MRGPRD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRGPRD
Entrez Gene ID	116512
Full Name	MAS related GPR family member D
Synonyms	MRGD,TGR7
General protein information	Preferred Names MAS related GPR family member D Names mas-related G-protein coupled receptor member D G-protein coupled receptor TGR7 MAS-related GPR, member D beta-alanine receptor mas-related G protein-coupled MRGD
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.3
Disorder MIM:	607231

mRNA and Protein(s)

mRNA	Protein	Name
NM_198923.2	NP_944605.2	mas-related G-protein coupled receptor member D

Pathways from BioSystems

Homologies

Homo sapiens (human)	MRGPRD	NP_944605.2
Pan troglodytes (chimpanzee)	MRGPRD	XP_522085.2
	LOC709555	XP_001101665.1
Bos taurus (cattle)	MRGPRD	XP_002699483.1
Rattus norvegicus (Norway rat)	Mrgprd	NP_001001506.1
Canis lupus familiaris (dog)	MRGPRD	XP_540806.1
Mus musculus (house mouse)	Mrgprd	NP_987075.1

Gene Ontology
Bibliography

Related articles in PubMed

Discovery and characterization of alamandine: a novel component of the renin-angiotensin system.
Lautner RQ, Villela DC, Fraga-Silva RA, Silva N, Verano-Braga T, Costa-Fraga F, Jankowski J, Jankowski V, Sousa F, Alzamora A, Soares E, Barbosa C, Kjeldsen F, Oliveira A, Braga J, Savergnini S, Maia G, Peluso AB, Passos-Silva D, Ferreira A, Alves F, Martins A, Raizada M, Paula R, Motta-Santos D, Klempin F, Kemplin F, Pimenta A, Alenina N, Sinisterra R, Bader M, Campagnole-Santos MJ, Santos RA
Circulation research112(8)1104-11(2013 Apr)

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
B?hm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W, Lebrecht A, Schmidt M, K?lbl H, Pfeiffer N, Grus FH
Oncology reports28(2)429-38(2012 Aug)

MRGD, a MAS-related G-protein coupled receptor, promotes tumorigenisis and is highly expressed in lung cancer.
Nishimura S, Uno M, Kaneta Y, Fukuchi K, Nishigohri H, Hasegawa J, Komori H, Takeda S, Enomoto K, Nara F, Agatsuma T
PloS one7(6)e38618(2012)

Angiotensin metabolites can stimulate receptors of the Mas-related genes family.
Gembardt F, Grajewski S, Vahl M, Schultheiss HP, Walther T
Molecular and cellular biochemistry319(1-2)115-23(2008 Dec)

Identification of a G protein-coupled receptor specifically responsive to beta-alanine.
Shinohara T, Harada M, Ogi K, Maruyama M, Fujii R, Tanaka H, Fukusumi S, Komatsu H, Hosoya M, Noguchi Y, Watanabe T, Moriya T, Itoh Y, Hinuma S
The Journal of biological chemistry279(22)23559-64(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Heptapeptide alamandine acts through Mas-related G-protein-coupled receptor member D producing physiological actions that resemble those generated by angiotensin-1-7.
Title: Discovery and characterization of alamandine: a novel component of the renin-angiotensin system.

MRGD could be involved in tumorigenesis and could also be a novel anticancer drug target.
Title: MRGD, a MAS-related G-protein coupled receptor, promotes tumorigenisis and is highly expressed in lung cancer.

Mas, MrgD, and MRG mediated Ang IV-stimulated AA release that was highest for Mas. While Ang III activated Mas and MrgX2, Ang II stimulated AA release via Mas and MRG.
Title: Angiotensin metabolites can stimulate receptors of the Mas-related genes family.

The following MRGPRD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRGPRD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29581	NM_198923.2 Latest version!	Homo sapiens MAS related GPR family member D (MRGPRD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRGPRD ( NM_198923.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_944605.2 Homo sapiens MAS related GPR family member D (MRGPRD), mRNA.

Price & Availability↑

CloneID	OHu29581
Clone ID Related Accession (Same CDS sequence)	NM_198923.2
Accession Version	NM_198923.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	mas-related G-protein coupled receptor member D
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY427820.1. On Feb 25, 2004 this sequence version replaced NM_198923.1. ##Evidence-Data-START## Transcript is intronless :: AB154410.1, AY427820.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309106.3/ ENSP00000310631.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAACCAGA CTTTGAATAG CAGTGGGACC GTGGAGTCAG CCCTAAACTA TTCCAGAGGG 
AGCACAGTGC ACACGGCCTA CCTGGTGCTG AGCTCCCTGG CCATGTTCAC CTGCCTGTGC 
GGGATGGCAG GCAACAGCAT GGTGATCTGG CTGCTGGGCT TTCGAATGCA CAGGAACCCC 
TTCTGCATCT ATATCCTCAA CCTGGCGGCA GCCGACCTCC TCTTCCTCTT CAGCATGGCT 
TCCACGCTCA GCCTGGAAAC CCAGCCCCTG GTCAATACCA CTGACAAGGT CCACGAGCTG 
ATGAAGAGAC TGATGTACTT TGCCTACACA GTGGGCCTGA GCCTGCTGAC GGCCATCAGC 
ACCCAGCGCT GTCTCTCTGT CCTCTTCCCT ATCTGGTTCA AGTGTCACCG GCCCAGGCAC 
CTGTCAGCCT GGGTGTGTGG CCTGCTGTGG ACACTCTGTC TCCTGATGAA CGGGTTGACC 
TCTTCCTTCT GCAGCAAGTT CTTGAAATTC AATGAAGATC GGTGCTTCAG GGTGGACATG 
GTCCAGGCCG CCCTCATCAT GGGGGTCTTA ACCCCAGTGA TGACTCTGTC CAGCCTGACC 
CTCTTTGTCT GGGTGCGGAG GAGCTCCCAG CAGTGGCGGC GGCAGCCCAC ACGGCTGTTC 
GTGGTGGTCC TGGCCTCTGT CCTGGTGTTC CTCATCTGTT CCCTGCCTCT GAGCATCTAC 
TGGTTTGTGC TCTACTGGTT GAGCCTGCCG CCCGAGATGC AGGTCCTGTG CTTCAGCTTG 
TCACGCCTCT CCTCGTCCGT AAGCAGCAGC GCCAACCCCG TCATCTACTT CCTGGTGGGC 
AGCCGGAGGA GCCACAGGCT GCCCACCAGG TCCCTGGGGA CTGTGCTCCA ACAGGCGCTT 
CGCGAGGAGC CCGAGCTGGA AGGTGGGGAG ACGCCCACCG TGGGCACCAA TGAGATGGGG 
GCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_944605.2
CDS	1..966
Translation	MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAGNSMVIWLLGFRMHRNPFCIYILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMKRLMYFAYTVGLSLLTAISTQRCLSVLFPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLTSSFCSKFLKFNEDRCFRVDMVQAALIMGVLTPVMTLSSLTLFVWVRRSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIYWFVLYWLSLPPEMQVLCFSLSRLSSSVSSSANPVIYFLVGSRRSHRLPTRSLGTVLQQALREEPELEGGETPTVGTNEMGA

Target ORF information:

RefSeq Version	NM_198923.2
Organism	Homo sapiens(human)
Definition	Homo sapiens MAS related GPR family member D (MRGPRD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198923.2

ORF Insert Sequence:

ATGAACCAGA CTTTGAATAG CAGTGGGACC GTGGAGTCAG CCCTAAACTA TTCCAGAGGG 
AGCACAGTGC ACACGGCCTA CCTGGTGCTG AGCTCCCTGG CCATGTTCAC CTGCCTGTGC 
GGGATGGCAG GCAACAGCAT GGTGATCTGG CTGCTGGGCT TTCGAATGCA CAGGAACCCC 
TTCTGCATCT ATATCCTCAA CCTGGCGGCA GCCGACCTCC TCTTCCTCTT CAGCATGGCT 
TCCACGCTCA GCCTGGAAAC CCAGCCCCTG GTCAATACCA CTGACAAGGT CCACGAGCTG 
ATGAAGAGAC TGATGTACTT TGCCTACACA GTGGGCCTGA GCCTGCTGAC GGCCATCAGC 
ACCCAGCGCT GTCTCTCTGT CCTCTTCCCT ATCTGGTTCA AGTGTCACCG GCCCAGGCAC 
CTGTCAGCCT GGGTGTGTGG CCTGCTGTGG ACACTCTGTC TCCTGATGAA CGGGTTGACC 
TCTTCCTTCT GCAGCAAGTT CTTGAAATTC AATGAAGATC GGTGCTTCAG GGTGGACATG 
GTCCAGGCCG CCCTCATCAT GGGGGTCTTA ACCCCAGTGA TGACTCTGTC CAGCCTGACC 
CTCTTTGTCT GGGTGCGGAG GAGCTCCCAG CAGTGGCGGC GGCAGCCCAC ACGGCTGTTC 
GTGGTGGTCC TGGCCTCTGT CCTGGTGTTC CTCATCTGTT CCCTGCCTCT GAGCATCTAC 
TGGTTTGTGC TCTACTGGTT GAGCCTGCCG CCCGAGATGC AGGTCCTGTG CTTCAGCTTG 
TCACGCCTCT CCTCGTCCGT AAGCAGCAGC GCCAACCCCG TCATCTACTT CCTGGTGGGC 
AGCCGGAGGA GCCACAGGCT GCCCACCAGG TCCCTGGGGA CTGTGCTCCA ACAGGCGCTT 
CGCGAGGAGC CCGAGCTGGA AGGTGGGGAG ACGCCCACCG TGGGCACCAA TGAGATGGGG 
GCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Discovery and characterization of alamandine: a novel component of the renin-angiotensin system.
Circulation research112(8)1104-11(2013 Apr)
Lautner RQ,Villela DC,Fraga-Silva RA,Silva N,Verano-Braga T,Costa-Fraga F,Jankowski J,Jankowski V,Sousa F,Alzamora A,Soares E,Barbosa C,Kjeldsen F,Oliveira A,Braga J,Savergnini S,Maia G,Peluso AB,Passos-Silva D,Ferreira A,Alves F,Martins A,Raizada M,Paula R,Motta-Santos D,Klempin F,Kemplin F,Pimenta A,Alenina N,Sinisterra R,Bader M,Campagnole-Santos MJ,Santos RA

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Oncology reports28(2)429-38(2012 Aug)
B?hm D,Keller K,Pieter J,Boehm N,Wolters D,Siggelkow W,Lebrecht A,Schmidt M,K?lbl H,Pfeiffer N,Grus FH

MRGD, a MAS-related G-protein coupled receptor, promotes tumorigenisis and is highly expressed in lung cancer.
PloS one7(6)e38618(2012)
Nishimura S,Uno M,Kaneta Y,Fukuchi K,Nishigohri H,Hasegawa J,Komori H,Takeda S,Enomoto K,Nara F,Agatsuma T

Angiotensin metabolites can stimulate receptors of the Mas-related genes family.
Molecular and cellular biochemistry319(1-2)115-23(2008 Dec)
Gembardt F,Grajewski S,Vahl M,Schultheiss HP,Walther T

Identification of a G protein-coupled receptor specifically responsive to beta-alanine.
The Journal of biological chemistry279(22)23559-64(2004 May)
Shinohara T,Harada M,Ogi K,Maruyama M,Fujii R,Tanaka H,Fukusumi S,Komatsu H,Hosoya M,Noguchi Y,Watanabe T,Moriya T,Itoh Y,Hinuma S

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MRGPRD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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