ARPC1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARPC1A
Entrez Gene ID	10552
Full Name	actin related protein 2/3 complex subunit 1A
Synonyms	Arc40,HEL-68,HEL-S-307,SOP2Hs,SOP2L
General protein information	Preferred Names actin related protein 2/3 complex subunit 1A Names actin-related protein 2/3 complex subunit 1A SOP2-like protein actin binding protein (Schizosaccharomyces pombe sop2-like) actin related protein 2/3 complex, subunit 1A, 41kDa epididymis luminal protein 68 epididymis secretory protein Li 307
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Disorder MIM:	604220

mRNA and Protein(s)

mRNA	Protein	Name
NM_006409.4	NP_006400.2	actin-related protein 2/3 complex subunit 1A isoform 1
NM_006409.3	NP_006400.2	actin-related protein 2/3 complex subunit 1A isoform 1
NM_001190996.1	NP_001177925.1	actin-related protein 2/3 complex subunit 1A isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ARPC1A	XP_536873.3
Kluyveromyces lactis	KLLA0F10615g	XP_455563.1
Rattus norvegicus (Norway rat)	Arpc1a	NP_112408.1
Danio rerio (zebrafish)	arpc1a	NP_958500.1
Eremothecium gossypii	AGOS_AFL022W	NP_985526.1
Homo sapiens (human)	ARPC1A	NP_006400.2
Pan troglodytes (chimpanzee)	ARPC1A	XP_003318677.1
Mus musculus (house mouse)	Arpc1a	NP_062741.1
Drosophila melanogaster (fruit fly)	Arpc1	NP_476596.1
Neurospora crassa	NCU02781	XP_964276.1
Caenorhabditis elegans (roundworm)	arx-3	NP_499570.1
Saccharomyces cerevisiae (baker's yeast)	ARC40	NP_009793.1
Magnaporthe oryzae (rice blast fungus)	MGG_04352	XP_003713462.1
	LOC718635	XP_002808394.1
Bos taurus (cattle)	ARPC1A	NP_001068827.1
Gallus gallus (chicken)	ARPC1A	NP_001072963.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008908	XP_319655.2
Schizosaccharomyces pombe (fission yeast)	arc1	NP_595909.1

Gene Ontology
Bibliography

Related articles in PubMed

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
Zhai G, Teumer A, Stolk L, Perry JR, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J, Eriksson A, Ernst F, Ferrucci L, Frayling TM, Glass D, Grundberg E, Haring R, Hedman AK, Hofman A, Kiel DP, Kroemer HK, Liu Y, Lunetta KL, Maggio M, Lorentzon M, Mangino M, Melzer D, Miljkovic I, , Nica A, Penninx BW, Vasan RS, Rivadeneira F, Small KS, Soranzo N, Uitterlinden AG, V?lzke H, Wilson SG, Xi L, Zhuang WV, Harris TB, Murabito JM, Ohlsson C, Murray A, de Jong FH, Spector TD, Wallaschofski H
PLoS genetics7(4)e1002025(2011 Apr)

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, King L, Pressman S, Haritunians T, Guo X, Targan SR, Rotter JI,
Human molecular genetics19(17)3468-76(2010 Sep)

Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.
Laurila E, Savinainen K, Kuuselo R, Karhu R, Kallioniemi A
Genes, chromosomes & cancer48(4)330-9(2009 Apr)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.
Piepoli A, Gentile A, Valvano MR, Barana D, Oliani C, Cotugno R, Quitadamo M, Andriulli A, Perri F
World journal of gastroenterology12(39)6343-8(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.

data implicate ARPC1A as a novel target for the 7q21-q22 amplification and a regulator of cell migration and invasion in pancreatic cancer
Title: Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.

Observational study of gene-disease association. (HuGE Navigator)
Title: Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.

The following ARPC1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARPC1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09338	NM_006409.4 Latest version!	Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu09363	NM_001190996.1 Latest version!	Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu09338	NM_006409.3	Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARPC1A ( NM_006409.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006400.2 Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09338
Clone ID Related Accession (Same CDS sequence)	NM_006409.4 , NM_006409.3
Accession Version	NM_006409.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	actin-related protein 2/3 complex subunit 1A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA089818.1, BC039594.1 and BC054027.1. On Nov 23, 2018 this sequence version replaced NM_006409.3. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: EU668326.1, SRR5189652.73939.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262942.10/ ENSP00000262942.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCACTGC ATCAGTTTTT ACTAGAGCCA ATCACCTGTC ATGCCTGGAA CAGGGATCGT 
ACTCAGATTG CCCTCAGTCC CAATAATCAC GAAGTGCACA TCTATAAGAA GAACGGGAGC 
CAGTGGGTGA AAGCTCATGA ACTCAAGGAG CACAACGGAC ACATCACAGG TATTGACTGG 
GCTCCCAAGA GCGACCGCAT TGTCACTTGT GGGGCAGACC GCAATGCCTA TGTCTGGAGT 
CAGAAAGATG GTGTTTGGAA GCCAACCCTG GTGATCCTGA GAATTAATCG CGCAGCTACT 
TTTGTGAAGT GGTCCCCCCT AGAGAACAAA TTTGCTGTGG GAAGTGGAGC ACGACTCATT 
TCTGTTTGTT ACTTTGAGTC TGAAAATGAC TGGTGGGTGA GCAAGCACAT TAAAAAGCCG 
ATTCGCTCCA CAGTCCTCAG CTTGGATTGG CATCCCAACA ACGTTTTGCT GGCAGCAGGA 
TCATGTGACT TCAAATGCAG AGTGTTTTCT GCCTACATTA AAGAAGTGGA TGAAAAGCCA 
GCCAGCACGC CCTGGGGCAG CAAGATGCCT TTTGGGCAGC TGATGTCAGA GTTTGGTGGC 
AGTGGCACTG GTGGCTGGGT CCACGGGGTA AGCTTCTCTG CCAGTGGGAG CCGCCTGGCC 
TGGGTCAGCC ACGACAGCAC CGTGTCTGTT GCTGATGCCT CAAAAAGTGT GCAGGTCTCG 
ACTCTGAAGA CAGAGTTCCT GCCGCTCCTA AGTGTGTCAT TTGTCTCAGA GAACAGCGTC 
GTGGCTGCTG GCCATGACTG CTGCCCAATG CTCTTTAACT ACGATGACCG CGGCTGCCTG 
ACCTTCGTCT CCAAGTTAGA TATTCCAAAA CAGAGCATCC AACGCAACAT GTCTGCCATG 
GAACGCTTCC GCAACATGGA CAAGAGAGCC ACAACTGAGG ACCGCAACAC GGCCTTGGAG 
ACGCTGCACC AGAATAGCAT CACTCAAGTC TCTATTTATG AGGTGGACAA GCAAGATTGT 
CGCAAATTTT GCACTACTGG CATCGATGGA GCCATGACAA TTTGGGATTT CAAGACCCTC 
GAGTCTTCCA TCCAGGGCCT CCGGATAATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006400.2
CDS	137..1249
Translation	MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM

Target ORF information:

RefSeq Version	NM_006409.4
Organism	Homo sapiens(human)
Definition	Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006409.4

ORF Insert Sequence:

ATGTCACTGC ATCAGTTTTT ACTAGAGCCA ATCACCTGTC ATGCCTGGAA CAGGGATCGT 
ACTCAGATTG CCCTCAGTCC CAATAATCAC GAAGTGCACA TCTATAAGAA GAACGGGAGC 
CAGTGGGTGA AAGCTCATGA ACTCAAGGAG CACAACGGAC ACATCACAGG TATTGACTGG 
GCTCCCAAGA GCGACCGCAT TGTCACTTGT GGGGCAGACC GCAATGCCTA TGTCTGGAGT 
CAGAAAGATG GTGTTTGGAA GCCAACCCTG GTGATCCTGA GAATTAATCG CGCAGCTACT 
TTTGTGAAGT GGTCCCCCCT AGAGAACAAA TTTGCTGTGG GAAGTGGAGC ACGACTCATT 
TCTGTTTGTT ACTTTGAGTC TGAAAATGAC TGGTGGGTGA GCAAGCACAT TAAAAAGCCG 
ATTCGCTCCA CAGTCCTCAG CTTGGATTGG CATCCCAACA ACGTTTTGCT GGCAGCAGGA 
TCATGTGACT TCAAATGCAG AGTGTTTTCT GCCTACATTA AAGAAGTGGA TGAAAAGCCA 
GCCAGCACGC CCTGGGGCAG CAAGATGCCT TTTGGGCAGC TGATGTCAGA GTTTGGTGGC 
AGTGGCACTG GTGGCTGGGT CCACGGGGTA AGCTTCTCTG CCAGTGGGAG CCGCCTGGCC 
TGGGTCAGCC ACGACAGCAC CGTGTCTGTT GCTGATGCCT CAAAAAGTGT GCAGGTCTCG 
ACTCTGAAGA CAGAGTTCCT GCCGCTCCTA AGTGTGTCAT TTGTCTCAGA GAACAGCGTC 
GTGGCTGCTG GCCATGACTG CTGCCCAATG CTCTTTAACT ACGATGACCG CGGCTGCCTG 
ACCTTCGTCT CCAAGTTAGA TATTCCAAAA CAGAGCATCC AACGCAACAT GTCTGCCATG 
GAACGCTTCC GCAACATGGA CAAGAGAGCC ACAACTGAGG ACCGCAACAC GGCCTTGGAG 
ACGCTGCACC AGAATAGCAT CACTCAAGTC TCTATTTATG AGGTGGACAA GCAAGATTGT 
CGCAAATTTT GCACTACTGG CATCGATGGA GCCATGACAA TTTGGGATTT CAAGACCCTC 
GAGTCTTCCA TCCAGGGCCT CCGGATAATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARPC1A ( NM_006409.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006400.2 Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09338
Clone ID Related Accession (Same CDS sequence)	NM_006409.4 , NM_006409.3
Accession Version	NM_006409.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	actin-related protein 2/3 complex subunit 1A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA089818.1, BC039594.1 and BC054027.1. On Jul 9, 2010 this sequence version replaced NM_006409.2. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: EU668326.1, SRR1803613.14091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCACTGC ATCAGTTTTT ACTAGAGCCA ATCACCTGTC ATGCCTGGAA CAGGGATCGT 
ACTCAGATTG CCCTCAGTCC CAATAATCAC GAAGTGCACA TCTATAAGAA GAACGGGAGC 
CAGTGGGTGA AAGCTCATGA ACTCAAGGAG CACAACGGAC ACATCACAGG TATTGACTGG 
GCTCCCAAGA GCGACCGCAT TGTCACTTGT GGGGCAGACC GCAATGCCTA TGTCTGGAGT 
CAGAAAGATG GTGTTTGGAA GCCAACCCTG GTGATCCTGA GAATTAATCG CGCAGCTACT 
TTTGTGAAGT GGTCCCCCCT AGAGAACAAA TTTGCTGTGG GAAGTGGAGC ACGACTCATT 
TCTGTTTGTT ACTTTGAGTC TGAAAATGAC TGGTGGGTGA GCAAGCACAT TAAAAAGCCG 
ATTCGCTCCA CAGTCCTCAG CTTGGATTGG CATCCCAACA ACGTTTTGCT GGCAGCAGGA 
TCATGTGACT TCAAATGCAG AGTGTTTTCT GCCTACATTA AAGAAGTGGA TGAAAAGCCA 
GCCAGCACGC CCTGGGGCAG CAAGATGCCT TTTGGGCAGC TGATGTCAGA GTTTGGTGGC 
AGTGGCACTG GTGGCTGGGT CCACGGGGTA AGCTTCTCTG CCAGTGGGAG CCGCCTGGCC 
TGGGTCAGCC ACGACAGCAC CGTGTCTGTT GCTGATGCCT CAAAAAGTGT GCAGGTCTCG 
ACTCTGAAGA CAGAGTTCCT GCCGCTCCTA AGTGTGTCAT TTGTCTCAGA GAACAGCGTC 
GTGGCTGCTG GCCATGACTG CTGCCCAATG CTCTTTAACT ACGATGACCG CGGCTGCCTG 
ACCTTCGTCT CCAAGTTAGA TATTCCAAAA CAGAGCATCC AACGCAACAT GTCTGCCATG 
GAACGCTTCC GCAACATGGA CAAGAGAGCC ACAACTGAGG ACCGCAACAC GGCCTTGGAG 
ACGCTGCACC AGAATAGCAT CACTCAAGTC TCTATTTATG AGGTGGACAA GCAAGATTGT 
CGCAAATTTT GCACTACTGG CATCGATGGA GCCATGACAA TTTGGGATTT CAAGACCCTC 
GAGTCTTCCA TCCAGGGCCT CCGGATAATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006400.2
CDS	162..1274
Translation	MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM

Target ORF information:

RefSeq Version	NM_006409.3
Organism	Homo sapiens(human)
Definition	Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006409.3

ORF Insert Sequence:

ATGTCACTGC ATCAGTTTTT ACTAGAGCCA ATCACCTGTC ATGCCTGGAA CAGGGATCGT 
ACTCAGATTG CCCTCAGTCC CAATAATCAC GAAGTGCACA TCTATAAGAA GAACGGGAGC 
CAGTGGGTGA AAGCTCATGA ACTCAAGGAG CACAACGGAC ACATCACAGG TATTGACTGG 
GCTCCCAAGA GCGACCGCAT TGTCACTTGT GGGGCAGACC GCAATGCCTA TGTCTGGAGT 
CAGAAAGATG GTGTTTGGAA GCCAACCCTG GTGATCCTGA GAATTAATCG CGCAGCTACT 
TTTGTGAAGT GGTCCCCCCT AGAGAACAAA TTTGCTGTGG GAAGTGGAGC ACGACTCATT 
TCTGTTTGTT ACTTTGAGTC TGAAAATGAC TGGTGGGTGA GCAAGCACAT TAAAAAGCCG 
ATTCGCTCCA CAGTCCTCAG CTTGGATTGG CATCCCAACA ACGTTTTGCT GGCAGCAGGA 
TCATGTGACT TCAAATGCAG AGTGTTTTCT GCCTACATTA AAGAAGTGGA TGAAAAGCCA 
GCCAGCACGC CCTGGGGCAG CAAGATGCCT TTTGGGCAGC TGATGTCAGA GTTTGGTGGC 
AGTGGCACTG GTGGCTGGGT CCACGGGGTA AGCTTCTCTG CCAGTGGGAG CCGCCTGGCC 
TGGGTCAGCC ACGACAGCAC CGTGTCTGTT GCTGATGCCT CAAAAAGTGT GCAGGTCTCG 
ACTCTGAAGA CAGAGTTCCT GCCGCTCCTA AGTGTGTCAT TTGTCTCAGA GAACAGCGTC 
GTGGCTGCTG GCCATGACTG CTGCCCAATG CTCTTTAACT ACGATGACCG CGGCTGCCTG 
ACCTTCGTCT CCAAGTTAGA TATTCCAAAA CAGAGCATCC AACGCAACAT GTCTGCCATG 
GAACGCTTCC GCAACATGGA CAAGAGAGCC ACAACTGAGG ACCGCAACAC GGCCTTGGAG 
ACGCTGCACC AGAATAGCAT CACTCAAGTC TCTATTTATG AGGTGGACAA GCAAGATTGT 
CGCAAATTTT GCACTACTGG CATCGATGGA GCCATGACAA TTTGGGATTT CAAGACCCTC 
GAGTCTTCCA TCCAGGGCCT CCGGATAATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARPC1A ( NM_001190996.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177925.1 Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09363
Clone ID Related Accession (Same CDS sequence)	NM_001190996.1
Accession Version	NM_001190996.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	actin-related protein 2/3 complex subunit 1A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA089818.1 and BC006445.1. Transcript Variant: This variant (2) lacks 2 nts at an alternate splice site in the 5' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC006445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGGAA CAGGGATCGT ACTCATTGCC CTCAGTCCCA ATAATCACGA AGTGCACATC 
TATAAGAAGA ACGGGAGCCA GTGGGTGAAA GCTCATGAAC TCAAGGAGCA CAACGGACAC 
ATCACAGGTA TTGACTGGGC TCCCAAGAGC GACCGCATTG TCACTTGTGG GGCAGACCGC 
AATGCCTATG TCTGGAGTCA GAAAGATGGT GTTTGGAAGC CAACCCTGGT GATCCTGAGA 
ATTAATCGCG CAGCTACTTT TGTGAAGTGG TCCCCCCTAG AGAACAAATT TGCTGTGGGA 
AGTGGAGCAC GACTCATTTC TGTTTGTTAC TTTGAGTCTG AAAATGACTG GTGGGTGAGC 
AAGCACATTA AAAAGCCGAT TCGCTCCACA GTCCTCAGCT TGGATTGGCA TCCCAACAAC 
GTTTTGCTGG CAGCAGGATC ATGTGACTTC AAATGCAGAG TGTTTTCTGC CTACATTAAA 
GAAGTGGATG AAAAGCCAGC CAGCACGCCC TGGGGCAGCA AGATGCCTTT TGGGCAGCTG 
ATGTCAGAGT TTGGTGGCAG TGGCACTGGT GGCTGGGTCC ACGGGGTAAG CTTCTCTGCC 
AGTGGGAGCC GCCTGGCCTG GGTCAGCCAC GACAGCACCG TGTCTGTTGC TGATGCCTCA 
AAAAGTGTGC AGGTCTCGAC TCTGAAGACA GAGTTCCTGC CGCTCCTAAG TGTGTCATTT 
GTCTCAGAGA ACAGCGTCGT GGCTGCTGGC CATGACTGCT GCCCAATGCT CTTTAACTAC 
GATGACCGCG GCTGCCTGAC CTTCGTCTCC AAGTTAGATA TTCCAAAACA GAGCATCCAA 
CGCAACATGT CTGCCATGGA ACGCTTCCGC AACATGGACA AGAGAGCCAC AACTGAGGAC 
CGCAACACGG CCTTGGAGAC GCTGCACCAG AATAGCATCA CTCAAGTCTC TATTTATGAG 
GTGGACAAGC AAGATTGTCG CAAATTTTGC ACTACTGGCA TCGATGGAGC CATGACAATT 
TGGGATTTCA AGACCCTCGA GTCTTCCATC CAGGGCCTCC GGATAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177925.1
CDS	202..1272
Translation	MPGTGIVLIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM

Target ORF information:

RefSeq Version	NM_001190996.1
Organism	Homo sapiens(human)
Definition	Homo sapiens actin related protein 2/3 complex subunit 1A (ARPC1A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190996.1

ORF Insert Sequence:

ATGCCTGGAA CAGGGATCGT ACTCATTGCC CTCAGTCCCA ATAATCACGA AGTGCACATC 
TATAAGAAGA ACGGGAGCCA GTGGGTGAAA GCTCATGAAC TCAAGGAGCA CAACGGACAC 
ATCACAGGTA TTGACTGGGC TCCCAAGAGC GACCGCATTG TCACTTGTGG GGCAGACCGC 
AATGCCTATG TCTGGAGTCA GAAAGATGGT GTTTGGAAGC CAACCCTGGT GATCCTGAGA 
ATTAATCGCG CAGCTACTTT TGTGAAGTGG TCCCCCCTAG AGAACAAATT TGCTGTGGGA 
AGTGGAGCAC GACTCATTTC TGTTTGTTAC TTTGAGTCTG AAAATGACTG GTGGGTGAGC 
AAGCACATTA AAAAGCCGAT TCGCTCCACA GTCCTCAGCT TGGATTGGCA TCCCAACAAC 
GTTTTGCTGG CAGCAGGATC ATGTGACTTC AAATGCAGAG TGTTTTCTGC CTACATTAAA 
GAAGTGGATG AAAAGCCAGC CAGCACGCCC TGGGGCAGCA AGATGCCTTT TGGGCAGCTG 
ATGTCAGAGT TTGGTGGCAG TGGCACTGGT GGCTGGGTCC ACGGGGTAAG CTTCTCTGCC 
AGTGGGAGCC GCCTGGCCTG GGTCAGCCAC GACAGCACCG TGTCTGTTGC TGATGCCTCA 
AAAAGTGTGC AGGTCTCGAC TCTGAAGACA GAGTTCCTGC CGCTCCTAAG TGTGTCATTT 
GTCTCAGAGA ACAGCGTCGT GGCTGCTGGC CATGACTGCT GCCCAATGCT CTTTAACTAC 
GATGACCGCG GCTGCCTGAC CTTCGTCTCC AAGTTAGATA TTCCAAAACA GAGCATCCAA 
CGCAACATGT CTGCCATGGA ACGCTTCCGC AACATGGACA AGAGAGCCAC AACTGAGGAC 
CGCAACACGG CCTTGGAGAC GCTGCACCAG AATAGCATCA CTCAAGTCTC TATTTATGAG 
GTGGACAAGC AAGATTGTCG CAAATTTTGC ACTACTGGCA TCGATGGAGC CATGACAATT 
TGGGATTTCA AGACCCTCGA GTCTTCCATC CAGGGCCTCC GGATAATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
PLoS genetics7(4)e1002025(2011 Apr)
Zhai G,Teumer A,Stolk L,Perry JR,Vandenput L,Coviello AD,Koster A,Bell JT,Bhasin S,Eriksson J,Eriksson A,Ernst F,Ferrucci L,Frayling TM,Glass D,Grundberg E,Haring R,Hedman AK,Hofman A,Kiel DP,Kroemer HK,Liu Y,Lunetta KL,Maggio M,Lorentzon M,Mangino M,Melzer D,Miljkovic I,,Nica A,Penninx BW,Vasan RS,Rivadeneira F,Small KS,Soranzo N,Uitterlinden AG,V?lzke H,Wilson SG,Xi L,Zhuang WV,Harris TB,Murabito JM,Ohlsson C,Murray A,de Jong FH,Spector TD,Wallaschofski H

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
Human molecular genetics19(17)3468-76(2010 Sep)
McGovern DP,Jones MR,Taylor KD,Marciante K,Yan X,Dubinsky M,Ippoliti A,Vasiliauskas E,Berel D,Derkowski C,Dutridge D,Fleshner P,Shih DQ,Melmed G,Mengesha E,King L,Pressman S,Haritunians T,Guo X,Targan SR,Rotter JI,

Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.
Genes, chromosomes & cancer48(4)330-9(2009 Apr)
Laurila E,Savinainen K,Kuuselo R,Karhu R,Kallioniemi A

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.
World journal of gastroenterology12(39)6343-8(2006 Oct)
Piepoli A,Gentile A,Valvano MR,Barana D,Oliani C,Cotugno R,Quitadamo M,Andriulli A,Perri F

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ARPC1A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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