VAMP5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VAMP5
Entrez Gene ID	10791
Full Name	vesicle associated membrane protein 5
General protein information	Preferred Names vesicle associated membrane protein 5 Names vesicle-associated membrane protein 5 VAMP-5 myobrevin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p11.2
Summary	Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:	607029

mRNA and Protein(s)

mRNA	Protein	Name
NM_006634.2	NP_006625.1	vesicle-associated membrane protein 5
NM_006634.3	NP_006625.1	vesicle-associated membrane protein 5

Pathways from BioSystems

Homologies

Homo sapiens (human)	VAMP5	NP_006625.1
Bos taurus (cattle)	VAMP5	NP_001039941.1
Mus musculus (house mouse)	Vamp5	NP_058568.1
Rattus norvegicus (Norway rat)	Vamp5	NP_446007.1
	VAMP5	XP_001084103.2
Canis lupus familiaris (dog)	VAMP5	XP_539938.2
Pan troglodytes (chimpanzee)	VAMP5	XP_525803.3

Gene Ontology
Bibliography

Related articles in PubMed

Potential association of VAMP5 polymorphisms with total colonic aganglionosis in Hirschsprung disease.
Shin JG, Kim DY, Seo JM, Oh JT, Park KW, Kim HY, Park BL, Kim JH, Shin HD
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society28(7)1055-63(2016 Jul)

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Kote-Jarai Z, Olama AA, Giles GG, Severi G, Schleutker J, Weischer M, Campa D, Riboli E, Key T, Gronberg H, Hunter DJ, Kraft P, Thun MJ, Ingles S, Chanock S, Albanes D, Hayes RB, Neal DE, Hamdy FC, Donovan JL, Pharoah P, Schumacher F, Henderson BE, Stanford JL, Ostrander EA, Sorensen KD, D?rk T, Andriole G, Dickinson JL, Cybulski C, Lubinski J, Spurdle A, Clements JA, Chambers S, Aitken J, Gardiner RA, Thibodeau SN, Schaid D, John EM, Maier C, Vogel W, Cooney KA, Park JY, Cannon-Albright L, Brenner H, Habuchi T, Zhang HW, Lu YJ, Kaneva R, Muir K, Benlloch S, Leongamornlert DA, Saunders EJ, Tymrakiewicz M, Mahmud N, Guy M, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English DR, Wahlfors T, Tammela TL, Klarskov P, Nordestgaard BG, R?der MA, Tybj?rg-Hansen A, Bojesen SE, Travis R, Canzian F, Kaaks R, Wiklund F, Aly M, Lindstrom S, Diver WR, Gapstur S, Stern MC, Corral R, Virtamo J, Cox A, Haiman CA, Le Marchand L, Fitzgerald L, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Meyer A, Serth J, Yeager M, Berndt SI, Marthick JR, Patterson B, Wokolorczyk D, Batra J, Lose F, McDonnell SK, Joshi AD, Shahabi A, Rinckleb AE, Ray A, Sellers TA, Lin HY, Stephenson RA, Farnham J, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V, Easton DF, Eeles RA, , ,
Nature genetics43(8)785-91(2011 Jul)

Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception.
Hasan N, Corbin D, Hu C
PloS one5(12)e14238(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings indicate that VAMP5 and VAMP8 are not involved in POAG in the Dutch population.
Title: VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma.

The following VAMP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VAMP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31014	NM_006634.3 Latest version!	Homo sapiens vesicle associated membrane protein 5 (VAMP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31014	NM_006634.2	Homo sapiens vesicle associated membrane protein 5 (VAMP5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VAMP5 ( NM_006634.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006625.1 Homo sapiens vesicle associated membrane protein 5 (VAMP5), mRNA.

Price & Availability↑

CloneID	OHu31014
Clone ID Related Accession (Same CDS sequence)	NM_006634.2 , NM_006634.3
Accession Version	NM_006634.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	vesicle-associated membrane protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC017891.1. On Jun 9, 2003 this sequence version replaced NM_006634.1. ##Evidence-Data-START## Transcript exon combination :: BC017891.1, SRR1163657.173055.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGGAA TAGAGTTGGA GCGGTGCCAG CAGCAGGCGA ACGAGGTGAC GGAAATTATG 
CGTAACAACT TCGGCAAGGT CCTGGAGCGT GGTGTGAAGC TGGCCGAACT GCAGCAGCGT 
TCAGACCAAC TCCTGGATAT GAGCTCAACC TTCAACAAGA CTACACAGAA CCTGGCCCAG 
AAGAAGTGCT GGGAGAACAT CCGTTACCGG ATCTGCGTGG GGCTGGTGGT GGTTGGTGTC 
CTGCTCATCA TCCTGATTGT GCTGCTGGTC GTCTTTCTCC CTCAGAGCAG TGACAGCAGT 
AGTGCCCCAC GGACCCAGGA TGCAGGCATT GCCTCAGGGC CTGGGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006625.1
CDS	84..434
Translation	MAGIELERCQQQANEVTEIMRNNFGKVLERGVKLAELQQRSDQLLDMSSTFNKTTQNLAQKKCWENIRYRICVGLVVVGVLLIILIVLLVVFLPQSSDSSSAPRTQDAGIASGPGN

Target ORF information:

RefSeq Version	NM_006634.2
Organism	Homo sapiens(human)
Definition	Homo sapiens vesicle associated membrane protein 5 (VAMP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006634.2

ORF Insert Sequence:

ATGGCAGGAA TAGAGTTGGA GCGGTGCCAG CAGCAGGCGA ACGAGGTGAC GGAAATTATG 
CGTAACAACT TCGGCAAGGT CCTGGAGCGT GGTGTGAAGC TGGCCGAACT GCAGCAGCGT 
TCAGACCAAC TCCTGGATAT GAGCTCAACC TTCAACAAGA CTACACAGAA CCTGGCCCAG 
AAGAAGTGCT GGGAGAACAT CCGTTACCGG ATCTGCGTGG GGCTGGTGGT GGTTGGTGTC 
CTGCTCATCA TCCTGATTGT GCTGCTGGTC GTCTTTCTCC CTCAGAGCAG TGACAGCAGT 
AGTGCCCCAC GGACCCAGGA TGCAGGCATT GCCTCAGGGC CTGGGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VAMP5 ( NM_006634.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006625.1 Homo sapiens vesicle associated membrane protein 5 (VAMP5), mRNA.

Price & Availability↑

CloneID	OHu31014
Clone ID Related Accession (Same CDS sequence)	NM_006634.2 , NM_006634.3
Accession Version	NM_006634.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	vesicle-associated membrane protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC017891.1 and AC016753.9. On Nov 23, 2018 this sequence version replaced NM_006634.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.541171.1, BC017891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000306384.5/ ENSP00000305647.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGGAA TAGAGTTGGA GCGGTGCCAG CAGCAGGCGA ACGAGGTGAC GGAAATTATG 
CGTAACAACT TCGGCAAGGT CCTGGAGCGT GGTGTGAAGC TGGCCGAACT GCAGCAGCGT 
TCAGACCAAC TCCTGGATAT GAGCTCAACC TTCAACAAGA CTACACAGAA CCTGGCCCAG 
AAGAAGTGCT GGGAGAACAT CCGTTACCGG ATCTGCGTGG GGCTGGTGGT GGTTGGTGTC 
CTGCTCATCA TCCTGATTGT GCTGCTGGTC GTCTTTCTCC CTCAGAGCAG TGACAGCAGT 
AGTGCCCCAC GGACCCAGGA TGCAGGCATT GCCTCAGGGC CTGGGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006625.1
CDS	61..411
Translation	MAGIELERCQQQANEVTEIMRNNFGKVLERGVKLAELQQRSDQLLDMSSTFNKTTQNLAQKKCWENIRYRICVGLVVVGVLLIILIVLLVVFLPQSSDSSSAPRTQDAGIASGPGN

Target ORF information:

RefSeq Version	NM_006634.3
Organism	Homo sapiens(human)
Definition	Homo sapiens vesicle associated membrane protein 5 (VAMP5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006634.3

ORF Insert Sequence:

ATGGCAGGAA TAGAGTTGGA GCGGTGCCAG CAGCAGGCGA ACGAGGTGAC GGAAATTATG 
CGTAACAACT TCGGCAAGGT CCTGGAGCGT GGTGTGAAGC TGGCCGAACT GCAGCAGCGT 
TCAGACCAAC TCCTGGATAT GAGCTCAACC TTCAACAAGA CTACACAGAA CCTGGCCCAG 
AAGAAGTGCT GGGAGAACAT CCGTTACCGG ATCTGCGTGG GGCTGGTGGT GGTTGGTGTC 
CTGCTCATCA TCCTGATTGT GCTGCTGGTC GTCTTTCTCC CTCAGAGCAG TGACAGCAGT 
AGTGCCCCAC GGACCCAGGA TGCAGGCATT GCCTCAGGGC CTGGGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Potential association of VAMP5 polymorphisms with total colonic aganglionosis in Hirschsprung disease.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society28(7)1055-63(2016 Jul)
Shin JG,Kim DY,Seo JM,Oh JT,Park KW,Kim HY,Park BL,Kim JH,Shin HD

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nature genetics43(8)785-91(2011 Jul)
Kote-Jarai Z,Olama AA,Giles GG,Severi G,Schleutker J,Weischer M,Campa D,Riboli E,Key T,Gronberg H,Hunter DJ,Kraft P,Thun MJ,Ingles S,Chanock S,Albanes D,Hayes RB,Neal DE,Hamdy FC,Donovan JL,Pharoah P,Schumacher F,Henderson BE,Stanford JL,Ostrander EA,Sorensen KD,D?rk T,Andriole G,Dickinson JL,Cybulski C,Lubinski J,Spurdle A,Clements JA,Chambers S,Aitken J,Gardiner RA,Thibodeau SN,Schaid D,John EM,Maier C,Vogel W,Cooney KA,Park JY,Cannon-Albright L,Brenner H,Habuchi T,Zhang HW,Lu YJ,Kaneva R,Muir K,Benlloch S,Leongamornlert DA,Saunders EJ,Tymrakiewicz M,Mahmud N,Guy M,O'Brien LT,Wilkinson RA,Hall AL,Sawyer EJ,Dadaev T,Morrison J,Dearnaley DP,Horwich A,Huddart RA,Khoo VS,Parker CC,Van As N,Woodhouse CJ,Thompson A,Christmas T,Ogden C,Cooper CS,Lophatonanon A,Southey MC,Hopper JL,English DR,Wahlfors T,Tammela TL,Klarskov P,Nordestgaard BG,R?der MA,Tybj?rg-Hansen A,Bojesen SE,Travis R,Canzian F,Kaaks R,Wiklund F,Aly M,Lindstrom S,Diver WR,Gapstur S,Stern MC,Corral R,Virtamo J,Cox A,Haiman CA,Le Marchand L,Fitzgerald L,Kolb S,Kwon EM,Karyadi DM,Orntoft TF,Borre M,Meyer A,Serth J,Yeager M,Berndt SI,Marthick JR,Patterson B,Wokolorczyk D,Batra J,Lose F,McDonnell SK,Joshi AD,Shahabi A,Rinckleb AE,Ray A,Sellers TA,Lin HY,Stephenson RA,Farnham J,Muller H,Rothenbacher D,Tsuchiya N,Narita S,Cao GW,Slavov C,Mitev V,Easton DF,Eeles RA,,,

Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception.
PloS one5(12)e14238(2010 Dec)
Hasan N,Corbin D,Hu C