KIR3DL3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KIR3DL3
Entrez Gene ID	115653
Full Name	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3
Synonyms	CD158Z,KIR3DL7,KIR44,KIRC1
General protein information	Preferred Names killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 Names killer cell immunoglobulin-like receptor 3DL3 CD158 antigen-like family member Z killer cell Ig-like receptor KIR3DL7 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 killer cell inhibitory receptor 1 killer-cell immunoglobulin-like receptor 3DL3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.42
Summary	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. [provided by RefSeq, Jul 2008].
Disorder MIM:	610095

mRNA and Protein(s)

mRNA	Protein	Name
NM_153443.4	NP_703144.3	killer cell immunoglobulin-like receptor 3DL3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	KIR3DL3	NP_703144.2
Mus musculus (house mouse)	Kir3dl1	NP_808417.2
	KIR3DL2	NP_001098022.1
Rattus norvegicus (Norway rat)	Kir3dl1	NP_852144.1
Pan troglodytes (chimpanzee)	KIR3DL3	XP_003316727.1
Mus musculus (house mouse)	Kir3dl2	NP_808416.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Natural Killer Cell Inhibitory Receptors is Associated with Significant Liver Injury in Chronic Hepatitis C in Children.
Mania A, Kaczmarek M, Kemnitz P, Figlerowicz M, Sikora J, Sluzewski W, Zeromski J
Annals of hepatology16(4)521-529(2017 Jul-Aug)

Partial duplication of chromosome 19 associated with syndromic duane retraction syndrome.
Abu-Amero KK, Kondkar AA, Al Otaibi A, Alorainy IA, Khan AO, Hellani AM, Oystreck DT, Bosley TM
Ophthalmic genetics36(1)14-20(2015 Mar)

The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans.
Hou L, Jiang B, Chen M, Ng J, Hurley CK
Immunogenetics63(9)549-59(2011 Sep)

Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.
Pyo CW, Guethlein LA, Vu Q, Wang R, Abi-Rached L, Norman PJ, Marsh SG, Miller JS, Parham P, Geraghty DE
PloS one5(12)e15115(2010 Dec)

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.
Wauquier N, Padilla C, Becquart P, Leroy E, Vieillard V
Immunogenetics62(11-12)767-71(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Array CGH showed a 95 Kb de novo duplication on chromosome 19q13.4 encompassing four killer cell immunoglobulin-like receptor (KIR) genes.
Title: Partial duplication of chromosome 19 associated with syndromic duane retraction syndrome.

The frequencies of alleles of killer cell immunoglobulin-like receptor genes, KIR3DL3 and KIR3DL2, and the carrier frequency of KIR2DL4 alleles have been determined from a population of African Americans by DNA sequencing of the coding regions.
Title: The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

Observational study of genotype prevalence. (HuGE Navigator)
Title: Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.

The following KIR3DL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KIR3DL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu74928	NM_153443.4 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 (KIR3DL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KIR3DL3 ( NM_153443.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_703144.3 Homo sapiens killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 (KIR3DL3), mRNA.

Price & Availability↑

CloneID	OHu74928
Clone ID Related Accession (Same CDS sequence)	NM_153443.4
Accession Version	NM_153443.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 3DL3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC136283.1, AJ938056.1, AC245128.3 and AJ938052.1. This sequence is a reference standard in the RefSeqGene project. On Jan 28, 2015 this sequence version replaced NM_153443.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF352324.1, AJ938052.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2158188, SAMN03465415 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCGCTCA TGGTCGTCAG CATGGCGTGT GTTGGGTTCT TCTTGCTGGA GGGGCCCTGG 
CCACATGTGG GTGGTCAGGA CAAGCCCTTC CTCTCTGCCT GGCCCGGCAC TGTGGTGTCT 
GAAGGACAAC ATGTGACTCT TCAGTGTCGC TCTCGTCTTG GGTTTAATGA ATTCAGTCTG 
TCCAAAGAAG ACGGGATGCC TGTCCCTGAG CTCTACAACA GAATATTCCG GAACAGCTTT 
CTCATGGGCC CTGTGACCCC AGCACATGCA GGGACCTACA GATGTTGCAG TTCACACCCA 
CACTCCCCCA CTGGGTGGTC GGCACCCAGC AACCCTGTGG TGATCATGGT CACAGGAGTC 
CACAGAAAAC CTTCCCTCCT GGCCCACCCA GGTCCCCTGG TGAAATCAGG AGAGACGGTC 
ATCCTGCAAT GTTGGTCAGA TGTCAGGTTT GAGCGCTTCC TTCTGCACAG AGAGGGGATC 
ACTGAGGACC CCTTGCGCCT CGTTGGACAG CTCCACGATG CGGGTTCCCA GGTCAACTAT 
TCCATGGGTC CCATGACACC TGCCCTTGCA GGGACCTACA GATGCTTTGG TTCTGTCACT 
CACTTACCCT ATGAGTTGTC GGCTCCCAGT GACCCTCTGG ACATCGTGGT CGTAGGTCTA 
TATGGGAAAC CTTCTCTCTC AGCCCAGCCG GGCCCCACGG TTCAGGCAGG AGAGAATGTG 
ACCTTGTCCT GCAGCTCCCG GAGCTTGTTT GACATTTACC ATCTATCCAG GGAGGCGGAG 
GCCGGTGAAC TTAGGCTCAC TGCAGTGCTG AGGGTCAATG GAACATTCCA GGCCAACTTC 
CCTCTGGGCC CTGTGACCCA CGGAGGGAAC TACAGATGCT TCGGCTCTTT CCGTGCCCTG 
CCCCATGCGT GGTCAGACCC GAGTGACCCA CTGCCCGTTT CTGTCACAGG TAACTCCAGA 
AACCTGCACG TTCTGATTGG GACCTCAGTG GTCATCATCC CCTTTGCTAT CCTCCTCTTC 
TTTCTCCTTC ATCGCTGGTG TGCCAACAAA AAGAATGCTG TTGTAATGGA CCAAGAGCCT 
GCAGGGAACA GAACAGTGAA CAGGGAGGAC TCTGATGAAC AAGACCCTCA GGAGGTGACA 
TACGCACAGT TGAATCACTG CGTTTTCACA CAGAGAAAAA TCACTCGCCC TTCTCAGAGG 
CCCAAGACAC CCCCAACAGA TACCAGCGTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_703144.3
CDS	51..1283
Translation	MSLMVVSMACVGFFLLEGPWPHVGGQDKPFLSAWPGTVVSEGQHVTLQCRSRLGFNEFSLSKEDGMPVPELYNRIFRNSFLMGPVTPAHAGTYRCCSSHPHSPTGWSAPSNPVVIMVTGVHRKPSLLAHPGPLVKSGETVILQCWSDVRFERFLLHREGITEDPLRLVGQLHDAGSQVNYSMGPMTPALAGTYRCFGSVTHLPYELSAPSDPLDIVVVGLYGKPSLSAQPGPTVQAGENVTLSCSSRSLFDIYHLSREAEAGELRLTAVLRVNGTFQANFPLGPVTHGGNYRCFGSFRALPHAWSDPSDPLPVSVTGNSRNLHVLIGTSVVIIPFAILLFFLLHRWCANKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDTSV

Target ORF information:

RefSeq Version	NM_153443.4
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 (KIR3DL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153443.4

ORF Insert Sequence:

ATGTCGCTCA TGGTCGTCAG CATGGCGTGT GTTGGGTTCT TCTTGCTGGA GGGGCCCTGG 
CCACATGTGG GTGGTCAGGA CAAGCCCTTC CTCTCTGCCT GGCCCGGCAC TGTGGTGTCT 
GAAGGACAAC ATGTGACTCT TCAGTGTCGC TCTCGTCTTG GGTTTAATGA ATTCAGTCTG 
TCCAAAGAAG ACGGGATGCC TGTCCCTGAG CTCTACAACA GAATATTCCG GAACAGCTTT 
CTCATGGGCC CTGTGACCCC AGCACATGCA GGGACCTACA GATGTTGCAG TTCACACCCA 
CACTCCCCCA CTGGGTGGTC GGCACCCAGC AACCCTGTGG TGATCATGGT CACAGGAGTC 
CACAGAAAAC CTTCCCTCCT GGCCCACCCA GGTCCCCTGG TGAAATCAGG AGAGACGGTC 
ATCCTGCAAT GTTGGTCAGA TGTCAGGTTT GAGCGCTTCC TTCTGCACAG AGAGGGGATC 
ACTGAGGACC CCTTGCGCCT CGTTGGACAG CTCCACGATG CGGGTTCCCA GGTCAACTAT 
TCCATGGGTC CCATGACACC TGCCCTTGCA GGGACCTACA GATGCTTTGG TTCTGTCACT 
CACTTACCCT ATGAGTTGTC GGCTCCCAGT GACCCTCTGG ACATCGTGGT CGTAGGTCTA 
TATGGGAAAC CTTCTCTCTC AGCCCAGCCG GGCCCCACGG TTCAGGCAGG AGAGAATGTG 
ACCTTGTCCT GCAGCTCCCG GAGCTTGTTT GACATTTACC ATCTATCCAG GGAGGCGGAG 
GCCGGTGAAC TTAGGCTCAC TGCAGTGCTG AGGGTCAATG GAACATTCCA GGCCAACTTC 
CCTCTGGGCC CTGTGACCCA CGGAGGGAAC TACAGATGCT TCGGCTCTTT CCGTGCCCTG 
CCCCATGCGT GGTCAGACCC GAGTGACCCA CTGCCCGTTT CTGTCACAGG TAACTCCAGA 
AACCTGCACG TTCTGATTGG GACCTCAGTG GTCATCATCC CCTTTGCTAT CCTCCTCTTC 
TTTCTCCTTC ATCGCTGGTG TGCCAACAAA AAGAATGCTG TTGTAATGGA CCAAGAGCCT 
GCAGGGAACA GAACAGTGAA CAGGGAGGAC TCTGATGAAC AAGACCCTCA GGAGGTGACA 
TACGCACAGT TGAATCACTG CGTTTTCACA CAGAGAAAAA TCACTCGCCC TTCTCAGAGG 
CCCAAGACAC CCCCAACAGA TACCAGCGTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Natural Killer Cell Inhibitory Receptors is Associated with Significant Liver Injury in Chronic Hepatitis C in Children.
Annals of hepatology16(4)521-529(2017 Jul-Aug)
Mania A,Kaczmarek M,Kemnitz P,Figlerowicz M,Sikora J,Sluzewski W,Zeromski J

Partial duplication of chromosome 19 associated with syndromic duane retraction syndrome.
Ophthalmic genetics36(1)14-20(2015 Mar)
Abu-Amero KK,Kondkar AA,Al Otaibi A,Alorainy IA,Khan AO,Hellani AM,Oystreck DT,Bosley TM

The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans.
Immunogenetics63(9)549-59(2011 Sep)
Hou L,Jiang B,Chen M,Ng J,Hurley CK

Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.
PloS one5(12)e15115(2010 Dec)
Pyo CW,Guethlein LA,Vu Q,Wang R,Abi-Rached L,Norman PJ,Marsh SG,Miller JS,Parham P,Geraghty DE

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.
Immunogenetics62(11-12)767-71(2010 Dec)
Wauquier N,Padilla C,Becquart P,Leroy E,Vieillard V

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

KIR3DL3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報