNGA2	NP_005131.1
Canis lupus familiaris (dog)	CNGA2	XP_005642014.1
Mus musculus (house mouse)	Cnga2	NP_031750.2
Gallus gallus (chicken)	CNGA2	XP_001234866.3

Gene Ontology
Bibliography

Related articles in PubMed

Isolated Congenital Anosmia and CNGA2 Mutation.
Sailani MR, Jingga I, MirMazlomi SH, Bitarafan F, Bernstein JA, Snyder MP, Garshasbi M
Scientific reports7(1)2667(2017 Jun)

The first mutation in CNGA2 in two brothers with anosmia.
Karstensen HG, Mang Y, Fark T, Hummel T, Tommerup N
Clinical genetics88(3)293-6(2015 Sep)

A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.
Qu W, Moorhouse AJ, Chandra M, Pierce KD, Lewis TM, Barry PH
The Journal of general physiology127(4)375-89(2006 Apr)

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.
Hofmann F, Biel M, Kaupp UB
Pharmacological reviews57(4)455-62(2005 Dec)

Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues.
Cheng KT, Chan FL, Huang Y, Chan WY, Yao X
Histochemistry and cell biology120(6)475-81(2003 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia.
Title: The first mutation in CNGA2 in two brothers with anosmia.

The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel.
Title: A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.

The following CNGA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CNGA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19425	NM_005140.1 Latest version!	Homo sapiens cyclic nucleotide gated channel subunit alpha 2 (CNGA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CNGA2 ( NM_005140.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_005131.1 Homo sapiens cyclic nucleotide gated channel subunit alpha 2 (CNGA2), mRNA.

Price & Availability↑

CloneID	OHu19425
Clone ID Related Accession (Same CDS sequence)	NM_005140.1
Accession Version	NM_005140.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1995bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	cyclic nucleotide-gated olfactory channel
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK128186.1. This sequence is a reference standard in the RefSeqGene project. On Mar 23, 2004 this sequence version replaced XM_372263.1. ##Evidence-Data-START## Transcript exon combination :: AK128186.1, BC126302.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGACCGAAA AAACCAATGG TGTGAAGAGC TCCCCAGCCA ATAATCACAA CCATCATGCA 
CCTCCTGCCA TCAAGGCCAA TGGCAAAGAT GACCACAGGA CAAGCAGCAG GCCACACTCT 
GCAGCTGACG ATGACACCTC CTCAGAACTG CAGAGGCTGG CAGACGTGGA TGCCCCACAG 
CAGGGAAGGA GTGGCTTCCG CAGGATAGTT CGCCTGGTGG GGATCATCAG AGAATGGGCC 
AACAAGAATT TCCGAGAGGA GGAACCTAGG CCTGACTCAT TCCTCGAGCG TTTTCGTGGG 
CCTGAACTCC AGACTGTGAC CACACAGGAG GGGGATGGCA AAGGCGACAA GGATGGCGAG 
GACAAAGGCA CCAAGAAGAA ATTTGAACTA TTTGTCTTGG ACCCAGCTGG GGATTGGTAC 
TACTGCTGGC TATTTGTCAT TGCCATGCCC GTCCTTTACA ACTGGTGCCT GCTGGTGGCC 
AGAGCCTGCT TCAGTGACCT ACAGAAAGGC TACTACCTGG TGTGGCTGGT GCTGGATTAT 
GTCTCAGATG TGGTCTACAT TGCGGACCTC TTCATCCGAT TGCGCACAGG TTTCCTGGAG 
CAGGGGCTGC TGGTCAAAGA TACCAAGAAA CTGCGAGACA ACTACATCCA CACCCTGCAG 
TTCAAGCTGG ATGTGGCTTC CATCATCCCC ACTGACCTGA TCTATTTTGC TGTGGACATC 
CACAGCCCTG AGGTGCGCTT CAACCGCCTG CTGCACTTTG CCCGCATGTT TGAGTTCTTT 
GACCGGACAG AGACACGCAC CAACTACCCT AACATCTTCC GCATCAGCAA CCTTGTCCTC 
TACATCTTGG TCATCATCCA CTGGAATGCC TGCATCTATT ATGCCATCTC CAAATCCATA 
GGCTTTGGGG TCGACACCTG GGTTTACCCA AACATCACTG ACCCTGAGTA TGGCTACCTG 
GCTAGGGAAT ACATCTATTG CCTTTACTGG TCCACACTGA CTCTCACTAC CATTGGGGAG 
ACACCACCCC CTGTAAAGGA TGAGGAGTAC CTATTTGTCA TCTTTGACTT CCTGATTGGC 
GTCCTCATCT TTGCCACCAT CGTGGGAAAT GTGGGCTCCA TGATCTCCAA CATGAATGCC 
ACCCGGGCAG AGTTCCAGGC TAAGATCGAT GCCGTGAAAC ACTACATGCA GTTCCGAAAG 
GTCAGCAAGG GGATGGAAGC CAAGGTCATT AGGTGGTTTG ACTACTTGTG GACCAATAAG 
AAGACAGTGG ATGAGCGAGA AATTCTCAAG AATCTGCCAG CCAAGCTCAG GGCTGAGATA 
GCCATCAATG TCCACTTGTC CACACTCAAG AAAGTGCGCA TCTTCCATGA TTGTGAGGCT 
GGCCTGCTGG TAGAGCTGGT ACTGAAACTC CGTCCTCAGG TCTTCAGTCC TGGGGATTAC 
ATTTGCCGCA AAGGGGACAT CGGCAAGGAG ATGTACATCA TTAAGGAGGG CAAACTGGCA 
GTGGTGGCTG ATGATGGTGT GACTCAGTAT GCTCTGCTGT CGGCTGGAAG CTGCTTTGGC 
GAGATCAGTA TCCTTAACAT TAAGGGCAGT AAAATGGGCA ATCGACGCAC AGCTAATATC 
CGCAGCCTGG GCTACTCAGA TCTCTTCTGC TTGTCCAAGG ATGATCTTAT GGAAGCTGTG 
ACTGAGTACC CTGATGCCAA GAAAGTCCTA GAAGAGAGGG GTCGGGAGAT CCTCATGAAG 
GAGGGACTGC TGGATGAGAA CGAAGTGGCA ACCAGCATGG AGGTCGACGT GCAGGAGAAG 
CTAGGGCAGC TGGAGACCAA CATGGAAACC TTGTACACTC GCTTTGGCCG CCTGCTGGCT 
GAGTACACGG GGGCCCAGCA GAAGCTCAAG CAGCGCATCA CAGTTCTGGA AACCAAGATG 
AAACAGAACA ATGAAGATGA CTACCTGTCT GATGGGATGA ACAGCCCTGA GCTGGCTGCT 
GCTGACGAGC CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005131.1
CDS	225..2219
Translation	MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP

Target ORF information:

RefSeq Version	NM_005140.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclic nucleotide gated channel subunit alpha 2 (CNGA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005140.1

ORF Insert Sequence:

ATGACCGAAA AAACCAATGG TGTGAAGAGC TCCCCAGCCA ATAATCACAA CCATCATGCA 
CCTCCTGCCA TCAAGGCCAA TGGCAAAGAT GACCACAGGA CAAGCAGCAG GCCACACTCT 
GCAGCTGACG ATGACACCTC CTCAGAACTG CAGAGGCTGG CAGACGTGGA TGCCCCACAG 
CAGGGAAGGA GTGGCTTCCG CAGGATAGTT CGCCTGGTGG GGATCATCAG AGAATGGGCC 
AACAAGAATT TCCGAGAGGA GGAACCTAGG CCTGACTCAT TCCTCGAGCG TTTTCGTGGG 
CCTGAACTCC AGACTGTGAC CACACAGGAG GGGGATGGCA AAGGCGACAA GGATGGCGAG 
GACAAAGGCA CCAAGAAGAA ATTTGAACTA TTTGTCTTGG ACCCAGCTGG GGATTGGTAC 
TACTGCTGGC TATTTGTCAT TGCCATGCCC GTCCTTTACA ACTGGTGCCT GCTGGTGGCC 
AGAGCCTGCT TCAGTGACCT ACAGAAAGGC TACTACCTGG TGTGGCTGGT GCTGGATTAT 
GTCTCAGATG TGGTCTACAT TGCGGACCTC TTCATCCGAT TGCGCACAGG TTTCCTGGAG 
CAGGGGCTGC TGGTCAAAGA TACCAAGAAA CTGCGAGACA ACTACATCCA CACCCTGCAG 
TTCAAGCTGG ATGTGGCTTC CATCATCCCC ACTGACCTGA TCTATTTTGC TGTGGACATC 
CACAGCCCTG AGGTGCGCTT CAACCGCCTG CTGCACTTTG CCCGCATGTT TGAGTTCTTT 
GACCGGACAG AGACACGCAC CAACTACCCT AACATCTTCC GCATCAGCAA CCTTGTCCTC 
TACATCTTGG TCATCATCCA CTGGAATGCC TGCATCTATT ATGCCATCTC CAAATCCATA 
GGCTTTGGGG TCGACACCTG GGTTTACCCA AACATCACTG ACCCTGAGTA TGGCTACCTG 
GCTAGGGAAT ACATCTATTG CCTTTACTGG TCCACACTGA CTCTCACTAC CATTGGGGAG 
ACACCACCCC CTGTAAAGGA TGAGGAGTAC CTATTTGTCA TCTTTGACTT CCTGATTGGC 
GTCCTCATCT TTGCCACCAT CGTGGGAAAT GTGGGCTCCA TGATCTCCAA CATGAATGCC 
ACCCGGGCAG AGTTCCAGGC TAAGATCGAT GCCGTGAAAC ACTACATGCA GTTCCGAAAG 
GTCAGCAAGG GGATGGAAGC CAAGGTCATT AGGTGGTTTG ACTACTTGTG GACCAATAAG 
AAGACAGTGG ATGAGCGAGA AATTCTCAAG AATCTGCCAG CCAAGCTCAG GGCTGAGATA 
GCCATCAATG TCCACTTGTC CACACTCAAG AAAGTGCGCA TCTTCCATGA TTGTGAGGCT 
GGCCTGCTGG TAGAGCTGGT ACTGAAACTC CGTCCTCAGG TCTTCAGTCC TGGGGATTAC 
ATTTGCCGCA AAGGGGACAT CGGCAAGGAG ATGTACATCA TTAAGGAGGG CAAACTGGCA 
GTGGTGGCTG ATGATGGTGT GACTCAGTAT GCTCTGCTGT CGGCTGGAAG CTGCTTTGGC 
GAGATCAGTA TCCTTAACAT TAAGGGCAGT AAAATGGGCA ATCGACGCAC AGCTAATATC 
CGCAGCCTGG GCTACTCAGA TCTCTTCTGC TTGTCCAAGG ATGATCTTAT GGAAGCTGTG 
ACTGAGTACC CTGATGCCAA GAAAGTCCTA GAAGAGAGGG GTCGGGAGAT CCTCATGAAG 
GAGGGACTGC TGGATGAGAA CGAAGTGGCA ACCAGCATGG AGGTCGACGT GCAGGAGAAG 
CTAGGGCAGC TGGAGACCAA CATGGAAACC TTGTACACTC GCTTTGGCCG CCTGCTGGCT 
GAGTACACGG GGGCCCAGCA GAAGCTCAAG CAGCGCATCA CAGTTCTGGA AACCAAGATG 
AAACAGAACA ATGAAGATGA CTACCTGTCT GATGGGATGA ACAGCCCTGA GCTGGCTGCT 
GCTGACGAGC CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Isolated Congenital Anosmia and CNGA2 Mutation.
Scientific reports7(1)2667(2017 Jun)
Sailani MR,Jingga I,MirMazlomi SH,Bitarafan F,Bernstein JA,Snyder MP,Garshasbi M

The first mutation in CNGA2 in two brothers with anosmia.
Clinical genetics88(3)293-6(2015 Sep)
Karstensen HG,Mang Y,Fark T,Hummel T,Tommerup N

A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.
The Journal of general physiology127(4)375-89(2006 Apr)
Qu W,Moorhouse AJ,Chandra M,Pierce KD,Lewis TM,Barry PH

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.
Pharmacological reviews57(4)455-62(2005 Dec)
Hofmann F,Biel M,Kaupp UB

Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues.
Histochemistry and cell biology120(6)475-81(2003 Dec)
Cheng KT,Chan FL,Huang Y,Chan WY,Yao X

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CNGA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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