THEM4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	THEM4
Entrez Gene ID	117145
Full Name	thioesterase superfamily member 4
Synonyms	CTMP
General protein information	Preferred Names thioesterase superfamily member 4 Names acyl-coenzyme A thioesterase THEM4 C-terminal modulator protein acyl-CoA thioesterase THEM4 carboxyl-terminal modulator protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008].
Disorder MIM:	606388

mRNA and Protein(s)

mRNA	Protein	Name
NM_053055.4	NP_444283.2	acyl-coenzyme A thioesterase THEM4
NM_053055.5	NP_444283.2	acyl-coenzyme A thioesterase THEM4
XM_011509142.2	XP_011507444.1	acyl-coenzyme A thioesterase THEM4 isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	zgc:158847	NP_001074103.1
Homo sapiens (human)	THEM4	NP_444283.2
Mus musculus (house mouse)	Them4	NP_083707.1
Xenopus tropicalis (tropical clawed frog)	them4	XP_004917621.1
Pan troglodytes (chimpanzee)	THEM4	XP_513806.2
Canis lupus familiaris (dog)	THEM4	XP_851465.1
	LOC711796	XP_001108969.2
Bos taurus (cattle)	THEM4	NP_001073837.1
Rattus norvegicus (Norway rat)	Them4	NP_001020188.1

Gene Ontology
Bibliography

Related articles in PubMed

CTMP, a predictive biomarker for trastuzumab resistance in HER2-enriched breast cancer patient.
Chen YC, Li HY, Liang JL, Ger LP, Chang HT, Hsiao M, Calkins MJ, Cheng HC, Chuang JH, Lu PJ
Oncotarget8(18)29699-29710(2017 May)

Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation.
Chang JW, Jung SN, Kim JH, Shim GA, Park HS, Liu L, Kim JM, Park J, Koo BS
Scientific reports628503(2016 Jun)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W
Nature508(7497)541-5(2014 Apr)

Genetic determinants influencing human serum metabolome among African Americans.
Yu B, Zheng Y, Alexander D, Morrison AC, Coresh J, Boerwinkle E
PLoS genetics10(3)e1004212(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells.
Title: Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4.
Title: The DNA methylome of pediatric acute lymphoblastic leukemia.

Phosphorylation on Ser37/Ser38 of CTMP is important for the prevention of mitochondrial localization of CTMP, eventually leading to cell death by binding to heat shock protein 70.
Title: Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.

Proper maturation of CTMP is essential for its pro-apoptotic function. CTMP delays PKB phosphorylation following cell death induction, suggesting that CTMP regulates apoptosis via inhibition of PKB.
Title: Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.

The following THEM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THEM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10917	NM_053055.5 Latest version!	Homo sapiens thioesterase superfamily member 4 (THEM4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu75035	XM_011509142.2 Latest version!	Homo sapiens thioesterase superfamily member 4 (THEM4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu10917	NM_053055.4	Homo sapiens thioesterase superfamily member 4 (THEM4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THEM4 ( NM_053055.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_444283.2 Homo sapiens thioesterase superfamily member 4 (THEM4), mRNA.

Price & Availability↑

CloneID	OHu10917
Clone ID Related Accession (Same CDS sequence)	NM_053055.4 , NM_053055.5
Accession Version	NM_053055.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	acyl-coenzyme A thioesterase THEM4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289494.1, DC353229.1, AL450992.17, AJ313515.1 and AF075119.1. On Apr 5, 2011 this sequence version replaced NM_053055.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.121570.1, SRR1803612.142979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGAGGA GCTGCGCCGC GCGCCTCCGC ACGCTGGGGG CTCTGTGCCT GCCGCCAGTA 
GGCCGGCGCC TGCCGGGAAG CGAGCCGCGA CCCGAGCTGA GGTCATTTTC TTCTGAGGAA 
GTCATTCTTA AGGACTGTTC TGTCCCCAAC CCCAGCTGGA ACAAGGACCT AAGACTGCTC 
TTTGACCAGT TTATGAAGAA ATGTGAAGAC GGCTCCTGGA AACGTTTGCC TTCATATAAA 
CGTACACCTA CTGAATGGAT TCAAGACTTC AAAACCCATT TTCTTGACCC AAAGCTTATG 
AAAGAAGAAC AAATGTCACA GGCCCAGCTC TTCACCAGAA GCTTTGATGA TGGCCTGGGC 
TTTGAATACG TGATGTTCTA CAATGACATT GAGAAAAGGA TGGTTTGCTT ATTTCAAGGA 
GGCCCTTACC TGGAAGGACC ACCTGGATTC ATTCATGGAG GTGCCATTGC AACCATGATT 
GATGCTACTG TTGGTATGTG TGCAATGATG GCTGGGGGAA TCGTCATGAC TGCCAATCTC 
AACATCAATT ATAAAAGACC TATCCCTCTT TGTTCTGTTG TTATGATAAA TAGCCAACTT 
GATAAAGTTG AAGGAAGGAA ATTTTTTGTT TCCTGTAATG TTCAGAGTGT TGATGAGAAG 
ACCCTATACT CAGAGGCGAC AAGCTTATTT ATAAAGCTGA ATCCTGCTAA AAGTCTGACA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444283.2
CDS	428..1150
Translation	MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT

Target ORF information:

RefSeq Version	NM_053055.4
Organism	Homo sapiens(human)
Definition	Homo sapiens thioesterase superfamily member 4 (THEM4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053055.4

ORF Insert Sequence:

ATGCTGAGGA GCTGCGCCGC GCGCCTCCGC ACGCTGGGGG CTCTGTGCCT GCCGCCAGTA 
GGCCGGCGCC TGCCGGGAAG CGAGCCGCGA CCCGAGCTGA GGTCATTTTC TTCTGAGGAA 
GTCATTCTTA AGGACTGTTC TGTCCCCAAC CCCAGCTGGA ACAAGGACCT AAGACTGCTC 
TTTGACCAGT TTATGAAGAA ATGTGAAGAC GGCTCCTGGA AACGTTTGCC TTCATATAAA 
CGTACACCTA CTGAATGGAT TCAAGACTTC AAAACCCATT TTCTTGACCC AAAGCTTATG 
AAAGAAGAAC AAATGTCACA GGCCCAGCTC TTCACCAGAA GCTTTGATGA TGGCCTGGGC 
TTTGAATACG TGATGTTCTA CAATGACATT GAGAAAAGGA TGGTTTGCTT ATTTCAAGGA 
GGCCCTTACC TGGAAGGACC ACCTGGATTC ATTCATGGAG GTGCCATTGC AACCATGATT 
GATGCTACTG TTGGTATGTG TGCAATGATG GCTGGGGGAA TCGTCATGAC TGCCAATCTC 
AACATCAATT ATAAAAGACC TATCCCTCTT TGTTCTGTTG TTATGATAAA TAGCCAACTT 
GATAAAGTTG AAGGAAGGAA ATTTTTTGTT TCCTGTAATG TTCAGAGTGT TGATGAGAAG 
ACCCTATACT CAGAGGCGAC AAGCTTATTT ATAAAGCTGA ATCCTGCTAA AAGTCTGACA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THEM4 ( NM_053055.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_444283.2 Homo sapiens thioesterase superfamily member 4 (THEM4), mRNA.

Price & Availability↑

CloneID	OHu10917
Clone ID Related Accession (Same CDS sequence)	NM_053055.4 , NM_053055.5
Accession Version	NM_053055.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	acyl-coenzyme A thioesterase THEM4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC353229.1, AL450992.17, AJ313515.1 and AF075119.1. On Nov 23, 2018 this sequence version replaced NM_053055.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.121570.1, SRR1803612.142979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368814.8/ ENSP00000357804.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGAGGA GCTGCGCCGC GCGCCTCCGC ACGCTGGGGG CTCTGTGCCT GCCGCCAGTA 
GGCCGGCGCC TGCCGGGAAG CGAGCCGCGA CCCGAGCTGA GGTCATTTTC TTCTGAGGAA 
GTCATTCTTA AGGACTGTTC TGTCCCCAAC CCCAGCTGGA ACAAGGACCT AAGACTGCTC 
TTTGACCAGT TTATGAAGAA ATGTGAAGAC GGCTCCTGGA AACGTTTGCC TTCATATAAA 
CGTACACCTA CTGAATGGAT TCAAGACTTC AAAACCCATT TTCTTGACCC AAAGCTTATG 
AAAGAAGAAC AAATGTCACA GGCCCAGCTC TTCACCAGAA GCTTTGATGA TGGCCTGGGC 
TTTGAATACG TGATGTTCTA CAATGACATT GAGAAAAGGA TGGTTTGCTT ATTTCAAGGA 
GGCCCTTACC TGGAAGGACC ACCTGGATTC ATTCATGGAG GTGCCATTGC AACCATGATT 
GATGCTACTG TTGGTATGTG TGCAATGATG GCTGGGGGAA TCGTCATGAC TGCCAATCTC 
AACATCAATT ATAAAAGACC TATCCCTCTT TGTTCTGTTG TTATGATAAA TAGCCAACTT 
GATAAAGTTG AAGGAAGGAA ATTTTTTGTT TCCTGTAATG TTCAGAGTGT TGATGAGAAG 
ACCCTATACT CAGAGGCGAC AAGCTTATTT ATAAAGCTGA ATCCTGCTAA AAGTCTGACA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444283.2
CDS	54..776
Translation	MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT

Target ORF information:

RefSeq Version	NM_053055.5
Organism	Homo sapiens(human)
Definition	Homo sapiens thioesterase superfamily member 4 (THEM4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053055.5

ORF Insert Sequence:

ATGCTGAGGA GCTGCGCCGC GCGCCTCCGC ACGCTGGGGG CTCTGTGCCT GCCGCCAGTA 
GGCCGGCGCC TGCCGGGAAG CGAGCCGCGA CCCGAGCTGA GGTCATTTTC TTCTGAGGAA 
GTCATTCTTA AGGACTGTTC TGTCCCCAAC CCCAGCTGGA ACAAGGACCT AAGACTGCTC 
TTTGACCAGT TTATGAAGAA ATGTGAAGAC GGCTCCTGGA AACGTTTGCC TTCATATAAA 
CGTACACCTA CTGAATGGAT TCAAGACTTC AAAACCCATT TTCTTGACCC AAAGCTTATG 
AAAGAAGAAC AAATGTCACA GGCCCAGCTC TTCACCAGAA GCTTTGATGA TGGCCTGGGC 
TTTGAATACG TGATGTTCTA CAATGACATT GAGAAAAGGA TGGTTTGCTT ATTTCAAGGA 
GGCCCTTACC TGGAAGGACC ACCTGGATTC ATTCATGGAG GTGCCATTGC AACCATGATT 
GATGCTACTG TTGGTATGTG TGCAATGATG GCTGGGGGAA TCGTCATGAC TGCCAATCTC 
AACATCAATT ATAAAAGACC TATCCCTCTT TGTTCTGTTG TTATGATAAA TAGCCAACTT 
GATAAAGTTG AAGGAAGGAA ATTTTTTGTT TCCTGTAATG TTCAGAGTGT TGATGAGAAG 
ACCCTATACT CAGAGGCGAC AAGCTTATTT ATAAAGCTGA ATCCTGCTAA AAGTCTGACA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THEM4 ( XM_011509142.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011507444.1 Homo sapiens thioesterase superfamily member 4 (THEM4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu75035
Clone ID Related Accession (Same CDS sequence)	XM_011509142.2
Accession Version	XM_011509142.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	acyl-coenzyme A thioesterase THEM4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011509142.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAAAT GTGAAGACGG CTCCTGGAAA CGTTTGCCTT CATATAAACG TACACCTACT 
GAATGGATTC AAGACTTCAA AACCCATTTT CTTGACCCAA AGCTTATGAA AGAAGAACAA 
ATGTCACAGG CCCAGCTCTT CACCAGAAGC TTTGATGATG GCCTGGGCTT TGAATACGTG 
ATGTTCTACA ATGACATTGA GAAAAGGATG GTTTGCTTAT TTCAAGGAGG CCCTTACCTG 
GAAGGACCAC CTGGATTCAT TCATGGAGGT GCCATTGCAA CCATGATTGA TGCTACTGTT 
GGTATGTGTG CAATGATGGC TGGGGGAATC GTCATGACTG CCAATCTCAA CATCAATTAT 
AAAAGACCTA TCCCTCTTTG TTCTGTTGTT ATGATAAATA GCCAACTTGA TAAAGTTGAA 
GGAAGGAAAT TTTTTGTTTC CTGTAATGTT CAGAGTGTTG ATGAGAAGAC CCTATACTCA 
GAGGCGACAA GCTTATTTAT AAAGCTGAAT CCTGCTAAAA GTCTGACATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011507444.1
CDS	278..808
Translation	MKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT

Target ORF information:

RefSeq Version	XM_011509142.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thioesterase superfamily member 4 (THEM4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011509142.2

ORF Insert Sequence:

ATGAAGAAAT GTGAAGACGG CTCCTGGAAA CGTTTGCCTT CATATAAACG TACACCTACT 
GAATGGATTC AAGACTTCAA AACCCATTTT CTTGACCCAA AGCTTATGAA AGAAGAACAA 
ATGTCACAGG CCCAGCTCTT CACCAGAAGC TTTGATGATG GCCTGGGCTT TGAATACGTG 
ATGTTCTACA ATGACATTGA GAAAAGGATG GTTTGCTTAT TTCAAGGAGG CCCTTACCTG 
GAAGGACCAC CTGGATTCAT TCATGGAGGT GCCATTGCAA CCATGATTGA TGCTACTGTT 
GGTATGTGTG CAATGATGGC TGGGGGAATC GTCATGACTG CCAATCTCAA CATCAATTAT 
AAAAGACCTA TCCCTCTTTG TTCTGTTGTT ATGATAAATA GCCAACTTGA TAAAGTTGAA 
GGAAGGAAAT TTTTTGTTTC CTGTAATGTT CAGAGTGTTG ATGAGAAGAC CCTATACTCA 
GAGGCGACAA GCTTATTTAT AAAGCTGAAT CCTGCTAAAA GTCTGACATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CTMP, a predictive biomarker for trastuzumab resistance in HER2-enriched breast cancer patient.
Oncotarget8(18)29699-29710(2017 May)
Chen YC,Li HY,Liang JL,Ger LP,Chang HT,Hsiao M,Calkins MJ,Cheng HC,Chuang JH,Lu PJ

Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation.
Scientific reports628503(2016 Jun)
Chang JW,Jung SN,Kim JH,Shim GA,Park HS,Liu L,Kim JM,Park J,Koo BS

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Nature508(7497)541-5(2014 Apr)
Liu P,Begley M,Michowski W,Inuzuka H,Ginzberg M,Gao D,Tsou P,Gan W,Papa A,Kim BM,Wan L,Singh A,Zhai B,Yuan M,Wang Z,Gygi SP,Lee TH,Lu KP,Toker A,Pandolfi PP,Asara JM,Kirschner MW,Sicinski P,Cantley L,Wei W

Genetic determinants influencing human serum metabolome among African Americans.
PLoS genetics10(3)e1004212(2014 Mar)
Yu B,Zheng Y,Alexander D,Morrison AC,Coresh J,Boerwinkle E

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THEM4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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