PRG3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRG3
Entrez Gene ID	10394
Full Name	proteoglycan 3, pro eosinophil major basic protein 2
Synonyms	MBP2,MBPH
General protein information	Preferred Names proteoglycan 3, pro eosinophil major basic protein 2 Names proteoglycan 3 eosinophil major basic protein homolog prepro-MBPH prepro-major basic protein homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q12.1
Disorder MIM:	606814

mRNA and Protein(s)

mRNA	Protein	Name
NM_006093.4	NP_006084.2	proteoglycan 3 precursor
NM_006093.3	NP_006084.2	proteoglycan 3 precursor

Pathways from BioSystems

Homologies

	PRG3	XP_001103106.1
Homo sapiens (human)	PRG3	NP_006084.2
Canis lupus familiaris (dog)	PRG3	XP_540613.3
Mus musculus (house mouse)	Prg3	NP_058610.1
Rattus norvegicus (Norway rat)	Prg3	NP_001099957.1
Pan troglodytes (chimpanzee)	PRG3	XP_521985.2

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM
Leukemia31(11)2426-2434(2017 Nov)

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO
BMC cancer14518(2014 Jul)

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I
PLoS genetics8(3)e1002559(2012)

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadi? M, Foretov? L, Cocco P, Gonz?lez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica96(2)323-7(2011 Feb)

Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.
Wagner LA, Ohnuki LE, Parsawar K, Gleich GJ, Nelson CC
The protein journal26(1)13-8(2007 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

contains 2 cysteine disulfide linkages (Cys20-Cys115 and Cys92-Cys107) and 6 cysteine residues with free sulfhydryl groups (Cys2, Cys23, Cys42, Cys43, Cys68, and Cys96). Amino acid positions are not based on the full-length protein sequence.
Title: Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.

The following PRG3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRG3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12441	NM_006093.4 Latest version!	Homo sapiens proteoglycan 3, pro eosinophil major basic protein 2 (PRG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12441	NM_006093.3	Homo sapiens proteoglycan 3, pro eosinophil major basic protein 2 (PRG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRG3 ( NM_006093.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006084.2 Homo sapiens proteoglycan 3, pro eosinophil major basic protein 2 (PRG3), mRNA.

Price & Availability↑

CloneID	OHu12441
Clone ID Related Accession (Same CDS sequence)	NM_006093.4 , NM_006093.3
Accession Version	NM_006093.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	proteoglycan 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF132209.2, AP000781.6 and AY358930.1. On May 17, 2019 this sequence version replaced NM_006093.3. ##Evidence-Data-START## Transcript exon combination :: AF132209.2, AY358930.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000287143.2/ ENSP00000287143.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAATGCC TCTTGCTCCT GCCCTTTCTC CTGCTGGGAA CAGTTTCTGC TCTTCATCTG 
GAGAATGATG CCCCCCATCT GGAGAGCCTA GAGACACAGG CAGACCTAGG CCAGGATCTG 
GATAGTTCAA AGGAGCAGGA GAGAGACTTG GCTCTGACGG AGGAGGTGAT TCAGGCAGAG 
GGAGAGGAGG TCAAGGCTTC TGCCTGTCAA GACAACTTTG AGGATGAGGA AGCCATGGAG 
TCGGACCCAG CTGCCTTAGA CAAGGACTTC CAGTGCCCCA GGGAAGAAGA CATTGTTGAA 
GTGCAGGGAA GTCCAAGGTG CAAGATCTGC CGCTACCTAT TGGTGCGGAC TCCTAAAACT 
TTTGCAGAAG CTCAGAATGT CTGCAGCAGA TGCTACGGAG GCAACCTTGT CTCTATCCAT 
GACTTCAACT TCAACTATCG CATTCAGTGC TGCACTAGCA CAGTCAACCA AGCCCAGGTC 
TGGATTGGAG GCAACCTCAG GGGCTGGTTC CTGTGGAAGC GGTTTTGCTG GACTGATGGG 
AGCCACTGGA ATTTTGCTTA CTGGTCCCCA GGGCAACCTG GGAATGGGCA AGGCTCCTGT 
GTGGCCCTAT GCACCAAAGG AGGTTATTGG CGACGAGCTC AATGCGACAA GCAACTGCCC 
TTCGTCTGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006084.2
CDS	111..788
Translation	MQCLLLLPFLLLGTVSALHLENDAPHLESLETQADLGQDLDSSKEQERDLALTEEVIQAEGEEVKASACQDNFEDEEAMESDPAALDKDFQCPREEDIVEVQGSPRCKICRYLLVRTPKTFAEAQNVCSRCYGGNLVSIHDFNFNYRIQCCTSTVNQAQVWIGGNLRGWFLWKRFCWTDGSHWNFAYWSPGQPGNGQGSCVALCTKGGYWRRAQCDKQLPFVCSF

Target ORF information:

RefSeq Version	NM_006093.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 3, pro eosinophil major basic protein 2 (PRG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006093.4

ORF Insert Sequence:

ATGCAATGCC TCTTGCTCCT GCCCTTTCTC CTGCTGGGAA CAGTTTCTGC TCTTCATCTG 
GAGAATGATG CCCCCCATCT GGAGAGCCTA GAGACACAGG CAGACCTAGG CCAGGATCTG 
GATAGTTCAA AGGAGCAGGA GAGAGACTTG GCTCTGACGG AGGAGGTGAT TCAGGCAGAG 
GGAGAGGAGG TCAAGGCTTC TGCCTGTCAA GACAACTTTG AGGATGAGGA AGCCATGGAG 
TCGGACCCAG CTGCCTTAGA CAAGGACTTC CAGTGCCCCA GGGAAGAAGA CATTGTTGAA 
GTGCAGGGAA GTCCAAGGTG CAAGATCTGC CGCTACCTAT TGGTGCGGAC TCCTAAAACT 
TTTGCAGAAG CTCAGAATGT CTGCAGCAGA TGCTACGGAG GCAACCTTGT CTCTATCCAT 
GACTTCAACT TCAACTATCG CATTCAGTGC TGCACTAGCA CAGTCAACCA AGCCCAGGTC 
TGGATTGGAG GCAACCTCAG GGGCTGGTTC CTGTGGAAGC GGTTTTGCTG GACTGATGGG 
AGCCACTGGA ATTTTGCTTA CTGGTCCCCA GGGCAACCTG GGAATGGGCA AGGCTCCTGT 
GTGGCCCTAT GCACCAAAGG AGGTTATTGG CGACGAGCTC AATGCGACAA GCAACTGCCC 
TTCGTCTGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRG3 ( NM_006093.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006084.2 Homo sapiens proteoglycan 3, pro eosinophil major basic protein 2 (PRG3), mRNA.

Price & Availability↑

CloneID	OHu12441
Clone ID Related Accession (Same CDS sequence)	NM_006093.4 , NM_006093.3
Accession Version	NM_006093.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	proteoglycan 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF132209.2, AP000781.6 and AY358930.1. On Feb 14, 2009 this sequence version replaced NM_006093.2. ##Evidence-Data-START## Transcript exon combination :: AF132209.2, BC069126.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2153307 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAATGCC TCTTGCTCCT GCCCTTTCTC CTGCTGGGAA CAGTTTCTGC TCTTCATCTG 
GAGAATGATG CCCCCCATCT GGAGAGCCTA GAGACACAGG CAGACCTAGG CCAGGATCTG 
GATAGTTCAA AGGAGCAGGA GAGAGACTTG GCTCTGACGG AGGAGGTGAT TCAGGCAGAG 
GGAGAGGAGG TCAAGGCTTC TGCCTGTCAA GACAACTTTG AGGATGAGGA AGCCATGGAG 
TCGGACCCAG CTGCCTTAGA CAAGGACTTC CAGTGCCCCA GGGAAGAAGA CATTGTTGAA 
GTGCAGGGAA GTCCAAGGTG CAAGATCTGC CGCTACCTAT TGGTGCGGAC TCCTAAAACT 
TTTGCAGAAG CTCAGAATGT CTGCAGCAGA TGCTACGGAG GCAACCTTGT CTCTATCCAT 
GACTTCAACT TCAACTATCG CATTCAGTGC TGCACTAGCA CAGTCAACCA AGCCCAGGTC 
TGGATTGGAG GCAACCTCAG GGGCTGGTTC CTGTGGAAGC GGTTTTGCTG GACTGATGGG 
AGCCACTGGA ATTTTGCTTA CTGGTCCCCA GGGCAACCTG GGAATGGGCA AGGCTCCTGT 
GTGGCCCTAT GCACCAAAGG AGGTTATTGG CGACGAGCTC AATGCGACAA GCAACTGCCC 
TTCGTCTGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006084.2
CDS	111..788
Translation	MQCLLLLPFLLLGTVSALHLENDAPHLESLETQADLGQDLDSSKEQERDLALTEEVIQAEGEEVKASACQDNFEDEEAMESDPAALDKDFQCPREEDIVEVQGSPRCKICRYLLVRTPKTFAEAQNVCSRCYGGNLVSIHDFNFNYRIQCCTSTVNQAQVWIGGNLRGWFLWKRFCWTDGSHWNFAYWSPGQPGNGQGSCVALCTKGGYWRRAQCDKQLPFVCSF

Target ORF information:

RefSeq Version	NM_006093.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteoglycan 3, pro eosinophil major basic protein 2 (PRG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006093.3

ORF Insert Sequence:

ATGCAATGCC TCTTGCTCCT GCCCTTTCTC CTGCTGGGAA CAGTTTCTGC TCTTCATCTG 
GAGAATGATG CCCCCCATCT GGAGAGCCTA GAGACACAGG CAGACCTAGG CCAGGATCTG 
GATAGTTCAA AGGAGCAGGA GAGAGACTTG GCTCTGACGG AGGAGGTGAT TCAGGCAGAG 
GGAGAGGAGG TCAAGGCTTC TGCCTGTCAA GACAACTTTG AGGATGAGGA AGCCATGGAG 
TCGGACCCAG CTGCCTTAGA CAAGGACTTC CAGTGCCCCA GGGAAGAAGA CATTGTTGAA 
GTGCAGGGAA GTCCAAGGTG CAAGATCTGC CGCTACCTAT TGGTGCGGAC TCCTAAAACT 
TTTGCAGAAG CTCAGAATGT CTGCAGCAGA TGCTACGGAG GCAACCTTGT CTCTATCCAT 
GACTTCAACT TCAACTATCG CATTCAGTGC TGCACTAGCA CAGTCAACCA AGCCCAGGTC 
TGGATTGGAG GCAACCTCAG GGGCTGGTTC CTGTGGAAGC GGTTTTGCTG GACTGATGGG 
AGCCACTGGA ATTTTGCTTA CTGGTCCCCA GGGCAACCTG GGAATGGGCA AGGCTCCTGT 
GTGGCCCTAT GCACCAAAGG AGGTTATTGG CGACGAGCTC AATGCGACAA GCAACTGCCC 
TTCGTCTGCT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Leukemia31(11)2426-2434(2017 Nov)
Glavey SV,Naba A,Manier S,Clauser K,Tahri S,Park J,Reagan MR,Moschetta M,Mishima Y,Gambella M,Rocci A,Sacco A,O'Dwyer ME,Asara JM,Palumbo A,Roccaro AM,Hynes RO,Ghobrial IM

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
BMC cancer14518(2014 Jul)
Naba A,Clauser KR,Whittaker CA,Carr SA,Tanabe KK,Hynes RO

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
PLoS genetics8(3)e1002559(2012)
Kenny EE,Pe'er I,Karban A,Ozelius L,Mitchell AA,Ng SM,Erazo M,Ostrer H,Abraham C,Abreu MT,Atzmon G,Barzilai N,Brant SR,Bressman S,Burns ER,Chowers Y,Clark LN,Darvasi A,Doheny D,Duerr RH,Eliakim R,Giladi N,Gregersen PK,Hakonarson H,Jones MR,Marder K,McGovern DP,Mulle J,Orr-Urtreger A,Proctor DD,Pulver A,Rotter JI,Silverberg MS,Ullman T,Warren ST,Waterman M,Zhang W,Bergman A,Mayer L,Katz S,Desnick RJ,Cho JH,Peter I

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Haematologica96(2)323-7(2011 Feb)
Casabonne D,Reina O,Benavente Y,Becker N,Maynadi? M,Foretov? L,Cocco P,Gonz?lez-Neira A,Nieters A,Boffetta P,Middeldorp JM,de Sanjose S

Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.
The protein journal26(1)13-8(2007 Jan)
Wagner LA,Ohnuki LE,Parsawar K,Gleich GJ,Nelson CC