PMVK cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PMVK
Entrez Gene ID	10654
Full Name	phosphomevalonate kinase
Synonyms	HUMPMKI,PMK,PMKA,PMKASE,POROK1
General protein information	Preferred Names phosphomevalonate kinase Names phosphomevalonate kinase testis tissue sperm-binding protein Li 95mP
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
Disorder MIM:	607622
Disorder Html:	Porokeratosis 1, multiple types, 175800 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006556.4	NP_006547.1	phosphomevalonate kinase isoform 1
NM_006556.3	NP_006547.1	phosphomevalonate kinase isoform 1
NM_001323011.3	NP_001309940.1	phosphomevalonate kinase isoform 2
NM_001323011.2	NP_001309940.1	phosphomevalonate kinase isoform 2
NM_001348696.1	NP_001335625.1	phosphomevalonate kinase isoform 4
NM_001323012.2	NP_001309941.1	phosphomevalonate kinase isoform 3
NM_001323012.3	NP_001309941.1	phosphomevalonate kinase isoform 3
NM_001348696.2	NP_001335625.1	phosphomevalonate kinase isoform 4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PMVK	XP_855082.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000338	XP_310779.4
Homo sapiens (human)	PMVK	NP_006547.1
Pan troglodytes (chimpanzee)	PMVK	XP_513842.3
Rattus norvegicus (Norway rat)	Pmvk	NP_001008353.1
Danio rerio (zebrafish)	pmvk	NP_001077048.1
Drosophila melanogaster (fruit fly)	CG10268	NP_609992.1
Bos taurus (cattle)	PMVK	NP_001039616.1
	PMVK	XP_001114509.1
Mus musculus (house mouse)	Pmvk	NP_081060.2
Gallus gallus (chicken)	PMVK	XP_004948319.1
Caenorhabditis elegans (roundworm)	F32D8.13	NP_001256276.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis.
Wang J, Liu Y, Liu F, Huang C, Han S, Lv Y, Liu CJ, Zhang S, Qin Y, Ling L, Gao M, Yu S, Li C, Huang M, Liao S, Hu X, Lu Z, Liu X, Jiang T, Tang Z, Zhang H, Guo AY, Liu M
Scientific reports624226(2016 Apr)

Genomic variations of the mevalonate pathway in porokeratosis.
Zhang Z, Li C, Wu F, Ma R, Luan J, Yang F, Liu W, Wang L, Zhang S, Liu Y, Gu J, Hua W, Fan M, Peng H, Meng X, Song N, Bi X, Gu C, Zhang Z, Huang Q, Chen L, Xiang L, Xu J, Zheng Z, Jiang Z
eLife4e06322(2015 Jul)

Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase.
Boonsri P, Neumann TS, Olson AL, Cai S, Herdendorf TJ, Miziorko HM, Hannongbua S, Sem DS
Biochemical and biophysical research communications430(1)313-9(2013 Jan)

Enzymes of the mevalonate pathway of isoprenoid biosynthesis.
Miziorko HM
Archives of biochemistry and biophysics505(2)131-43(2011 Jan)

Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism.
Olson AL, Yao H, Herdendorf TJ, Miziorko HM, Hannongbua S, Saparpakorn P, Cai S, Sem DS
Proteins75(1)127-38(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that exome sequencing revealed disseminated superficial porokeratosis (DSP)-associated mutations in phosphomevalonate kinase gene (PMVK).
Title: Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Binding of mevalonate 5-phosphate causes the phosphomevalonate kinase structure to compress (tau(c) = 13.5 nsec), whereas subsequent binding of Mg-ADP opens the structure up (tau(c) = 15.6 nsec).
Title: Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism.

Observational study of gene-disease association. (HuGE Navigator)
Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

The following PMVK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PMVK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25006	NM_006556.4 Latest version!	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu102164	NM_001323012.3 Latest version!	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu64228	NM_001323011.3 Latest version!	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu102215	NM_001348696.2 Latest version!	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu25006	NM_006556.3	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu64228	NM_001323011.2	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu102164	NM_001323012.2	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu102215	NM_001348696.1	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PMVK ( NM_006556.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006547.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25006
Clone ID Related Accession (Same CDS sequence)	NM_006556.4 , NM_006556.3
Accession Version	NM_006556.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007694.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006556.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.65833.1, BC007694.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368467.4/ ENSP00000357452.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCCGC TGGGAGGCGC CCCGCGGCTG GTACTGCTGT TCAGCGGCAA GAGGAAATCC 
GGGAAGGACT TCGTGACCGA GGCGCTGCAG AGCAGACTTG GAGCTGATGT CTGTGCTGTC 
CTCCGGCTCT CTGGTCCACT CAAGGAACAG TATGCTCAGG AGCATGGCTT GAACTTCCAG 
AGACTCCTGG ACACCAGCAC CTACAAGGAG GCCTTTCGGA AGGACATGAT CCGCTGGGGA 
GAGGAGAAAC GCCAGGCTGA CCCAGGCTTC TTTTGCAGGA AGATTGTGGA GGGCATCTCC 
CAGCCCATCT GGCTGGTGAG TGACACACGG AGAGTGTCTG ACATCCAGTG GTTTCGGGAG 
GCCTATGGGG CCGTGACGCA GACGGTCCGC GTTGTAGCGT TGGAGCAGAG CCGACAGCAG 
CGGGGCTGGG TGTTCACGCC AGGGGTGGAC GATGCTGAGT CAGAATGTGG CCTGGACAAC 
TTCGGGGACT TTGACTGGGT CATCGAGAAC CATGGAGTTG AACAGCGCCT GGAGGAGCAG 
TTGGAGAACC TGATAGAATT TATCCGCTCC AGACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006547.1
CDS	35..613
Translation	MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_006556.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006556.4

ORF Insert Sequence:

ATGGCCCCGC TGGGAGGCGC CCCGCGGCTG GTACTGCTGT TCAGCGGCAA GAGGAAATCC 
GGGAAGGACT TCGTGACCGA GGCGCTGCAG AGCAGACTTG GAGCTGATGT CTGTGCTGTC 
CTCCGGCTCT CTGGTCCACT CAAGGAACAG TATGCTCAGG AGCATGGCTT GAACTTCCAG 
AGACTCCTGG ACACCAGCAC CTACAAGGAG GCCTTTCGGA AGGACATGAT CCGCTGGGGA 
GAGGAGAAAC GCCAGGCTGA CCCAGGCTTC TTTTGCAGGA AGATTGTGGA GGGCATCTCC 
CAGCCCATCT GGCTGGTGAG TGACACACGG AGAGTGTCTG ACATCCAGTG GTTTCGGGAG 
GCCTATGGGG CCGTGACGCA GACGGTCCGC GTTGTAGCGT TGGAGCAGAG CCGACAGCAG 
CGGGGCTGGG TGTTCACGCC AGGGGTGGAC GATGCTGAGT CAGAATGTGG CCTGGACAAC 
TTCGGGGACT TTGACTGGGT CATCGAGAAC CATGGAGTTG AACAGCGCCT GGAGGAGCAG 
TTGGAGAACC TGATAGAATT TATCCGCTCC AGACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMVK ( NM_006556.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006547.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25006
Clone ID Related Accession (Same CDS sequence)	NM_006556.4 , NM_006556.3
Accession Version	NM_006556.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ061044.1, BC007694.2 and BF221848.1. This sequence is a reference standard in the RefSeqGene project. On Oct 7, 2006 this sequence version replaced NM_006556.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005718.1, BC006089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCGC TGGGAGGCGC CCCGCGGCTG GTACTGCTGT TCAGCGGCAA GAGGAAATCC 
GGGAAGGACT TCGTGACCGA GGCGCTGCAG AGCAGACTTG GAGCTGATGT CTGTGCTGTC 
CTCCGGCTCT CTGGTCCACT CAAGGAACAG TATGCTCAGG AGCATGGCTT GAACTTCCAG 
AGACTCCTGG ACACCAGCAC CTACAAGGAG GCCTTTCGGA AGGACATGAT CCGCTGGGGA 
GAGGAGAAAC GCCAGGCTGA CCCAGGCTTC TTTTGCAGGA AGATTGTGGA GGGCATCTCC 
CAGCCCATCT GGCTGGTGAG TGACACACGG AGAGTGTCTG ACATCCAGTG GTTTCGGGAG 
GCCTATGGGG CCGTGACGCA GACGGTCCGC GTTGTAGCGT TGGAGCAGAG CCGACAGCAG 
CGGGGCTGGG TGTTCACGCC AGGGGTGGAC GATGCTGAGT CAGAATGTGG CCTGGACAAC 
TTCGGGGACT TTGACTGGGT CATCGAGAAC CATGGAGTTG AACAGCGCCT GGAGGAGCAG 
TTGGAGAACC TGATAGAATT TATCCGCTCC AGACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006547.1
CDS	324..902
Translation	MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_006556.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006556.3

ORF Insert Sequence:

ATGGCCCCGC TGGGAGGCGC CCCGCGGCTG GTACTGCTGT TCAGCGGCAA GAGGAAATCC 
GGGAAGGACT TCGTGACCGA GGCGCTGCAG AGCAGACTTG GAGCTGATGT CTGTGCTGTC 
CTCCGGCTCT CTGGTCCACT CAAGGAACAG TATGCTCAGG AGCATGGCTT GAACTTCCAG 
AGACTCCTGG ACACCAGCAC CTACAAGGAG GCCTTTCGGA AGGACATGAT CCGCTGGGGA 
GAGGAGAAAC GCCAGGCTGA CCCAGGCTTC TTTTGCAGGA AGATTGTGGA GGGCATCTCC 
CAGCCCATCT GGCTGGTGAG TGACACACGG AGAGTGTCTG ACATCCAGTG GTTTCGGGAG 
GCCTATGGGG CCGTGACGCA GACGGTCCGC GTTGTAGCGT TGGAGCAGAG CCGACAGCAG 
CGGGGCTGGG TGTTCACGCC AGGGGTGGAC GATGCTGAGT CAGAATGTGG CCTGGACAAC 
TTCGGGGACT TTGACTGGGT CATCGAGAAC CATGGAGTTG AACAGCGCCT GGAGGAGCAG 
TTGGAGAACC TGATAGAATT TATCCGCTCC AGACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMVK ( NM_001323012.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309941.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu102164
Clone ID Related Accession (Same CDS sequence)	NM_001323012.2 , NM_001323012.3
Accession Version	NM_001323012.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL451085.20, BQ057770.1 and HM005718.1. On Feb 12, 2017 this sequence version replaced NM_001323012.1. Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.556058.1, SRR1163658.571610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCGCT GGGGAGAGGA GAAACGCCAG GCTGACCCAG GCTTCTTTTG CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309941.1
CDS	245..598
Translation	MIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_001323012.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323012.2

ORF Insert Sequence:

ATGATCCGCT GGGGAGAGGA GAAACGCCAG GCTGACCCAG GCTTCTTTTG CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMVK ( NM_001323012.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309941.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu102164
Clone ID Related Accession (Same CDS sequence)	NM_001323012.2 , NM_001323012.3
Accession Version	NM_001323012.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL451085.20, BQ057770.1 and HM005718.1. On May 31, 2019 this sequence version replaced NM_001323012.2. Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.473123.1, SRR1163655.446494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCGCT GGGGAGAGGA GAAACGCCAG GCTGACCCAG GCTTCTTTTG CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309941.1
CDS	214..567
Translation	MIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_001323012.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323012.3

ORF Insert Sequence:

ATGATCCGCT GGGGAGAGGA GAAACGCCAG GCTGACCCAG GCTTCTTTTG CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMVK ( NM_001323011.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309940.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu64228
Clone ID Related Accession (Same CDS sequence)	NM_001323011.3 , NM_001323011.2
Accession Version	NM_001323011.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL451085.20, CN344384.1 and HM005718.1. On May 31, 2019 this sequence version replaced NM_001323011.2. Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.404686.1, SRR1163658.192048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCACCAT TACATAAAAC AGTAGTCTAC ACAGGCGAGC CTCAAAGAAG CAGACTTGGA 
GCTGATGTCT GTGCTGTCCT CCGGCTCTCT GGTCCACTCA AGGAACAGTA TGCTCAGGAG 
CATGGCTTGA ACTTCCAGAG ACTCCTGGAC ACCAGCACCT ACAAGGAGGC CTTTCGGAAG 
GACATGATCC GCTGGGGAGA GGAGAAACGC CAGGCTGACC CAGGCTTCTT TTGCAGGAAG 
ATTGTGGAGG GCATCTCCCA GCCCATCTGG CTGGTGAGTG ACACACGGAG AGTGTCTGAC 
ATCCAGTGGT TTCGGGAGGC CTATGGGGCC GTGACGCAGA CGGTCCGCGT TGTAGCGTTG 
GAGCAGAGCC GACAGCAGCG GGGCTGGGTG TTCACGCCAG GGGTGGACGA TGCTGAGTCA 
GAATGTGGCC TGGACAACTT CGGGGACTTT GACTGGGTCA TCGAGAACCA TGGAGTTGAA 
CAGCGCCTGG AGGAGCAGTT GGAGAACCTG ATAGAATTTA TCCGCTCCAG ACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309940.1
CDS	273..809
Translation	MPPLHKTVVYTGEPQRSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_001323011.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323011.3

ORF Insert Sequence:

ATGCCACCAT TACATAAAAC AGTAGTCTAC ACAGGCGAGC CTCAAAGAAG CAGACTTGGA 
GCTGATGTCT GTGCTGTCCT CCGGCTCTCT GGTCCACTCA AGGAACAGTA TGCTCAGGAG 
CATGGCTTGA ACTTCCAGAG ACTCCTGGAC ACCAGCACCT ACAAGGAGGC CTTTCGGAAG 
GACATGATCC GCTGGGGAGA GGAGAAACGC CAGGCTGACC CAGGCTTCTT TTGCAGGAAG 
ATTGTGGAGG GCATCTCCCA GCCCATCTGG CTGGTGAGTG ACACACGGAG AGTGTCTGAC 
ATCCAGTGGT TTCGGGAGGC CTATGGGGCC GTGACGCAGA CGGTCCGCGT TGTAGCGTTG 
GAGCAGAGCC GACAGCAGCG GGGCTGGGTG TTCACGCCAG GGGTGGACGA TGCTGAGTCA 
GAATGTGGCC TGGACAACTT CGGGGACTTT GACTGGGTCA TCGAGAACCA TGGAGTTGAA 
CAGCGCCTGG AGGAGCAGTT GGAGAACCTG ATAGAATTTA TCCGCTCCAG ACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMVK ( NM_001323011.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309940.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 2, mRNA.

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CloneID	OHu64228
Clone ID Related Accession (Same CDS sequence)	NM_001323011.3 , NM_001323011.2
Accession Version	NM_001323011.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL451085.20, CN344384.1 and HM005718.1. On Feb 12, 2017 this sequence version replaced NM_001323011.1. Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.192048.1, SRR1163657.404686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCACCAT TACATAAAAC AGTAGTCTAC ACAGGCGAGC CTCAAAGAAG CAGACTTGGA 
GCTGATGTCT GTGCTGTCCT CCGGCTCTCT GGTCCACTCA AGGAACAGTA TGCTCAGGAG 
CATGGCTTGA ACTTCCAGAG ACTCCTGGAC ACCAGCACCT ACAAGGAGGC CTTTCGGAAG 
GACATGATCC GCTGGGGAGA GGAGAAACGC CAGGCTGACC CAGGCTTCTT TTGCAGGAAG 
ATTGTGGAGG GCATCTCCCA GCCCATCTGG CTGGTGAGTG ACACACGGAG AGTGTCTGAC 
ATCCAGTGGT TTCGGGAGGC CTATGGGGCC GTGACGCAGA CGGTCCGCGT TGTAGCGTTG 
GAGCAGAGCC GACAGCAGCG GGGCTGGGTG TTCACGCCAG GGGTGGACGA TGCTGAGTCA 
GAATGTGGCC TGGACAACTT CGGGGACTTT GACTGGGTCA TCGAGAACCA TGGAGTTGAA 
CAGCGCCTGG AGGAGCAGTT GGAGAACCTG ATAGAATTTA TCCGCTCCAG ACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309940.1
CDS	187..723
Translation	MPPLHKTVVYTGEPQRSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_001323011.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001323011.2

ORF Insert Sequence:

ATGCCACCAT TACATAAAAC AGTAGTCTAC ACAGGCGAGC CTCAAAGAAG CAGACTTGGA 
GCTGATGTCT GTGCTGTCCT CCGGCTCTCT GGTCCACTCA AGGAACAGTA TGCTCAGGAG 
CATGGCTTGA ACTTCCAGAG ACTCCTGGAC ACCAGCACCT ACAAGGAGGC CTTTCGGAAG 
GACATGATCC GCTGGGGAGA GGAGAAACGC CAGGCTGACC CAGGCTTCTT TTGCAGGAAG 
ATTGTGGAGG GCATCTCCCA GCCCATCTGG CTGGTGAGTG ACACACGGAG AGTGTCTGAC 
ATCCAGTGGT TTCGGGAGGC CTATGGGGCC GTGACGCAGA CGGTCCGCGT TGTAGCGTTG 
GAGCAGAGCC GACAGCAGCG GGGCTGGGTG TTCACGCCAG GGGTGGACGA TGCTGAGTCA 
GAATGTGGCC TGGACAACTT CGGGGACTTT GACTGGGTCA TCGAGAACCA TGGAGTTGAA 
CAGCGCCTGG AGGAGCAGTT GGAGAACCTG ATAGAATTTA TCCGCTCCAG ACTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMVK ( NM_001348696.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335625.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu102215
Clone ID Related Accession (Same CDS sequence)	NM_001348696.1 , NM_001348696.2
Accession Version	NM_001348696.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HM005718.1, BM793483.1 and BQ057770.1. Transcript Variant: This variant (4) uses an alternate splice site in the coding region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279844.7075.1, BM793483.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTGC TGTCCTCCGG CTCTCTGGTC CACTCAAGGA ACAGTATGCT CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335625.1
CDS	430..783
Translation	MSVLSSGSLVHSRNSMLRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_001348696.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348696.1

ORF Insert Sequence:

ATGTCTGTGC TGTCCTCCGG CTCTCTGGTC CACTCAAGGA ACAGTATGCT CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMVK ( NM_001348696.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335625.1 Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu102215
Clone ID Related Accession (Same CDS sequence)	NM_001348696.1 , NM_001348696.2
Accession Version	NM_001348696.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	phosphomevalonate kinase isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HM005718.1, BM793483.1 and BQ057770.1. On May 31, 2019 this sequence version replaced NM_001348696.1. Transcript Variant: This variant (4) uses an alternate splice site in the coding region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279844.7075.1, BM793483.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTGC TGTCCTCCGG CTCTCTGGTC CACTCAAGGA ACAGTATGCT CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335625.1
CDS	141..494
Translation	MSVLSSGSLVHSRNSMLRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Target ORF information:

RefSeq Version	NM_001348696.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphomevalonate kinase (PMVK), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348696.2

ORF Insert Sequence:

ATGTCTGTGC TGTCCTCCGG CTCTCTGGTC CACTCAAGGA ACAGTATGCT CAGGAAGATT 
GTGGAGGGCA TCTCCCAGCC CATCTGGCTG GTGAGTGACA CACGGAGAGT GTCTGACATC 
CAGTGGTTTC GGGAGGCCTA TGGGGCCGTG ACGCAGACGG TCCGCGTTGT AGCGTTGGAG 
CAGAGCCGAC AGCAGCGGGG CTGGGTGTTC ACGCCAGGGG TGGACGATGC TGAGTCAGAA 
TGTGGCCTGG ACAACTTCGG GGACTTTGAC TGGGTCATCG AGAACCATGG AGTTGAACAG 
CGCCTGGAGG AGCAGTTGGA GAACCTGATA GAATTTATCC GCTCCAGACT TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis.
Scientific reports624226(2016 Apr)
Wang J,Liu Y,Liu F,Huang C,Han S,Lv Y,Liu CJ,Zhang S,Qin Y,Ling L,Gao M,Yu S,Li C,Huang M,Liao S,Hu X,Lu Z,Liu X,Jiang T,Tang Z,Zhang H,Guo AY,Liu M

Genomic variations of the mevalonate pathway in porokeratosis.
eLife4e06322(2015 Jul)
Zhang Z,Li C,Wu F,Ma R,Luan J,Yang F,Liu W,Wang L,Zhang S,Liu Y,Gu J,Hua W,Fan M,Peng H,Meng X,Song N,Bi X,Gu C,Zhang Z,Huang Q,Chen L,Xiang L,Xu J,Zheng Z,Jiang Z

Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase.
Biochemical and biophysical research communications430(1)313-9(2013 Jan)
Boonsri P,Neumann TS,Olson AL,Cai S,Herdendorf TJ,Miziorko HM,Hannongbua S,Sem DS

Enzymes of the mevalonate pathway of isoprenoid biosynthesis.
Archives of biochemistry and biophysics505(2)131-43(2011 Jan)
Miziorko HM

Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism.
Proteins75(1)127-38(2009 Apr)
Olson AL,Yao H,Herdendorf TJ,Miziorko HM,Hannongbua S,Saparpakorn P,Cai S,Sem DS

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PMVK cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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