SLC6A14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC6A14
Entrez Gene ID	11254
Full Name	solute carrier family 6 member 14
Synonyms	BMIQ11
General protein information	Preferred Names solute carrier family 6 member 14 Names sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) amino acid transporter ATB0+ amino acid transporter B0+ solute carrier family 6 (amino acid transporter), member 14 solute carrier family 6 (neurotransmitter transporter), member 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq23
Summary	This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010].
Disorder MIM:	300444
Disorder Html:	{Obesity, susceptibility to, BMIQ11}, 300306 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_007231.4	NP_009162.1	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
NM_007231.5	NP_009162.1	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC6A14	NP_009162.1
Bos taurus (cattle)	SLC6A14	NP_001091931.1
Danio rerio (zebrafish)	slc6a14	XP_001923596.1
Rattus norvegicus (Norway rat)	Slc6a14	NP_001032633.1
Xenopus tropicalis (tropical clawed frog)	slc6a14.1	XP_002939712.2
Pan troglodytes (chimpanzee)	SLC6A14	XP_003317696.1
	SLC6A14	XP_001104391.1
Canis lupus familiaris (dog)	SLC6A14	XP_549207.2
Mus musculus (house mouse)	Slc6a14	NP_064433.3
Gallus gallus (chicken)	SLC6A14	XP_003641183.1

Gene Ontology
Bibliography

Related articles in PubMed

Di Paola M, Park AJ, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM
mBio8(6)(2017 Dec)

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer.
Coothankandaswamy V, Cao S, Xu Y, Prasad PD, Singh PK, Reynolds CP, Yang S, Ogura J, Ganapathy V, Bhutia YD
British journal of pharmacology173(23)3292-3306(2016 Dec)

Four Single Nucleotide Polymorphisms in INSR, SLC6A14, TAS2R38, and OR2W3 Genes in Association with Idiopathic Infertility in Persian Men.
Siasi E, Aleyasin A
The Journal of reproductive medicine61(3-4)145-52(2016 Mar-Apr)

SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.
Miranda RC, Vetter SB, Genro JP, Campagnolo PD, Mattevi VS, Vitolo MR, Almeida S
Clinical biochemistry48(18)1277-82(2015 Dec)

Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma.
Penheiter AR, Erdogan S, Murphy SJ, Hart SN, Felipe Lima J, Rakhshan Rohakhtar F, O'Brien DR, Bamlet WR, Wuertz RE, Smyrk TC, Couch FJ, Vasmatzis G, Bender CE, Carlson SK
BioMed research international2015593572(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results indicate a significant correlation between T132903C and C109869T single nucleotide polymorphisms in the insulin receptor and solute carrier family 6 member 14 amino acid transporter(SLC6A14) genes with idiopathic infertility in Persian males
Title: Four Single Nucleotide Polymorphisms in INSR, SLC6A14, TAS2R38, and OR2W3 Genes in Association with Idiopathic Infertility in Persian Men.

SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.
Title: SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.

Very little is known about the role of SLC6A14 in PDAC and our results demonstrate that this target merits further investigation as a candidate transporter for functional imaging of pancreatic ductal adenocarcinoma .
Title: Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma.

Single nucleotide polymorphism in SLC6A14 gene is associated with cystic fibrosis.
Title: Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

The following SLC6A14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC6A14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21263	NM_007231.5 Latest version!	Homo sapiens solute carrier family 6 member 14 (SLC6A14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu21263	NM_007231.4	Homo sapiens solute carrier family 6 member 14 (SLC6A14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC6A14 ( NM_007231.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009162.1 Homo sapiens solute carrier family 6 member 14 (SLC6A14), mRNA.

Price & Availability↑

CloneID	OHu21263
Clone ID Related Accession (Same CDS sequence)	NM_007231.4 , NM_007231.5
Accession Version	NM_007231.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313390.1, BC093710.1, AF151978.1, DB207722.1, AC241580.2 and BU686768.1. This sequence is a reference standard in the RefSeqGene project. On Sep 12, 2013 this sequence version replaced NM_007231.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF151978.1, AK313390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAAGT TGAAATGCCC GAGTTTCTTC AAGTGCAGGG AGAAGGAGAA AGTGTCGGCT 
TCATCAGAGA ATTTCCATGT TGGTGAAAAT GATGAGAATC AGGACCGTGG TAACTGGTCC 
AAAAAATCGG ATTATCTTCT ATCTATGATT GGATACGCAG TGGGATTAGG AAATGTGTGG 
AGATTTCCAT ATCTGACCTA CAGCAATGGT GGAGGCGCCT TCTTGATACC TTATGCAATT 
ATGTTAGCAT TGGCTGGTTT ACCTTTGTTC TTTCTGGAGT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT CTTCCATTGT TTCAAGGTGT GGGAATTACA 
ATGGTCCTGA TCTCCATTTT TGTGACAATC TATTACAATG TCATAATTGC CTATAGTCTT 
TACTACATGT TTGCTTCTTT TCAAAGTGAA CTACCATGGA AAAATTGTTC TTCGTGGTCA 
GATAAAAACT GTAGCAGATC ACCAATAGTA ACTCACTGTA ATGTGAGTAC AGTGAATAAA 
GGAATACAAG AGATCATCCA AATGAATAAA AGCTGGGTAG ACATCAACAA TTTTACCTGC 
ATCAACGGCA GTGAAATTTA TCAGCCAGGG CAGCTTCCCA GTGAACAATA TTGGAATAAA 
GTGGCGCTCC AACGGTCAAG TGGAATGAAT GAGACTGGAG TAATTGTTTG GTATTTAGCA 
CTTTGTCTTC TTCTGGCTTG GCTCATAGTT GGAGCAGCAC TATTTAAAGG AATCAAATCG 
TCTGGCAAGG TGGTATATTT TACAGCTCTT TTCCCCTATG TGGTCCTACT CATCCTGTTA 
GTACGAGGTG CAACTCTGGA GGGTGCTTCA AAAGGCATTT CATACTATAT TGGAGCCCAG 
TCAAATTTTA CAAAACTTAA GGAAGCTGAG GTATGGAAAG ATGCTGCCAC TCAGATATTT 
TACTCCCTTT CAGTGGCTTG GGGTGGCTTA GTTGCTCTAT CATCTTACAA TAAGTTCAAA 
AACAACTGCT TCTCTGATGC CATTGTGGTT TGTTTGACAA ACTGTCTCAC TAGCGTGTTT 
GCTGGATTTG CTATTTTTTC TATATTGGGA CACATGGCCC ATATATCTGG AAAGGAAGTT 
TCTCAAGTTG TAAAATCAGG TTTTGATTTG GCATTCATTG CCTATCCAGA GGCTCTAGCC 
CAACTCCCAG GTGGTCCATT TTGGTCCATA TTATTTTTTT TCATGCTTTT AACTTTGGGT 
CTCGATTCTC AGTTTGCTTC GATTGAAACG ATCACAACAA CAATTCAAGA TTTATTTCCC 
AAAGTGATGA AGAAAATGAG GGTTCCCATA ACTTTGGGCT GCTGCTTGGT TTTGTTTCTC 
CTTGGTCTCG TCTGTGTGAC TCAGGCTGGA ATTTACTGGG TTCATCTGAT TGACCACTTC 
TGTGCTGGAT GGGGCATTTT AATTGCAGCT ATACTGGAGC TAGTTGGAAT CATCTGGATT 
TATGGAGGGA ACAGATTCAT TGAGGATACA GAAATGATGA TTGGAGCAAA GAGGTGGATA 
TTCTGGCTAT GGTGGAGAGC TTGCTGGTTT GTAATTACGC CTATCCTTTT GATTGCAATA 
TTTATCTGGT CATTGGTGCA ATTTCATAGA CCTAATTATG GCGCAATTCC ATACCCTGAC 
TGGGGAGTTG CTTTAGGCTG GTGTATGATT GTTTTCTGCA TTATTTGGAT TCCAATTATG 
GCTATCATAA AAATAATTCA GGCTAAAGGA AACATCTTTC AACGCCTTAT AAGTTGCTGC 
AGACCAGCTT CTAACTGGGG TCCATACCTG GAACAACATC GTGGGGAAAG ATATAAAGAC 
ATGGTAGATC CTAAAAAAGA GGCTGACCAT GAAATACCTA CTGTTAGTGG CAGCAGAAAA 
CCGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009162.1
CDS	132..2060
Translation	MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

Target ORF information:

RefSeq Version	NM_007231.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 14 (SLC6A14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007231.4

ORF Insert Sequence:

ATGGACAAGT TGAAATGCCC GAGTTTCTTC AAGTGCAGGG AGAAGGAGAA AGTGTCGGCT 
TCATCAGAGA ATTTCCATGT TGGTGAAAAT GATGAGAATC AGGACCGTGG TAACTGGTCC 
AAAAAATCGG ATTATCTTCT ATCTATGATT GGATACGCAG TGGGATTAGG AAATGTGTGG 
AGATTTCCAT ATCTGACCTA CAGCAATGGT GGAGGCGCCT TCTTGATACC TTATGCAATT 
ATGTTAGCAT TGGCTGGTTT ACCTTTGTTC TTTCTGGAGT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT CTTCCATTGT TTCAAGGTGT GGGAATTACA 
ATGGTCCTGA TCTCCATTTT TGTGACAATC TATTACAATG TCATAATTGC CTATAGTCTT 
TACTACATGT TTGCTTCTTT TCAAAGTGAA CTACCATGGA AAAATTGTTC TTCGTGGTCA 
GATAAAAACT GTAGCAGATC ACCAATAGTA ACTCACTGTA ATGTGAGTAC AGTGAATAAA 
GGAATACAAG AGATCATCCA AATGAATAAA AGCTGGGTAG ACATCAACAA TTTTACCTGC 
ATCAACGGCA GTGAAATTTA TCAGCCAGGG CAGCTTCCCA GTGAACAATA TTGGAATAAA 
GTGGCGCTCC AACGGTCAAG TGGAATGAAT GAGACTGGAG TAATTGTTTG GTATTTAGCA 
CTTTGTCTTC TTCTGGCTTG GCTCATAGTT GGAGCAGCAC TATTTAAAGG AATCAAATCG 
TCTGGCAAGG TGGTATATTT TACAGCTCTT TTCCCCTATG TGGTCCTACT CATCCTGTTA 
GTACGAGGTG CAACTCTGGA GGGTGCTTCA AAAGGCATTT CATACTATAT TGGAGCCCAG 
TCAAATTTTA CAAAACTTAA GGAAGCTGAG GTATGGAAAG ATGCTGCCAC TCAGATATTT 
TACTCCCTTT CAGTGGCTTG GGGTGGCTTA GTTGCTCTAT CATCTTACAA TAAGTTCAAA 
AACAACTGCT TCTCTGATGC CATTGTGGTT TGTTTGACAA ACTGTCTCAC TAGCGTGTTT 
GCTGGATTTG CTATTTTTTC TATATTGGGA CACATGGCCC ATATATCTGG AAAGGAAGTT 
TCTCAAGTTG TAAAATCAGG TTTTGATTTG GCATTCATTG CCTATCCAGA GGCTCTAGCC 
CAACTCCCAG GTGGTCCATT TTGGTCCATA TTATTTTTTT TCATGCTTTT AACTTTGGGT 
CTCGATTCTC AGTTTGCTTC GATTGAAACG ATCACAACAA CAATTCAAGA TTTATTTCCC 
AAAGTGATGA AGAAAATGAG GGTTCCCATA ACTTTGGGCT GCTGCTTGGT TTTGTTTCTC 
CTTGGTCTCG TCTGTGTGAC TCAGGCTGGA ATTTACTGGG TTCATCTGAT TGACCACTTC 
TGTGCTGGAT GGGGCATTTT AATTGCAGCT ATACTGGAGC TAGTTGGAAT CATCTGGATT 
TATGGAGGGA ACAGATTCAT TGAGGATACA GAAATGATGA TTGGAGCAAA GAGGTGGATA 
TTCTGGCTAT GGTGGAGAGC TTGCTGGTTT GTAATTACGC CTATCCTTTT GATTGCAATA 
TTTATCTGGT CATTGGTGCA ATTTCATAGA CCTAATTATG GCGCAATTCC ATACCCTGAC 
TGGGGAGTTG CTTTAGGCTG GTGTATGATT GTTTTCTGCA TTATTTGGAT TCCAATTATG 
GCTATCATAA AAATAATTCA GGCTAAAGGA AACATCTTTC AACGCCTTAT AAGTTGCTGC 
AGACCAGCTT CTAACTGGGG TCCATACCTG GAACAACATC GTGGGGAAAG ATATAAAGAC 
ATGGTAGATC CTAAAAAAGA GGCTGACCAT GAAATACCTA CTGTTAGTGG CAGCAGAAAA 
CCGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC6A14 ( NM_007231.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_009162.1 Homo sapiens solute carrier family 6 member 14 (SLC6A14), mRNA.

Price & Availability↑

CloneID	OHu21263
Clone ID Related Accession (Same CDS sequence)	NM_007231.4 , NM_007231.5
Accession Version	NM_007231.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313390.1, BC093710.1, AF151978.1, DB207722.1, AC241580.2 and BU686768.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_007231.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF151978.1, AK313390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000598581.3/ ENSP00000470801.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACAAGT TGAAATGCCC GAGTTTCTTC AAGTGCAGGG AGAAGGAGAA AGTGTCGGCT 
TCATCAGAGA ATTTCCATGT TGGTGAAAAT GATGAGAATC AGGACCGTGG TAACTGGTCC 
AAAAAATCGG ATTATCTTCT ATCTATGATT GGATACGCAG TGGGATTAGG AAATGTGTGG 
AGATTTCCAT ATCTGACCTA CAGCAATGGT GGAGGCGCCT TCTTGATACC TTATGCAATT 
ATGTTAGCAT TGGCTGGTTT ACCTTTGTTC TTTCTGGAGT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT CTTCCATTGT TTCAAGGTGT GGGAATTACA 
ATGGTCCTGA TCTCCATTTT TGTGACAATC TATTACAATG TCATAATTGC CTATAGTCTT 
TACTACATGT TTGCTTCTTT TCAAAGTGAA CTACCATGGA AAAATTGTTC TTCGTGGTCA 
GATAAAAACT GTAGCAGATC ACCAATAGTA ACTCACTGTA ATGTGAGTAC AGTGAATAAA 
GGAATACAAG AGATCATCCA AATGAATAAA AGCTGGGTAG ACATCAACAA TTTTACCTGC 
ATCAACGGCA GTGAAATTTA TCAGCCAGGG CAGCTTCCCA GTGAACAATA TTGGAATAAA 
GTGGCGCTCC AACGGTCAAG TGGAATGAAT GAGACTGGAG TAATTGTTTG GTATTTAGCA 
CTTTGTCTTC TTCTGGCTTG GCTCATAGTT GGAGCAGCAC TATTTAAAGG AATCAAATCG 
TCTGGCAAGG TGGTATATTT TACAGCTCTT TTCCCCTATG TGGTCCTACT CATCCTGTTA 
GTACGAGGTG CAACTCTGGA GGGTGCTTCA AAAGGCATTT CATACTATAT TGGAGCCCAG 
TCAAATTTTA CAAAACTTAA GGAAGCTGAG GTATGGAAAG ATGCTGCCAC TCAGATATTT 
TACTCCCTTT CAGTGGCTTG GGGTGGCTTA GTTGCTCTAT CATCTTACAA TAAGTTCAAA 
AACAACTGCT TCTCTGATGC CATTGTGGTT TGTTTGACAA ACTGTCTCAC TAGCGTGTTT 
GCTGGATTTG CTATTTTTTC TATATTGGGA CACATGGCCC ATATATCTGG AAAGGAAGTT 
TCTCAAGTTG TAAAATCAGG TTTTGATTTG GCATTCATTG CCTATCCAGA GGCTCTAGCC 
CAACTCCCAG GTGGTCCATT TTGGTCCATA TTATTTTTTT TCATGCTTTT AACTTTGGGT 
CTCGATTCTC AGTTTGCTTC GATTGAAACG ATCACAACAA CAATTCAAGA TTTATTTCCC 
AAAGTGATGA AGAAAATGAG GGTTCCCATA ACTTTGGGCT GCTGCTTGGT TTTGTTTCTC 
CTTGGTCTCG TCTGTGTGAC TCAGGCTGGA ATTTACTGGG TTCATCTGAT TGACCACTTC 
TGTGCTGGAT GGGGCATTTT AATTGCAGCT ATACTGGAGC TAGTTGGAAT CATCTGGATT 
TATGGAGGGA ACAGATTCAT TGAGGATACA GAAATGATGA TTGGAGCAAA GAGGTGGATA 
TTCTGGCTAT GGTGGAGAGC TTGCTGGTTT GTAATTACGC CTATCCTTTT GATTGCAATA 
TTTATCTGGT CATTGGTGCA ATTTCATAGA CCTAATTATG GCGCAATTCC ATACCCTGAC 
TGGGGAGTTG CTTTAGGCTG GTGTATGATT GTTTTCTGCA TTATTTGGAT TCCAATTATG 
GCTATCATAA AAATAATTCA GGCTAAAGGA AACATCTTTC AACGCCTTAT AAGTTGCTGC 
AGACCAGCTT CTAACTGGGG TCCATACCTG GAACAACATC GTGGGGAAAG ATATAAAGAC 
ATGGTAGATC CTAAAAAAGA GGCTGACCAT GAAATACCTA CTGTTAGTGG CAGCAGAAAA 
CCGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009162.1
CDS	105..2033
Translation	MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

Target ORF information:

RefSeq Version	NM_007231.5
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 6 member 14 (SLC6A14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007231.5

ORF Insert Sequence:

ATGGACAAGT TGAAATGCCC GAGTTTCTTC AAGTGCAGGG AGAAGGAGAA AGTGTCGGCT 
TCATCAGAGA ATTTCCATGT TGGTGAAAAT GATGAGAATC AGGACCGTGG TAACTGGTCC 
AAAAAATCGG ATTATCTTCT ATCTATGATT GGATACGCAG TGGGATTAGG AAATGTGTGG 
AGATTTCCAT ATCTGACCTA CAGCAATGGT GGAGGCGCCT TCTTGATACC TTATGCAATT 
ATGTTAGCAT TGGCTGGTTT ACCTTTGTTC TTTCTGGAGT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT CTTCCATTGT TTCAAGGTGT GGGAATTACA 
ATGGTCCTGA TCTCCATTTT TGTGACAATC TATTACAATG TCATAATTGC CTATAGTCTT 
TACTACATGT TTGCTTCTTT TCAAAGTGAA CTACCATGGA AAAATTGTTC TTCGTGGTCA 
GATAAAAACT GTAGCAGATC ACCAATAGTA ACTCACTGTA ATGTGAGTAC AGTGAATAAA 
GGAATACAAG AGATCATCCA AATGAATAAA AGCTGGGTAG ACATCAACAA TTTTACCTGC 
ATCAACGGCA GTGAAATTTA TCAGCCAGGG CAGCTTCCCA GTGAACAATA TTGGAATAAA 
GTGGCGCTCC AACGGTCAAG TGGAATGAAT GAGACTGGAG TAATTGTTTG GTATTTAGCA 
CTTTGTCTTC TTCTGGCTTG GCTCATAGTT GGAGCAGCAC TATTTAAAGG AATCAAATCG 
TCTGGCAAGG TGGTATATTT TACAGCTCTT TTCCCCTATG TGGTCCTACT CATCCTGTTA 
GTACGAGGTG CAACTCTGGA GGGTGCTTCA AAAGGCATTT CATACTATAT TGGAGCCCAG 
TCAAATTTTA CAAAACTTAA GGAAGCTGAG GTATGGAAAG ATGCTGCCAC TCAGATATTT 
TACTCCCTTT CAGTGGCTTG GGGTGGCTTA GTTGCTCTAT CATCTTACAA TAAGTTCAAA 
AACAACTGCT TCTCTGATGC CATTGTGGTT TGTTTGACAA ACTGTCTCAC TAGCGTGTTT 
GCTGGATTTG CTATTTTTTC TATATTGGGA CACATGGCCC ATATATCTGG AAAGGAAGTT 
TCTCAAGTTG TAAAATCAGG TTTTGATTTG GCATTCATTG CCTATCCAGA GGCTCTAGCC 
CAACTCCCAG GTGGTCCATT TTGGTCCATA TTATTTTTTT TCATGCTTTT AACTTTGGGT 
CTCGATTCTC AGTTTGCTTC GATTGAAACG ATCACAACAA CAATTCAAGA TTTATTTCCC 
AAAGTGATGA AGAAAATGAG GGTTCCCATA ACTTTGGGCT GCTGCTTGGT TTTGTTTCTC 
CTTGGTCTCG TCTGTGTGAC TCAGGCTGGA ATTTACTGGG TTCATCTGAT TGACCACTTC 
TGTGCTGGAT GGGGCATTTT AATTGCAGCT ATACTGGAGC TAGTTGGAAT CATCTGGATT 
TATGGAGGGA ACAGATTCAT TGAGGATACA GAAATGATGA TTGGAGCAAA GAGGTGGATA 
TTCTGGCTAT GGTGGAGAGC TTGCTGGTTT GTAATTACGC CTATCCTTTT GATTGCAATA 
TTTATCTGGT CATTGGTGCA ATTTCATAGA CCTAATTATG GCGCAATTCC ATACCCTGAC 
TGGGGAGTTG CTTTAGGCTG GTGTATGATT GTTTTCTGCA TTATTTGGAT TCCAATTATG 
GCTATCATAA AAATAATTCA GGCTAAAGGA AACATCTTTC AACGCCTTAT AAGTTGCTGC 
AGACCAGCTT CTAACTGGGG TCCATACCTG GAACAACATC GTGGGGAAAG ATATAAAGAC 
ATGGTAGATC CTAAAAAAGA GGCTGACCAT GAAATACCTA CTGTTAGTGG CAGCAGAAAA 
CCGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

mBio8(6)(2017 Dec)
Di Paola M,Park AJ,Ahmadi S,Roach EJ,Wu YS,Struder-Kypke M,Lam JS,Bear CE,Khursigara CM

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer.
British journal of pharmacology173(23)3292-3306(2016 Dec)
Coothankandaswamy V,Cao S,Xu Y,Prasad PD,Singh PK,Reynolds CP,Yang S,Ogura J,Ganapathy V,Bhutia YD

Four Single Nucleotide Polymorphisms in INSR, SLC6A14, TAS2R38, and OR2W3 Genes in Association with Idiopathic Infertility in Persian Men.
The Journal of reproductive medicine61(3-4)145-52(2016 Mar-Apr)
Siasi E,Aleyasin A

SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.
Clinical biochemistry48(18)1277-82(2015 Dec)
Miranda RC,Vetter SB,Genro JP,Campagnolo PD,Mattevi VS,Vitolo MR,Almeida S

Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma.
BioMed research international2015593572(2015)
Penheiter AR,Erdogan S,Murphy SJ,Hart SN,Felipe Lima J,Rakhshan Rohakhtar F,O'Brien DR,Bamlet WR,Wuertz RE,Smyrk TC,Couch FJ,Vasmatzis G,Bender CE,Carlson SK

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SLC6A14 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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