AFG3L2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AFG3L2
Entrez Gene ID	10939
Full Name	AFG3 like matrix AAA peptidase subunit 2
Synonyms	SCA28,SPAX5
General protein information	Preferred Names AFG3 like matrix AAA peptidase subunit 2 Names AFG3-like protein 2 AFG3 ATPase family gene 3-like 2 AFG3 ATPase family member 3-like 2 AFG3 like AAA ATPase 2 ATPase family gene 3, yeast paraplegin-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18p11.21
Summary	This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. [provided by RefSeq, Jul 2008].
Disorder MIM:	604581
Disorder Html:	Spinocerebellar ataxia 28, 610246 (3); Spastic ataxia 5, autosomal recessive, 614487 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011525601.3	XP_011523903.1	AFG3-like protein 2 isoform X1
XM_011525601.2	XP_011523903.1	AFG3-like protein 2 isoform X1
NM_006796.2	NP_006787.2	AFG3-like protein 2
NM_006796.3	NP_006787.2	AFG3-like protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	AFG3L2	NP_006787.2
Pan troglodytes (chimpanzee)	AFG3L2	XP_512199.2
Saccharomyces cerevisiae (baker's yeast)	AFG3	NP_010933.1
Eremothecium gossypii	AGOS_AAR025C	NP_982566.2
Arabidopsis thaliana (thale cress)	ftsh10	NP_172231.2
Bos taurus (cattle)	AFG3L2	NP_001039676.1
Mus musculus (house mouse)	Afg3l2	NP_081406.1
Arabidopsis thaliana (thale cress)	ftsh3	NP_850129.1
	AFG3L2	XP_001094146.1
Gallus gallus (chicken)	AFG3L2	XP_419121.2
Drosophila melanogaster (fruit fly)	CG6512	NP_730248.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006949	XP_308807.4
Caenorhabditis elegans (roundworm)	spg-7	NP_491165.2
Danio rerio (zebrafish)	afg3l2	NP_001104667.1
Oryza sativa (rice)	Os05g0458400	NP_001055745.1
Canis lupus familiaris (dog)	AFG3L2	XP_547682.2
Rattus norvegicus (Norway rat)	Afg3l2	NP_001128336.1
Oryza sativa (rice)	Os01g0842600	NP_001044774.1
Xenopus tropicalis (tropical clawed frog)	afg3l2	NP_001072759.1

Gene Ontology
Bibliography

Related articles in PubMed

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
K?nig T, Tr?der SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, M?hlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T
Molecular cell64(1)148-162(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AOA2 with myoclonus associated with mutations in SETX and AFG3L2
Title: An atypical form of AOA2 with myoclonus associated with mutations in SETX and AFG3L2.

This study that AFG3L2 mutations are another important cause, albeit rare, of a late-onset ataxic PEO phenotype due to a disturbance of mtDNA maintenance.
Title: Clonal expansion of secondary mitochondrial DNA deletions associated with spinocerebellar ataxia type 28.

Deletion of AFG3L2 associated with spinocerebellar ataxia type 28 in the context of multiple genomic anomalies.
Title: Deletion of AFG3L2 associated with spinocerebellar ataxia type 28 in the context of multiple genomic anomalies.

Identification of a partial AFG3L2 deletion and subsequent functional studies reveal loss of function as the most likely disease mechanism.
Title: Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.

StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON protease and the inner membrane complexes of the metalloproteases AFG3L2 and AFG3L2:SPG7/paraplegin.
Title: StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation.

The following AFG3L2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AFG3L2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26959	NM_006796.3 Latest version!	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu64530	XM_011525601.3 Latest version!	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu64530	XM_011525601.2	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OHu26959	NM_006796.2	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AFG3L2 ( NM_006796.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006787.2 Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), mRNA.

Price & Availability↑

CloneID	OHu26959
Clone ID Related Accession (Same CDS sequence)	NM_006796.2 , NM_006796.3
Accession Version	NM_006796.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2394bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	AFG3-like protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN993083.1, BC024282.1, BU786821.1 and BX091241.1. This sequence is a reference standard in the RefSeqGene project. On Jul 7, 2010 this sequence version replaced NM_006796.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.86372.1, SRR1803616.258412.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGG TATCCATCAT CCCACGTGGC 
AAAGGACTAG GTTATGCTCA GTATTTACCA AAAGAACAAT ACCTCTATAC CAAAGAGCAG 
CTCTTGGATA GGATGTGTAT GACTTTAGGT GGTCGAGTCT CTGAAGAAAT CTTCTTTGGA 
AGAATTACAA CTGGTGCTCA AGATGACTTG AGAAAAGTAA CTCAGAGTGC ATATGCCCAA 
ATTGTTCAGT TTGGCATGAA TGAAAAGGTT GGGCAAATCT CCTTTGACCT CCCACGTCAG 
GGGGACATGG TATTGGAGAA ACCTTACAGT GAAGCCACTG CAAGATTGAT AGATGATGAA 
GTACGAATAC TTATTAATGA TGCTTATAAA AGAACAGTAG CTCTTCTCAC AGAAAAGAAA 
GCTGACGTGG AGAAGGTTGC TCTTCTGTTG TTAGAAAAAG AAGTATTAGA TAAGAATGAT 
ATGGTTGAAC TTTTGGGCCC CAGACCATTT GCGGAAAAAT CTACCTATGA AGAATTTGTG 
GAAGGCACTG GCAGCTTGGA TGAGGACACC TCACTTCCAG AAGGCCTTAA GGACTGGAAC 
AAGGAGCGGG AAAAGGAGAA AGAGGAGCCC CCGGGTGAGA AAGTTGCCAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006787.2
CDS	195..2588
Translation	MAHRCLRLWGRGGCWPRGLQQLLVPGGVGPGEQPCLRTLYRFVTTQARASRNSLLTDIIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPPGEKVAN

Target ORF information:

RefSeq Version	NM_006796.2
Organism	Homo sapiens(human)
Definition	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006796.2

ORF Insert Sequence:

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGG TATCCATCAT CCCACGTGGC 
AAAGGACTAG GTTATGCTCA GTATTTACCA AAAGAACAAT ACCTCTATAC CAAAGAGCAG 
CTCTTGGATA GGATGTGTAT GACTTTAGGT GGTCGAGTCT CTGAAGAAAT CTTCTTTGGA 
AGAATTACAA CTGGTGCTCA AGATGACTTG AGAAAAGTAA CTCAGAGTGC ATATGCCCAA 
ATTGTTCAGT TTGGCATGAA TGAAAAGGTT GGGCAAATCT CCTTTGACCT CCCACGTCAG 
GGGGACATGG TATTGGAGAA ACCTTACAGT GAAGCCACTG CAAGATTGAT AGATGATGAA 
GTACGAATAC TTATTAATGA TGCTTATAAA AGAACAGTAG CTCTTCTCAC AGAAAAGAAA 
GCTGACGTGG AGAAGGTTGC TCTTCTGTTG TTAGAAAAAG AAGTATTAGA TAAGAATGAT 
ATGGTTGAAC TTTTGGGCCC CAGACCATTT GCGGAAAAAT CTACCTATGA AGAATTTGTG 
GAAGGCACTG GCAGCTTGGA TGAGGACACC TCACTTCCAG AAGGCCTTAA GGACTGGAAC 
AAGGAGCGGG AAAAGGAGAA AGAGGAGCCC CCGGGTGAGA AAGTTGCCAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AFG3L2 ( NM_006796.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006787.2 Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), mRNA.

Price & Availability↑

CloneID	OHu26959
Clone ID Related Accession (Same CDS sequence)	NM_006796.2 , NM_006796.3
Accession Version	NM_006796.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2394bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	AFG3-like protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN993083.1, BC024282.1, BU786821.1 and BX091241.1. On Aug 31, 2019 this sequence version replaced NM_006796.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065016.1, Y18314.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGG TATCCATCAT CCCACGTGGC 
AAAGGACTAG GTTATGCTCA GTATTTACCA AAAGAACAAT ACCTCTATAC CAAAGAGCAG 
CTCTTGGATA GGATGTGTAT GACTTTAGGT GGTCGAGTCT CTGAAGAAAT CTTCTTTGGA 
AGAATTACAA CTGGTGCTCA AGATGACTTG AGAAAAGTAA CTCAGAGTGC ATATGCCCAA 
ATTGTTCAGT TTGGCATGAA TGAAAAGGTT GGGCAAATCT CCTTTGACCT CCCACGTCAG 
GGGGACATGG TATTGGAGAA ACCTTACAGT GAAGCCACTG CAAGATTGAT AGATGATGAA 
GTACGAATAC TTATTAATGA TGCTTATAAA AGAACAGTAG CTCTTCTCAC AGAAAAGAAA 
GCTGACGTGG AGAAGGTTGC TCTTCTGTTG TTAGAAAAAG AAGTATTAGA TAAGAATGAT 
ATGGTTGAAC TTTTGGGCCC CAGACCATTT GCGGAAAAAT CTACCTATGA AGAATTTGTG 
GAAGGCACTG GCAGCTTGGA TGAGGACACC TCACTTCCAG AAGGCCTTAA GGACTGGAAC 
AAGGAGCGGG AAAAGGAGAA AGAGGAGCCC CCGGGTGAGA AAGTTGCCAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006787.2
CDS	146..2539
Translation	MAHRCLRLWGRGGCWPRGLQQLLVPGGVGPGEQPCLRTLYRFVTTQARASRNSLLTDIIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPPGEKVAN

Target ORF information:

RefSeq Version	NM_006796.3
Organism	Homo sapiens(human)
Definition	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006796.3

ORF Insert Sequence:

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGG TATCCATCAT CCCACGTGGC 
AAAGGACTAG GTTATGCTCA GTATTTACCA AAAGAACAAT ACCTCTATAC CAAAGAGCAG 
CTCTTGGATA GGATGTGTAT GACTTTAGGT GGTCGAGTCT CTGAAGAAAT CTTCTTTGGA 
AGAATTACAA CTGGTGCTCA AGATGACTTG AGAAAAGTAA CTCAGAGTGC ATATGCCCAA 
ATTGTTCAGT TTGGCATGAA TGAAAAGGTT GGGCAAATCT CCTTTGACCT CCCACGTCAG 
GGGGACATGG TATTGGAGAA ACCTTACAGT GAAGCCACTG CAAGATTGAT AGATGATGAA 
GTACGAATAC TTATTAATGA TGCTTATAAA AGAACAGTAG CTCTTCTCAC AGAAAAGAAA 
GCTGACGTGG AGAAGGTTGC TCTTCTGTTG TTAGAAAAAG AAGTATTAGA TAAGAATGAT 
ATGGTTGAAC TTTTGGGCCC CAGACCATTT GCGGAAAAAT CTACCTATGA AGAATTTGTG 
GAAGGCACTG GCAGCTTGGA TGAGGACACC TCACTTCCAG AAGGCCTTAA GGACTGGAAC 
AAGGAGCGGG AAAAGGAGAA AGAGGAGCCC CCGGGTGAGA AAGTTGCCAA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AFG3L2 ( XM_011525601.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523903.1 Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), transcript variant X1, mRNA.

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CloneID	OHu64530
Clone ID Related Accession (Same CDS sequence)	XM_011525601.3 , XM_011525601.2
Accession Version	XM_011525601.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2193bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	AFG3-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011525601.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGA TTGTTCAGTT TGGCATGAAT 
GAAAAGGTTG GGCAAATCTC CTTTGACCTC CCACGTCAGG GGGACATGGT ATTGGAGAAA 
CCTTACAGTG AAGCCACTGC AAGATTGATA GATGATGAAG TACGAATACT TATTAATGAT 
GCTTATAAAA GAACAGTAGC TCTTCTCACA GAAAAGAAAG CTGACGTGGA GAAGGTTGCT 
CTTCTGTTGT TAGAAAAAGA AGTATTAGAT AAGAATGATA TGGTTGAACT TTTGGGCCCC 
AGACCATTTG CGGAAAAATC TACCTATGAA GAATTTGTGG AAGGCACTGG CAGCTTGGAT 
GAGGACACCT CACTTCCAGA AGGCCTTAAG GACTGGAACA AGGAGCGGGA AAAGGAGAAA 
GAGGAGCCCC CGGGTGAGAA AGTTGCCAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523903.1
CDS	228..2420
Translation	MAHRCLRLWGRGGCWPRGLQQLLVPGGVGPGEQPCLRTLYRFVTTQARASRNSLLTDIIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPPGEKVAN

Target ORF information:

RefSeq Version	XM_011525601.3
Organism	Homo sapiens(human)
Definition	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525601.3

ORF Insert Sequence:

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGA TTGTTCAGTT TGGCATGAAT 
GAAAAGGTTG GGCAAATCTC CTTTGACCTC CCACGTCAGG GGGACATGGT ATTGGAGAAA 
CCTTACAGTG AAGCCACTGC AAGATTGATA GATGATGAAG TACGAATACT TATTAATGAT 
GCTTATAAAA GAACAGTAGC TCTTCTCACA GAAAAGAAAG CTGACGTGGA GAAGGTTGCT 
CTTCTGTTGT TAGAAAAAGA AGTATTAGAT AAGAATGATA TGGTTGAACT TTTGGGCCCC 
AGACCATTTG CGGAAAAATC TACCTATGAA GAATTTGTGG AAGGCACTGG CAGCTTGGAT 
GAGGACACCT CACTTCCAGA AGGCCTTAAG GACTGGAACA AGGAGCGGGA AAAGGAGAAA 
GAGGAGCCCC CGGGTGAGAA AGTTGCCAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AFG3L2 ( XM_011525601.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523903.1 Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64530
Clone ID Related Accession (Same CDS sequence)	XM_011525601.3 , XM_011525601.2
Accession Version	XM_011525601.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2193bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	AFG3-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011525601.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGA TTGTTCAGTT TGGCATGAAT 
GAAAAGGTTG GGCAAATCTC CTTTGACCTC CCACGTCAGG GGGACATGGT ATTGGAGAAA 
CCTTACAGTG AAGCCACTGC AAGATTGATA GATGATGAAG TACGAATACT TATTAATGAT 
GCTTATAAAA GAACAGTAGC TCTTCTCACA GAAAAGAAAG CTGACGTGGA GAAGGTTGCT 
CTTCTGTTGT TAGAAAAAGA AGTATTAGAT AAGAATGATA TGGTTGAACT TTTGGGCCCC 
AGACCATTTG CGGAAAAATC TACCTATGAA GAATTTGTGG AAGGCACTGG CAGCTTGGAT 
GAGGACACCT CACTTCCAGA AGGCCTTAAG GACTGGAACA AGGAGCGGGA AAAGGAGAAA 
GAGGAGCCCC CGGGTGAGAA AGTTGCCAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523903.1
CDS	228..2420
Translation	MAHRCLRLWGRGGCWPRGLQQLLVPGGVGPGEQPCLRTLYRFVTTQARASRNSLLTDIIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYLLLKRSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDWNKEREKEKEEPPGEKVAN

Target ORF information:

RefSeq Version	XM_011525601.2
Organism	Homo sapiens(human)
Definition	Homo sapiens AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525601.2

ORF Insert Sequence:

ATGGCGCACC GCTGTTTGCG GCTGTGGGGC CGGGGCGGCT GCTGGCCCCG CGGCCTACAG 
CAGCTCCTCG TGCCTGGCGG CGTGGGCCCG GGCGAGCAGC CCTGCCTCCG GACGCTTTAC 
CGATTTGTTA CAACTCAAGC AAGGGCCAGC AGAAATTCTC TTTTGACAGA TATAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCCCCA AAAGGATTTG AAAAATACTT TCCTAATGGA 
AAAAATGGAA AAAAAGCTAG TGAACCTAAA GAAGTTATGG GAGAGAAAAA AGAATCAAAG 
CCAGCTGCTA CCACACGCTC TTCTGGAGGA GGAGGTGGTG GCGGTGGAAA ACGAGGTGGC 
AAGAAAGATG ATTCTCACTG GTGGTCCAGG TTTCAGAAGG GTGACATTCC ATGGGACGAC 
AAGGATTTCA GGATGTTCTT CCTCTGGACT GCTCTGTTCT GGGGTGGAGT CATGTTTTAC 
TTGCTGCTCA AGAGATCCGG GAGAGAAATC ACTTGGAAGG ACTTTGTCAA TAACTATCTT 
TCAAAAGGAG TAGTAGACAG ATTGGAAGTC GTCAACAAGC GTTTTGTTCG AGTGACCTTT 
ACACCAGGAA AAACTCCTGT TGATGGGCAA TACGTTTGGT TTAATATTGG CAGTGTGGAC 
ACCTTTGAAC GGAATCTGGA AACTTTACAG CAGGAATTGG GCATAGAAGG AGAAAATCGG 
GTGCCTGTTG TCTACATTGC TGAAAGTGAT GGCTCTTTTC TGCTGAGCAT GCTGCCTACG 
GTGCTCATCA TCGCCTTCTT GCTCTACACC ATCAGAAGAG GGCCTGCTGG CATTGGCCGG 
ACAGGCCGAG GGATGGGCGG ACTCTTCAGT GTCGGAGAAA CCACTGCCAA GGTCTTAAAG 
GATGAAATTG ATGTGAAGTT CAAAGATGTG GCTGGCTGTG AGGAGGCCAA GCTAGAGATC 
ATGGAATTTG TGAATTTCTT GAAAAACCCA AAGCAGTATC AAGACCTAGG AGCAAAAATC 
CCAAAGGGTG CCATTCTCAC TGGTCCTCCA GGCACTGGGA AGACGCTGCT AGCTAAGGCC 
ACAGCCGGAG AAGCCAATGT CCCCTTCATC ACCGTTAGTG GATCTGAGTT TTTGGAGATG 
TTCGTTGGTG TGGGCCCTGC TAGAGTCCGA GACTTATTTG CCCTTGCTCG GAAGAATGCC 
CCTTGCATCC TCTTCATCGA TGAAATCGAT GCGGTGGGAA GGAAGAGAGG AAGAGGCAAC 
TTTGGAGGGC AGAGTGAGCA GGAGAACACA CTCAACCAGC TGCTGGTGGA GATGGATGGT 
TTTAATACAA CAACAAATGT CGTCATTTTG GCCGGCACCA ATCGACCAGA TATCCTGGAC 
CCCGCGCTGC TTAGGCCGGG GCGTTTCGAC AGGCAGATCT TTATTGGACC ACCAGACATA 
AAAGGAAGAG CTTCTATTTT CAAAGTTCAT CTCCGACCGC TAAAACTGGA CAGTACCCTG 
GAGAAGGATA AATTGGCAAG AAAACTGGCA TCTTTAACTC CAGGGTTTTC AGGTGCTGAT 
GTTGCTAATG TCTGTAATGA AGCTGCGTTG ATTGCTGCAA GGCATCTGTC AGATTCCATA 
AATCAGAAAC ACTTTGAACA GGCAATTGAA CGAGTGATTG GTGGCTTAGA GAAGAAAACG 
CAGGTTCTGC AGCCTGAGGA GAAGAAGACT GTGGCATACC ACGAAGCAGG CCATGCGGTT 
GCCGGCTGGT ATCTGGAGCA CGCAGACCCG CTTTTAAAGA TTGTTCAGTT TGGCATGAAT 
GAAAAGGTTG GGCAAATCTC CTTTGACCTC CCACGTCAGG GGGACATGGT ATTGGAGAAA 
CCTTACAGTG AAGCCACTGC AAGATTGATA GATGATGAAG TACGAATACT TATTAATGAT 
GCTTATAAAA GAACAGTAGC TCTTCTCACA GAAAAGAAAG CTGACGTGGA GAAGGTTGCT 
CTTCTGTTGT TAGAAAAAGA AGTATTAGAT AAGAATGATA TGGTTGAACT TTTGGGCCCC 
AGACCATTTG CGGAAAAATC TACCTATGAA GAATTTGTGG AAGGCACTGG CAGCTTGGAT 
GAGGACACCT CACTTCCAGA AGGCCTTAAG GACTGGAACA AGGAGCGGGA AAAGGAGAAA 
GAGGAGCCCC CGGGTGAGAA AGTTGCCAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
Molecular cell64(1)148-162(2016 Oct)
K?nig T,Tr?der SE,Bakka K,Korwitz A,Richter-Dennerlein R,Lampe PA,Patron M,M?hlmeister M,Guerrero-Castillo S,Brandt U,Decker T,Lauria I,Paggio A,Rizzuto R,Rugarli EI,De Stefani D,Langer T

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AFG3L2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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