KLHL41 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLHL41
Entrez Gene ID	10324
Full Name	kelch like family member 41
Synonyms	KBTBD10,Krp1,SARCOSIN
General protein information	Preferred Names kelch like family member 41 Names kelch-like protein 41 kel-like protein 23 kelch repeat and BTB (POZ) domain containing 10 kelch-related protein 1 sarcomeric muscle protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015].
Disorder MIM:	607701
Disorder Html:	Nemaline myopathy 9, 615731 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006063.2	NP_006054.2	kelch-like protein 41
NM_006063.3	NP_006054.2	kelch-like protein 41

Pathways from BioSystems

Homologies

Homo sapiens (human)	KLHL41	NP_006054.2
Canis lupus familiaris (dog)	KLHL41	XP_535949.1
Gallus gallus (chicken)	KBTBD10	XP_422010.1
Xenopus tropicalis (tropical clawed frog)	klhl41	NP_989214.1
Mus musculus (house mouse)	Klhl41	NP_001074556.1
Danio rerio (zebrafish)	klhl41a	XP_001922967.1
Pan troglodytes (chimpanzee)	KBTBD10	XP_001135383.1
	KBTBD10	XP_001104263.1
Danio rerio (zebrafish)	klhl41b	NP_945330.1
Rattus norvegicus (Norway rat)	Klhl41	NP_476539.1
Bos taurus (cattle)	KBTBD10	NP_001076846.1

Gene Ontology
Bibliography

Related articles in PubMed

Nebulin interactions with actin and tropomyosin are altered by disease-causing mutations.
Marttila M, Hanif M, Lemola E, Nowak KJ, Laitila J, Gr?nholm M, Wallgren-Pettersson C, Pelin K
Skeletal muscle415(2014)

Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy.
Gupta VA, Ravenscroft G, Shaheen R, Todd EJ, Swanson LC, Shiina M, Ogata K, Hsu C, Clarke NF, Darras BT, Farrar MA, Hashem A, Manton ND, Muntoni F, North KN, Sandaradura SA, Nishino I, Hayashi YK, Sewry CA, Thompson EM, Yau KS, Brownstein CA, Yu TW, Allcock RJ, Davis MR, Wallgren-Pettersson C, Matsumoto N, Alkuraya FS, Laing NG, Beggs AH
American journal of human genetics93(6)1108-17(2013 Dec)

Update on the Kelch-like (KLHL) gene family.
Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS
Human genomics713(2013 May)

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Blandin G, Marchand S, Charton K, Dani?le N, Gicquel E, Boucheteil JB, Bentaib A, Barrault L, Stockholm D, Bartoli M, Richard I
Skeletal muscle3(1)3(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutations in KLHL41 showed phenotype-genotype correlation: Frameshift mutations resulted in severe phenotypes with neonatal death, whereas missense changes resulted in impaired motor function with survival into late childhood and/or early adulthood.
Title: Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy.

The following KLHL41 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLHL41 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16098	NM_006063.3 Latest version!	Homo sapiens kelch like family member 41 (KLHL41), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16098	NM_006063.2	Homo sapiens kelch like family member 41 (KLHL41), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLHL41 ( NM_006063.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006054.2 Homo sapiens kelch like family member 41 (KLHL41), mRNA.

Price & Availability↑

CloneID	OHu16098
Clone ID Related Accession (Same CDS sequence)	NM_006063.2 , NM_006063.3
Accession Version	NM_006063.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1821bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	kelch-like protein 41
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF333387.1, BC006534.2, AF056929.1 and AA194290.1. This sequence is a reference standard in the RefSeqGene project. On Feb 23, 2004 this sequence version replaced NM_006063.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF333387.1, SRR1660809.122045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTCCC AGCGGGAACT TGCAGAGGAA CTGCGGCTTT ACCAATCCAC CCTTCTTCAG 
GATGGTCTAA AAGATCTCCT GGATGAGAAA AAATTCATCG ATTGCACCCT AAAAGCAGGT 
GACAAAAGTC TTCCTTGCCA CAGATTGATT TTGTCAGCTT GTAGTCCTTA CTTCCGTGAG 
TACTTTTTAT CTGAAATTGA TGAGGCGAAA AAAAAGGAGG TAGTGCTAGA CAATGTGGAT 
CCTGCTATAC TTGATTTAAT CATCAAATAC CTGTACTCTG CCAGTATTGA TCTCAATGAC 
GGAAATGTGC AAGATATTTT TGCATTGGCC AGCCGCTTTC AGATCCCCTC AGTGTTTACT 
GTCTGCGTTT CTTATCTTCA GAAAAGACTT GCTCCTGGTA ACTGTCTAGC CATCCTAAGA 
TTAGGACTTC TTCTTGACTG CCCGAGACTC GCCATTTCTG CCCGTGAATT TGTGTCTGAT 
CGCTTTGTAC AGATTTGTAA GGAAGAGGAC TTTATGCAAC TGTCTCCACA GGAACTGATC 
TCAGTCATTT CAAATGACAG CCTAAATGTA GAAAAAGAAG AAGCAGTATT TGAGGCAGTG 
ATGAAATGGG TGCGAACAGA CAAGGAAAAC AGGGTTAAAA ACCTTAGTGA AGTGTTTGAT 
TGTATCCGTT TTCGCCTTAT GACAGAAAAA TATTTTAAGG ATCATGTTGA GAAAGATGAT 
ATAATTAAAA GCAACCCAGA CCTCCAGAAA AAAATCAAAG TTCTAAAAGA TGCTTTCGCA 
GGCAAACTCC CAGAACCTAG CAAAAATGCC GCGAAGACTG GGGCTGGTGA GGTGAATGGT 
GATGTTGGTG ATGAAGATTT ACTTCCTGGT TACCTGAATG ACATTCCCAG GCATGGAATG 
TTTGTAAAAG ACCTCATCCT CTTGGTTAAT GACACAGCAG CAGTGGCTTA TGACCCCACG 
GAAAATGAAT GCTACCTTAC TGCACTGGCT GAGCAGATTC CCAGAAATCA TTCCAGCATT 
GTTACCCAGC AAAATCAGAT ATATGTGGTA GGAGGACTAT ATGTGGATGA AGAAAATAAG 
GATCAACCTC TACAGTCATA CTTCTTCCAG CTCGATAGCA TAGCATCTGA ATGGGTTGGA 
CTTCCACCTC TGCCTTCAGC CAGGTGTCTC TTCGGTCTGG GAGAGGTGGA TGATAAAATC 
TATGTAGTTG CAGGCAAAGA CCTTCAAACA GAGGCTTCGC TGGATTCAGT ATTATGCTAT 
GATCCTGTGG CTGCAAAATG GAACGAAGTA AAAAAACTCC CTATCAAAGT CTATGGCCAT 
AATGTGATTT CACATAAAGG GATGATATAT TGTCTAGGAG GAAAGACAGA TGACAAAAAA 
TGTACAAACA GGGTGTTTAT CTTCAACCCC AAAAAAGGAG ATTGGAAAGA TCTGGCTCCA 
ATGAAAATTC CTCGTTCCAT GTTTGGAGTA GCAGTCCATA AAGGCAAAAT TGTGATTGCA 
GGAGGTGTCA CTGAAGATGG TCTTTCAGCT TCAGTTGAAG CTTTTGACCT TACAACAAAT 
AAATGGGATG TAATGACCGA ATTTCCCCAA GAAAGAAGCT CCATCAGTTT GGTCAGCCTG 
GCTGGATCTC TGTATGCAAT TGGTGGTTTT GCTATGATTC AACTGGAGTC TAAAGAATTT 
GCACCCACTG AAGTCAATGA CATATGGAAG TATGAAGATG ATAAAAAAGA ATGGGCTGGG 
ATGTTGAAGG AAATACGTTA TGCTTCAGGA GCTAGTTGCC TAGCAACACG TTTAAATCTC 
TTCAAACTGT CTAAACTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006054.2
CDS	78..1898
Translation	MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL

Target ORF information:

RefSeq Version	NM_006063.2
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 41 (KLHL41), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006063.2

ORF Insert Sequence:

ATGGATTCCC AGCGGGAACT TGCAGAGGAA CTGCGGCTTT ACCAATCCAC CCTTCTTCAG 
GATGGTCTAA AAGATCTCCT GGATGAGAAA AAATTCATCG ATTGCACCCT AAAAGCAGGT 
GACAAAAGTC TTCCTTGCCA CAGATTGATT TTGTCAGCTT GTAGTCCTTA CTTCCGTGAG 
TACTTTTTAT CTGAAATTGA TGAGGCGAAA AAAAAGGAGG TAGTGCTAGA CAATGTGGAT 
CCTGCTATAC TTGATTTAAT CATCAAATAC CTGTACTCTG CCAGTATTGA TCTCAATGAC 
GGAAATGTGC AAGATATTTT TGCATTGGCC AGCCGCTTTC AGATCCCCTC AGTGTTTACT 
GTCTGCGTTT CTTATCTTCA GAAAAGACTT GCTCCTGGTA ACTGTCTAGC CATCCTAAGA 
TTAGGACTTC TTCTTGACTG CCCGAGACTC GCCATTTCTG CCCGTGAATT TGTGTCTGAT 
CGCTTTGTAC AGATTTGTAA GGAAGAGGAC TTTATGCAAC TGTCTCCACA GGAACTGATC 
TCAGTCATTT CAAATGACAG CCTAAATGTA GAAAAAGAAG AAGCAGTATT TGAGGCAGTG 
ATGAAATGGG TGCGAACAGA CAAGGAAAAC AGGGTTAAAA ACCTTAGTGA AGTGTTTGAT 
TGTATCCGTT TTCGCCTTAT GACAGAAAAA TATTTTAAGG ATCATGTTGA GAAAGATGAT 
ATAATTAAAA GCAACCCAGA CCTCCAGAAA AAAATCAAAG TTCTAAAAGA TGCTTTCGCA 
GGCAAACTCC CAGAACCTAG CAAAAATGCC GCGAAGACTG GGGCTGGTGA GGTGAATGGT 
GATGTTGGTG ATGAAGATTT ACTTCCTGGT TACCTGAATG ACATTCCCAG GCATGGAATG 
TTTGTAAAAG ACCTCATCCT CTTGGTTAAT GACACAGCAG CAGTGGCTTA TGACCCCACG 
GAAAATGAAT GCTACCTTAC TGCACTGGCT GAGCAGATTC CCAGAAATCA TTCCAGCATT 
GTTACCCAGC AAAATCAGAT ATATGTGGTA GGAGGACTAT ATGTGGATGA AGAAAATAAG 
GATCAACCTC TACAGTCATA CTTCTTCCAG CTCGATAGCA TAGCATCTGA ATGGGTTGGA 
CTTCCACCTC TGCCTTCAGC CAGGTGTCTC TTCGGTCTGG GAGAGGTGGA TGATAAAATC 
TATGTAGTTG CAGGCAAAGA CCTTCAAACA GAGGCTTCGC TGGATTCAGT ATTATGCTAT 
GATCCTGTGG CTGCAAAATG GAACGAAGTA AAAAAACTCC CTATCAAAGT CTATGGCCAT 
AATGTGATTT CACATAAAGG GATGATATAT TGTCTAGGAG GAAAGACAGA TGACAAAAAA 
TGTACAAACA GGGTGTTTAT CTTCAACCCC AAAAAAGGAG ATTGGAAAGA TCTGGCTCCA 
ATGAAAATTC CTCGTTCCAT GTTTGGAGTA GCAGTCCATA AAGGCAAAAT TGTGATTGCA 
GGAGGTGTCA CTGAAGATGG TCTTTCAGCT TCAGTTGAAG CTTTTGACCT TACAACAAAT 
AAATGGGATG TAATGACCGA ATTTCCCCAA GAAAGAAGCT CCATCAGTTT GGTCAGCCTG 
GCTGGATCTC TGTATGCAAT TGGTGGTTTT GCTATGATTC AACTGGAGTC TAAAGAATTT 
GCACCCACTG AAGTCAATGA CATATGGAAG TATGAAGATG ATAAAAAAGA ATGGGCTGGG 
ATGTTGAAGG AAATACGTTA TGCTTCAGGA GCTAGTTGCC TAGCAACACG TTTAAATCTC 
TTCAAACTGT CTAAACTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KLHL41 ( NM_006063.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006054.2 Homo sapiens kelch like family member 41 (KLHL41), mRNA.

Price & Availability↑

CloneID	OHu16098
Clone ID Related Accession (Same CDS sequence)	NM_006063.2 , NM_006063.3
Accession Version	NM_006063.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1821bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	kelch-like protein 41
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF333387.1, BC006534.2, AF056929.1 and AA194290.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_006063.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.230697.1, SRR1660809.122045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000284669.2/ ENSP00000284669.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATTCCC AGCGGGAACT TGCAGAGGAA CTGCGGCTTT ACCAATCCAC CCTTCTTCAG 
GATGGTCTAA AAGATCTCCT GGATGAGAAA AAATTCATCG ATTGCACCCT AAAAGCAGGT 
GACAAAAGTC TTCCTTGCCA CAGATTGATT TTGTCAGCTT GTAGTCCTTA CTTCCGTGAG 
TACTTTTTAT CTGAAATTGA TGAGGCGAAA AAAAAGGAGG TAGTGCTAGA CAATGTGGAT 
CCTGCTATAC TTGATTTAAT CATCAAATAC CTGTACTCTG CCAGTATTGA TCTCAATGAC 
GGAAATGTGC AAGATATTTT TGCATTGGCC AGCCGCTTTC AGATCCCCTC AGTGTTTACT 
GTCTGCGTTT CTTATCTTCA GAAAAGACTT GCTCCTGGTA ACTGTCTAGC CATCCTAAGA 
TTAGGACTTC TTCTTGACTG CCCGAGACTC GCCATTTCTG CCCGTGAATT TGTGTCTGAT 
CGCTTTGTAC AGATTTGTAA GGAAGAGGAC TTTATGCAAC TGTCTCCACA GGAACTGATC 
TCAGTCATTT CAAATGACAG CCTAAATGTA GAAAAAGAAG AAGCAGTATT TGAGGCAGTG 
ATGAAATGGG TGCGAACAGA CAAGGAAAAC AGGGTTAAAA ACCTTAGTGA AGTGTTTGAT 
TGTATCCGTT TTCGCCTTAT GACAGAAAAA TATTTTAAGG ATCATGTTGA GAAAGATGAT 
ATAATTAAAA GCAACCCAGA CCTCCAGAAA AAAATCAAAG TTCTAAAAGA TGCTTTCGCA 
GGCAAACTCC CAGAACCTAG CAAAAATGCC GCGAAGACTG GGGCTGGTGA GGTGAATGGT 
GATGTTGGTG ATGAAGATTT ACTTCCTGGT TACCTGAATG ACATTCCCAG GCATGGAATG 
TTTGTAAAAG ACCTCATCCT CTTGGTTAAT GACACAGCAG CAGTGGCTTA TGACCCCACG 
GAAAATGAAT GCTACCTTAC TGCACTGGCT GAGCAGATTC CCAGAAATCA TTCCAGCATT 
GTTACCCAGC AAAATCAGAT ATATGTGGTA GGAGGACTAT ATGTGGATGA AGAAAATAAG 
GATCAACCTC TACAGTCATA CTTCTTCCAG CTCGATAGCA TAGCATCTGA ATGGGTTGGA 
CTTCCACCTC TGCCTTCAGC CAGGTGTCTC TTCGGTCTGG GAGAGGTGGA TGATAAAATC 
TATGTAGTTG CAGGCAAAGA CCTTCAAACA GAGGCTTCGC TGGATTCAGT ATTATGCTAT 
GATCCTGTGG CTGCAAAATG GAACGAAGTA AAAAAACTCC CTATCAAAGT CTATGGCCAT 
AATGTGATTT CACATAAAGG GATGATATAT TGTCTAGGAG GAAAGACAGA TGACAAAAAA 
TGTACAAACA GGGTGTTTAT CTTCAACCCC AAAAAAGGAG ATTGGAAAGA TCTGGCTCCA 
ATGAAAATTC CTCGTTCCAT GTTTGGAGTA GCAGTCCATA AAGGCAAAAT TGTGATTGCA 
GGAGGTGTCA CTGAAGATGG TCTTTCAGCT TCAGTTGAAG CTTTTGACCT TACAACAAAT 
AAATGGGATG TAATGACCGA ATTTCCCCAA GAAAGAAGCT CCATCAGTTT GGTCAGCCTG 
GCTGGATCTC TGTATGCAAT TGGTGGTTTT GCTATGATTC AACTGGAGTC TAAAGAATTT 
GCACCCACTG AAGTCAATGA CATATGGAAG TATGAAGATG ATAAAAAAGA ATGGGCTGGG 
ATGTTGAAGG AAATACGTTA TGCTTCAGGA GCTAGTTGCC TAGCAACACG TTTAAATCTC 
TTCAAACTGT CTAAACTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006054.2
CDS	78..1898
Translation	MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL

Target ORF information:

RefSeq Version	NM_006063.3
Organism	Homo sapiens(human)
Definition	Homo sapiens kelch like family member 41 (KLHL41), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006063.3

ORF Insert Sequence:

ATGGATTCCC AGCGGGAACT TGCAGAGGAA CTGCGGCTTT ACCAATCCAC CCTTCTTCAG 
GATGGTCTAA AAGATCTCCT GGATGAGAAA AAATTCATCG ATTGCACCCT AAAAGCAGGT 
GACAAAAGTC TTCCTTGCCA CAGATTGATT TTGTCAGCTT GTAGTCCTTA CTTCCGTGAG 
TACTTTTTAT CTGAAATTGA TGAGGCGAAA AAAAAGGAGG TAGTGCTAGA CAATGTGGAT 
CCTGCTATAC TTGATTTAAT CATCAAATAC CTGTACTCTG CCAGTATTGA TCTCAATGAC 
GGAAATGTGC AAGATATTTT TGCATTGGCC AGCCGCTTTC AGATCCCCTC AGTGTTTACT 
GTCTGCGTTT CTTATCTTCA GAAAAGACTT GCTCCTGGTA ACTGTCTAGC CATCCTAAGA 
TTAGGACTTC TTCTTGACTG CCCGAGACTC GCCATTTCTG CCCGTGAATT TGTGTCTGAT 
CGCTTTGTAC AGATTTGTAA GGAAGAGGAC TTTATGCAAC TGTCTCCACA GGAACTGATC 
TCAGTCATTT CAAATGACAG CCTAAATGTA GAAAAAGAAG AAGCAGTATT TGAGGCAGTG 
ATGAAATGGG TGCGAACAGA CAAGGAAAAC AGGGTTAAAA ACCTTAGTGA AGTGTTTGAT 
TGTATCCGTT TTCGCCTTAT GACAGAAAAA TATTTTAAGG ATCATGTTGA GAAAGATGAT 
ATAATTAAAA GCAACCCAGA CCTCCAGAAA AAAATCAAAG TTCTAAAAGA TGCTTTCGCA 
GGCAAACTCC CAGAACCTAG CAAAAATGCC GCGAAGACTG GGGCTGGTGA GGTGAATGGT 
GATGTTGGTG ATGAAGATTT ACTTCCTGGT TACCTGAATG ACATTCCCAG GCATGGAATG 
TTTGTAAAAG ACCTCATCCT CTTGGTTAAT GACACAGCAG CAGTGGCTTA TGACCCCACG 
GAAAATGAAT GCTACCTTAC TGCACTGGCT GAGCAGATTC CCAGAAATCA TTCCAGCATT 
GTTACCCAGC AAAATCAGAT ATATGTGGTA GGAGGACTAT ATGTGGATGA AGAAAATAAG 
GATCAACCTC TACAGTCATA CTTCTTCCAG CTCGATAGCA TAGCATCTGA ATGGGTTGGA 
CTTCCACCTC TGCCTTCAGC CAGGTGTCTC TTCGGTCTGG GAGAGGTGGA TGATAAAATC 
TATGTAGTTG CAGGCAAAGA CCTTCAAACA GAGGCTTCGC TGGATTCAGT ATTATGCTAT 
GATCCTGTGG CTGCAAAATG GAACGAAGTA AAAAAACTCC CTATCAAAGT CTATGGCCAT 
AATGTGATTT CACATAAAGG GATGATATAT TGTCTAGGAG GAAAGACAGA TGACAAAAAA 
TGTACAAACA GGGTGTTTAT CTTCAACCCC AAAAAAGGAG ATTGGAAAGA TCTGGCTCCA 
ATGAAAATTC CTCGTTCCAT GTTTGGAGTA GCAGTCCATA AAGGCAAAAT TGTGATTGCA 
GGAGGTGTCA CTGAAGATGG TCTTTCAGCT TCAGTTGAAG CTTTTGACCT TACAACAAAT 
AAATGGGATG TAATGACCGA ATTTCCCCAA GAAAGAAGCT CCATCAGTTT GGTCAGCCTG 
GCTGGATCTC TGTATGCAAT TGGTGGTTTT GCTATGATTC AACTGGAGTC TAAAGAATTT 
GCACCCACTG AAGTCAATGA CATATGGAAG TATGAAGATG ATAAAAAAGA ATGGGCTGGG 
ATGTTGAAGG AAATACGTTA TGCTTCAGGA GCTAGTTGCC TAGCAACACG TTTAAATCTC 
TTCAAACTGT CTAAACTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nebulin interactions with actin and tropomyosin are altered by disease-causing mutations.
Skeletal muscle415(2014)
Marttila M,Hanif M,Lemola E,Nowak KJ,Laitila J,Gr?nholm M,Wallgren-Pettersson C,Pelin K

Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy.
American journal of human genetics93(6)1108-17(2013 Dec)
Gupta VA,Ravenscroft G,Shaheen R,Todd EJ,Swanson LC,Shiina M,Ogata K,Hsu C,Clarke NF,Darras BT,Farrar MA,Hashem A,Manton ND,Muntoni F,North KN,Sandaradura SA,Nishino I,Hayashi YK,Sewry CA,Thompson EM,Yau KS,Brownstein CA,Yu TW,Allcock RJ,Davis MR,Wallgren-Pettersson C,Matsumoto N,Alkuraya FS,Laing NG,Beggs AH

Update on the Kelch-like (KLHL) gene family.
Human genomics713(2013 May)
Dhanoa BS,Cogliati T,Satish AG,Bruford EA,Friedman JS

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Skeletal muscle3(1)3(2013 Feb)
Blandin G,Marchand S,Charton K,Dani?le N,Gicquel E,Boucheteil JB,Bentaib A,Barrault L,Stockholm D,Bartoli M,Richard I

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KLHL41 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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