CRISP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRISP3
Entrez Gene ID	10321
Full Name	cysteine rich secretory protein 3
Synonyms	Aeg2,CRISP-3,CRS3,SGP28,dJ442L6.3
General protein information	Preferred Names cysteine rich secretory protein 3 Names cysteine-rich secretory protein 3 specific granule protein (28 kDa)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p12.3
Summary	This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_006061.4	NP_006052.2	cysteine-rich secretory protein 3 isoform 1 precursor
NM_001190986.2	NP_001177915.1	cysteine-rich secretory protein 3 isoform 2
NM_006061.3	NP_006052.2	cysteine-rich secretory protein 3 isoform 1 precursor
NM_006061.2	NP_006052.2	cysteine-rich secretory protein 3 isoform 1 precursor
NM_001368123.1	NP_001355052.1	cysteine-rich secretory protein 3 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	CRISP3	NP_006052.2
	CRISP3	XP_001105287.1
Pan troglodytes (chimpanzee)	CRISP3	XP_001148602.1
Canis lupus familiaris (dog)	LOC481834	XP_005627519.1

Gene Ontology
Bibliography

Related articles in PubMed

Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer.
Noh BJ, Sung JY, Kim YW, Chang SG, Park YK
Oncology letters11(6)3621-3630(2016 Jun)

Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.
Pathak BR, Breed AA, Apte S, Acharya K, Mahale SD
Molecular and cellular biochemistry411(1-2)11-21(2016 Jan)

A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.
Skov V, Burton M, Thomassen M, Stauffer Larsen T, Riley CH, Brinch Madelung A, Kj?r L, Bondo H, Stamp I, Ehinger M, Dahl-S?rensen R, Brochmann N, Nielsen K, Thiele J, Jensen MK, Weis Bjerrum O, Kruse TA, Hasselbalch HC
PloS one11(8)e0161570(2016)

Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalent.
Chen F, Duggal P, Klein BE, Lee KE, Truitt B, Klein R, Iyengar SK, Klein AP
Molecular vision22783-96(2016)

From the epididymis to the egg: participation of CRISP proteins in mammalian fertilization.
Da Ros VG, Mu?oz MW, Battistone MA, Brukman NG, Carvajal G, Curci L, G?mez-ElIas MD, Cohen DB, Cuasnicu PS
Asian journal of andrology17(5)711-5(2015 Sep-Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that overexpression of CRISP-3 in prostate tumor may maintain higher PSA expression and lower ANXA1 expression
Title: Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.

These data suggest roles for epithelial and neutrophil-derived CRISP3 in postmenstrual endometrial repair and regeneration
Title: Endometrial CRISP3 is regulated throughout the mouse estrous and human menstrual cycle and facilitates adhesion and proliferation of endometrial epithelial cells.

up-regulation of the mRNA encoding cysteine-rich secretory protein 3 (CRISP3), a glycoprotein with unknown function that is secreted from multiple exocrine glands, was correlated with HCV resistance.
Title: Cysteine-rich secretory protein 3 inhibits hepatitis C virus at the initial phase of infection.

Strong CRISP3 expression is associated with unfavorable tumor phenotype and early recurrence in prostate cancers
Title: Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence.

terminal beta-strands of PSP94 contact the first alpha-helix and the hinge region of CRISP-3
Title: Mapping of the binding sites involved in PSP94-CRISP-3 interaction by molecular dissection of the complex.

The following CRISP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRISP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12339	NM_006061.4 Latest version!	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10881	NM_001190986.2 Latest version!	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu107912	NM_001368123.1 Latest version!	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu12339	NM_006061.3	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12339	NM_006061.2	Homo sapiens cysteine-rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRISP3 ( NM_006061.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006052.2 Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12339
Clone ID Related Accession (Same CDS sequence)	NM_006061.4 , NM_006061.3 , NM_006061.2
Accession Version	NM_006061.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	cysteine-rich secretory protein 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB210604.1, X95240.1 and AL121950.8. On Jun 2, 2019 this sequence version replaced NM_006061.3. Transcript Variant: This variant (1) encodes isoform 1. CCDS Note: The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. The updated start codon is found only in primates and it has a weak Kozak signal. It is possible that ribosomal leaky scanning may sometimes allow the better conserved downstream start codon to be used. There is no experimental evidence to indicate which start codon is preferentially used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X95240.1, X94323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAA TGACATTATT CCCAGTGCTG 
TTGTTCCTGG TTGCTGGGCT GCTTCCATCT TTTCCAGCAA ATGAAGATAA GGATCCCGCT 
TTTACTGCTT TGTTAACCAC CCAAACACAA GTGCAAAGGG AGATTGTGAA TAAGCACAAT 
GAACTGAGGA GAGCAGTATC TCCCCCTGCC AGAAACATGC TGAAGATGGA ATGGAACAAA 
GAGGCTGCAG CAAATGCCCA AAAGTGGGCA AACCAGTGCA ATTACAGACA CAGTAACCCA 
AAGGATCGAA TGACAAGTCT AAAATGTGGT GAGAATCTCT ACATGTCAAG TGCCTCCAGC 
TCATGGTCAC AAGCAATCCA AAGCTGGTTT GATGAGTACA ATGATTTTGA CTTTGGTGTA 
GGGCCAAAGA CTCCCAACGC AGTGGTTGGA CATTATACAC AGGTTGTTTG GTACTCTTCA 
TACCTCGTTG GATGTGGAAA TGCCTACTGT CCCAATCAAA AAGTTCTAAA ATACTACTAT 
GTTTGCCAAT ATTGTCCTGC TGGTAATTGG GCTAATAGAC TATATGTCCC TTATGAACAA 
GGAGCACCTT GTGCCAGTTG CCCAGATAAC TGTGACGATG GACTATGCAC CAATGGTTGC 
AAGTACGAAG ATCTCTATAG TAACTGTAAA AGTTTGAAGC TCACATTAAC CTGTAAACAT 
CAGTTGGTCA GGGACAGTTG CAAGGCCTCC TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006052.2
CDS	22..798
Translation	MKQILHPALETTAMTLFPVLLFLVAGLLPSFPANEDKDPAFTALLTTQTQVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASSSWSQAIQSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANRLYVPYEQGAPCASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY

Target ORF information:

RefSeq Version	NM_006061.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006061.4

ORF Insert Sequence:

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAA TGACATTATT CCCAGTGCTG 
TTGTTCCTGG TTGCTGGGCT GCTTCCATCT TTTCCAGCAA ATGAAGATAA GGATCCCGCT 
TTTACTGCTT TGTTAACCAC CCAAACACAA GTGCAAAGGG AGATTGTGAA TAAGCACAAT 
GAACTGAGGA GAGCAGTATC TCCCCCTGCC AGAAACATGC TGAAGATGGA ATGGAACAAA 
GAGGCTGCAG CAAATGCCCA AAAGTGGGCA AACCAGTGCA ATTACAGACA CAGTAACCCA 
AAGGATCGAA TGACAAGTCT AAAATGTGGT GAGAATCTCT ACATGTCAAG TGCCTCCAGC 
TCATGGTCAC AAGCAATCCA AAGCTGGTTT GATGAGTACA ATGATTTTGA CTTTGGTGTA 
GGGCCAAAGA CTCCCAACGC AGTGGTTGGA CATTATACAC AGGTTGTTTG GTACTCTTCA 
TACCTCGTTG GATGTGGAAA TGCCTACTGT CCCAATCAAA AAGTTCTAAA ATACTACTAT 
GTTTGCCAAT ATTGTCCTGC TGGTAATTGG GCTAATAGAC TATATGTCCC TTATGAACAA 
GGAGCACCTT GTGCCAGTTG CCCAGATAAC TGTGACGATG GACTATGCAC CAATGGTTGC 
AAGTACGAAG ATCTCTATAG TAACTGTAAA AGTTTGAAGC TCACATTAAC CTGTAAACAT 
CAGTTGGTCA GGGACAGTTG CAAGGCCTCC TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRISP3 ( NM_006061.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006052.2 Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12339
Clone ID Related Accession (Same CDS sequence)	NM_006061.4 , NM_006061.3 , NM_006061.2
Accession Version	NM_006061.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Homo sapiens(human)
Product	cysteine-rich secretory protein 3 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB210604.1, X95240.1 and AL121950.8. On Nov 5, 2016 this sequence version replaced NM_006061.2. Transcript Variant: This variant (1) encodes isoform 1. CCDS Note: The coding region has been updated to extend the N-terminus to one that is more supported by the available transcript data. The updated start codon is found only in primates and it has a weak Kozak signal. It is possible that ribosomal leaky scanning may sometimes allow the better conserved downstream start codon to be used. There is no experimental evidence to indicate which start codon is preferentially used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.153457.1, ERR279828.4956.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAA TGACATTATT CCCAGTGCTG 
TTGTTCCTGG TTGCTGGGCT GCTTCCATCT TTTCCAGCAA ATGAAGATAA GGATCCCGCT 
TTTACTGCTT TGTTAACCAC CCAAACACAA GTGCAAAGGG AGATTGTGAA TAAGCACAAT 
GAACTGAGGA GAGCAGTATC TCCCCCTGCC AGAAACATGC TGAAGATGGA ATGGAACAAA 
GAGGCTGCAG CAAATGCCCA AAAGTGGGCA AACCAGTGCA ATTACAGACA CAGTAACCCA 
AAGGATCGAA TGACAAGTCT AAAATGTGGT GAGAATCTCT ACATGTCAAG TGCCTCCAGC 
TCATGGTCAC AAGCAATCCA AAGCTGGTTT GATGAGTACA ATGATTTTGA CTTTGGTGTA 
GGGCCAAAGA CTCCCAACGC AGTGGTTGGA CATTATACAC AGGTTGTTTG GTACTCTTCA 
TACCTCGTTG GATGTGGAAA TGCCTACTGT CCCAATCAAA AAGTTCTAAA ATACTACTAT 
GTTTGCCAAT ATTGTCCTGC TGGTAATTGG GCTAATAGAC TATATGTCCC TTATGAACAA 
GGAGCACCTT GTGCCAGTTG CCCAGATAAC TGTGACGATG GACTATGCAC CAATGGTTGC 
AAGTACGAAG ATCTCTATAG TAACTGTAAA AGTTTGAAGC TCACATTAAC CTGTAAACAT 
CAGTTGGTCA GGGACAGTTG CAAGGCCTCC TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006052.2
CDS	89..865
Translation	MKQILHPALETTAMTLFPVLLFLVAGLLPSFPANEDKDPAFTALLTTQTQVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASSSWSQAIQSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANRLYVPYEQGAPCASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY

Target ORF information:

RefSeq Version	NM_006061.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006061.3

ORF Insert Sequence:

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAA TGACATTATT CCCAGTGCTG 
TTGTTCCTGG TTGCTGGGCT GCTTCCATCT TTTCCAGCAA ATGAAGATAA GGATCCCGCT 
TTTACTGCTT TGTTAACCAC CCAAACACAA GTGCAAAGGG AGATTGTGAA TAAGCACAAT 
GAACTGAGGA GAGCAGTATC TCCCCCTGCC AGAAACATGC TGAAGATGGA ATGGAACAAA 
GAGGCTGCAG CAAATGCCCA AAAGTGGGCA AACCAGTGCA ATTACAGACA CAGTAACCCA 
AAGGATCGAA TGACAAGTCT AAAATGTGGT GAGAATCTCT ACATGTCAAG TGCCTCCAGC 
TCATGGTCAC AAGCAATCCA AAGCTGGTTT GATGAGTACA ATGATTTTGA CTTTGGTGTA 
GGGCCAAAGA CTCCCAACGC AGTGGTTGGA CATTATACAC AGGTTGTTTG GTACTCTTCA 
TACCTCGTTG GATGTGGAAA TGCCTACTGT CCCAATCAAA AAGTTCTAAA ATACTACTAT 
GTTTGCCAAT ATTGTCCTGC TGGTAATTGG GCTAATAGAC TATATGTCCC TTATGAACAA 
GGAGCACCTT GTGCCAGTTG CCCAGATAAC TGTGACGATG GACTATGCAC CAATGGTTGC 
AAGTACGAAG ATCTCTATAG TAACTGTAAA AGTTTGAAGC TCACATTAAC CTGTAAACAT 
CAGTTGGTCA GGGACAGTTG CAAGGCCTCC TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRISP3 ( NM_006061.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006052.2 Homo sapiens cysteine-rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12339
Clone ID Related Accession (Same CDS sequence)	NM_006061.4 , NM_006061.3 , NM_006061.2
Accession Version	NM_006061.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	cysteine-rich secretory protein 3 isoform 1 precursor
Comment

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAA TGACATTATT CCCAGTGCTG 
TTGTTCCTGG TTGCTGGGCT GCTTCCATCT TTTCCAGCAA ATGAAGATAA GGATCCCGCT 
TTTACTGCTT TGTTAACCAC CCAAACACAA GTGCAAAGGG AGATTGTGAA TAAGCACAAT 
GAACTGAGGA GAGCAGTATC TCCCCCTGCC AGAAACATGC TGAAGATGGA ATGGAACAAA 
GAGGCTGCAG CAAATGCCCA AAAGTGGGCA AACCAGTGCA ATTACAGACA CAGTAACCCA 
AAGGATCGAA TGACAAGTCT AAAATGTGGT GAGAATCTCT ACATGTCAAG TGCCTCCAGC 
TCATGGTCAC AAGCAATCCA AAGCTGGTTT GATGAGTACA ATGATTTTGA CTTTGGTGTA 
GGGCCAAAGA CTCCCAACGC AGTGGTTGGA CATTATACAC AGGTTGTTTG GTACTCTTCA 
TACCTCGTTG GATGTGGAAA TGCCTACTGT CCCAATCAAA AAGTTCTAAA ATACTACTAT 
GTTTGCCAAT ATTGTCCTGC TGGTAATTGG GCTAATAGAC TATATGTCCC TTATGAACAA 
GGAGCACCTT GTGCCAGTTG CCCAGATAAC TGTGACGATG GACTATGCAC CAATGGTTGC 
AAGTACGAAG ATCTCTATAG TAACTGTAAA AGTTTGAAGC TCACATTAAC CTGTAAACAT 
CAGTTGGTCA GGGACAGTTG CAAGGCCTCC TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006052.2
Translation	MKQILHPALETTAMTLFPVLLFLVAGLLPSFPANEDKDPAFTALLTTQTQVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASSSWSQAIQSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANRLYVPYEQGAPCASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY

Target ORF information:

RefSeq Version	NM_006061.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens cysteine-rich secretory protein 3 (CRISP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006061.2

ORF Insert Sequence:

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAA TGACATTATT CCCAGTGCTG 
TTGTTCCTGG TTGCTGGGCT GCTTCCATCT TTTCCAGCAA ATGAAGATAA GGATCCCGCT 
TTTACTGCTT TGTTAACCAC CCAAACACAA GTGCAAAGGG AGATTGTGAA TAAGCACAAT 
GAACTGAGGA GAGCAGTATC TCCCCCTGCC AGAAACATGC TGAAGATGGA ATGGAACAAA 
GAGGCTGCAG CAAATGCCCA AAAGTGGGCA AACCAGTGCA ATTACAGACA CAGTAACCCA 
AAGGATCGAA TGACAAGTCT AAAATGTGGT GAGAATCTCT ACATGTCAAG TGCCTCCAGC 
TCATGGTCAC AAGCAATCCA AAGCTGGTTT GATGAGTACA ATGATTTTGA CTTTGGTGTA 
GGGCCAAAGA CTCCCAACGC AGTGGTTGGA CATTATACAC AGGTTGTTTG GTACTCTTCA 
TACCTCGTTG GATGTGGAAA TGCCTACTGT CCCAATCAAA AAGTTCTAAA ATACTACTAT 
GTTTGCCAAT ATTGTCCTGC TGGTAATTGG GCTAATAGAC TATATGTCCC TTATGAACAA 
GGAGCACCTT GTGCCAGTTG CCCAGATAAC TGTGACGATG GACTATGCAC CAATGGTTGC 
AAGTACGAAG ATCTCTATAG TAACTGTAAA AGTTTGAAGC TCACATTAAC CTGTAAACAT 
CAGTTGGTCA GGGACAGTTG CAAGGCCTCC TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRISP3 ( NM_001190986.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177915.1 Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10881
Clone ID Related Accession (Same CDS sequence)	NM_001190986.2
Accession Version	NM_001190986.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	cysteine-rich secretory protein 3 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB210604.1, DB206136.1, BC069580.1, X95240.1 and AL121950.8. On Nov 5, 2016 this sequence version replaced NM_001190986.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is longer than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGATC CCTGTTCCAC CGGTTTTGTT 
TTCCCAGCAA TGACATTATT CCCAGTGCTG TTGTTCCTGG TTGCTGGGCT GCTTCCATCT 
TTTCCAGCAA ATGAAGATAA GGATCCCGCT TTTACTGCTT TGTTAACCAC CCAAACACAA 
GTGCAAAGGG AGATTGTGAA TAAGCACAAT GAACTGAGGA GAGCAGTATC TCCCCCTGCC 
AGAAACATGC TGAAGATGGA ATGGAACAAA GAGGCTGCAG CAAATGCCCA AAAGTGGGCA 
AACCAGTGCA ATTACAGACA CAGTAACCCA AAGGATCGAA TGACAAGTCT AAAATGTGGT 
GAGAATCTCT ACATGTCAAG TGCCTCCAGC TCATGGTCAC AAGCAATCCA AAGCTGGTTT 
GATGAGTACA ATGATTTTGA CTTTGGTGTA GGGCCAAAGA CTCCCAACGC AGTGGTTGGA 
CATTATACAC AGGTTGTTTG GTACTCTTCA TACCTCGTTG GATGTGGAAA TGCCTACTGT 
CCCAATCAAA AAGTTCTAAA ATACTACTAT GTTTGCCAAT ATTGTCCTGC TGGTAATTGG 
GCTAATAGAC TATATGTCCC TTATGAACAA GGAGCACCTT GTGCCAGTTG CCCAGATAAC 
TGTGACGATG GACTATGCAC CAATGGTTGC AAGTACGAAG ATCTCTATAG TAACTGTAAA 
AGTTTGAAGC TCACATTAAC CTGTAAACAT CAGTTGGTCA GGGACAGTTG CAAGGCCTCC 
TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177915.1
CDS	89..895
Translation	MKQILHPALETTDPCSTGFVFPAMTLFPVLLFLVAGLLPSFPANEDKDPAFTALLTTQTQVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASSSWSQAIQSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANRLYVPYEQGAPCASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY

Target ORF information:

RefSeq Version	NM_001190986.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190986.2

ORF Insert Sequence:

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGATC CCTGTTCCAC CGGTTTTGTT 
TTCCCAGCAA TGACATTATT CCCAGTGCTG TTGTTCCTGG TTGCTGGGCT GCTTCCATCT 
TTTCCAGCAA ATGAAGATAA GGATCCCGCT TTTACTGCTT TGTTAACCAC CCAAACACAA 
GTGCAAAGGG AGATTGTGAA TAAGCACAAT GAACTGAGGA GAGCAGTATC TCCCCCTGCC 
AGAAACATGC TGAAGATGGA ATGGAACAAA GAGGCTGCAG CAAATGCCCA AAAGTGGGCA 
AACCAGTGCA ATTACAGACA CAGTAACCCA AAGGATCGAA TGACAAGTCT AAAATGTGGT 
GAGAATCTCT ACATGTCAAG TGCCTCCAGC TCATGGTCAC AAGCAATCCA AAGCTGGTTT 
GATGAGTACA ATGATTTTGA CTTTGGTGTA GGGCCAAAGA CTCCCAACGC AGTGGTTGGA 
CATTATACAC AGGTTGTTTG GTACTCTTCA TACCTCGTTG GATGTGGAAA TGCCTACTGT 
CCCAATCAAA AAGTTCTAAA ATACTACTAT GTTTGCCAAT ATTGTCCTGC TGGTAATTGG 
GCTAATAGAC TATATGTCCC TTATGAACAA GGAGCACCTT GTGCCAGTTG CCCAGATAAC 
TGTGACGATG GACTATGCAC CAATGGTTGC AAGTACGAAG ATCTCTATAG TAACTGTAAA 
AGTTTGAAGC TCACATTAAC CTGTAAACAT CAGTTGGTCA GGGACAGTTG CAAGGCCTCC 
TGCAATTGTT CAAACAGCAT TTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRISP3 ( NM_001368123.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001355052.1 Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 3, mRNA.

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CloneID	OHu107912
Clone ID Related Accession (Same CDS sequence)	NM_001368123.1
Accession Version	NM_001368123.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	cysteine-rich secretory protein 3 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121974.16, DB204588.1 and AL121950.8. Transcript Variant: This variant (3) encodes the longest isoform (3). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAT GTACCAATCA TTTTAATGCA 
GATCCCTGTT CCACCGGTTT TGTTTTCCCA GCAATGACAT TATTCCCAGT GCTGTTGTTC 
CTGGTTGCTG GGCTGCTTCC ATCTTTTCCA GCAAATGAAG ATAAGGATCC CGCTTTTACT 
GCTTTGTTAA CCACCCAAAC ACAAGTGCAA AGGGAGATTG TGAATAAGCA CAATGAACTG 
AGGAGAGCAG TATCTCCCCC TGCCAGAAAC ATGCTGAAGA TGGAATGGAA CAAAGAGGCT 
GCAGCAAATG CCCAAAAGTG GGCAAACCAG TGCAATTACA GACACAGTAA CCCAAAGGAT 
CGAATGACAA GTCTAAAATG TGGTGAGAAT CTCTACATGT CAAGTGCCTC CAGCTCATGG 
TCACAAGCAA TCCAAAGCTG GTTTGATGAG TACAATGATT TTGACTTTGG TGTAGGGCCA 
AAGACTCCCA ACGCAGTGGT TGGACATTAT ACACAGGTTG TTTGGTACTC TTCATACCTC 
GTTGGATGTG GAAATGCCTA CTGTCCCAAT CAAAAAGTTC TAAAATACTA CTATGTTTGC 
CAATATTGTC CTGCTGGTAA TTGGGCTAAT AGACTATATG TCCCTTATGA ACAAGGAGCA 
CCTTGTGCCA GTTGCCCAGA TAACTGTGAC GATGGACTAT GCACCAATGG TTGCAAGTAC 
GAAGATCTCT ATAGTAACTG TAAAAGTTTG AAGCTCACAT TAACCTGTAA ACATCAGTTG 
GTCAGGGACA GTTGCAAGGC CTCCTGCAAT TGTTCAAACA GCATTTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001355052.1
CDS	22..852
Translation	MKQILHPALETTACTNHFNADPCSTGFVFPAMTLFPVLLFLVAGLLPSFPANEDKDPAFTALLTTQTQVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSLKCGENLYMSSASSSWSQAIQSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPAGNWANRLYVPYEQGAPCASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY

Target ORF information:

RefSeq Version	NM_001368123.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cysteine rich secretory protein 3 (CRISP3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001368123.1

ORF Insert Sequence:

ATGAAACAAA TACTTCATCC TGCTCTGGAA ACCACTGCAT GTACCAATCA TTTTAATGCA 
GATCCCTGTT CCACCGGTTT TGTTTTCCCA GCAATGACAT TATTCCCAGT GCTGTTGTTC 
CTGGTTGCTG GGCTGCTTCC ATCTTTTCCA GCAAATGAAG ATAAGGATCC CGCTTTTACT 
GCTTTGTTAA CCACCCAAAC ACAAGTGCAA AGGGAGATTG TGAATAAGCA CAATGAACTG 
AGGAGAGCAG TATCTCCCCC TGCCAGAAAC ATGCTGAAGA TGGAATGGAA CAAAGAGGCT 
GCAGCAAATG CCCAAAAGTG GGCAAACCAG TGCAATTACA GACACAGTAA CCCAAAGGAT 
CGAATGACAA GTCTAAAATG TGGTGAGAAT CTCTACATGT CAAGTGCCTC CAGCTCATGG 
TCACAAGCAA TCCAAAGCTG GTTTGATGAG TACAATGATT TTGACTTTGG TGTAGGGCCA 
AAGACTCCCA ACGCAGTGGT TGGACATTAT ACACAGGTTG TTTGGTACTC TTCATACCTC 
GTTGGATGTG GAAATGCCTA CTGTCCCAAT CAAAAAGTTC TAAAATACTA CTATGTTTGC 
CAATATTGTC CTGCTGGTAA TTGGGCTAAT AGACTATATG TCCCTTATGA ACAAGGAGCA 
CCTTGTGCCA GTTGCCCAGA TAACTGTGAC GATGGACTAT GCACCAATGG TTGCAAGTAC 
GAAGATCTCT ATAGTAACTG TAAAAGTTTG AAGCTCACAT TAACCTGTAA ACATCAGTTG 
GTCAGGGACA GTTGCAAGGC CTCCTGCAAT TGTTCAAACA GCATTTATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer.
Oncology letters11(6)3621-3630(2016 Jun)
Noh BJ,Sung JY,Kim YW,Chang SG,Park YK

Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.
Molecular and cellular biochemistry411(1-2)11-21(2016 Jan)
Pathak BR,Breed AA,Apte S,Acharya K,Mahale SD

A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.
PloS one11(8)e0161570(2016)
Skov V,Burton M,Thomassen M,Stauffer Larsen T,Riley CH,Brinch Madelung A,Kj?r L,Bondo H,Stamp I,Ehinger M,Dahl-S?rensen R,Brochmann N,Nielsen K,Thiele J,Jensen MK,Weis Bjerrum O,Kruse TA,Hasselbalch HC

Variation in PTCHD2, CRISP3, NAP1L4, FSCB, and AP3B2 associated with spherical equivalent.
Molecular vision22783-96(2016)
Chen F,Duggal P,Klein BE,Lee KE,Truitt B,Klein R,Iyengar SK,Klein AP

From the epididymis to the egg: participation of CRISP proteins in mammalian fertilization.
Asian journal of andrology17(5)711-5(2015 Sep-Oct)
Da Ros VG,Mu?oz MW,Battistone MA,Brukman NG,Carvajal G,Curci L,G?mez-ElIas MD,Cohen DB,Cuasnicu PS

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CRISP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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