CD2BP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD2BP2
Entrez Gene ID	10421
Full Name	CD2 cytoplasmic tail binding protein 2
Synonyms	FWP010,LIN1,PPP1R59,Snu40,U5-52K
General protein information	Preferred Names CD2 cytoplasmic tail binding protein 2 Names CD2 antigen cytoplasmic tail-binding protein 2 CD2 cytoplasmic domain-binding protein 2 U5 snRNP 52K protein protein phosphatase 1, regulatory subunit 59
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008].
Disorder MIM:	604470

mRNA and Protein(s)

mRNA	Protein	Name
NM_006110.2	NP_006101.1	CD2 antigen cytoplasmic tail-binding protein 2
NM_006110.3	NP_006101.1	CD2 antigen cytoplasmic tail-binding protein 2
NM_001243646.1	NP_001230575.1	CD2 antigen cytoplasmic tail-binding protein 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	cd2bp2	NP_957255.1
Drosophila melanogaster (fruit fly)	holn1	NP_609404.2
Homo sapiens (human)	CD2BP2	NP_006101.1
	CD2BP2	XP_001110433.1
Canis lupus familiaris (dog)	CD2BP2	XP_547057.2
Bos taurus (cattle)	CD2BP2	NP_001077151.1
Mus musculus (house mouse)	Cd2bp2	NP_001272834.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011494	XP_317806.4
Rattus norvegicus (Norway rat)	Cd2bp2	NP_001099767.1
Caenorhabditis elegans (roundworm)	teg-1	NP_499455.2
Xenopus tropicalis (tropical clawed frog)	clip4	NP_989351.3

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.
Wang C, Gupta P, Fressigne L, Boss? GD, Wang X, Simard MJ, Hansen D
Nucleic acids research45(3)1488-1500(2017 02)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Dynamic protein-protein interaction wiring of the human spliceosome.
Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, L?hrmann R, Stelzl U
Molecular cell45(4)567-80(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knockdown of CD2BP2 results in reduced miRNA levels. CD2BP2 stabilizes miRISC and mature miRNAs, maintaining them at levels necessary to properly regulate target gene expression.
Title: TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.

findings indicate that CD2BP2 is not a constitutive binding partner or key regulator of CD2-mediated signaling events
Title: Investigating the functional role of CD2BP2 in T cells.

interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), coupled with CD2BP2's absence from the tri-snRNP, suggests it might function in tri-snRNP assembly
Title: The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.

there is a function of the GYF domain of CD2BP2 in mediating protein-protein interactions within the spliceosome
Title: Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.

CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments.
Title: Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.

The following CD2BP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD2BP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02290	NM_006110.3 Latest version!	Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu02290	NM_001243646.1 Latest version!	Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu02290	NM_006110.2	Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD2BP2 ( NM_006110.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006101.1 Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02290
Clone ID Related Accession (Same CDS sequence)	NM_006110.2 , NM_006110.3 , NM_001243646.1
Accession Version	NM_006110.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	CD2 antigen cytoplasmic tail-binding protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB135964.1, BC001947.1, AB033004.1 and BC106082.1. On Nov 20, 2008 this sequence version replaced NM_006110.1. Transcript Variant: This variant (1) represents the shorter and more abundant transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.124003.1, SRR1660809.127513.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAAAGA GGAAAGTGAC CTTCCAAGGC GTGGGAGATG AGGAGGATGA GGATGAAATC 
ATTGTCCCCA AGAAGAAGCT GGTGGACCCT GTGGCTGGGT CAGGGGGTCC TGGGAGCCGC 
TTTAAAGGCA AACACTCTTT GGATAGCGAT GAGGAGGAGG ATGATGATGA TGGGGGGTCC 
AGCAAATATG ACATCTTGGC CTCAGAGGAT GTAGAAGGTC AGGAGGCAGC CACACTCCCC 
AGCGAGGGGG GTGTTCGGAT CACACCCTTT AACCTGCAGG AGGAGATGGA GGAAGGCCAC 
TTTGATGCCG ATGGCAACTA CTTCCTGAAC CGGGATGCTC AGATCCGAGA CAGCTGGCTG 
GACAACATTG ACTGGGTGAA GATCCGGGAG CGGCCACCTG GCCAGCGCCA GGCCTCAGAC 
TCGGAGGAGG AGGACAGCTT GGGCCAGACC TCAATGAGTG CCCAAGCCCT CTTGGAGGGA 
CTTTTGGAGC TCCTATTGCC TAGAGAGACA GTGGCTGGGG CACTGAGGCG TCTGGGGGCC 
CGAGGAGGAG GCAAAGGGAG AAAGGGGCCT GGGCAACCCA GTTCCCCTCA GCGCCTGGAC 
CGGCTCTCCG GGTTGGCCGA CCAGATGGTG GCCCGGGGCA ACCTTGGTGT GTACCAGGAA 
ACAAGGGAAC GGTTGGCTAT GCGTCTGAAG GGTTTGGGGT GTCAGACCCT AGGACCCCAC 
AATCCCACAC CCCCACCCTC CCTGGACATG TTCGCTGAGG AGTTGGCGGA GGAGGAACTG 
GAGACCCCAA CCCCTACCCA GAGAGGAGAA GCAGAGTCGC GGGGAGATGG TCTGGTGGAT 
GTGATGTGGG AATATAAGTG GGAGAACACG GGGGATGCCG AGCTGTATGG GCCCTTCACC 
AGCGCCCAGA TGCAGACCTG GGTGAGTGAA GGCTACTTCC CGGACGGTGT TTATTGCCGG 
AAGCTGGACC CCCCTGGTGG TCAGTTCTAC AACTCCAAAC GCATTGACTT TGACCTCTAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006101.1
CDS	177..1202
Translation	MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT

Target ORF information:

RefSeq Version	NM_006110.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006110.2

ORF Insert Sequence:

ATGCCAAAGA GGAAAGTGAC CTTCCAAGGC GTGGGAGATG AGGAGGATGA GGATGAAATC 
ATTGTCCCCA AGAAGAAGCT GGTGGACCCT GTGGCTGGGT CAGGGGGTCC TGGGAGCCGC 
TTTAAAGGCA AACACTCTTT GGATAGCGAT GAGGAGGAGG ATGATGATGA TGGGGGGTCC 
AGCAAATATG ACATCTTGGC CTCAGAGGAT GTAGAAGGTC AGGAGGCAGC CACACTCCCC 
AGCGAGGGGG GTGTTCGGAT CACACCCTTT AACCTGCAGG AGGAGATGGA GGAAGGCCAC 
TTTGATGCCG ATGGCAACTA CTTCCTGAAC CGGGATGCTC AGATCCGAGA CAGCTGGCTG 
GACAACATTG ACTGGGTGAA GATCCGGGAG CGGCCACCTG GCCAGCGCCA GGCCTCAGAC 
TCGGAGGAGG AGGACAGCTT GGGCCAGACC TCAATGAGTG CCCAAGCCCT CTTGGAGGGA 
CTTTTGGAGC TCCTATTGCC TAGAGAGACA GTGGCTGGGG CACTGAGGCG TCTGGGGGCC 
CGAGGAGGAG GCAAAGGGAG AAAGGGGCCT GGGCAACCCA GTTCCCCTCA GCGCCTGGAC 
CGGCTCTCCG GGTTGGCCGA CCAGATGGTG GCCCGGGGCA ACCTTGGTGT GTACCAGGAA 
ACAAGGGAAC GGTTGGCTAT GCGTCTGAAG GGTTTGGGGT GTCAGACCCT AGGACCCCAC 
AATCCCACAC CCCCACCCTC CCTGGACATG TTCGCTGAGG AGTTGGCGGA GGAGGAACTG 
GAGACCCCAA CCCCTACCCA GAGAGGAGAA GCAGAGTCGC GGGGAGATGG TCTGGTGGAT 
GTGATGTGGG AATATAAGTG GGAGAACACG GGGGATGCCG AGCTGTATGG GCCCTTCACC 
AGCGCCCAGA TGCAGACCTG GGTGAGTGAA GGCTACTTCC CGGACGGTGT TTATTGCCGG 
AAGCTGGACC CCCCTGGTGG TCAGTTCTAC AACTCCAAAC GCATTGACTT TGACCTCTAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD2BP2 ( NM_006110.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006101.1 Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02290
Clone ID Related Accession (Same CDS sequence)	NM_006110.2 , NM_006110.3 , NM_001243646.1
Accession Version	NM_006110.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	CD2 antigen cytoplasmic tail-binding protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB135964.1, BC001947.1 and AB033004.1. On Nov 23, 2018 this sequence version replaced NM_006110.2. Transcript Variant: This variant (1) represents the shorter and more abundant transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.218207.1, SRR1803614.124003.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305596.8/ ENSP00000304903.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCAAAGA GGAAAGTGAC CTTCCAAGGC GTGGGAGATG AGGAGGATGA GGATGAAATC 
ATTGTCCCCA AGAAGAAGCT GGTGGACCCT GTGGCTGGGT CAGGGGGTCC TGGGAGCCGC 
TTTAAAGGCA AACACTCTTT GGATAGCGAT GAGGAGGAGG ATGATGATGA TGGGGGGTCC 
AGCAAATATG ACATCTTGGC CTCAGAGGAT GTAGAAGGTC AGGAGGCAGC CACACTCCCC 
AGCGAGGGGG GTGTTCGGAT CACACCCTTT AACCTGCAGG AGGAGATGGA GGAAGGCCAC 
TTTGATGCCG ATGGCAACTA CTTCCTGAAC CGGGATGCTC AGATCCGAGA CAGCTGGCTG 
GACAACATTG ACTGGGTGAA GATCCGGGAG CGGCCACCTG GCCAGCGCCA GGCCTCAGAC 
TCGGAGGAGG AGGACAGCTT GGGCCAGACC TCAATGAGTG CCCAAGCCCT CTTGGAGGGA 
CTTTTGGAGC TCCTATTGCC TAGAGAGACA GTGGCTGGGG CACTGAGGCG TCTGGGGGCC 
CGAGGAGGAG GCAAAGGGAG AAAGGGGCCT GGGCAACCCA GTTCCCCTCA GCGCCTGGAC 
CGGCTCTCCG GGTTGGCCGA CCAGATGGTG GCCCGGGGCA ACCTTGGTGT GTACCAGGAA 
ACAAGGGAAC GGTTGGCTAT GCGTCTGAAG GGTTTGGGGT GTCAGACCCT AGGACCCCAC 
AATCCCACAC CCCCACCCTC CCTGGACATG TTCGCTGAGG AGTTGGCGGA GGAGGAACTG 
GAGACCCCAA CCCCTACCCA GAGAGGAGAA GCAGAGTCGC GGGGAGATGG TCTGGTGGAT 
GTGATGTGGG AATATAAGTG GGAGAACACG GGGGATGCCG AGCTGTATGG GCCCTTCACC 
AGCGCCCAGA TGCAGACCTG GGTGAGTGAA GGCTACTTCC CGGACGGTGT TTATTGCCGG 
AAGCTGGACC CCCCTGGTGG TCAGTTCTAC AACTCCAAAC GCATTGACTT TGACCTCTAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006101.1
CDS	124..1149
Translation	MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT

Target ORF information:

RefSeq Version	NM_006110.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006110.3

ORF Insert Sequence:

ATGCCAAAGA GGAAAGTGAC CTTCCAAGGC GTGGGAGATG AGGAGGATGA GGATGAAATC 
ATTGTCCCCA AGAAGAAGCT GGTGGACCCT GTGGCTGGGT CAGGGGGTCC TGGGAGCCGC 
TTTAAAGGCA AACACTCTTT GGATAGCGAT GAGGAGGAGG ATGATGATGA TGGGGGGTCC 
AGCAAATATG ACATCTTGGC CTCAGAGGAT GTAGAAGGTC AGGAGGCAGC CACACTCCCC 
AGCGAGGGGG GTGTTCGGAT CACACCCTTT AACCTGCAGG AGGAGATGGA GGAAGGCCAC 
TTTGATGCCG ATGGCAACTA CTTCCTGAAC CGGGATGCTC AGATCCGAGA CAGCTGGCTG 
GACAACATTG ACTGGGTGAA GATCCGGGAG CGGCCACCTG GCCAGCGCCA GGCCTCAGAC 
TCGGAGGAGG AGGACAGCTT GGGCCAGACC TCAATGAGTG CCCAAGCCCT CTTGGAGGGA 
CTTTTGGAGC TCCTATTGCC TAGAGAGACA GTGGCTGGGG CACTGAGGCG TCTGGGGGCC 
CGAGGAGGAG GCAAAGGGAG AAAGGGGCCT GGGCAACCCA GTTCCCCTCA GCGCCTGGAC 
CGGCTCTCCG GGTTGGCCGA CCAGATGGTG GCCCGGGGCA ACCTTGGTGT GTACCAGGAA 
ACAAGGGAAC GGTTGGCTAT GCGTCTGAAG GGTTTGGGGT GTCAGACCCT AGGACCCCAC 
AATCCCACAC CCCCACCCTC CCTGGACATG TTCGCTGAGG AGTTGGCGGA GGAGGAACTG 
GAGACCCCAA CCCCTACCCA GAGAGGAGAA GCAGAGTCGC GGGGAGATGG TCTGGTGGAT 
GTGATGTGGG AATATAAGTG GGAGAACACG GGGGATGCCG AGCTGTATGG GCCCTTCACC 
AGCGCCCAGA TGCAGACCTG GGTGAGTGAA GGCTACTTCC CGGACGGTGT TTATTGCCGG 
AAGCTGGACC CCCCTGGTGG TCAGTTCTAC AACTCCAAAC GCATTGACTT TGACCTCTAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CD2BP2 ( NM_001243646.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001230575.1 Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02290
Clone ID Related Accession (Same CDS sequence)	NM_006110.2 , NM_006110.3 , NM_001243646.1
Accession Version	NM_001243646.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	CD2 antigen cytoplasmic tail-binding protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013854.1, AB033004.1 and BM678260.1. On Aug 19, 2011 this sequence version replaced NR_024465.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013854.1, SRR1803617.12476.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAAAGA GGAAAGTGAC CTTCCAAGGC GTGGGAGATG AGGAGGATGA GGATGAAATC 
ATTGTCCCCA AGAAGAAGCT GGTGGACCCT GTGGCTGGGT CAGGGGGTCC TGGGAGCCGC 
TTTAAAGGCA AACACTCTTT GGATAGCGAT GAGGAGGAGG ATGATGATGA TGGGGGGTCC 
AGCAAATATG ACATCTTGGC CTCAGAGGAT GTAGAAGGTC AGGAGGCAGC CACACTCCCC 
AGCGAGGGGG GTGTTCGGAT CACACCCTTT AACCTGCAGG AGGAGATGGA GGAAGGCCAC 
TTTGATGCCG ATGGCAACTA CTTCCTGAAC CGGGATGCTC AGATCCGAGA CAGCTGGCTG 
GACAACATTG ACTGGGTGAA GATCCGGGAG CGGCCACCTG GCCAGCGCCA GGCCTCAGAC 
TCGGAGGAGG AGGACAGCTT GGGCCAGACC TCAATGAGTG CCCAAGCCCT CTTGGAGGGA 
CTTTTGGAGC TCCTATTGCC TAGAGAGACA GTGGCTGGGG CACTGAGGCG TCTGGGGGCC 
CGAGGAGGAG GCAAAGGGAG AAAGGGGCCT GGGCAACCCA GTTCCCCTCA GCGCCTGGAC 
CGGCTCTCCG GGTTGGCCGA CCAGATGGTG GCCCGGGGCA ACCTTGGTGT GTACCAGGAA 
ACAAGGGAAC GGTTGGCTAT GCGTCTGAAG GGTTTGGGGT GTCAGACCCT AGGACCCCAC 
AATCCCACAC CCCCACCCTC CCTGGACATG TTCGCTGAGG AGTTGGCGGA GGAGGAACTG 
GAGACCCCAA CCCCTACCCA GAGAGGAGAA GCAGAGTCGC GGGGAGATGG TCTGGTGGAT 
GTGATGTGGG AATATAAGTG GGAGAACACG GGGGATGCCG AGCTGTATGG GCCCTTCACC 
AGCGCCCAGA TGCAGACCTG GGTGAGTGAA GGCTACTTCC CGGACGGTGT TTATTGCCGG 
AAGCTGGACC CCCCTGGTGG TCAGTTCTAC AACTCCAAAC GCATTGACTT TGACCTCTAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001230575.1
CDS	254..1279
Translation	MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT

Target ORF information:

RefSeq Version	NM_001243646.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CD2 cytoplasmic tail binding protein 2 (CD2BP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001243646.1

ORF Insert Sequence:

ATGCCAAAGA GGAAAGTGAC CTTCCAAGGC GTGGGAGATG AGGAGGATGA GGATGAAATC 
ATTGTCCCCA AGAAGAAGCT GGTGGACCCT GTGGCTGGGT CAGGGGGTCC TGGGAGCCGC 
TTTAAAGGCA AACACTCTTT GGATAGCGAT GAGGAGGAGG ATGATGATGA TGGGGGGTCC 
AGCAAATATG ACATCTTGGC CTCAGAGGAT GTAGAAGGTC AGGAGGCAGC CACACTCCCC 
AGCGAGGGGG GTGTTCGGAT CACACCCTTT AACCTGCAGG AGGAGATGGA GGAAGGCCAC 
TTTGATGCCG ATGGCAACTA CTTCCTGAAC CGGGATGCTC AGATCCGAGA CAGCTGGCTG 
GACAACATTG ACTGGGTGAA GATCCGGGAG CGGCCACCTG GCCAGCGCCA GGCCTCAGAC 
TCGGAGGAGG AGGACAGCTT GGGCCAGACC TCAATGAGTG CCCAAGCCCT CTTGGAGGGA 
CTTTTGGAGC TCCTATTGCC TAGAGAGACA GTGGCTGGGG CACTGAGGCG TCTGGGGGCC 
CGAGGAGGAG GCAAAGGGAG AAAGGGGCCT GGGCAACCCA GTTCCCCTCA GCGCCTGGAC 
CGGCTCTCCG GGTTGGCCGA CCAGATGGTG GCCCGGGGCA ACCTTGGTGT GTACCAGGAA 
ACAAGGGAAC GGTTGGCTAT GCGTCTGAAG GGTTTGGGGT GTCAGACCCT AGGACCCCAC 
AATCCCACAC CCCCACCCTC CCTGGACATG TTCGCTGAGG AGTTGGCGGA GGAGGAACTG 
GAGACCCCAA CCCCTACCCA GAGAGGAGAA GCAGAGTCGC GGGGAGATGG TCTGGTGGAT 
GTGATGTGGG AATATAAGTG GGAGAACACG GGGGATGCCG AGCTGTATGG GCCCTTCACC 
AGCGCCCAGA TGCAGACCTG GGTGAGTGAA GGCTACTTCC CGGACGGTGT TTATTGCCGG 
AAGCTGGACC CCCCTGGTGG TCAGTTCTAC AACTCCAAAC GCATTGACTT TGACCTCTAC 
ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.
Nucleic acids research45(3)1488-1500(2017 02)
Wang C,Gupta P,Fressigne L,Boss? GD,Wang X,Simard MJ,Hansen D

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Dynamic protein-protein interaction wiring of the human spliceosome.
Molecular cell45(4)567-80(2012 Feb)
Hegele A,Kamburov A,Grossmann A,Sourlis C,Wowro S,Weimann M,Will CL,Pena V,L?hrmann R,Stelzl U

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CD2BP2 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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