CD300LB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD300LB
Entrez Gene ID	124599
Full Name	CD300 molecule like family member b
Synonyms	CD300b,CLM-7,CLM7,CMRF35-A2,IREM-3,IREM3,TREM-5,TREM5
General protein information	Preferred Names CD300 molecule like family member b Names CMRF35-like molecule 7 CD300 antigen like family member B immune receptor expressed on myeloid cells 3 leukocyte mono-Ig-like receptor 5 triggering receptor expressed on myeloid cells 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.1
Summary	CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610705

mRNA and Protein(s)

mRNA	Protein	Name
NM_174892.4	NP_777552.3	CMRF35-like molecule 7 precursor
XM_005257027.3	XP_005257084.1	CMRF35-like molecule 7 isoform X1
NM_174892.3	NP_777552.3	CMRF35-like molecule 7 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cd300lb	NP_001161136.1
Pan troglodytes (chimpanzee)	CD300LB	XP_523708.2
	CD300LB	XP_001090960.1
Mus musculus (house mouse)	Cd300lb	NP_954691.2
Homo sapiens (human)	CD300LB	NP_777552.3

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock.
Voss OH, Murakami Y, Pena MY, Lee HN, Tian L, Margulies DH, Street JM, Yuen PS, Qi CF, Krzewski K, Coligan JE
Immunity44(6)1365-78(2016 06)

CD300 molecule regulation of human dendritic cell functions.
Gasiorowski RE, Ju X, Hart DN, Clark GJ
Immunology letters149(1-2)93-100(2013 Jan)

New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes and immunity11(3)232-8(2010 Apr)

The CD300 molecules regulate monocyte and dendritic cell functions.
Clark GJ, Ju X, Azlan M, Tate C, Ding Y, Hart DN
Immunobiology214(9-10)730-6(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD300LB expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

this paper identified CD300b as an lipopolysaccharide-recognizing receptor that regulated TLR4 signaling
Title: Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock.

CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.
Title: CD300 molecule regulation of human dendritic cell functions.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

The following CD300LB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD300LB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10103	NM_174892.4 Latest version!	Homo sapiens CD300 molecule like family member b (CD300LB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu50088	XM_005257027.3 Latest version!	Homo sapiens CD300 molecule like family member b (CD300LB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu10103	NM_174892.3	Homo sapiens CD300 molecule like family member b (CD300LB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD300LB ( NM_174892.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_777552.3 Homo sapiens CD300 molecule like family member b (CD300LB), mRNA.

Price & Availability↑

CloneID	OHu10103
Clone ID Related Accession (Same CDS sequence)	NM_174892.4 , NM_174892.3
Accession Version	NM_174892.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	CMRF35-like molecule 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079325.10, AK290925.1 and BC028091.1. On Nov 22, 2018 this sequence version replaced NM_174892.3. ##Evidence-Data-START## Transcript exon combination :: BC028091.1, AY359025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal MANE Ensembl match :: ENST00000392621.6/ ENSP00000376397.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGCTGC CCCCTGCTCT GCTCCTTCTC AGCCTCTCAG GCTGTTTCTC CATCCAAGGC 
CCAGAGTCTG TGAGAGCCCC AGAGCAGGGG TCCCTGACGG TTCAATGCCA CTATAAGCAA 
GGATGGGAGA CCTACATTAA GTGGTGGTGC CGAGGGGTGC GCTGGGATAC ATGCAAGATC 
CTCATTGAAA CCAGAGGGTC GGAGCAAGGA GAGAAGAGTG ACCGTGTGTC CATCAAGGAC 
AATCAGAAAG ACCGCACGTT CACTGTGACC ATGGAGGGGC TCAGGCGAGA TGACGCAGAT 
GTTTACTGGT GTGGGATTGA AAGAAGAGGA CCTGACCTTG GGACTCAAGT GAAAGTGATC 
GTTGACCCAG AGGGAGCGGC TTCCACAACA GCAAGCTCAC CTACCAACAG CAATATGGCA 
GTGTTCATCG GCTCCCACAA GAGGAACCAC TACATGCTCC TGGTATTTGT GAAGGTGCCC 
ATCTTGCTCA TCTTGGTCAC TGCCATCCTC TGGTTGAAGG GGTCTCAGAG GGTCCCTGAG 
GAGCCAGGGG AACAGCCTAT CTACATGAAC TTCTCCGAAC CTCTGACTAA AGACATGGCC 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777552.3
CDS	126..731
Translation	MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT

Target ORF information:

RefSeq Version	NM_174892.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CD300 molecule like family member b (CD300LB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174892.4

ORF Insert Sequence:

ATGTGGCTGC CCCCTGCTCT GCTCCTTCTC AGCCTCTCAG GCTGTTTCTC CATCCAAGGC 
CCAGAGTCTG TGAGAGCCCC AGAGCAGGGG TCCCTGACGG TTCAATGCCA CTATAAGCAA 
GGATGGGAGA CCTACATTAA GTGGTGGTGC CGAGGGGTGC GCTGGGATAC ATGCAAGATC 
CTCATTGAAA CCAGAGGGTC GGAGCAAGGA GAGAAGAGTG ACCGTGTGTC CATCAAGGAC 
AATCAGAAAG ACCGCACGTT CACTGTGACC ATGGAGGGGC TCAGGCGAGA TGACGCAGAT 
GTTTACTGGT GTGGGATTGA AAGAAGAGGA CCTGACCTTG GGACTCAAGT GAAAGTGATC 
GTTGACCCAG AGGGAGCGGC TTCCACAACA GCAAGCTCAC CTACCAACAG CAATATGGCA 
GTGTTCATCG GCTCCCACAA GAGGAACCAC TACATGCTCC TGGTATTTGT GAAGGTGCCC 
ATCTTGCTCA TCTTGGTCAC TGCCATCCTC TGGTTGAAGG GGTCTCAGAG GGTCCCTGAG 
GAGCCAGGGG AACAGCCTAT CTACATGAAC TTCTCCGAAC CTCTGACTAA AGACATGGCC 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD300LB ( NM_174892.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_777552.3 Homo sapiens CD300 molecule like family member b (CD300LB), mRNA.

Price & Availability↑

CloneID	OHu10103
Clone ID Related Accession (Same CDS sequence)	NM_174892.4 , NM_174892.3
Accession Version	NM_174892.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	CMRF35-like molecule 7 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK290925.1 and BC028091.1. On Jun 7, 2013 this sequence version replaced NM_174892.2. ##Evidence-Data-START## Transcript exon combination :: BC028091.1, AY359025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGCTGC CCCCTGCTCT GCTCCTTCTC AGCCTCTCAG GCTGTTTCTC CATCCAAGGC 
CCAGAGTCTG TGAGAGCCCC AGAGCAGGGG TCCCTGACGG TTCAATGCCA CTATAAGCAA 
GGATGGGAGA CCTACATTAA GTGGTGGTGC CGAGGGGTGC GCTGGGATAC ATGCAAGATC 
CTCATTGAAA CCAGAGGGTC GGAGCAAGGA GAGAAGAGTG ACCGTGTGTC CATCAAGGAC 
AATCAGAAAG ACCGCACGTT CACTGTGACC ATGGAGGGGC TCAGGCGAGA TGACGCAGAT 
GTTTACTGGT GTGGGATTGA AAGAAGAGGA CCTGACCTTG GGACTCAAGT GAAAGTGATC 
GTTGACCCAG AGGGAGCGGC TTCCACAACA GCAAGCTCAC CTACCAACAG CAATATGGCA 
GTGTTCATCG GCTCCCACAA GAGGAACCAC TACATGCTCC TGGTATTTGT GAAGGTGCCC 
ATCTTGCTCA TCTTGGTCAC TGCCATCCTC TGGTTGAAGG GGTCTCAGAG GGTCCCTGAG 
GAGCCAGGGG AACAGCCTAT CTACATGAAC TTCTCCGAAC CTCTGACTAA AGACATGGCC 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777552.3
CDS	125..730
Translation	MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT

Target ORF information:

RefSeq Version	NM_174892.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD300 molecule like family member b (CD300LB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174892.3

ORF Insert Sequence:

ATGTGGCTGC CCCCTGCTCT GCTCCTTCTC AGCCTCTCAG GCTGTTTCTC CATCCAAGGC 
CCAGAGTCTG TGAGAGCCCC AGAGCAGGGG TCCCTGACGG TTCAATGCCA CTATAAGCAA 
GGATGGGAGA CCTACATTAA GTGGTGGTGC CGAGGGGTGC GCTGGGATAC ATGCAAGATC 
CTCATTGAAA CCAGAGGGTC GGAGCAAGGA GAGAAGAGTG ACCGTGTGTC CATCAAGGAC 
AATCAGAAAG ACCGCACGTT CACTGTGACC ATGGAGGGGC TCAGGCGAGA TGACGCAGAT 
GTTTACTGGT GTGGGATTGA AAGAAGAGGA CCTGACCTTG GGACTCAAGT GAAAGTGATC 
GTTGACCCAG AGGGAGCGGC TTCCACAACA GCAAGCTCAC CTACCAACAG CAATATGGCA 
GTGTTCATCG GCTCCCACAA GAGGAACCAC TACATGCTCC TGGTATTTGT GAAGGTGCCC 
ATCTTGCTCA TCTTGGTCAC TGCCATCCTC TGGTTGAAGG GGTCTCAGAG GGTCCCTGAG 
GAGCCAGGGG AACAGCCTAT CTACATGAAC TTCTCCGAAC CTCTGACTAA AGACATGGCC 
ACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD300LB ( XM_005257027.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005257084.1 Homo sapiens CD300 molecule like family member b (CD300LB), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu50088
Clone ID Related Accession (Same CDS sequence)	XM_005257027.3
Accession Version	XM_005257027.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	CMRF35-like molecule 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005257027.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCAGAA GGTGCAAGCC AGAGCTCAGG CAGAACTTCC AGAGTGCATC TGGGATCTGC 
ATTTGCCACT GGTTGCAGAT CAGGCGGACG AGGAGCCGGG AAGGCAGAGC CATGTGGCTG 
CCCCCTGCTC TGCTCCTTCT CAGCCTCTCA GGCTGTTTCT CCATCCAAGG CCCAGAGTCT 
GTGAGAGCCC CAGAGCAGGG GTCCCTGACG GTTCAATGCC ACTATAAGCA AGGATGGGAG 
ACCTACATTA AGTGGTGGTG CCGAGGGGTG CGCTGGGATA CATGCAAGAT CCTCATTGAA 
ACCAGAGGGT CGGAGCAAGG AGAGAAGAGT GACCGTGTGT CCATCAAGGA CAATCAGAAA 
GACCGCACGT TCACTGTGAC CATGGAGGGG CTCAGGCGAG ATGACGCAGA TGTTTACTGG 
TGTGGGATTG AAAGAAGAGG ACCTGACCTT GGGACTCAAG TGAAAGTGAT CGTTGACCCA 
GAGGGAGCGG CTTCCACAAC AGCAAGCTCA CCTACCAACA GCAATATGGC AGTGTTCATC 
GGCTCCCACA AGAGGTCTCT GGCCAATGAT GGGCCTGAAA ATTCCATAAT GGCCAGAGAG 
GAGAGTTCGA GCCCGGCTAA GATCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005257084.1
CDS	14..643
Translation	MCRRCKPELRQNFQSASGICICHWLQIRRTRSREGRAMWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRSLANDGPENSIMAREESSSPAKIP

Target ORF information:

RefSeq Version	XM_005257027.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD300 molecule like family member b (CD300LB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005257027.3

ORF Insert Sequence:

ATGTGCAGAA GGTGCAAGCC AGAGCTCAGG CAGAACTTCC AGAGTGCATC TGGGATCTGC 
ATTTGCCACT GGTTGCAGAT CAGGCGGACG AGGAGCCGGG AAGGCAGAGC CATGTGGCTG 
CCCCCTGCTC TGCTCCTTCT CAGCCTCTCA GGCTGTTTCT CCATCCAAGG CCCAGAGTCT 
GTGAGAGCCC CAGAGCAGGG GTCCCTGACG GTTCAATGCC ACTATAAGCA AGGATGGGAG 
ACCTACATTA AGTGGTGGTG CCGAGGGGTG CGCTGGGATA CATGCAAGAT CCTCATTGAA 
ACCAGAGGGT CGGAGCAAGG AGAGAAGAGT GACCGTGTGT CCATCAAGGA CAATCAGAAA 
GACCGCACGT TCACTGTGAC CATGGAGGGG CTCAGGCGAG ATGACGCAGA TGTTTACTGG 
TGTGGGATTG AAAGAAGAGG ACCTGACCTT GGGACTCAAG TGAAAGTGAT CGTTGACCCA 
GAGGGAGCGG CTTCCACAAC AGCAAGCTCA CCTACCAACA GCAATATGGC AGTGTTCATC 
GGCTCCCACA AGAGGTCTCT GGCCAATGAT GGGCCTGAAA ATTCCATAAT GGCCAGAGAG 
GAGAGTTCGA GCCCGGCTAA GATCCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock.
Immunity44(6)1365-78(2016 06)
Voss OH,Murakami Y,Pena MY,Lee HN,Tian L,Margulies DH,Street JM,Yuen PS,Qi CF,Krzewski K,Coligan JE

CD300 molecule regulation of human dendritic cell functions.
Immunology letters149(1-2)93-100(2013 Jan)
Gasiorowski RE,Ju X,Hart DN,Clark GJ

New genetic associations detected in a host response study to hepatitis B vaccine.
Genes and immunity11(3)232-8(2010 Apr)
Davila S,Froeling FE,Tan A,Bonnard C,Boland GJ,Snippe H,Hibberd ML,Seielstad M

The CD300 molecules regulate monocyte and dendritic cell functions.
Immunobiology214(9-10)730-6(2009)
Clark GJ,Ju X,Azlan M,Tate C,Ding Y,Hart DN

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CD300LB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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