ASCL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ASCL4
Entrez Gene ID	121549
Full Name	achaete-scute family bHLH transcription factor 4
Synonyms	HASH4,bHLHa44
General protein information	Preferred Names achaete-scute family bHLH transcription factor 4 Names achaete-scute homolog 4 ASH-4 achaete-scute complex homolog 4 achaete-scute complex-like 4 achaete-scute-like protein 4 class A basic helix-loop-helix protein 44 class II bHLH protein ASCL4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q23.3
Summary	Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609155

mRNA and Protein(s)

mRNA	Protein	Name
NM_203436.2	NP_982260.2	achaete-scute homolog 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ASCL4	XP_522519.3
Mus musculus (house mouse)	Ascl4	NP_001157086.1
Gallus gallus (chicken)	ASCL4	XP_004937863.1
Canis lupus familiaris (dog)	ASCL4	XP_005625991.1
Bos taurus (cattle)	ASCL4	XP_005206856.1
Rattus norvegicus (Norway rat)	Ascl4	XP_006241232.1
Homo sapiens (human)	ASCL4	NP_982260.2
	ASCL4	XP_001101479.2

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

Role of intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line.
Mele PG, Duarte A, Paz C, Capponi A, Podest? EJ
Endocrinology153(7)3284-94(2012 Jul)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

The XLMR gene ACSL4 plays a role in dendritic spine architecture.
Meloni I, Parri V, De Filippis R, Ariani F, Artuso R, Bruttini M, Katzaki E, Longo I, Mari F, Bellan C, Dotti CG, Renieri A
Neuroscience159(2)657-69(2009 Mar)

Hash4, a novel human achaete-scute homologue found in fetal skin.
Jonsson M, Bj?rntorp Mark E, Brantsing C, Brandner JM, Lindahl A, Asp J
Genomics84(5)859-66(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis have roles in NCI-H295R adrenocortical cell line
Title: Role of intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line.

In neuron reduced levels of ACSL4 led to a significant reduction in dendritic spine density and an alteration in spine/filopodia distribution.
Title: The XLMR gene ACSL4 plays a role in dendritic spine architecture.

HASH4 is involved in skin development.
Title: Hash4, a novel human achaete-scute homologue found in fetal skin.

The following ASCL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASCL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31654	NM_203436.2 Latest version!	Homo sapiens achaete-scute family bHLH transcription factor 4 (ASCL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ASCL4 ( NM_203436.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_982260.2 Homo sapiens achaete-scute family bHLH transcription factor 4 (ASCL4), mRNA.

Price & Availability↑

CloneID	OHu31654
Clone ID Related Accession (Same CDS sequence)	NM_203436.2
Accession Version	NM_203436.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	achaete-scute homolog 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY238895.1 and AI290227.1. On Sep 25, 2008 this sequence version replaced NM_203436.1. ##Evidence-Data-START## Transcript is intronless :: AY238895.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATGGAGA CGCGTAAACC GGCGGAACGG CTGGCCTTGC CATACTCGCT GCGCACCGCG 
CCCCTGGGCG TTCCGGGGAC CCTGCCCGGA CTCCCGCGGA GGGACCCCCT CAGGGTCGCC 
CTGCGTCTGG ACGCCGCGTG CTGGGAGTGG GCGCGCAGCG GCTGCGCACG GGGATGGCAG 
TACTTGCCCG TGCCGCTGGA CAGCGCCTTC GAGCCCGCCT TCCTCCGCAA GCGCAACGAG 
CGCGAGCGGC AGCGGGTGCG CTGCGTGAAC GAGGGCTATG CGCGCCTCCG AGACCACCTG 
CCCCGGGAGC TGGCAGACAA GCGCCTCAGC AAAGTGGAGA CGCTCCGCGC TGCCATCGAC 
TACATCAAGC ACCTGCAGGA GCTGCTGGAG CGCCAGGCCT GGGGGCTCGA GGGCGCGGCC 
GGCGCCGTCC CCCAGCGCAG GGCGGAATGC AACAGCGACG GGGAGTCCAA GGCCTCTTCG 
GCGCCTTCGC CCAGCAGCGA GCCCGAGGAG GGGGGCAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_982260.2
CDS	832..1353
Translation	MMETRKPAERLALPYSLRTAPLGVPGTLPGLPRRDPLRVALRLDAACWEWARSGCARGWQYLPVPLDSAFEPAFLRKRNERERQRVRCVNEGYARLRDHLPRELADKRLSKVETLRAAIDYIKHLQELLERQAWGLEGAAGAVPQRRAECNSDGESKASSAPSPSSEPEEGGS

Target ORF information:

RefSeq Version	NM_203436.2
Organism	Homo sapiens(human)
Definition	Homo sapiens achaete-scute family bHLH transcription factor 4 (ASCL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203436.2

ORF Insert Sequence:

ATGATGGAGA CGCGTAAACC GGCGGAACGG CTGGCCTTGC CATACTCGCT GCGCACCGCG 
CCCCTGGGCG TTCCGGGGAC CCTGCCCGGA CTCCCGCGGA GGGACCCCCT CAGGGTCGCC 
CTGCGTCTGG ACGCCGCGTG CTGGGAGTGG GCGCGCAGCG GCTGCGCACG GGGATGGCAG 
TACTTGCCCG TGCCGCTGGA CAGCGCCTTC GAGCCCGCCT TCCTCCGCAA GCGCAACGAG 
CGCGAGCGGC AGCGGGTGCG CTGCGTGAAC GAGGGCTATG CGCGCCTCCG AGACCACCTG 
CCCCGGGAGC TGGCAGACAA GCGCCTCAGC AAAGTGGAGA CGCTCCGCGC TGCCATCGAC 
TACATCAAGC ACCTGCAGGA GCTGCTGGAG CGCCAGGCCT GGGGGCTCGA GGGCGCGGCC 
GGCGCCGTCC CCCAGCGCAG GGCGGAATGC AACAGCGACG GGGAGTCCAA GGCCTCTTCG 
GCGCCTTCGC CCAGCAGCGA GCCCGAGGAG GGGGGCAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

Role of intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line.
Endocrinology153(7)3284-94(2012 Jul)
Mele PG,Duarte A,Paz C,Capponi A,Podest? EJ

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

The XLMR gene ACSL4 plays a role in dendritic spine architecture.
Neuroscience159(2)657-69(2009 Mar)
Meloni I,Parri V,De Filippis R,Ariani F,Artuso R,Bruttini M,Katzaki E,Longo I,Mari F,Bellan C,Dotti CG,Renieri A

Hash4, a novel human achaete-scute homologue found in fetal skin.
Genomics84(5)859-66(2004 Nov)
Jonsson M,Bj?rntorp Mark E,Brantsing C,Brandner JM,Lindahl A,Asp J

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ASCL4 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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