GJD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GJD3
Entrez Gene ID	125111
Full Name	gap junction protein delta 3
Synonyms	CX31.9,Cx30.2,GJA11,GJC1
General protein information	Preferred Names gap junction protein delta 3 Names gap junction delta-3 protein connexin-31.9 gap junction alpha-11 protein gap junction chi-1 protein gap junction protein, delta 3, 31.9kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.2
Summary	This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	607425

mRNA and Protein(s)

mRNA	Protein	Name
NM_152219.3	NP_689343.3	gap junction delta-3 protein
NM_152219.4	NP_689343.3	gap junction delta-3 protein

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	gjd3	XP_002940263.1
Pan troglodytes (chimpanzee)	GJD3	XP_003315500.1
	GJD3	XP_001097309.1
Rattus norvegicus (Norway rat)	Gjd3	XP_006247504.1
Canis lupus familiaris (dog)	GJD3	XP_003639318.1
Mus musculus (house mouse)	Gjd3	NP_848711.2
Homo sapiens (human)	GJD3	NP_689343.3
Bos taurus (cattle)	GJD3	XP_005220837.1

Gene Ontology
Bibliography

Related articles in PubMed

Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system.
Kreuzberg MM, Liebermann M, Segschneider S, Dobrowolski R, Dobrzynski H, Kaba R, Rowlinson G, Dupont E, Severs NJ, Willecke K
Journal of molecular and cellular cardiology46(4)553-9(2009 Apr)

Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.
Gemel J, Lin X, Collins R, Veenstra RD, Beyer EC
Biochemical and biophysical research communications369(2)388-94(2008 May)

Tissue-specific effects of wild-type and mutant connexin 31: a role in neurite outgrowth.
Unsworth HC, Aasen T, McElwaine S, Kelsell DP
Human molecular genetics16(2)165-72(2007 Jan)

Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart.
Bukauskas FF, Kreuzberg MM, Rackauskas M, Bukauskiene A, Bennett MV, Verselis VK, Willecke K
Proceedings of the National Academy of Sciences of the United States of America103(25)9726-31(2006 Jun)

Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.
S?hl G, Nielsen PA, Eiberger J, Willecke K
Cell communication & adhesion10(1)27-36(2003 Jan-Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cx31.9 protein, unlike its counterpart in the mouse, is not expressed in detectable quantities and is thus unlikely to contribute to the impulse generation and conduction system or the working myocardium of the human heart.
Title: Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system.

Our data suggest that connexin30.2 can form heteromers with the other cardiac connexins.
Title: Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.

Exogenous Cx31 expression induced neurite outgrowth in human neuronal cell lines, but not differentiation in primary human keratinocytes.
Title: Tissue-specific effects of wild-type and mutant connexin 31: a role in neurite outgrowth.

Hemichannels formed of mCx30.2 and hCx31.9 may slow propagation of excitation in the sinoatrial and atrioventricular nodes by shortening the space constant and depolarizing the excitable membrane
Title: Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart.

expression patterns differ from mouse orthologs [Cx30.2; Cx40.1]
Title: Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.

The following GJD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GJD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30599	NM_152219.4 Latest version!	Homo sapiens gap junction protein delta 3 (GJD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu30599	NM_152219.3	Homo sapiens gap junction protein delta 3 (GJD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GJD3 ( NM_152219.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689343.3 Homo sapiens gap junction protein delta 3 (GJD3), mRNA.

Price & Availability↑

CloneID	OHu30599
Clone ID Related Accession (Same CDS sequence)	NM_152219.3 , NM_152219.4
Accession Version	NM_152219.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	gap junction delta-3 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC080112.15. On Jun 15, 2007 this sequence version replaced NM_152219.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. COMPLETENESS: complete on the 3' end.

ATGGGGGAGT GGGCGTTCCT GGGCTCGCTG CTGGACGCCG TGCAGCTGCA GTCGCCGCTC 
GTGGGCCGCC TCTGGCTGGT GGTCATGCTG ATCTTCCGCA TCCTGGTGCT GGCCACGGTG 
GGCGGCGCCG TGTTCGAGGA CGAGCAAGAG GAGTTCGTGT GCAACACGCT GCAGCCGGGC 
TGTCGCCAGA CCTGCTACGA CCGCGCCTTC CCGGTCTCCC ACTACCGCTT CTGGCTCTTC 
CACATCCTGC TGCTCTCGGC GCCCCCGGTG CTGTTCGTCG TCTACTCCAT GCACCGGGCA 
GGCAAGGAGG CGGGCGGCGC TGAGGCGGCG GCGCAGTGCG CCCCCGGACT GCCCGAGGCC 
CAGTGCGCGC CGTGCGCCCT GCGCGCCCGC CGCGCGCGCC GCTGCTACCT GCTGAGCGTG 
GCGCTGCGCC TGCTGGCCGA GCTGACCTTC CTGGGCGGCC AGGCGCTGCT CTACGGCTTC 
CGCGTGGCCC CGCACTTCGC GTGCGCCGGT CCGCCCTGCC CGCACACGGT CGACTGCTTC 
GTGAGCCGGC CCACCGAGAA GACCGTCTTC GTGCTCTTCT ATTTCGCGGT GGGGCTGCTG 
TCGGCGCTGC TCAGCGTAGC CGAGCTGGGC CACCTGCTCT GGAAGGGCCG CCCGCGCGCC 
GGGGAGCGTG ACAACCGCTG CAACCGTGCA CACGAAGAGG CGCAGAAGCT GCTCCCGCCG 
CCGCCGCCGC CACCTCCGCC ACCGGCCCTG CCCTCCCGGC GCCCCGGCCC CGAGCCGTGC 
GCCCCGCCGG CCTATGCGCA CCCGGCGCCG GCCAGCCTCC GCGAGTGCGG CAGCGGCCGC 
GGCAAGGCGT CACCGGCCAC CGGCCGCCGA GATCTGGCCA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689343.3
CDS	879..1763
Translation	MGEWAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPGCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKEAGGAEAAAQCAPGLPEAQCAPCALRARRARRCYLLSVALRLLAELTFLGGQALLYGFRVAPHFACAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGERDNRCNRAHEEAQKLLPPPPPPPPPPALPSRRPGPEPCAPPAYAHPAPASLRECGSGRGKASPATGRRDLAI

Target ORF information:

RefSeq Version	NM_152219.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein delta 3 (GJD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152219.3

ORF Insert Sequence:

ATGGGGGAGT GGGCGTTCCT GGGCTCGCTG CTGGACGCCG TGCAGCTGCA GTCGCCGCTC 
GTGGGCCGCC TCTGGCTGGT GGTCATGCTG ATCTTCCGCA TCCTGGTGCT GGCCACGGTG 
GGCGGCGCCG TGTTCGAGGA CGAGCAAGAG GAGTTCGTGT GCAACACGCT GCAGCCGGGC 
TGTCGCCAGA CCTGCTACGA CCGCGCCTTC CCGGTCTCCC ACTACCGCTT CTGGCTCTTC 
CACATCCTGC TGCTCTCGGC GCCCCCGGTG CTGTTCGTCG TCTACTCCAT GCACCGGGCA 
GGCAAGGAGG CGGGCGGCGC TGAGGCGGCG GCGCAGTGCG CCCCCGGACT GCCCGAGGCC 
CAGTGCGCGC CGTGCGCCCT GCGCGCCCGC CGCGCGCGCC GCTGCTACCT GCTGAGCGTG 
GCGCTGCGCC TGCTGGCCGA GCTGACCTTC CTGGGCGGCC AGGCGCTGCT CTACGGCTTC 
CGCGTGGCCC CGCACTTCGC GTGCGCCGGT CCGCCCTGCC CGCACACGGT CGACTGCTTC 
GTGAGCCGGC CCACCGAGAA GACCGTCTTC GTGCTCTTCT ATTTCGCGGT GGGGCTGCTG 
TCGGCGCTGC TCAGCGTAGC CGAGCTGGGC CACCTGCTCT GGAAGGGCCG CCCGCGCGCC 
GGGGAGCGTG ACAACCGCTG CAACCGTGCA CACGAAGAGG CGCAGAAGCT GCTCCCGCCG 
CCGCCGCCGC CACCTCCGCC ACCGGCCCTG CCCTCCCGGC GCCCCGGCCC CGAGCCGTGC 
GCCCCGCCGG CCTATGCGCA CCCGGCGCCG GCCAGCCTCC GCGAGTGCGG CAGCGGCCGC 
GGCAAGGCGT CACCGGCCAC CGGCCGCCGA GATCTGGCCA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GJD3 ( NM_152219.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689343.3 Homo sapiens gap junction protein delta 3 (GJD3), mRNA.

Price & Availability↑

CloneID	OHu30599
Clone ID Related Accession (Same CDS sequence)	NM_152219.3 , NM_152219.4
Accession Version	NM_152219.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	gap junction delta-3 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC080112.15. On May 17, 2019 this sequence version replaced NM_152219.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript is intronless :: DRR138518.655719.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000578689.2/ ENSP00000463752.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAGT GGGCGTTCCT GGGCTCGCTG CTGGACGCCG TGCAGCTGCA GTCGCCGCTC 
GTGGGCCGCC TCTGGCTGGT GGTCATGCTG ATCTTCCGCA TCCTGGTGCT GGCCACGGTG 
GGCGGCGCCG TGTTCGAGGA CGAGCAAGAG GAGTTCGTGT GCAACACGCT GCAGCCGGGC 
TGTCGCCAGA CCTGCTACGA CCGCGCCTTC CCGGTCTCCC ACTACCGCTT CTGGCTCTTC 
CACATCCTGC TGCTCTCGGC GCCCCCGGTG CTGTTCGTCG TCTACTCCAT GCACCGGGCA 
GGCAAGGAGG CGGGCGGCGC TGAGGCGGCG GCGCAGTGCG CCCCCGGACT GCCCGAGGCC 
CAGTGCGCGC CGTGCGCCCT GCGCGCCCGC CGCGCGCGCC GCTGCTACCT GCTGAGCGTG 
GCGCTGCGCC TGCTGGCCGA GCTGACCTTC CTGGGCGGCC AGGCGCTGCT CTACGGCTTC 
CGCGTGGCCC CGCACTTCGC GTGCGCCGGT CCGCCCTGCC CGCACACGGT CGACTGCTTC 
GTGAGCCGGC CCACCGAGAA GACCGTCTTC GTGCTCTTCT ATTTCGCGGT GGGGCTGCTG 
TCGGCGCTGC TCAGCGTAGC CGAGCTGGGC CACCTGCTCT GGAAGGGCCG CCCGCGCGCC 
GGGGAGCGTG ACAACCGCTG CAACCGTGCA CACGAAGAGG CGCAGAAGCT GCTCCCGCCG 
CCGCCGCCGC CACCTCCGCC ACCGGCCCTG CCCTCCCGGC GCCCCGGCCC CGAGCCGTGC 
GCCCCGCCGG CCTATGCGCA CCCGGCGCCG GCCAGCCTCC GCGAGTGCGG CAGCGGCCGC 
GGCAAGGCGT CACCGGCCAC CGGCCGCCGA GATCTGGCCA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689343.3
CDS	923..1807
Translation	MGEWAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPGCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKEAGGAEAAAQCAPGLPEAQCAPCALRARRARRCYLLSVALRLLAELTFLGGQALLYGFRVAPHFACAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGERDNRCNRAHEEAQKLLPPPPPPPPPPALPSRRPGPEPCAPPAYAHPAPASLRECGSGRGKASPATGRRDLAI

Target ORF information:

RefSeq Version	NM_152219.4
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein delta 3 (GJD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152219.4

ORF Insert Sequence:

ATGGGGGAGT GGGCGTTCCT GGGCTCGCTG CTGGACGCCG TGCAGCTGCA GTCGCCGCTC 
GTGGGCCGCC TCTGGCTGGT GGTCATGCTG ATCTTCCGCA TCCTGGTGCT GGCCACGGTG 
GGCGGCGCCG TGTTCGAGGA CGAGCAAGAG GAGTTCGTGT GCAACACGCT GCAGCCGGGC 
TGTCGCCAGA CCTGCTACGA CCGCGCCTTC CCGGTCTCCC ACTACCGCTT CTGGCTCTTC 
CACATCCTGC TGCTCTCGGC GCCCCCGGTG CTGTTCGTCG TCTACTCCAT GCACCGGGCA 
GGCAAGGAGG CGGGCGGCGC TGAGGCGGCG GCGCAGTGCG CCCCCGGACT GCCCGAGGCC 
CAGTGCGCGC CGTGCGCCCT GCGCGCCCGC CGCGCGCGCC GCTGCTACCT GCTGAGCGTG 
GCGCTGCGCC TGCTGGCCGA GCTGACCTTC CTGGGCGGCC AGGCGCTGCT CTACGGCTTC 
CGCGTGGCCC CGCACTTCGC GTGCGCCGGT CCGCCCTGCC CGCACACGGT CGACTGCTTC 
GTGAGCCGGC CCACCGAGAA GACCGTCTTC GTGCTCTTCT ATTTCGCGGT GGGGCTGCTG 
TCGGCGCTGC TCAGCGTAGC CGAGCTGGGC CACCTGCTCT GGAAGGGCCG CCCGCGCGCC 
GGGGAGCGTG ACAACCGCTG CAACCGTGCA CACGAAGAGG CGCAGAAGCT GCTCCCGCCG 
CCGCCGCCGC CACCTCCGCC ACCGGCCCTG CCCTCCCGGC GCCCCGGCCC CGAGCCGTGC 
GCCCCGCCGG CCTATGCGCA CCCGGCGCCG GCCAGCCTCC GCGAGTGCGG CAGCGGCCGC 
GGCAAGGCGT CACCGGCCAC CGGCCGCCGA GATCTGGCCA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system.
Journal of molecular and cellular cardiology46(4)553-9(2009 Apr)
Kreuzberg MM,Liebermann M,Segschneider S,Dobrowolski R,Dobrzynski H,Kaba R,Rowlinson G,Dupont E,Severs NJ,Willecke K

Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.
Biochemical and biophysical research communications369(2)388-94(2008 May)
Gemel J,Lin X,Collins R,Veenstra RD,Beyer EC

Tissue-specific effects of wild-type and mutant connexin 31: a role in neurite outgrowth.
Human molecular genetics16(2)165-72(2007 Jan)
Unsworth HC,Aasen T,McElwaine S,Kelsell DP

Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart.
Proceedings of the National Academy of Sciences of the United States of America103(25)9726-31(2006 Jun)
Bukauskas FF,Kreuzberg MM,Rackauskas M,Bukauskiene A,Bennett MV,Verselis VK,Willecke K

Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.
Cell communication & adhesion10(1)27-36(2003 Jan-Feb)
S?hl G,Nielsen PA,Eiberger J,Willecke K

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GJD3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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