ANP32B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANP32B
Entrez Gene ID	10541
Full Name	acidic nuclear phosphoprotein 32 family member B
Synonyms	APRIL,PHAPI2,SSP29
General protein information	Preferred Names acidic nuclear phosphoprotein 32 family member B Names acidic leucine-rich nuclear phosphoprotein 32 family member B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B acidic protein rich in leucines putative HLA-DR-associated protein I-2 silver-stainable protein SSP29
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q22.33

mRNA and Protein(s)

mRNA	Protein	Name
NM_006401.2	NP_006392.1	acidic leucine-rich nuclear phosphoprotein 32 family member B
NM_006401.3	NP_006392.1	acidic leucine-rich nuclear phosphoprotein 32 family member B

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANP32B	NP_006392.1
	ANP32B	XP_001113699.1
Canis lupus familiaris (dog)	ANP32B	XP_532006.3
Bos taurus (cattle)	ANP32B	NP_001030246.1
Danio rerio (zebrafish)	anp32b	NP_997768.2
Pan troglodytes (chimpanzee)	ANP32B	XP_001156957.1
Xenopus tropicalis (tropical clawed frog)	anp32b	NP_001025567.1

Gene Ontology
Bibliography

Related articles in PubMed

Prothymosin ? interacts with SET, ANP32A and ANP32B and other cytoplasmic and mitochondrial proteins in proliferating cells.
Barbeito P, Sarandeses CS, D?az-Jullien C, Muras J, Covelo G, Moreira D, Freire-Cobo C, Freire M
Archives of biochemistry and biophysics63574-86(2017 Dec)

Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma.
Ohno Y, Koizumi M, Nakayama H, Watanabe T, Hirooka M, Tokumoto Y, Kuroda T, Abe M, Fukuda S, Higashiyama S, Kumagi T, Hiasa Y
PloS one12(5)e0177343(2017)

Caspase-3-resistant uncleavable form of acidic leucine-rich nuclear phosphoprotein 32B potentiates leukemic cell apoptosis.
Li CX, Shen SM, Wang LS, Yu Y
Molecular medicine reports11(4)2813-8(2015 Apr)

ANP32B is a nuclear target of henipavirus M proteins.
Bauer A, Neumann S, Karger A, Henning AK, Maisner A, Lamp B, Dietzel E, Kwasnitschka L, Balkema-Buschmann A, Keil GM, Finke S
PloS one9(5)e97233(2014)

Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
Malinowski JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D, Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo IJ, Chute CG, Chisholm RL, Jarvik GP, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M, Ritchie MD, Crawford DC
PloS one9(12)e111301(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

According to the cellular function of the characterized targets of ProTalpha, and the evolution in the composition of the diverse ProTalpha-complexes when proliferation activity was reduced or apoptosis induced, leads to hypothesized that ProTalpha interactions might be related to the proliferation activity and control of the cell survival.
Title: Prothymosin ? interacts with SET, ANP32A and ANP32B and other cytoplasmic and mitochondrial proteins in proliferating cells.

ANP32B modulates Bad phosphorylation as well as Bak and Bax expression, resulting in regulation of apoptosis in HCC. These findings indicate the potential value of ANP32B as a therapeutic target for HCC
Title: Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma.

Caspase-3-resistant uncleavable form of acidic leucine-rich nuclear phosphoprotein 32B potentiates leukemic cell apoptosis.
Title: Caspase-3-resistant uncleavable form of acidic leucine-rich nuclear phosphoprotein 32B potentiates leukemic cell apoptosis.

ANP32B is a nuclear target of henipavirus M proteins.
Title: ANP32B is a nuclear target of henipavirus M proteins.

this is the first demonstration that ANP32B expression was down-regulated during differentiation induction of leukemic cells by all-trans retinoic acid.
Title: Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) contributes to retinoic acid-induced differentiation of leukemic cells.

The following ANP32B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANP32B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05512	NM_006401.3 Latest version!	Homo sapiens acidic nuclear phosphoprotein 32 family member B (ANP32B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05512	NM_006401.2	Homo sapiens acidic nuclear phosphoprotein 32 family member B (ANP32B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANP32B ( NM_006401.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006392.1 Homo sapiens acidic nuclear phosphoprotein 32 family member B (ANP32B), mRNA.

Price & Availability↑

CloneID	OHu05512
Clone ID Related Accession (Same CDS sequence)	NM_006401.2 , NM_006401.3
Accession Version	NM_006401.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	acidic leucine-rich nuclear phosphoprotein 32 family member B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW296974.1, BC019658.1 and BP395780.1. On Dec 6, 2006 this sequence version replaced NM_006401.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.139483.1, SRR1163655.23425.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGACATGA AGAGGAGGAT CCACCTGGAG CTGAGGAACC GGACCCCGGC AGCTGTTCGA 
GAACTTGTCT TGGACAATTG CAAATCAAAT GATGGAAAAA TTGAGGGCTT AACAGCTGAA 
TTTGTGAACT TAGAGTTCCT CAGTTTAATA AATGTAGGCT TGATCTCAGT TTCAAATCTC 
CCCAAGCTGC CTAAATTGAA AAAGCTTGAA CTCAGTGAAA ATAGAATCTT TGGAGGTCTG 
GACATGTTAG CTGAAAAACT TCCAAATCTC ACACATCTAA ACTTAAGTGG AAATAAACTG 
AAAGATATCA GCACCTTGGA ACCTTTGAAA AAGTTAGAAT GTCTGAAAAG CCTGGACCTC 
TTTAACTGTG AGGTTACCAA CCTGAATGAC TACCGAGAGA GTGTCTTCAA GCTCCTGCCC 
CAGCTTACCT ACTTGGATGG CTATGACCGA GAGGACCAGG AAGCACCTGA CTCAGATGCC 
GAGGTGGATG GTGTGGATGA AGAGGAGGAG GACGAAGAAG GAGAAGATGA GGAAGACGAG 
GACGATGAGG ATGGTGAAGA AGAGGAGTTT GATGAAGAAG ATGATGAAGA TGAAGATGTA 
GAAGGGGATG AGGACGACGA TGAAGTCAGT GAGGAGGAAG AAGAATTTGG ACTTGATGAA 
GAAGATGAAG ATGAGGATGA GGATGAAGAG GAGGAAGAAG GTGGGAAAGG TGAAAAGAGG 
AAGAGAGAAA CAGATGATGA AGGAGAAGAT GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006392.1
CDS	350..1105
Translation	MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEEGGKGEKRKRETDDEGEDD

Target ORF information:

RefSeq Version	NM_006401.2
Organism	Homo sapiens(human)
Definition	Homo sapiens acidic nuclear phosphoprotein 32 family member B (ANP32B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006401.2

ORF Insert Sequence:

ATGGACATGA AGAGGAGGAT CCACCTGGAG CTGAGGAACC GGACCCCGGC AGCTGTTCGA 
GAACTTGTCT TGGACAATTG CAAATCAAAT GATGGAAAAA TTGAGGGCTT AACAGCTGAA 
TTTGTGAACT TAGAGTTCCT CAGTTTAATA AATGTAGGCT TGATCTCAGT TTCAAATCTC 
CCCAAGCTGC CTAAATTGAA AAAGCTTGAA CTCAGTGAAA ATAGAATCTT TGGAGGTCTG 
GACATGTTAG CTGAAAAACT TCCAAATCTC ACACATCTAA ACTTAAGTGG AAATAAACTG 
AAAGATATCA GCACCTTGGA ACCTTTGAAA AAGTTAGAAT GTCTGAAAAG CCTGGACCTC 
TTTAACTGTG AGGTTACCAA CCTGAATGAC TACCGAGAGA GTGTCTTCAA GCTCCTGCCC 
CAGCTTACCT ACTTGGATGG CTATGACCGA GAGGACCAGG AAGCACCTGA CTCAGATGCC 
GAGGTGGATG GTGTGGATGA AGAGGAGGAG GACGAAGAAG GAGAAGATGA GGAAGACGAG 
GACGATGAGG ATGGTGAAGA AGAGGAGTTT GATGAAGAAG ATGATGAAGA TGAAGATGTA 
GAAGGGGATG AGGACGACGA TGAAGTCAGT GAGGAGGAAG AAGAATTTGG ACTTGATGAA 
GAAGATGAAG ATGAGGATGA GGATGAAGAG GAGGAAGAAG GTGGGAAAGG TGAAAAGAGG 
AAGAGAGAAA CAGATGATGA AGGAGAAGAT GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANP32B ( NM_006401.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006392.1 Homo sapiens acidic nuclear phosphoprotein 32 family member B (ANP32B), mRNA.

Price & Availability↑

CloneID	OHu05512
Clone ID Related Accession (Same CDS sequence)	NM_006401.2 , NM_006401.3
Accession Version	NM_006401.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	acidic leucine-rich nuclear phosphoprotein 32 family member B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW296974.1, BC019658.1 and BP395780.1. On Nov 22, 2018 this sequence version replaced NM_006401.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.903297.1, SRR3476690.857482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000339399.5/ ENSP00000345848.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACATGA AGAGGAGGAT CCACCTGGAG CTGAGGAACC GGACCCCGGC AGCTGTTCGA 
GAACTTGTCT TGGACAATTG CAAATCAAAT GATGGAAAAA TTGAGGGCTT AACAGCTGAA 
TTTGTGAACT TAGAGTTCCT CAGTTTAATA AATGTAGGCT TGATCTCAGT TTCAAATCTC 
CCCAAGCTGC CTAAATTGAA AAAGCTTGAA CTCAGTGAAA ATAGAATCTT TGGAGGTCTG 
GACATGTTAG CTGAAAAACT TCCAAATCTC ACACATCTAA ACTTAAGTGG AAATAAACTG 
AAAGATATCA GCACCTTGGA ACCTTTGAAA AAGTTAGAAT GTCTGAAAAG CCTGGACCTC 
TTTAACTGTG AGGTTACCAA CCTGAATGAC TACCGAGAGA GTGTCTTCAA GCTCCTGCCC 
CAGCTTACCT ACTTGGATGG CTATGACCGA GAGGACCAGG AAGCACCTGA CTCAGATGCC 
GAGGTGGATG GTGTGGATGA AGAGGAGGAG GACGAAGAAG GAGAAGATGA GGAAGACGAG 
GACGATGAGG ATGGTGAAGA AGAGGAGTTT GATGAAGAAG ATGATGAAGA TGAAGATGTA 
GAAGGGGATG AGGACGACGA TGAAGTCAGT GAGGAGGAAG AAGAATTTGG ACTTGATGAA 
GAAGATGAAG ATGAGGATGA GGATGAAGAG GAGGAAGAAG GTGGGAAAGG TGAAAAGAGG 
AAGAGAGAAA CAGATGATGA AGGAGAAGAT GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006392.1
CDS	216..971
Translation	MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEEGGKGEKRKRETDDEGEDD

Target ORF information:

RefSeq Version	NM_006401.3
Organism	Homo sapiens(human)
Definition	Homo sapiens acidic nuclear phosphoprotein 32 family member B (ANP32B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006401.3

ORF Insert Sequence:

ATGGACATGA AGAGGAGGAT CCACCTGGAG CTGAGGAACC GGACCCCGGC AGCTGTTCGA 
GAACTTGTCT TGGACAATTG CAAATCAAAT GATGGAAAAA TTGAGGGCTT AACAGCTGAA 
TTTGTGAACT TAGAGTTCCT CAGTTTAATA AATGTAGGCT TGATCTCAGT TTCAAATCTC 
CCCAAGCTGC CTAAATTGAA AAAGCTTGAA CTCAGTGAAA ATAGAATCTT TGGAGGTCTG 
GACATGTTAG CTGAAAAACT TCCAAATCTC ACACATCTAA ACTTAAGTGG AAATAAACTG 
AAAGATATCA GCACCTTGGA ACCTTTGAAA AAGTTAGAAT GTCTGAAAAG CCTGGACCTC 
TTTAACTGTG AGGTTACCAA CCTGAATGAC TACCGAGAGA GTGTCTTCAA GCTCCTGCCC 
CAGCTTACCT ACTTGGATGG CTATGACCGA GAGGACCAGG AAGCACCTGA CTCAGATGCC 
GAGGTGGATG GTGTGGATGA AGAGGAGGAG GACGAAGAAG GAGAAGATGA GGAAGACGAG 
GACGATGAGG ATGGTGAAGA AGAGGAGTTT GATGAAGAAG ATGATGAAGA TGAAGATGTA 
GAAGGGGATG AGGACGACGA TGAAGTCAGT GAGGAGGAAG AAGAATTTGG ACTTGATGAA 
GAAGATGAAG ATGAGGATGA GGATGAAGAG GAGGAAGAAG GTGGGAAAGG TGAAAAGAGG 
AAGAGAGAAA CAGATGATGA AGGAGAAGAT GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prothymosin ? interacts with SET, ANP32A and ANP32B and other cytoplasmic and mitochondrial proteins in proliferating cells.
Archives of biochemistry and biophysics63574-86(2017 Dec)
Barbeito P,Sarandeses CS,D?az-Jullien C,Muras J,Covelo G,Moreira D,Freire-Cobo C,Freire M

Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma.
PloS one12(5)e0177343(2017)
Ohno Y,Koizumi M,Nakayama H,Watanabe T,Hirooka M,Tokumoto Y,Kuroda T,Abe M,Fukuda S,Higashiyama S,Kumagi T,Hiasa Y

Caspase-3-resistant uncleavable form of acidic leucine-rich nuclear phosphoprotein 32B potentiates leukemic cell apoptosis.
Molecular medicine reports11(4)2813-8(2015 Apr)
Li CX,Shen SM,Wang LS,Yu Y

ANP32B is a nuclear target of henipavirus M proteins.
PloS one9(5)e97233(2014)
Bauer A,Neumann S,Karger A,Henning AK,Maisner A,Lamp B,Dietzel E,Kwasnitschka L,Balkema-Buschmann A,Keil GM,Finke S

Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
PloS one9(12)e111301(2014)
Malinowski JR,Denny JC,Bielinski SJ,Basford MA,Bradford Y,Peissig PL,Carrell D,Crosslin DR,Pathak J,Rasmussen L,Pacheco J,Kho A,Newton KM,Li R,Kullo IJ,Chute CG,Chisholm RL,Jarvik GP,Larson EB,McCarty CA,Masys DR,Roden DM,de Andrade M,Ritchie MD,Crawford DC

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ANP32B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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