CLK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLK1
Entrez Gene ID	1195
Full Name	CDC like kinase 1
Synonyms	CLK,CLK/STY,STY
General protein information	Preferred Names CDC like kinase 1 Names dual specificity protein kinase CLK1 CDC28/CDC2-like kinase protein tyrosine kinase STY
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q33.1
Summary	This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Disorder MIM:	601951

mRNA and Protein(s)

mRNA	Protein	Name
NM_004071.3	NP_004062.2	dual specificity protein kinase CLK1 isoform 1
NM_001162407.1	NP_001155879.1	dual specificity protein kinase CLK1 isoform 2
NM_004071.4	NP_004062.2	dual specificity protein kinase CLK1 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CLK1	XP_003641631.1
Homo sapiens (human)	CLK1	NP_001155879.1
Canis lupus familiaris (dog)	CLK1	XP_858089.3
Rattus norvegicus (Norway rat)	Clk1	NP_001100383.2
Pan troglodytes (chimpanzee)	CLK1	XP_001170743.2
	CLK1	XP_001093219.1
Mus musculus (house mouse)	Clk1	NP_001036099.1
Xenopus tropicalis (tropical clawed frog)	clk1	NP_001016921.1

Gene Ontology
Bibliography

Related articles in PubMed

Mobilization of A Splicing Factor Through A Nuclear Kinase-Kinase Complex.
Aubol BE, Keshwani MM, Fattet L, Adams JA
The Biochemical journal(2018 Jan)

Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
Zhang L, Yang H, Zhang W, Liang Z, Huang Q, Xu G, Zhen X, Zheng LT
Journal of neurochemistry142(4)574-588(2017 Aug)

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S
Nature communications8(1)7(2017 02)

Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing.
Aubol BE, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA
Molecular cell63(2)218-228(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that mitochondrial Clk1 regulated chemoresistance in glioma cells through AMPK/mTOR/HIF-1alpha mediated glycolysis pathway
Title: Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.

Global CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor has been described.
Title: CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

SRPK1 interacts with an RS-like domain in the N terminus of CLK1 to facilitate the release of phosphorylated SR proteins, which then promotes efficient splice-site recognition and subsequent spliceosome assembly.
Title: Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing.

Clk1, Clk2 and Clk4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.
Title: Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.

These results thus reveal a large program of CLK1-regulated periodic alternative splicing intimately associated with cell cycle control.
Title: An extensive program of periodic alternative splicing linked to cell cycle progression.

The following CLK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09081	NM_004071.4 Latest version!	Homo sapiens CDC like kinase 1 (CLK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu31947	NM_001162407.1 Latest version!	Homo sapiens CDC like kinase 1 (CLK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu09081	NM_004071.3	Homo sapiens CDC like kinase 1 (CLK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLK1 ( NM_004071.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004062.2 Homo sapiens CDC like kinase 1 (CLK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09081
Clone ID Related Accession (Same CDS sequence)	NM_004071.3 , NM_004071.4
Accession Version	NM_004071.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1455bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	dual specificity protein kinase CLK1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA225472.1, BC031549.1 and AI251890.1. On Jun 23, 2009 this sequence version replaced NM_004071.2. Transcript Variant: This variant (1) encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.166555.1, SRR1803616.5552.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGACACT CAAAGAGAAC TTACTGTCCT GATTGGGATG ACAAGGATTG GGATTATGGA 
AAATGGAGGA GCAGCAGCAG TCATAAAAGA AGGAAGAGAT CACATAGCAG TGCCCAGGAG 
AACAAGCGCT GCAAATACAA TCACTCTAAA ATGTGTGATA GCCATTATTT GGAAAGCAGG 
TCTATAAATG AGAAAGATTA TCATAGTCGA CGCTACATTG ATGAGTACAG AAATGACTAC 
ACTCAAGGAT GTGAACCTGG ACATCGCCAA AGAGACCATG AAAGCCGGTA TCAGAACCAT 
AGTAGCAAGT CTTCTGGTAG AAGTGGAAGA AGTAGTTATA AAAGCAAACA CAGGATTCAC 
CACAGTACTT CACATCGTCG TTCACATGGG AAGAGTCACC GAAGGAAAAG AACCAGGAGT 
GTAGAGGATG ATGAGGAGGG TCACCTGATC TGTCAGAGTG GAGACGTACT AAGTGCAAGA 
TATGAAATTG TTGATACTTT AGGTGAAGGA GCTTTTGGAA AAGTTGTGGA GTGCATCGAT 
CATAAAGCGG GAGGTAGACA TGTAGCAGTA AAAATAGTTA AAAATGTGGA TAGATACTGT 
GAAGCTGCTC GCTCAGAAAT ACAAGTTCTG GAACATCTGA ATACAACAGA CCCCAACAGT 
ACTTTCCGCT GTGTCCAGAT GTTGGAATGG TTTGAGCATC ATGGTCACAT TTGCATTGTT 
TTTGAACTAT TGGGACTTAG TACTTACGAC TTCATTAAAG AAAATGGTTT TCTACCATTT 
CGACTGGATC ATATCAGAAA GATGGCATAT CAGATATGCA AGTCTGTGAA TTTTTTGCAC 
AGTAATAAGT TGACTCACAC AGACTTAAAG CCTGAAAACA TCTTATTTGT GCAGTCTGAC 
TACACAGAGG CGTATAATCC CAAAATAAAA CGTGATGAAC GCACCTTAAT AAATCCAGAT 
ATTAAAGTTG TAGACTTTGG TAGTGCAACA TATGATGACG AACATCACAG TACATTGGTA 
TCTACAAGAC ATTATAGAGC ACCTGAAGTT ATTTTAGCCC TAGGGTGGTC CCAACCATGT 
GATGTCTGGA GCATAGGATG CATTCTTATT GAATACTATC TTGGGTTTAC CGTATTTCCA 
ACACACGATA GTAAGGAGCA TTTAGCAATG ATGGAAAGGA TTCTTGGACC TCTACCAAAA 
CATATGATAC AGAAAACCAG GAAACGTAAA TATTTTCACC ACGATCGATT AGACTGGGAT 
GAACACAGTT CTGCCGGCAG ATATGTTTCA AGACGCTGTA AACCTCTGAA GGAATTTATG 
CTTTCTCAAG ATGTTGAACA TGAGCGTCTC TTTGACCTCA TTCAGAAAAT GTTGGAGTAT 
GATCCAGCCA AAAGAATTAC TCTCAGAGAA GCCTTAAAGC ATCCTTTCTT TGACCTTCTG 
AAGAAAAGTA TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004062.2
CDS	182..1636
Translation	MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI

Target ORF information:

RefSeq Version	NM_004071.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CDC like kinase 1 (CLK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004071.3

ORF Insert Sequence:

ATGAGACACT CAAAGAGAAC TTACTGTCCT GATTGGGATG ACAAGGATTG GGATTATGGA 
AAATGGAGGA GCAGCAGCAG TCATAAAAGA AGGAAGAGAT CACATAGCAG TGCCCAGGAG 
AACAAGCGCT GCAAATACAA TCACTCTAAA ATGTGTGATA GCCATTATTT GGAAAGCAGG 
TCTATAAATG AGAAAGATTA TCATAGTCGA CGCTACATTG ATGAGTACAG AAATGACTAC 
ACTCAAGGAT GTGAACCTGG ACATCGCCAA AGAGACCATG AAAGCCGGTA TCAGAACCAT 
AGTAGCAAGT CTTCTGGTAG AAGTGGAAGA AGTAGTTATA AAAGCAAACA CAGGATTCAC 
CACAGTACTT CACATCGTCG TTCACATGGG AAGAGTCACC GAAGGAAAAG AACCAGGAGT 
GTAGAGGATG ATGAGGAGGG TCACCTGATC TGTCAGAGTG GAGACGTACT AAGTGCAAGA 
TATGAAATTG TTGATACTTT AGGTGAAGGA GCTTTTGGAA AAGTTGTGGA GTGCATCGAT 
CATAAAGCGG GAGGTAGACA TGTAGCAGTA AAAATAGTTA AAAATGTGGA TAGATACTGT 
GAAGCTGCTC GCTCAGAAAT ACAAGTTCTG GAACATCTGA ATACAACAGA CCCCAACAGT 
ACTTTCCGCT GTGTCCAGAT GTTGGAATGG TTTGAGCATC ATGGTCACAT TTGCATTGTT 
TTTGAACTAT TGGGACTTAG TACTTACGAC TTCATTAAAG AAAATGGTTT TCTACCATTT 
CGACTGGATC ATATCAGAAA GATGGCATAT CAGATATGCA AGTCTGTGAA TTTTTTGCAC 
AGTAATAAGT TGACTCACAC AGACTTAAAG CCTGAAAACA TCTTATTTGT GCAGTCTGAC 
TACACAGAGG CGTATAATCC CAAAATAAAA CGTGATGAAC GCACCTTAAT AAATCCAGAT 
ATTAAAGTTG TAGACTTTGG TAGTGCAACA TATGATGACG AACATCACAG TACATTGGTA 
TCTACAAGAC ATTATAGAGC ACCTGAAGTT ATTTTAGCCC TAGGGTGGTC CCAACCATGT 
GATGTCTGGA GCATAGGATG CATTCTTATT GAATACTATC TTGGGTTTAC CGTATTTCCA 
ACACACGATA GTAAGGAGCA TTTAGCAATG ATGGAAAGGA TTCTTGGACC TCTACCAAAA 
CATATGATAC AGAAAACCAG GAAACGTAAA TATTTTCACC ACGATCGATT AGACTGGGAT 
GAACACAGTT CTGCCGGCAG ATATGTTTCA AGACGCTGTA AACCTCTGAA GGAATTTATG 
CTTTCTCAAG ATGTTGAACA TGAGCGTCTC TTTGACCTCA TTCAGAAAAT GTTGGAGTAT 
GATCCAGCCA AAAGAATTAC TCTCAGAGAA GCCTTAAAGC ATCCTTTCTT TGACCTTCTG 
AAGAAAAGTA TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLK1 ( NM_004071.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004062.2 Homo sapiens CDC like kinase 1 (CLK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09081
Clone ID Related Accession (Same CDS sequence)	NM_004071.3 , NM_004071.4
Accession Version	NM_004071.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1455bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	dual specificity protein kinase CLK1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA225472.1, BC031549.1 and AI251890.1. On Nov 25, 2018 this sequence version replaced NM_004071.3. Transcript Variant: This variant (1) encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.206101.1, SRR1803616.166555.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000321356.9/ ENSP00000326830.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGACACT CAAAGAGAAC TTACTGTCCT GATTGGGATG ACAAGGATTG GGATTATGGA 
AAATGGAGGA GCAGCAGCAG TCATAAAAGA AGGAAGAGAT CACATAGCAG TGCCCAGGAG 
AACAAGCGCT GCAAATACAA TCACTCTAAA ATGTGTGATA GCCATTATTT GGAAAGCAGG 
TCTATAAATG AGAAAGATTA TCATAGTCGA CGCTACATTG ATGAGTACAG AAATGACTAC 
ACTCAAGGAT GTGAACCTGG ACATCGCCAA AGAGACCATG AAAGCCGGTA TCAGAACCAT 
AGTAGCAAGT CTTCTGGTAG AAGTGGAAGA AGTAGTTATA AAAGCAAACA CAGGATTCAC 
CACAGTACTT CACATCGTCG TTCACATGGG AAGAGTCACC GAAGGAAAAG AACCAGGAGT 
GTAGAGGATG ATGAGGAGGG TCACCTGATC TGTCAGAGTG GAGACGTACT AAGTGCAAGA 
TATGAAATTG TTGATACTTT AGGTGAAGGA GCTTTTGGAA AAGTTGTGGA GTGCATCGAT 
CATAAAGCGG GAGGTAGACA TGTAGCAGTA AAAATAGTTA AAAATGTGGA TAGATACTGT 
GAAGCTGCTC GCTCAGAAAT ACAAGTTCTG GAACATCTGA ATACAACAGA CCCCAACAGT 
ACTTTCCGCT GTGTCCAGAT GTTGGAATGG TTTGAGCATC ATGGTCACAT TTGCATTGTT 
TTTGAACTAT TGGGACTTAG TACTTACGAC TTCATTAAAG AAAATGGTTT TCTACCATTT 
CGACTGGATC ATATCAGAAA GATGGCATAT CAGATATGCA AGTCTGTGAA TTTTTTGCAC 
AGTAATAAGT TGACTCACAC AGACTTAAAG CCTGAAAACA TCTTATTTGT GCAGTCTGAC 
TACACAGAGG CGTATAATCC CAAAATAAAA CGTGATGAAC GCACCTTAAT AAATCCAGAT 
ATTAAAGTTG TAGACTTTGG TAGTGCAACA TATGATGACG AACATCACAG TACATTGGTA 
TCTACAAGAC ATTATAGAGC ACCTGAAGTT ATTTTAGCCC TAGGGTGGTC CCAACCATGT 
GATGTCTGGA GCATAGGATG CATTCTTATT GAATACTATC TTGGGTTTAC CGTATTTCCA 
ACACACGATA GTAAGGAGCA TTTAGCAATG ATGGAAAGGA TTCTTGGACC TCTACCAAAA 
CATATGATAC AGAAAACCAG GAAACGTAAA TATTTTCACC ACGATCGATT AGACTGGGAT 
GAACACAGTT CTGCCGGCAG ATATGTTTCA AGACGCTGTA AACCTCTGAA GGAATTTATG 
CTTTCTCAAG ATGTTGAACA TGAGCGTCTC TTTGACCTCA TTCAGAAAAT GTTGGAGTAT 
GATCCAGCCA AAAGAATTAC TCTCAGAGAA GCCTTAAAGC ATCCTTTCTT TGACCTTCTG 
AAGAAAAGTA TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004062.2
CDS	96..1550
Translation	MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI

Target ORF information:

RefSeq Version	NM_004071.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CDC like kinase 1 (CLK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004071.4

ORF Insert Sequence:

ATGAGACACT CAAAGAGAAC TTACTGTCCT GATTGGGATG ACAAGGATTG GGATTATGGA 
AAATGGAGGA GCAGCAGCAG TCATAAAAGA AGGAAGAGAT CACATAGCAG TGCCCAGGAG 
AACAAGCGCT GCAAATACAA TCACTCTAAA ATGTGTGATA GCCATTATTT GGAAAGCAGG 
TCTATAAATG AGAAAGATTA TCATAGTCGA CGCTACATTG ATGAGTACAG AAATGACTAC 
ACTCAAGGAT GTGAACCTGG ACATCGCCAA AGAGACCATG AAAGCCGGTA TCAGAACCAT 
AGTAGCAAGT CTTCTGGTAG AAGTGGAAGA AGTAGTTATA AAAGCAAACA CAGGATTCAC 
CACAGTACTT CACATCGTCG TTCACATGGG AAGAGTCACC GAAGGAAAAG AACCAGGAGT 
GTAGAGGATG ATGAGGAGGG TCACCTGATC TGTCAGAGTG GAGACGTACT AAGTGCAAGA 
TATGAAATTG TTGATACTTT AGGTGAAGGA GCTTTTGGAA AAGTTGTGGA GTGCATCGAT 
CATAAAGCGG GAGGTAGACA TGTAGCAGTA AAAATAGTTA AAAATGTGGA TAGATACTGT 
GAAGCTGCTC GCTCAGAAAT ACAAGTTCTG GAACATCTGA ATACAACAGA CCCCAACAGT 
ACTTTCCGCT GTGTCCAGAT GTTGGAATGG TTTGAGCATC ATGGTCACAT TTGCATTGTT 
TTTGAACTAT TGGGACTTAG TACTTACGAC TTCATTAAAG AAAATGGTTT TCTACCATTT 
CGACTGGATC ATATCAGAAA GATGGCATAT CAGATATGCA AGTCTGTGAA TTTTTTGCAC 
AGTAATAAGT TGACTCACAC AGACTTAAAG CCTGAAAACA TCTTATTTGT GCAGTCTGAC 
TACACAGAGG CGTATAATCC CAAAATAAAA CGTGATGAAC GCACCTTAAT AAATCCAGAT 
ATTAAAGTTG TAGACTTTGG TAGTGCAACA TATGATGACG AACATCACAG TACATTGGTA 
TCTACAAGAC ATTATAGAGC ACCTGAAGTT ATTTTAGCCC TAGGGTGGTC CCAACCATGT 
GATGTCTGGA GCATAGGATG CATTCTTATT GAATACTATC TTGGGTTTAC CGTATTTCCA 
ACACACGATA GTAAGGAGCA TTTAGCAATG ATGGAAAGGA TTCTTGGACC TCTACCAAAA 
CATATGATAC AGAAAACCAG GAAACGTAAA TATTTTCACC ACGATCGATT AGACTGGGAT 
GAACACAGTT CTGCCGGCAG ATATGTTTCA AGACGCTGTA AACCTCTGAA GGAATTTATG 
CTTTCTCAAG ATGTTGAACA TGAGCGTCTC TTTGACCTCA TTCAGAAAAT GTTGGAGTAT 
GATCCAGCCA AAAGAATTAC TCTCAGAGAA GCCTTAAAGC ATCCTTTCTT TGACCTTCTG 
AAGAAAAGTA TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLK1 ( NM_001162407.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001155879.1 Homo sapiens CDC like kinase 1 (CLK1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31947
Clone ID Related Accession (Same CDS sequence)	NM_001162407.1
Accession Version	NM_001162407.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	dual specificity protein kinase CLK1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK294295.1 and AI251890.1. Transcript Variant: This variant (2) uses an alternate splice site and upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294295.1, SRR1803613.64749.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTG GGCGGAGGCC GGCTTCGGCC CTGTGGCCGG AAAGGCGAGG CTCCCCGTTG 
AGGGGGGATT TGCTGGGGTT CCAGAATGTG CGTGAGCCAA GCAGCTGTGG GGAAACGTTG 
TCTGGAATGA GACACTCAAA GAGAACTTAC TGTCCTGATT GGGATGACAA GGATTGGGAT 
TATGGAAAAT GGAGGAGCAG CAGCAGTCAT AAAAGAAGGA AGAGATCACA TAGCAGTGCC 
CAGGAGAACA AGCGCTGCAA ATACAATCAC TCTAAAATGT GTGATAGCCA TTATTTGGAA 
AGCAGGTCTA TAAATGAGAA AGATTATCAT AGTCGACGCT ACATTGATGA GTACAGAAAT 
GACTACACTC AAGGATGTGA ACCTGGACAT CGCCAAAGAG ACCATGAAAG CCGGTATCAG 
AACCATAGTA GCAAGTCTTC TGGTAGAAGT GGAAGAAGTA GTTATAAAAG CAAACACAGG 
ATTCACCACA GTACTTCACA TCGTCGTTCA CATGGGAAGA GTCACCGAAG GAAAAGAACC 
AGGAGTGTAG AGGATGATGA GGAGGGTCAC CTGATCTGTC AGAGTGGAGA CGTACTAAGT 
GCAAGATATG AAATTGTTGA TACTTTAGGT GAAGGAGCTT TTGGAAAAGT TGTGGAGTGC 
ATCGATCATA AAGCGGGAGG TAGACATGTA GCAGTAAAAA TAGTTAAAAA TGTGGATAGA 
TACTGTGAAG CTGCTCGCTC AGAAATACAA GTTCTGGAAC ATCTGAATAC AACAGACCCC 
AACAGTACTT TCCGCTGTGT CCAGATGTTG GAATGGTTTG AGCATCATGG TCACATTTGC 
ATTGTTTTTG AACTATTGGG ACTTAGTACT TACGACTTCA TTAAAGAAAA TGGTTTTCTA 
CCATTTCGAC TGGATCATAT CAGAAAGATG GCATATCAGA TATGCAAGTC TGTGAATTTT 
TTGCACAGTA ATAAGTTGAC TCACACAGAC TTAAAGCCTG AAAACATCTT ATTTGTGCAG 
TCTGACTACA CAGAGGCGTA TAATCCCAAA ATAAAACGTG ATGAACGCAC CTTAATAAAT 
CCAGATATTA AAGTTGTAGA CTTTGGTAGT GCAACATATG ATGACGAACA TCACAGTACA 
TTGGTATCTA CAAGACATTA TAGAGCACCT GAAGTTATTT TAGCCCTAGG GTGGTCCCAA 
CCATGTGATG TCTGGAGCAT AGGATGCATT CTTATTGAAT ACTATCTTGG GTTTACCGTA 
TTTCCAACAC ACGATAGTAA GGAGCATTTA GCAATGATGG AAAGGATTCT TGGACCTCTA 
CCAAAACATA TGATACAGAA AACCAGGAAA CGTAAATATT TTCACCACGA TCGATTAGAC 
TGGGATGAAC ACAGTTCTGC CGGCAGATAT GTTTCAAGAC GCTGTAAACC TCTGAAGGAA 
TTTATGCTTT CTCAAGATGT TGAACATGAG CGTCTCTTTG ACCTCATTCA GAAAATGTTG 
GAGTATGATC CAGCCAAAAG AATTACTCTC AGAGAAGCCT TAAAGCATCC TTTCTTTGAC 
CTTCTGAAGA AAAGTATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155879.1
CDS	336..1916
Translation	MAAGRRPASALWPERRGSPLRGDLLGFQNVREPSSCGETLSGMRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI

Target ORF information:

RefSeq Version	NM_001162407.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CDC like kinase 1 (CLK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001162407.1

ORF Insert Sequence:

ATGGCGGCTG GGCGGAGGCC GGCTTCGGCC CTGTGGCCGG AAAGGCGAGG CTCCCCGTTG 
AGGGGGGATT TGCTGGGGTT CCAGAATGTG CGTGAGCCAA GCAGCTGTGG GGAAACGTTG 
TCTGGAATGA GACACTCAAA GAGAACTTAC TGTCCTGATT GGGATGACAA GGATTGGGAT 
TATGGAAAAT GGAGGAGCAG CAGCAGTCAT AAAAGAAGGA AGAGATCACA TAGCAGTGCC 
CAGGAGAACA AGCGCTGCAA ATACAATCAC TCTAAAATGT GTGATAGCCA TTATTTGGAA 
AGCAGGTCTA TAAATGAGAA AGATTATCAT AGTCGACGCT ACATTGATGA GTACAGAAAT 
GACTACACTC AAGGATGTGA ACCTGGACAT CGCCAAAGAG ACCATGAAAG CCGGTATCAG 
AACCATAGTA GCAAGTCTTC TGGTAGAAGT GGAAGAAGTA GTTATAAAAG CAAACACAGG 
ATTCACCACA GTACTTCACA TCGTCGTTCA CATGGGAAGA GTCACCGAAG GAAAAGAACC 
AGGAGTGTAG AGGATGATGA GGAGGGTCAC CTGATCTGTC AGAGTGGAGA CGTACTAAGT 
GCAAGATATG AAATTGTTGA TACTTTAGGT GAAGGAGCTT TTGGAAAAGT TGTGGAGTGC 
ATCGATCATA AAGCGGGAGG TAGACATGTA GCAGTAAAAA TAGTTAAAAA TGTGGATAGA 
TACTGTGAAG CTGCTCGCTC AGAAATACAA GTTCTGGAAC ATCTGAATAC AACAGACCCC 
AACAGTACTT TCCGCTGTGT CCAGATGTTG GAATGGTTTG AGCATCATGG TCACATTTGC 
ATTGTTTTTG AACTATTGGG ACTTAGTACT TACGACTTCA TTAAAGAAAA TGGTTTTCTA 
CCATTTCGAC TGGATCATAT CAGAAAGATG GCATATCAGA TATGCAAGTC TGTGAATTTT 
TTGCACAGTA ATAAGTTGAC TCACACAGAC TTAAAGCCTG AAAACATCTT ATTTGTGCAG 
TCTGACTACA CAGAGGCGTA TAATCCCAAA ATAAAACGTG ATGAACGCAC CTTAATAAAT 
CCAGATATTA AAGTTGTAGA CTTTGGTAGT GCAACATATG ATGACGAACA TCACAGTACA 
TTGGTATCTA CAAGACATTA TAGAGCACCT GAAGTTATTT TAGCCCTAGG GTGGTCCCAA 
CCATGTGATG TCTGGAGCAT AGGATGCATT CTTATTGAAT ACTATCTTGG GTTTACCGTA 
TTTCCAACAC ACGATAGTAA GGAGCATTTA GCAATGATGG AAAGGATTCT TGGACCTCTA 
CCAAAACATA TGATACAGAA AACCAGGAAA CGTAAATATT TTCACCACGA TCGATTAGAC 
TGGGATGAAC ACAGTTCTGC CGGCAGATAT GTTTCAAGAC GCTGTAAACC TCTGAAGGAA 
TTTATGCTTT CTCAAGATGT TGAACATGAG CGTCTCTTTG ACCTCATTCA GAAAATGTTG 
GAGTATGATC CAGCCAAAAG AATTACTCTC AGAGAAGCCT TAAAGCATCC TTTCTTTGAC 
CTTCTGAAGA AAAGTATATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mobilization of A Splicing Factor Through A Nuclear Kinase-Kinase Complex.
The Biochemical journal(2018 Jan)
Aubol BE,Keshwani MM,Fattet L,Adams JA

Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
Journal of neurochemistry142(4)574-588(2017 Aug)
Zhang L,Yang H,Zhang W,Liang Z,Huang Q,Xu G,Zhen X,Zheng LT

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Nature communications8(1)7(2017 02)
Funnell T,Tasaki S,Oloumi A,Araki S,Kong E,Yap D,Nakayama Y,Hughes CS,Cheng SG,Tozaki H,Iwatani M,Sasaki S,Ohashi T,Miyazaki T,Morishita N,Morishita D,Ogasawara-Shimizu M,Ohori M,Nakao S,Karashima M,Sano M,Murai A,Nomura T,Uchiyama N,Kawamoto T,Hara R,Nakanishi O,Shumansky K,Rosner J,Wan A,McKinney S,Morin GB,Nakanishi A,Shah S,Toyoshiba H,Aparicio S

Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing.
Molecular cell63(2)218-228(2016 Jul)
Aubol BE,Wu G,Keshwani MM,Movassat M,Fattet L,Hertel KJ,Fu XD,Adams JA

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CLK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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