CLCN4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLCN4
Entrez Gene ID	1183
Full Name	chloride voltage-gated channel 4
Synonyms	CLC4,ClC-4,ClC-4A,MRX15,MRX49
General protein information	Preferred Names chloride voltage-gated channel 4 Names H(+)/Cl(-) exchange transporter 4 chloride channel 4 chloride channel protein 4 chloride channel, voltage-sensitive 4 chloride transporter ClC-4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.2
Summary	The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012].
Disorder MIM:	302910
Disorder Html:	Mental retardation, X-linked 49/15, 300114 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256944.1	NP_001243873.1	H(+)/Cl(-) exchange transporter 4 isoform 2
NM_001830.3	NP_001821.2	H(+)/Cl(-) exchange transporter 4 isoform 1
NM_001830.4	NP_001821.2	H(+)/Cl(-) exchange transporter 4 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CLCN4	NP_001026927.1
Gallus gallus (chicken)	CLCN4	XP_425575.4
Canis lupus familiaris (dog)	CLCN4	XP_848379.1
Rattus norvegicus (Norway rat)	Clcn4	NP_071534.2
Magnaporthe oryzae (rice blast fungus)	MGG_00468	XP_003718596.1
Xenopus tropicalis (tropical clawed frog)	clcn4	NP_001120070.1
Mus musculus (house mouse)	Clcn4-2	NP_035464.3
Danio rerio (zebrafish)	clcn4	NP_001070786.1
Homo sapiens (human)	CLCN4	NP_001821.2
Neurospora crassa	NCU06444	XP_957335.2

Gene Ontology
Bibliography

Related articles in PubMed

Preferential Association with ClC-3 Permits Sorting of ClC-4 into Endosomal Compartments.
Guzman RE, Bungert-Pl?mke S, Franzen A, Fahlke C
The Journal of biological chemistry(2017 Sep)

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Palmer EE, Stuhlmann T, Weinert S, Haan E, Van Esch H, Holvoet M, Boyle J, Leffler M, Raynaud M, Moraine C, van Bokhoven H, Kleefstra T, Kahrizi K, Najmabadi H, Ropers HH, Delgado MR, Sirsi D, Golla S, Sommer A, Pietryga MP, Chung WK, Wynn J, Rohena L, Bernardo E, Hamlin D, Faux BM, Grange DK, Manwaring L, Tolmie J, Joss S, , Cobben JM, Duijkers FA, Goehringer JM, Challman TD, Hennig F, Fischer U, Grimme A, Suckow V, Musante L, Nicholl J, Shaw M, Lodh SP, Niu Z, Rosenfeld JA, Stankiewicz P, Jentsch TJ, Gecz J, Field M, Kalscheuer VM
Molecular psychiatry(2016 Aug)

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu H, Haas SA, Chelly J, Van Esch H, Raynaud M, de Brouwer AP, Weinert S, Froyen G, Frints SG, Laumonnier F, Zemojtel T, Love MI, Richard H, Emde AK, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Dorseuil O, Billuart P, Stuhlmann T, Shaw M, Corbett MA, Gardner A, Willis-Owen S, Tan C, Friend KL, Belet S, van Roozendaal KE, Jimenez-Pocquet M, Moizard MP, Ronce N, Sun R, O'Keeffe S, Chenna R, van B?mmel A, G?ke J, Hackett A, Field M, Christie L, Boyle J, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, M?ller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Biele?ska A, Ousager LB, Wieacker P, Rodr?guez Criado G, Bondeson ML, Anner?n G, Dufke A, Cohen M, Van Maldergem L, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns JP, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker TF, Tzschach A, van Bokhoven H, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer VM
Molecular psychiatry21(1)133-48(2016 Jan)

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.
Veeramah KR, Johnstone L, Karafet TM, Wolf D, Sprissler R, Salogiannis J, Barth-Maron A, Greenberg ME, Stuhlmann T, Weinert S, Jentsch TJ, Pazzi M, Restifo LL, Talwar D, Erickson RP, Hammer MF
Epilepsia54(7)1270-81(2013 Jul)

Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions.
Orhan G, Fahlke C, Alekov AK
Biophysical journal100(5)1233-41(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans.
Title: Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

the voltage dependence of uncoupled ClC-4 by protons and anions
Title: Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions.

CLCN4 is a novel driver of colon cancer progression.
Title: Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases.

The proposed mechanism results in anion-dependent conversion of ClC-type exchanger into an anion channel with typical attributes of ClC anion channels.
Title: Channel-like slippage modes in the human anion/proton exchanger ClC-4.

Studies showed that three novel CLC-5 mutations were identified, and mutations in OCRL1, CLC-4 and cofilin excluded in causing Dent's disease.
Title: Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease.

The following CLCN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLCN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07636	NM_001256944.1 Latest version!	Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu19335	NM_001830.4 Latest version!	Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu19335	NM_001830.3	Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLCN4 ( NM_001256944.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243873.1 Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07636
Clone ID Related Accession (Same CDS sequence)	NM_001256944.1
Accession Version	NM_001256944.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-04
Organism	Homo sapiens(human)
Product	H(+)/Cl(-) exchange transporter 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP310547.1, AK299611.1 and AC003666.1. Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1660803.209060.1, SRR1660807.238279.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMN03465407 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGGACC TGAAGGAGGG GGTCTGCCTG TCTGCCTTCT GGTATAGCCA TGAGCAGTGT 
TGCTGGACTT CTAACGAGAC CACTTTTGAG GACAGAGACA AGTGTCCCCT GTGGCAGAAA 
TGGTCGGAGC TGCTGGTGAA TCAGTCAGAG GGTGCCAGTG CTTACATTCT GAATTACTTA 
ATGTACATCC TATGGGCGCT GCTGTTTGCA TTTTTGGCTG TCTCCCTGGT GCGTGTATTT 
GCACCATATG CCTGTGGCTC TGGCATACCA GAGATAAAGA CCATTTTGAG CGGCTTTATC 
ATCAGGGGCT ACTTGGGGAA GTGGACCCTG CTAATCAAGA CAGTCACGCT GGTGCTGGTA 
GTGTCCTCCG GTCTGAGCCT TGGGAAGGAA GGGCCGCTAG TGCACGTGGC TTGTTGCTGT 
GGCAACTTCT TCAGCAGCCT TTTCTCCAAG TACAGCAAGA ATGAGGGCAA GAGGCGGGAG 
GTGCTTTCAG CTGCAGCGGC TGCTGGAGTC TCTGTTGCCT TTGGTGCACC AATTGGAGGC 
GTGCTTTTCA GTCTAGAAGA GGTCAGTTAC TACTTTCCCC TGAAGACCTT GTGGAGGTCA 
TTTTTCGCAG CCCTGGTGGC GGCCTTTACG CTGAGATCCA TCAATCCCTT TGGGAATAGC 
CGTCTCGTTC TCTTTTATGT GGAATACCAC ACGCCCTGGT ACATGGCTGA ACTCTTCCCC 
TTCATCCTGC TTGGGGTCTT CGGGGGCTTG TGGGGAACCC TCTTCATCCG CTGCAACATC 
GCCTGGTGCA GGAGGCGCAA GACCACCAGG CTGGGGAAGT ACCCGGTGCT GGAGGTCATT 
GTGGTGACTG CCATCACTGC CATCATTGCC TACCCCAATC CCTACACACG CCAGAGCACC 
AGCGAGCTCA TTTCTGAGCT GTTCAATGAC TGTGGAGCCC TTGAGTCTTC CCAGCTCTGT 
GACTACATCA ATGACCCCAA CATGACTCGG CCTGTGGATG ACATTCCAGA CCGGCCGGCT 
GGTGTCGGTG TTTACACGGC CATGTGGCAG CTGGCCCTGG CACTGATCTT CAAAATCGTC 
GTTACCATAT TTACCTTTGG CATGAAGATC CCGTCGGGCC TCTTCATCCC CAGCATGGCT 
GTGGGCGCGA TAGCGGGCAG GATGGTGGGA ATTGGCGTGG AGCAGCTGGC CTACCATCAC 
CATGACTGGA TCATCTTCAG GAACTGGTGC AGACCCGGTG CAGACTGTGT CACGCCAGGG 
CTGTACGCAA TGGTGGGAGC TGCGGCCTGC CTCGGTGGAG TTACCAGGAT GACGGTGTCA 
TTGGTGGTCA TCATGTTTGA ATTAACCGGG GGTCTGGAGT ACATCGTGCC CCTGATGGCG 
GCGGCTGTGA CCAGCAAGTG GGTAGCTGAT GCATTTGGGA AAGAAGGCAT CTACGAGGCC 
CACATCCACT TAAATGGGTA CCCTTTCCTT GACGTGAAGG ACGAGTTTAC TCACCGCACA 
CTGGCCACCG ACGTCATGCG GCCCCGGCGG GGAGAGCCGC CACTGTCGGT GCTCACCCAG 
GACAGCATGA CTGTCGAGGA CGTGGAGACG CTCATCAAGG AGACCGACTA CAACGGCTTC 
CCCGTGGTGG TCTCCAGAGA CTCCGAGCGC CTCATTGGAT TTGCCCAGAG GAGGGAACTG 
ATTCTCGCAA TAAAGAACGC CAGACAGAGG CAGGAGGGCA TTGTGAGCAA TTCCATCATG 
TACTTCACGG AGGAACCCCC CGAGCTGCCG GCCAACAGCC CACATCCCCT GAAGCTGCGG 
CGCATCCTGA ACCTCAGCCC GTTTACAGTG ACAGACCACA CTCCGATGGA AACGGTGGTG 
GATATCTTCC GGAAACTGGG GCTTCGGCAG TGCCTGGTGA CGCGGAGCGG GAGACTTCTT 
GGCATCATCA CAAAAAAGGA TGTTCTGAGA CATATGGCCC AGATGGCAAA CCAGGACCCC 
GAATCCATCA TGTTTAATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243873.1
CDS	458..2458
Translation	MTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN

Target ORF information:

RefSeq Version	NM_001256944.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256944.1

ORF Insert Sequence:

ATGACGGACC TGAAGGAGGG GGTCTGCCTG TCTGCCTTCT GGTATAGCCA TGAGCAGTGT 
TGCTGGACTT CTAACGAGAC CACTTTTGAG GACAGAGACA AGTGTCCCCT GTGGCAGAAA 
TGGTCGGAGC TGCTGGTGAA TCAGTCAGAG GGTGCCAGTG CTTACATTCT GAATTACTTA 
ATGTACATCC TATGGGCGCT GCTGTTTGCA TTTTTGGCTG TCTCCCTGGT GCGTGTATTT 
GCACCATATG CCTGTGGCTC TGGCATACCA GAGATAAAGA CCATTTTGAG CGGCTTTATC 
ATCAGGGGCT ACTTGGGGAA GTGGACCCTG CTAATCAAGA CAGTCACGCT GGTGCTGGTA 
GTGTCCTCCG GTCTGAGCCT TGGGAAGGAA GGGCCGCTAG TGCACGTGGC TTGTTGCTGT 
GGCAACTTCT TCAGCAGCCT TTTCTCCAAG TACAGCAAGA ATGAGGGCAA GAGGCGGGAG 
GTGCTTTCAG CTGCAGCGGC TGCTGGAGTC TCTGTTGCCT TTGGTGCACC AATTGGAGGC 
GTGCTTTTCA GTCTAGAAGA GGTCAGTTAC TACTTTCCCC TGAAGACCTT GTGGAGGTCA 
TTTTTCGCAG CCCTGGTGGC GGCCTTTACG CTGAGATCCA TCAATCCCTT TGGGAATAGC 
CGTCTCGTTC TCTTTTATGT GGAATACCAC ACGCCCTGGT ACATGGCTGA ACTCTTCCCC 
TTCATCCTGC TTGGGGTCTT CGGGGGCTTG TGGGGAACCC TCTTCATCCG CTGCAACATC 
GCCTGGTGCA GGAGGCGCAA GACCACCAGG CTGGGGAAGT ACCCGGTGCT GGAGGTCATT 
GTGGTGACTG CCATCACTGC CATCATTGCC TACCCCAATC CCTACACACG CCAGAGCACC 
AGCGAGCTCA TTTCTGAGCT GTTCAATGAC TGTGGAGCCC TTGAGTCTTC CCAGCTCTGT 
GACTACATCA ATGACCCCAA CATGACTCGG CCTGTGGATG ACATTCCAGA CCGGCCGGCT 
GGTGTCGGTG TTTACACGGC CATGTGGCAG CTGGCCCTGG CACTGATCTT CAAAATCGTC 
GTTACCATAT TTACCTTTGG CATGAAGATC CCGTCGGGCC TCTTCATCCC CAGCATGGCT 
GTGGGCGCGA TAGCGGGCAG GATGGTGGGA ATTGGCGTGG AGCAGCTGGC CTACCATCAC 
CATGACTGGA TCATCTTCAG GAACTGGTGC AGACCCGGTG CAGACTGTGT CACGCCAGGG 
CTGTACGCAA TGGTGGGAGC TGCGGCCTGC CTCGGTGGAG TTACCAGGAT GACGGTGTCA 
TTGGTGGTCA TCATGTTTGA ATTAACCGGG GGTCTGGAGT ACATCGTGCC CCTGATGGCG 
GCGGCTGTGA CCAGCAAGTG GGTAGCTGAT GCATTTGGGA AAGAAGGCAT CTACGAGGCC 
CACATCCACT TAAATGGGTA CCCTTTCCTT GACGTGAAGG ACGAGTTTAC TCACCGCACA 
CTGGCCACCG ACGTCATGCG GCCCCGGCGG GGAGAGCCGC CACTGTCGGT GCTCACCCAG 
GACAGCATGA CTGTCGAGGA CGTGGAGACG CTCATCAAGG AGACCGACTA CAACGGCTTC 
CCCGTGGTGG TCTCCAGAGA CTCCGAGCGC CTCATTGGAT TTGCCCAGAG GAGGGAACTG 
ATTCTCGCAA TAAAGAACGC CAGACAGAGG CAGGAGGGCA TTGTGAGCAA TTCCATCATG 
TACTTCACGG AGGAACCCCC CGAGCTGCCG GCCAACAGCC CACATCCCCT GAAGCTGCGG 
CGCATCCTGA ACCTCAGCCC GTTTACAGTG ACAGACCACA CTCCGATGGA AACGGTGGTG 
GATATCTTCC GGAAACTGGG GCTTCGGCAG TGCCTGGTGA CGCGGAGCGG GAGACTTCTT 
GGCATCATCA CAAAAAAGGA TGTTCTGAGA CATATGGCCC AGATGGCAAA CCAGGACCCC 
GAATCCATCA TGTTTAATTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLCN4 ( NM_001830.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001821.2 Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19335
Clone ID Related Accession (Same CDS sequence)	NM_001830.3 , NM_001830.4
Accession Version	NM_001830.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	H(+)/Cl(-) exchange transporter 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP310547.1, AB019432.1 and AC003666.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_005274443.1, NM_001830.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.127665.1, SRR1803617.93164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTCAATG CGGGAGCGAT GAGTGGCTCT GGAAACCTGA TGGATTTCCT CGATGAGCCG 
TTCCCTGATG TGGGGACGTA TGAGGACTTC CACACCATCG ACTGGCTAAG GGAAAAGTCA 
CGGGACACCG ACAGACACAG GAAGATCACC AGCAAGAGCA AGGAGTCCAT ATGGGAGTTC 
ATCAAGAGCC TGCTGGATGC CTGGTCGGGA TGGGTGGTGA TGCTGCTCAT CGGCCTGCTG 
GCGGGCACCT TGGCTGGGGT CATCGATCTC GCCGTGGACT GGATGACGGA CCTGAAGGAG 
GGGGTCTGCC TGTCTGCCTT CTGGTATAGC CATGAGCAGT GTTGCTGGAC TTCTAACGAG 
ACCACTTTTG AGGACAGAGA CAAGTGTCCC CTGTGGCAGA AATGGTCGGA GCTGCTGGTG 
AATCAGTCAG AGGGTGCCAG TGCTTACATT CTGAATTACT TAATGTACAT CCTATGGGCG 
CTGCTGTTTG CATTTTTGGC TGTCTCCCTG GTGCGTGTAT TTGCACCATA TGCCTGTGGC 
TCTGGCATAC CAGAGATAAA GACCATTTTG AGCGGCTTTA TCATCAGGGG CTACTTGGGG 
AAGTGGACCC TGCTAATCAA GACAGTCACG CTGGTGCTGG TAGTGTCCTC CGGTCTGAGC 
CTTGGGAAGG AAGGGCCGCT AGTGCACGTG GCTTGTTGCT GTGGCAACTT CTTCAGCAGC 
CTTTTCTCCA AGTACAGCAA GAATGAGGGC AAGAGGCGGG AGGTGCTTTC AGCTGCAGCG 
GCTGCTGGAG TCTCTGTTGC CTTTGGTGCA CCAATTGGAG GCGTGCTTTT CAGTCTAGAA 
GAGGTCAGTT ACTACTTTCC CCTGAAGACC TTGTGGAGGT CATTTTTCGC AGCCCTGGTG 
GCGGCCTTTA CGCTGAGATC CATCAATCCC TTTGGGAATA GCCGTCTCGT TCTCTTTTAT 
GTGGAATACC ACACGCCCTG GTACATGGCT GAACTCTTCC CCTTCATCCT GCTTGGGGTC 
TTCGGGGGCT TGTGGGGAAC CCTCTTCATC CGCTGCAACA TCGCCTGGTG CAGGAGGCGC 
AAGACCACCA GGCTGGGGAA GTACCCGGTG CTGGAGGTCA TTGTGGTGAC TGCCATCACT 
GCCATCATTG CCTACCCCAA TCCCTACACA CGCCAGAGCA CCAGCGAGCT CATTTCTGAG 
CTGTTCAATG ACTGTGGAGC CCTTGAGTCT TCCCAGCTCT GTGACTACAT CAATGACCCC 
AACATGACTC GGCCTGTGGA TGACATTCCA GACCGGCCGG CTGGTGTCGG TGTTTACACG 
GCCATGTGGC AGCTGGCCCT GGCACTGATC TTCAAAATCG TCGTTACCAT ATTTACCTTT 
GGCATGAAGA TCCCGTCGGG CCTCTTCATC CCCAGCATGG CTGTGGGCGC GATAGCGGGC 
AGGATGGTGG GAATTGGCGT GGAGCAGCTG GCCTACCATC ACCATGACTG GATCATCTTC 
AGGAACTGGT GCAGACCCGG TGCAGACTGT GTCACGCCAG GGCTGTACGC AATGGTGGGA 
GCTGCGGCCT GCCTCGGTGG AGTTACCAGG ATGACGGTGT CATTGGTGGT CATCATGTTT 
GAATTAACCG GGGGTCTGGA GTACATCGTG CCCCTGATGG CGGCGGCTGT GACCAGCAAG 
TGGGTAGCTG ATGCATTTGG GAAAGAAGGC ATCTACGAGG CCCACATCCA CTTAAATGGG 
TACCCTTTCC TTGACGTGAA GGACGAGTTT ACTCACCGCA CACTGGCCAC CGACGTCATG 
CGGCCCCGGC GGGGAGAGCC GCCACTGTCG GTGCTCACCC AGGACAGCAT GACTGTCGAG 
GACGTGGAGA CGCTCATCAA GGAGACCGAC TACAACGGCT TCCCCGTGGT GGTCTCCAGA 
GACTCCGAGC GCCTCATTGG ATTTGCCCAG AGGAGGGAAC TGATTCTCGC AATAAAGAAC 
GCCAGACAGA GGCAGGAGGG CATTGTGAGC AATTCCATCA TGTACTTCAC GGAGGAACCC 
CCCGAGCTGC CGGCCAACAG CCCACATCCC CTGAAGCTGC GGCGCATCCT GAACCTCAGC 
CCGTTTACAG TGACAGACCA CACTCCGATG GAAACGGTGG TGGATATCTT CCGGAAACTG 
GGGCTTCGGC AGTGCCTGGT GACGCGGAGC GGGAGACTTC TTGGCATCAT CACAAAAAAG 
GATGTTCTGA GACATATGGC CCAGATGGCA AACCAGGACC CCGAATCCAT CATGTTTAAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001821.2
CDS	431..2713
Translation	MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN

Target ORF information:

RefSeq Version	NM_001830.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001830.3

ORF Insert Sequence:

ATGGTCAATG CGGGAGCGAT GAGTGGCTCT GGAAACCTGA TGGATTTCCT CGATGAGCCG 
TTCCCTGATG TGGGGACGTA TGAGGACTTC CACACCATCG ACTGGCTAAG GGAAAAGTCA 
CGGGACACCG ACAGACACAG GAAGATCACC AGCAAGAGCA AGGAGTCCAT ATGGGAGTTC 
ATCAAGAGCC TGCTGGATGC CTGGTCGGGA TGGGTGGTGA TGCTGCTCAT CGGCCTGCTG 
GCGGGCACCT TGGCTGGGGT CATCGATCTC GCCGTGGACT GGATGACGGA CCTGAAGGAG 
GGGGTCTGCC TGTCTGCCTT CTGGTATAGC CATGAGCAGT GTTGCTGGAC TTCTAACGAG 
ACCACTTTTG AGGACAGAGA CAAGTGTCCC CTGTGGCAGA AATGGTCGGA GCTGCTGGTG 
AATCAGTCAG AGGGTGCCAG TGCTTACATT CTGAATTACT TAATGTACAT CCTATGGGCG 
CTGCTGTTTG CATTTTTGGC TGTCTCCCTG GTGCGTGTAT TTGCACCATA TGCCTGTGGC 
TCTGGCATAC CAGAGATAAA GACCATTTTG AGCGGCTTTA TCATCAGGGG CTACTTGGGG 
AAGTGGACCC TGCTAATCAA GACAGTCACG CTGGTGCTGG TAGTGTCCTC CGGTCTGAGC 
CTTGGGAAGG AAGGGCCGCT AGTGCACGTG GCTTGTTGCT GTGGCAACTT CTTCAGCAGC 
CTTTTCTCCA AGTACAGCAA GAATGAGGGC AAGAGGCGGG AGGTGCTTTC AGCTGCAGCG 
GCTGCTGGAG TCTCTGTTGC CTTTGGTGCA CCAATTGGAG GCGTGCTTTT CAGTCTAGAA 
GAGGTCAGTT ACTACTTTCC CCTGAAGACC TTGTGGAGGT CATTTTTCGC AGCCCTGGTG 
GCGGCCTTTA CGCTGAGATC CATCAATCCC TTTGGGAATA GCCGTCTCGT TCTCTTTTAT 
GTGGAATACC ACACGCCCTG GTACATGGCT GAACTCTTCC CCTTCATCCT GCTTGGGGTC 
TTCGGGGGCT TGTGGGGAAC CCTCTTCATC CGCTGCAACA TCGCCTGGTG CAGGAGGCGC 
AAGACCACCA GGCTGGGGAA GTACCCGGTG CTGGAGGTCA TTGTGGTGAC TGCCATCACT 
GCCATCATTG CCTACCCCAA TCCCTACACA CGCCAGAGCA CCAGCGAGCT CATTTCTGAG 
CTGTTCAATG ACTGTGGAGC CCTTGAGTCT TCCCAGCTCT GTGACTACAT CAATGACCCC 
AACATGACTC GGCCTGTGGA TGACATTCCA GACCGGCCGG CTGGTGTCGG TGTTTACACG 
GCCATGTGGC AGCTGGCCCT GGCACTGATC TTCAAAATCG TCGTTACCAT ATTTACCTTT 
GGCATGAAGA TCCCGTCGGG CCTCTTCATC CCCAGCATGG CTGTGGGCGC GATAGCGGGC 
AGGATGGTGG GAATTGGCGT GGAGCAGCTG GCCTACCATC ACCATGACTG GATCATCTTC 
AGGAACTGGT GCAGACCCGG TGCAGACTGT GTCACGCCAG GGCTGTACGC AATGGTGGGA 
GCTGCGGCCT GCCTCGGTGG AGTTACCAGG ATGACGGTGT CATTGGTGGT CATCATGTTT 
GAATTAACCG GGGGTCTGGA GTACATCGTG CCCCTGATGG CGGCGGCTGT GACCAGCAAG 
TGGGTAGCTG ATGCATTTGG GAAAGAAGGC ATCTACGAGG CCCACATCCA CTTAAATGGG 
TACCCTTTCC TTGACGTGAA GGACGAGTTT ACTCACCGCA CACTGGCCAC CGACGTCATG 
CGGCCCCGGC GGGGAGAGCC GCCACTGTCG GTGCTCACCC AGGACAGCAT GACTGTCGAG 
GACGTGGAGA CGCTCATCAA GGAGACCGAC TACAACGGCT TCCCCGTGGT GGTCTCCAGA 
GACTCCGAGC GCCTCATTGG ATTTGCCCAG AGGAGGGAAC TGATTCTCGC AATAAAGAAC 
GCCAGACAGA GGCAGGAGGG CATTGTGAGC AATTCCATCA TGTACTTCAC GGAGGAACCC 
CCCGAGCTGC CGGCCAACAG CCCACATCCC CTGAAGCTGC GGCGCATCCT GAACCTCAGC 
CCGTTTACAG TGACAGACCA CACTCCGATG GAAACGGTGG TGGATATCTT CCGGAAACTG 
GGGCTTCGGC AGTGCCTGGT GACGCGGAGC GGGAGACTTC TTGGCATCAT CACAAAAAAG 
GATGTTCTGA GACATATGGC CCAGATGGCA AACCAGGACC CCGAATCCAT CATGTTTAAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLCN4 ( NM_001830.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001821.2 Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 1, mRNA.

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CloneID	OHu19335
Clone ID Related Accession (Same CDS sequence)	NM_001830.3 , NM_001830.4
Accession Version	NM_001830.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	H(+)/Cl(-) exchange transporter 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP310547.1, AB019432.1 and AC003666.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001830.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.127665.1, SRR1803617.93164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380833.9/ ENSP00000370213.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTCAATG CGGGAGCGAT GAGTGGCTCT GGAAACCTGA TGGATTTCCT CGATGAGCCG 
TTCCCTGATG TGGGGACGTA TGAGGACTTC CACACCATCG ACTGGCTAAG GGAAAAGTCA 
CGGGACACCG ACAGACACAG GAAGATCACC AGCAAGAGCA AGGAGTCCAT ATGGGAGTTC 
ATCAAGAGCC TGCTGGATGC CTGGTCGGGA TGGGTGGTGA TGCTGCTCAT CGGCCTGCTG 
GCGGGCACCT TGGCTGGGGT CATCGATCTC GCCGTGGACT GGATGACGGA CCTGAAGGAG 
GGGGTCTGCC TGTCTGCCTT CTGGTATAGC CATGAGCAGT GTTGCTGGAC TTCTAACGAG 
ACCACTTTTG AGGACAGAGA CAAGTGTCCC CTGTGGCAGA AATGGTCGGA GCTGCTGGTG 
AATCAGTCAG AGGGTGCCAG TGCTTACATT CTGAATTACT TAATGTACAT CCTATGGGCG 
CTGCTGTTTG CATTTTTGGC TGTCTCCCTG GTGCGTGTAT TTGCACCATA TGCCTGTGGC 
TCTGGCATAC CAGAGATAAA GACCATTTTG AGCGGCTTTA TCATCAGGGG CTACTTGGGG 
AAGTGGACCC TGCTAATCAA GACAGTCACG CTGGTGCTGG TAGTGTCCTC CGGTCTGAGC 
CTTGGGAAGG AAGGGCCGCT AGTGCACGTG GCTTGTTGCT GTGGCAACTT CTTCAGCAGC 
CTTTTCTCCA AGTACAGCAA GAATGAGGGC AAGAGGCGGG AGGTGCTTTC AGCTGCAGCG 
GCTGCTGGAG TCTCTGTTGC CTTTGGTGCA CCAATTGGAG GCGTGCTTTT CAGTCTAGAA 
GAGGTCAGTT ACTACTTTCC CCTGAAGACC TTGTGGAGGT CATTTTTCGC AGCCCTGGTG 
GCGGCCTTTA CGCTGAGATC CATCAATCCC TTTGGGAATA GCCGTCTCGT TCTCTTTTAT 
GTGGAATACC ACACGCCCTG GTACATGGCT GAACTCTTCC CCTTCATCCT GCTTGGGGTC 
TTCGGGGGCT TGTGGGGAAC CCTCTTCATC CGCTGCAACA TCGCCTGGTG CAGGAGGCGC 
AAGACCACCA GGCTGGGGAA GTACCCGGTG CTGGAGGTCA TTGTGGTGAC TGCCATCACT 
GCCATCATTG CCTACCCCAA TCCCTACACA CGCCAGAGCA CCAGCGAGCT CATTTCTGAG 
CTGTTCAATG ACTGTGGAGC CCTTGAGTCT TCCCAGCTCT GTGACTACAT CAATGACCCC 
AACATGACTC GGCCTGTGGA TGACATTCCA GACCGGCCGG CTGGTGTCGG TGTTTACACG 
GCCATGTGGC AGCTGGCCCT GGCACTGATC TTCAAAATCG TCGTTACCAT ATTTACCTTT 
GGCATGAAGA TCCCGTCGGG CCTCTTCATC CCCAGCATGG CTGTGGGCGC GATAGCGGGC 
AGGATGGTGG GAATTGGCGT GGAGCAGCTG GCCTACCATC ACCATGACTG GATCATCTTC 
AGGAACTGGT GCAGACCCGG TGCAGACTGT GTCACGCCAG GGCTGTACGC AATGGTGGGA 
GCTGCGGCCT GCCTCGGTGG AGTTACCAGG ATGACGGTGT CATTGGTGGT CATCATGTTT 
GAATTAACCG GGGGTCTGGA GTACATCGTG CCCCTGATGG CGGCGGCTGT GACCAGCAAG 
TGGGTAGCTG ATGCATTTGG GAAAGAAGGC ATCTACGAGG CCCACATCCA CTTAAATGGG 
TACCCTTTCC TTGACGTGAA GGACGAGTTT ACTCACCGCA CACTGGCCAC CGACGTCATG 
CGGCCCCGGC GGGGAGAGCC GCCACTGTCG GTGCTCACCC AGGACAGCAT GACTGTCGAG 
GACGTGGAGA CGCTCATCAA GGAGACCGAC TACAACGGCT TCCCCGTGGT GGTCTCCAGA 
GACTCCGAGC GCCTCATTGG ATTTGCCCAG AGGAGGGAAC TGATTCTCGC AATAAAGAAC 
GCCAGACAGA GGCAGGAGGG CATTGTGAGC AATTCCATCA TGTACTTCAC GGAGGAACCC 
CCCGAGCTGC CGGCCAACAG CCCACATCCC CTGAAGCTGC GGCGCATCCT GAACCTCAGC 
CCGTTTACAG TGACAGACCA CACTCCGATG GAAACGGTGG TGGATATCTT CCGGAAACTG 
GGGCTTCGGC AGTGCCTGGT GACGCGGAGC GGGAGACTTC TTGGCATCAT CACAAAAAAG 
GATGTTCTGA GACATATGGC CCAGATGGCA AACCAGGACC CCGAATCCAT CATGTTTAAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001821.2
CDS	401..2683
Translation	MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN

Target ORF information:

RefSeq Version	NM_001830.4
Organism	Homo sapiens(human)
Definition	Homo sapiens chloride voltage-gated channel 4 (CLCN4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001830.4

ORF Insert Sequence:

ATGGTCAATG CGGGAGCGAT GAGTGGCTCT GGAAACCTGA TGGATTTCCT CGATGAGCCG 
TTCCCTGATG TGGGGACGTA TGAGGACTTC CACACCATCG ACTGGCTAAG GGAAAAGTCA 
CGGGACACCG ACAGACACAG GAAGATCACC AGCAAGAGCA AGGAGTCCAT ATGGGAGTTC 
ATCAAGAGCC TGCTGGATGC CTGGTCGGGA TGGGTGGTGA TGCTGCTCAT CGGCCTGCTG 
GCGGGCACCT TGGCTGGGGT CATCGATCTC GCCGTGGACT GGATGACGGA CCTGAAGGAG 
GGGGTCTGCC TGTCTGCCTT CTGGTATAGC CATGAGCAGT GTTGCTGGAC TTCTAACGAG 
ACCACTTTTG AGGACAGAGA CAAGTGTCCC CTGTGGCAGA AATGGTCGGA GCTGCTGGTG 
AATCAGTCAG AGGGTGCCAG TGCTTACATT CTGAATTACT TAATGTACAT CCTATGGGCG 
CTGCTGTTTG CATTTTTGGC TGTCTCCCTG GTGCGTGTAT TTGCACCATA TGCCTGTGGC 
TCTGGCATAC CAGAGATAAA GACCATTTTG AGCGGCTTTA TCATCAGGGG CTACTTGGGG 
AAGTGGACCC TGCTAATCAA GACAGTCACG CTGGTGCTGG TAGTGTCCTC CGGTCTGAGC 
CTTGGGAAGG AAGGGCCGCT AGTGCACGTG GCTTGTTGCT GTGGCAACTT CTTCAGCAGC 
CTTTTCTCCA AGTACAGCAA GAATGAGGGC AAGAGGCGGG AGGTGCTTTC AGCTGCAGCG 
GCTGCTGGAG TCTCTGTTGC CTTTGGTGCA CCAATTGGAG GCGTGCTTTT CAGTCTAGAA 
GAGGTCAGTT ACTACTTTCC CCTGAAGACC TTGTGGAGGT CATTTTTCGC AGCCCTGGTG 
GCGGCCTTTA CGCTGAGATC CATCAATCCC TTTGGGAATA GCCGTCTCGT TCTCTTTTAT 
GTGGAATACC ACACGCCCTG GTACATGGCT GAACTCTTCC CCTTCATCCT GCTTGGGGTC 
TTCGGGGGCT TGTGGGGAAC CCTCTTCATC CGCTGCAACA TCGCCTGGTG CAGGAGGCGC 
AAGACCACCA GGCTGGGGAA GTACCCGGTG CTGGAGGTCA TTGTGGTGAC TGCCATCACT 
GCCATCATTG CCTACCCCAA TCCCTACACA CGCCAGAGCA CCAGCGAGCT CATTTCTGAG 
CTGTTCAATG ACTGTGGAGC CCTTGAGTCT TCCCAGCTCT GTGACTACAT CAATGACCCC 
AACATGACTC GGCCTGTGGA TGACATTCCA GACCGGCCGG CTGGTGTCGG TGTTTACACG 
GCCATGTGGC AGCTGGCCCT GGCACTGATC TTCAAAATCG TCGTTACCAT ATTTACCTTT 
GGCATGAAGA TCCCGTCGGG CCTCTTCATC CCCAGCATGG CTGTGGGCGC GATAGCGGGC 
AGGATGGTGG GAATTGGCGT GGAGCAGCTG GCCTACCATC ACCATGACTG GATCATCTTC 
AGGAACTGGT GCAGACCCGG TGCAGACTGT GTCACGCCAG GGCTGTACGC AATGGTGGGA 
GCTGCGGCCT GCCTCGGTGG AGTTACCAGG ATGACGGTGT CATTGGTGGT CATCATGTTT 
GAATTAACCG GGGGTCTGGA GTACATCGTG CCCCTGATGG CGGCGGCTGT GACCAGCAAG 
TGGGTAGCTG ATGCATTTGG GAAAGAAGGC ATCTACGAGG CCCACATCCA CTTAAATGGG 
TACCCTTTCC TTGACGTGAA GGACGAGTTT ACTCACCGCA CACTGGCCAC CGACGTCATG 
CGGCCCCGGC GGGGAGAGCC GCCACTGTCG GTGCTCACCC AGGACAGCAT GACTGTCGAG 
GACGTGGAGA CGCTCATCAA GGAGACCGAC TACAACGGCT TCCCCGTGGT GGTCTCCAGA 
GACTCCGAGC GCCTCATTGG ATTTGCCCAG AGGAGGGAAC TGATTCTCGC AATAAAGAAC 
GCCAGACAGA GGCAGGAGGG CATTGTGAGC AATTCCATCA TGTACTTCAC GGAGGAACCC 
CCCGAGCTGC CGGCCAACAG CCCACATCCC CTGAAGCTGC GGCGCATCCT GAACCTCAGC 
CCGTTTACAG TGACAGACCA CACTCCGATG GAAACGGTGG TGGATATCTT CCGGAAACTG 
GGGCTTCGGC AGTGCCTGGT GACGCGGAGC GGGAGACTTC TTGGCATCAT CACAAAAAAG 
GATGTTCTGA GACATATGGC CCAGATGGCA AACCAGGACC CCGAATCCAT CATGTTTAAT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Preferential Association with ClC-3 Permits Sorting of ClC-4 into Endosomal Compartments.
The Journal of biological chemistry(2017 Sep)
Guzman RE,Bungert-Pl?mke S,Franzen A,Fahlke C

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.
Molecular psychiatry(2016 Aug)
Palmer EE,Stuhlmann T,Weinert S,Haan E,Van Esch H,Holvoet M,Boyle J,Leffler M,Raynaud M,Moraine C,van Bokhoven H,Kleefstra T,Kahrizi K,Najmabadi H,Ropers HH,Delgado MR,Sirsi D,Golla S,Sommer A,Pietryga MP,Chung WK,Wynn J,Rohena L,Bernardo E,Hamlin D,Faux BM,Grange DK,Manwaring L,Tolmie J,Joss S,,Cobben JM,Duijkers FA,Goehringer JM,Challman TD,Hennig F,Fischer U,Grimme A,Suckow V,Musante L,Nicholl J,Shaw M,Lodh SP,Niu Z,Rosenfeld JA,Stankiewicz P,Jentsch TJ,Gecz J,Field M,Kalscheuer VM

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Molecular psychiatry21(1)133-48(2016 Jan)
Hu H,Haas SA,Chelly J,Van Esch H,Raynaud M,de Brouwer AP,Weinert S,Froyen G,Frints SG,Laumonnier F,Zemojtel T,Love MI,Richard H,Emde AK,Bienek M,Jensen C,Hambrock M,Fischer U,Langnick C,Feldkamp M,Wissink-Lindhout W,Lebrun N,Castelnau L,Rucci J,Montjean R,Dorseuil O,Billuart P,Stuhlmann T,Shaw M,Corbett MA,Gardner A,Willis-Owen S,Tan C,Friend KL,Belet S,van Roozendaal KE,Jimenez-Pocquet M,Moizard MP,Ronce N,Sun R,O'Keeffe S,Chenna R,van B?mmel A,G?ke J,Hackett A,Field M,Christie L,Boyle J,Haan E,Nelson J,Turner G,Baynam G,Gillessen-Kaesbach G,M?ller U,Steinberger D,Budny B,Badura-Stronka M,Latos-Biele?ska A,Ousager LB,Wieacker P,Rodr?guez Criado G,Bondeson ML,Anner?n G,Dufke A,Cohen M,Van Maldergem L,Vincent-Delorme C,Echenne B,Simon-Bouy B,Kleefstra T,Willemsen M,Fryns JP,Devriendt K,Ullmann R,Vingron M,Wrogemann K,Wienker TF,Tzschach A,van Bokhoven H,Gecz J,Jentsch TJ,Chen W,Ropers HH,Kalscheuer VM

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.
Epilepsia54(7)1270-81(2013 Jul)
Veeramah KR,Johnstone L,Karafet TM,Wolf D,Sprissler R,Salogiannis J,Barth-Maron A,Greenberg ME,Stuhlmann T,Weinert S,Jentsch TJ,Pazzi M,Restifo LL,Talwar D,Erickson RP,Hammer MF

Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions.
Biophysical journal100(5)1233-41(2011 Mar)
Orhan G,Fahlke C,Alekov AK

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CLCN4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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