TOPORS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TOPORS
Entrez Gene ID	10210
Full Name	TOP1 binding arginine/serine rich protein
Synonyms	LUN,P53BP3,RP31,TP53BPL
General protein information	Preferred Names TOP1 binding arginine/serine rich protein Names E3 ubiquitin-protein ligase Topors RING-type E3 ubiquitin transferase Topors SUMO1-protein E3 ligase Topors topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase topoisomerase I-binding RING finger protein tumor suppressor p53-binding protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.1
Summary	This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010].
Disorder MIM:	609507
Disorder Html:	Retinitis pigmentosa 31, 609923 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001195622.1	NP_001182551.1	E3 ubiquitin-protein ligase Topors isoform 2
NM_005802.5	NP_005793.2	E3 ubiquitin-protein ligase Topors isoform 1
NM_005802.4	NP_005793.2	E3 ubiquitin-protein ligase Topors isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TOPORS	XP_003639434.1
Bos taurus (cattle)	TOPORS	NP_001179507.2
Mus musculus (house mouse)	Topors	NP_598858.2
Homo sapiens (human)	TOPORS	NP_005793.2
Pan troglodytes (chimpanzee)	TOPORS	XP_003951457.1
	TOPORS	XP_001092273.2
Gallus gallus (chicken)	TOPORS	XP_424920.4
Rattus norvegicus (Norway rat)	Topors	NP_001102128.1
Xenopus tropicalis (tropical clawed frog)	topors	XP_002940310.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel mutation in the dominantly inherited TOPORS gene supports haploinsufficiency as the mechanism of retinitis pigmentosa.
Latasiewicz M, Salvetti AP, MacLaren RE
Ophthalmic genetics38(6)562-566(2017 Dec)

TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.
Czub B, Shah AZ, Alfano G, Kruczek PM, Chakarova CF, Bhattacharya SS
PloS one11(2)e0148678(2016)

TOPORS modulates H2AX discriminating genotoxic stresses.
Seong KM, Nam SY, Kim JY, Yang KH, An S, Jin YW, Kim CS
Journal of biochemical and molecular toxicology26(11)429-38(2012 Nov)

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Kennedy RB, Ovsyannikova IG, Pankratz VS, Haralambieva IH, Vierkant RA, Poland GA
Human genetics131(9)1403-21(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A novel mutation of the TOPORS gene was identified, c.2539C>T p.(Arg847Ter), resulting in a premature termination codon and suggesting haploinsufficiency as the pathological mechanism.
Title: A novel mutation in the dominantly inherited TOPORS gene supports haploinsufficiency as the mechanism of retinitis pigmentosa.

P26s4 Associates with the C-Terminal Region of TOPORS.
Title: TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.

Data suggest that TOPORS plays key role in turnover of H2AX (H2A histone family, member X protein) depending on the type of oxidative stress/DNA damage; TOPORS may act as an E3 ubiquitin ligase for histones.
Title: TOPORS modulates H2AX discriminating genotoxic stresses.

Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy).
Title: Disturbed flow: p53 SUMOylation in the turnover of endothelial cells.

In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes.
Title: TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.

The following TOPORS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOPORS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16707	NM_001195622.1 Latest version!	Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu18284	NM_005802.5 Latest version!	Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$384.30 $549.00
View Old Accession Versions >>
OHu18284	NM_005802.4	Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$384.30 $549.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TOPORS ( NM_001195622.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182551.1 Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16707
Clone ID Related Accession (Same CDS sequence)	NM_001195622.1
Accession Version	NM_001195622.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2943bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase Topors isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA238762.1, BC060884.1, AB045733.1, U82939.1, BU674865.1, BJ993131.1 and BQ007035.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB045733.1, DA941882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END##

ATGATAATGG CATCAGCTGC TAAGGAATTT AAAATGGACA ACTTTTCACC TAAAGCTGGC 
ACTAGCAAAT TGCAACAGAC AGTACCAGCT GATGCATCTC CTGATTCTAA GTGTCCTATA 
TGCTTGGATA GATTTGATAA TGTGTCTTAC TTAGATCGCT GCTTACATAA GTTCTGTTTT 
CGCTGTGTAC AGGAGTGGTC AAAAAACAAA GCTGAATGCC CACTATGTAA ACAGCCCTTT 
GATTCTATTT TCCATTCTGT GAGGGCAGAA GATGACTTCA AGGAGTATGT CCTAAGGCCT 
TCGTATAATG GTTCTTTTGT CACCCCTGAT CGACGATTTC GCTACCGTAC AACTCTGACA 
AGGGAACGAA ATGCTTCTGT GTATTCACCT AGTGGTCCTG TGAACAGAAG AACAACAACT 
CCACCGGATA GTGGAGTACT GTTTGAAGGG TTAGGCATTT CAACAAGACC TAGAGATGTT 
GAAATTCCTC AGTTTATGAG ACAGATTGCA GTAAGGAGGC CAACTACGGC AGATGAAAGA 
TCTTTGCGGA AAATTCAAGA ACAAGATATT ATTAATTTTA GACGAACTCT TTATCGTGCT 
GGTGCTCGAG TTAGAAATAT TGAAGATGGT GGCCGCTACA GGGATATTTC AGCTGAATTT 
TTCCGTAGAA ATCCAGCTTG CCTTCACAGA TTAGTCCCCT GGTTAAAACG TGAACTTACA 
GTTCTTTTTG GAGCTCATGG ATCTTTAGTG AATATTGTCC AGCATATTAT CATGAGTAAT 
GTTACTCGCT ATGACTTGGA GAGTCAGGCA TTTGTGTCTG ATTTAAGACC ATTTTTACTT 
AATCGAACTG AGCATTTTAT ACATGAATTT ATCAGTTTTG CCCGATCTCC TTTTAACATG 
GCAGCCTTTG ACCAGCATGC CAATTATGAT TGCCCTGCTC CTTCATACGA AGAAGGCAGC 
CATTCTGATT CTTCAGTCAT AACAATATCT CCAGATGAGG CTGAGACCCA AGAGCTGGAT 
ATTAATGTAG CCACTGTTAG TCAGGCACCA TGGGATGATG AAACTCCAGG ACCATCTTAC 
TCAAGCTCAG AGCAGGTACA CGTTACTATG TCTTCTCTTT TAAATACTTC TGACAGTTCA 
GATGAAGAAC TTGTCACAGG AGGAGCCACG TCTCAGATAC AAGGAGTACA AACCAATGAC 
GACCTAAATA ATGACAGTGA TGATTCTTCA GATAATTGTG TCATTGTTGG GTTTGTTAAA 
CCACTAGCTG AGAGGACCCC AGAACTTGTT GAACTGTCCT CTGATTCTGA GGACTTAGGT 
TCTTATGAGA AAATGGAGAC AGTGAAGACA CAAGAACAGG AGCAATCTTA CAGTTCTGGT 
GATAGCGATG TTAGTAGATG CTCATCTCCA CACTCTGTCC TTGGAAAGGA TGAACAAATA 
AATAAAGGTC ATTGTGATTC TAGTACAAGA ATCAAATCAA AGAAGGAAGA GAAACGATCT 
ACATCATTGT CATCTCCCAG AAACCTGAAC TCATCTGTAA GAGGAGACAG AGTATATTCT 
CCATATAACC ATAGACACAG AAAGAGGGGA AGATCAAGAA GTTCAGATTC ACGTTCTCAG 
AGTAGAAGTG GGCATGATCA GAAGAATCAT AGAAAGCATC ATGGGAAGAA AAGAATGAAA 
AGTAAACGAT CCAGAAGCAG GGAAAGTAGC AGACCTAGAG GGAGAAGAGA CAAAAAGAGA 
TCAAGAACTA GAGATAGCAG TTGGTCCAGA AGAAGCCAAA CTCTGTCTCT AAGTAGTGAA 
AGCACAAGCA GATCAAGGTC TCGTAGCAGT GATCATGGTA AAAGAAGATC ACGGAGCAGA 
AATAGAGATC GTTATTATTT AAGAAATAAT TATGGAAGCA GATACAAATG GGAGTATACT 
TATTACAGTA GAAACAAGGA CAGGGATGGG TACGAATCAT CTTACAGGAG GAGGACTCTG 
TCCAGAGCTC ATTATTCTAG ACAGTCTTCA AGTCCAGAAT TTAGAGTTCA GTCCTTTTCT 
GAAAGAACAA ATGCTAGGAA AAAAAATAAT CACAGTGAGA GGAAGTATTA CTACTATGAA 
AGGCACAGAT CAAGGAGCCT GTCTAGTAAC AGATCAAGGA CTGCATCTAC CGGGACTGAC 
CGGGTGAGAA ATGAAAAGCC TGGAGGGAAA CGAAAATACA AAACACGGCA TTTGGAGGGT 
ACTAACGAAG TGGCTCAGCC ATCTCGTGAA TTTGCTTCTA AAGCAAAGGA CAGTCATTAC 
CAAAAATCTT CATCAAAATT GGATGGAAAC TACAAAAATG AGAGTGATAC CTTTTCAGAC 
AGCCGATCAT CAGACAGAGA GACAAAACAC AAAAGGAGAA AAAGGAAGAC CCGGAGCCTA 
AGTGTAGAGA TAGTTTATGA AGGAAAAGCT ACTGATACAA CTAAACACCA TAAAAAGAAA 
AAGAAGAAAC ATAAGAAGAA GCATAAGAAA CACCATGGAG ATAATGCTTC ACGTTCCCCA 
GTTGTAATTA CCATTGACAG TGACAGTGAT AAGGATTCTG AAGTAAAGGA GGATACAGAA 
TGTGACAATA GTGGTCCTCA AGACCCTCTA CAAAATGAGT TTTTGGCTCC TTCCTTGGAA 
CCATTTGAAA CTAAAGATGT AGTTACAATA GAAGCTGAAT TTGGTGTGCT GGACAAGGAA 
TGTGATATTG CCACACTTAG TAACAACTTG AATAATGCCA ACAAAACTGT AGATAATATT 
CCACCTCTGG CAGCTTCAGT TGAACAAACT CTCGATGTAA GAGAAGAGAG CACCTTTGTT 
TCTGATTTGG AGAACCAGCC CAGTAACATT GTGTCTCTTC AAACTGAGCC ATCAAGGCAA 
TTGCCATCGC CACGGACATC ATTAATGTCA GTATGTCTTG GTAGAGACTG TGATATGTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182551.1
CDS	193..3135
Translation	MIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRDCDMS

Target ORF information:

RefSeq Version	NM_001195622.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195622.1

ORF Insert Sequence:

ATGATAATGG CATCAGCTGC TAAGGAATTT AAAATGGACA ACTTTTCACC TAAAGCTGGC 
ACTAGCAAAT TGCAACAGAC AGTACCAGCT GATGCATCTC CTGATTCTAA GTGTCCTATA 
TGCTTGGATA GATTTGATAA TGTGTCTTAC TTAGATCGCT GCTTACATAA GTTCTGTTTT 
CGCTGTGTAC AGGAGTGGTC AAAAAACAAA GCTGAATGCC CACTATGTAA ACAGCCCTTT 
GATTCTATTT TCCATTCTGT GAGGGCAGAA GATGACTTCA AGGAGTATGT CCTAAGGCCT 
TCGTATAATG GTTCTTTTGT CACCCCTGAT CGACGATTTC GCTACCGTAC AACTCTGACA 
AGGGAACGAA ATGCTTCTGT GTATTCACCT AGTGGTCCTG TGAACAGAAG AACAACAACT 
CCACCGGATA GTGGAGTACT GTTTGAAGGG TTAGGCATTT CAACAAGACC TAGAGATGTT 
GAAATTCCTC AGTTTATGAG ACAGATTGCA GTAAGGAGGC CAACTACGGC AGATGAAAGA 
TCTTTGCGGA AAATTCAAGA ACAAGATATT ATTAATTTTA GACGAACTCT TTATCGTGCT 
GGTGCTCGAG TTAGAAATAT TGAAGATGGT GGCCGCTACA GGGATATTTC AGCTGAATTT 
TTCCGTAGAA ATCCAGCTTG CCTTCACAGA TTAGTCCCCT GGTTAAAACG TGAACTTACA 
GTTCTTTTTG GAGCTCATGG ATCTTTAGTG AATATTGTCC AGCATATTAT CATGAGTAAT 
GTTACTCGCT ATGACTTGGA GAGTCAGGCA TTTGTGTCTG ATTTAAGACC ATTTTTACTT 
AATCGAACTG AGCATTTTAT ACATGAATTT ATCAGTTTTG CCCGATCTCC TTTTAACATG 
GCAGCCTTTG ACCAGCATGC CAATTATGAT TGCCCTGCTC CTTCATACGA AGAAGGCAGC 
CATTCTGATT CTTCAGTCAT AACAATATCT CCAGATGAGG CTGAGACCCA AGAGCTGGAT 
ATTAATGTAG CCACTGTTAG TCAGGCACCA TGGGATGATG AAACTCCAGG ACCATCTTAC 
TCAAGCTCAG AGCAGGTACA CGTTACTATG TCTTCTCTTT TAAATACTTC TGACAGTTCA 
GATGAAGAAC TTGTCACAGG AGGAGCCACG TCTCAGATAC AAGGAGTACA AACCAATGAC 
GACCTAAATA ATGACAGTGA TGATTCTTCA GATAATTGTG TCATTGTTGG GTTTGTTAAA 
CCACTAGCTG AGAGGACCCC AGAACTTGTT GAACTGTCCT CTGATTCTGA GGACTTAGGT 
TCTTATGAGA AAATGGAGAC AGTGAAGACA CAAGAACAGG AGCAATCTTA CAGTTCTGGT 
GATAGCGATG TTAGTAGATG CTCATCTCCA CACTCTGTCC TTGGAAAGGA TGAACAAATA 
AATAAAGGTC ATTGTGATTC TAGTACAAGA ATCAAATCAA AGAAGGAAGA GAAACGATCT 
ACATCATTGT CATCTCCCAG AAACCTGAAC TCATCTGTAA GAGGAGACAG AGTATATTCT 
CCATATAACC ATAGACACAG AAAGAGGGGA AGATCAAGAA GTTCAGATTC ACGTTCTCAG 
AGTAGAAGTG GGCATGATCA GAAGAATCAT AGAAAGCATC ATGGGAAGAA AAGAATGAAA 
AGTAAACGAT CCAGAAGCAG GGAAAGTAGC AGACCTAGAG GGAGAAGAGA CAAAAAGAGA 
TCAAGAACTA GAGATAGCAG TTGGTCCAGA AGAAGCCAAA CTCTGTCTCT AAGTAGTGAA 
AGCACAAGCA GATCAAGGTC TCGTAGCAGT GATCATGGTA AAAGAAGATC ACGGAGCAGA 
AATAGAGATC GTTATTATTT AAGAAATAAT TATGGAAGCA GATACAAATG GGAGTATACT 
TATTACAGTA GAAACAAGGA CAGGGATGGG TACGAATCAT CTTACAGGAG GAGGACTCTG 
TCCAGAGCTC ATTATTCTAG ACAGTCTTCA AGTCCAGAAT TTAGAGTTCA GTCCTTTTCT 
GAAAGAACAA ATGCTAGGAA AAAAAATAAT CACAGTGAGA GGAAGTATTA CTACTATGAA 
AGGCACAGAT CAAGGAGCCT GTCTAGTAAC AGATCAAGGA CTGCATCTAC CGGGACTGAC 
CGGGTGAGAA ATGAAAAGCC TGGAGGGAAA CGAAAATACA AAACACGGCA TTTGGAGGGT 
ACTAACGAAG TGGCTCAGCC ATCTCGTGAA TTTGCTTCTA AAGCAAAGGA CAGTCATTAC 
CAAAAATCTT CATCAAAATT GGATGGAAAC TACAAAAATG AGAGTGATAC CTTTTCAGAC 
AGCCGATCAT CAGACAGAGA GACAAAACAC AAAAGGAGAA AAAGGAAGAC CCGGAGCCTA 
AGTGTAGAGA TAGTTTATGA AGGAAAAGCT ACTGATACAA CTAAACACCA TAAAAAGAAA 
AAGAAGAAAC ATAAGAAGAA GCATAAGAAA CACCATGGAG ATAATGCTTC ACGTTCCCCA 
GTTGTAATTA CCATTGACAG TGACAGTGAT AAGGATTCTG AAGTAAAGGA GGATACAGAA 
TGTGACAATA GTGGTCCTCA AGACCCTCTA CAAAATGAGT TTTTGGCTCC TTCCTTGGAA 
CCATTTGAAA CTAAAGATGT AGTTACAATA GAAGCTGAAT TTGGTGTGCT GGACAAGGAA 
TGTGATATTG CCACACTTAG TAACAACTTG AATAATGCCA ACAAAACTGT AGATAATATT 
CCACCTCTGG CAGCTTCAGT TGAACAAACT CTCGATGTAA GAGAAGAGAG CACCTTTGTT 
TCTGATTTGG AGAACCAGCC CAGTAACATT GTGTCTCTTC AAACTGAGCC ATCAAGGCAA 
TTGCCATCGC CACGGACATC ATTAATGTCA GTATGTCTTG GTAGAGACTG TGATATGTCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPORS ( NM_005802.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005793.2 Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18284
Clone ID Related Accession (Same CDS sequence)	NM_005802.5 , NM_005802.4
Accession Version	NM_005802.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3138bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase Topors isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA238762.1, BC060884.1, U82939.1, BU674865.1, BJ993131.1 and BQ007035.1. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_005802.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.8885.1, SRR1803614.20080.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000360538.7/ ENSP00000353735.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGTCGC AGCCGCCGCT GGGGTCTCCG CTGTCTCGCG AGGAGGGTGA AGCGCCCCCG 
CCTGCTCCCG CTTCGGAGGG TAGGCGGAGA AGTCGCCGGG TACGCCTTCG CGGATCCTGC 
CGACACCGAC CTAGCTTTCT GGGCTGCCGG GAGCTCGCGG CGAGCGCCCC AGCCAGGCCT 
GCGCCGGCAT CCTCCGAGAT AATGGCATCA GCTGCTAAGG AATTTAAAAT GGACAACTTT 
TCACCTAAAG CTGGCACTAG CAAATTGCAA CAGACAGTAC CAGCTGATGC ATCTCCTGAT 
TCTAAGTGTC CTATATGCTT GGATAGATTT GATAATGTGT CTTACTTAGA TCGCTGCTTA 
CATAAGTTCT GTTTTCGCTG TGTACAGGAG TGGTCAAAAA ACAAAGCTGA ATGCCCACTA 
TGTAAACAGC CCTTTGATTC TATTTTCCAT TCTGTGAGGG CAGAAGATGA CTTCAAGGAG 
TATGTCCTAA GGCCTTCGTA TAATGGTTCT TTTGTCACCC CTGATCGACG ATTTCGCTAC 
CGTACAACTC TGACAAGGGA ACGAAATGCT TCTGTGTATT CACCTAGTGG TCCTGTGAAC 
AGAAGAACAA CAACTCCACC GGATAGTGGA GTACTGTTTG AAGGGTTAGG CATTTCAACA 
AGACCTAGAG ATGTTGAAAT TCCTCAGTTT ATGAGACAGA TTGCAGTAAG GAGGCCAACT 
ACGGCAGATG AAAGATCTTT GCGGAAAATT CAAGAACAAG ATATTATTAA TTTTAGACGA 
ACTCTTTATC GTGCTGGTGC TCGAGTTAGA AATATTGAAG ATGGTGGCCG CTACAGGGAT 
ATTTCAGCTG AATTTTTCCG TAGAAATCCA GCTTGCCTTC ACAGATTAGT CCCCTGGTTA 
AAACGTGAAC TTACAGTTCT TTTTGGAGCT CATGGATCTT TAGTGAATAT TGTCCAGCAT 
ATTATCATGA GTAATGTTAC TCGCTATGAC TTGGAGAGTC AGGCATTTGT GTCTGATTTA 
AGACCATTTT TACTTAATCG AACTGAGCAT TTTATACATG AATTTATCAG TTTTGCCCGA 
TCTCCTTTTA ACATGGCAGC CTTTGACCAG CATGCCAATT ATGATTGCCC TGCTCCTTCA 
TACGAAGAAG GCAGCCATTC TGATTCTTCA GTCATAACAA TATCTCCAGA TGAGGCTGAG 
ACCCAAGAGC TGGATATTAA TGTAGCCACT GTTAGTCAGG CACCATGGGA TGATGAAACT 
CCAGGACCAT CTTACTCAAG CTCAGAGCAG GTACACGTTA CTATGTCTTC TCTTTTAAAT 
ACTTCTGACA GTTCAGATGA AGAACTTGTC ACAGGAGGAG CCACGTCTCA GATACAAGGA 
GTACAAACCA ATGACGACCT AAATAATGAC AGTGATGATT CTTCAGATAA TTGTGTCATT 
GTTGGGTTTG TTAAACCACT AGCTGAGAGG ACCCCAGAAC TTGTTGAACT GTCCTCTGAT 
TCTGAGGACT TAGGTTCTTA TGAGAAAATG GAGACAGTGA AGACACAAGA ACAGGAGCAA 
TCTTACAGTT CTGGTGATAG CGATGTTAGT AGATGCTCAT CTCCACACTC TGTCCTTGGA 
AAGGATGAAC AAATAAATAA AGGTCATTGT GATTCTAGTA CAAGAATCAA ATCAAAGAAG 
GAAGAGAAAC GATCTACATC ATTGTCATCT CCCAGAAACC TGAACTCATC TGTAAGAGGA 
GACAGAGTAT ATTCTCCATA TAACCATAGA CACAGAAAGA GGGGAAGATC AAGAAGTTCA 
GATTCACGTT CTCAGAGTAG AAGTGGGCAT GATCAGAAGA ATCATAGAAA GCATCATGGG 
AAGAAAAGAA TGAAAAGTAA ACGATCCAGA AGCAGGGAAA GTAGCAGACC TAGAGGGAGA 
AGAGACAAAA AGAGATCAAG AACTAGAGAT AGCAGTTGGT CCAGAAGAAG CCAAACTCTG 
TCTCTAAGTA GTGAAAGCAC AAGCAGATCA AGGTCTCGTA GCAGTGATCA TGGTAAAAGA 
AGATCACGGA GCAGAAATAG AGATCGTTAT TATTTAAGAA ATAATTATGG AAGCAGATAC 
AAATGGGAGT ATACTTATTA CAGTAGAAAC AAGGACAGGG ATGGGTACGA ATCATCTTAC 
AGGAGGAGGA CTCTGTCCAG AGCTCATTAT TCTAGACAGT CTTCAAGTCC AGAATTTAGA 
GTTCAGTCCT TTTCTGAAAG AACAAATGCT AGGAAAAAAA ATAATCACAG TGAGAGGAAG 
TATTACTACT ATGAAAGGCA CAGATCAAGG AGCCTGTCTA GTAACAGATC AAGGACTGCA 
TCTACCGGGA CTGACCGGGT GAGAAATGAA AAGCCTGGAG GGAAACGAAA ATACAAAACA 
CGGCATTTGG AGGGTACTAA CGAAGTGGCT CAGCCATCTC GTGAATTTGC TTCTAAAGCA 
AAGGACAGTC ATTACCAAAA ATCTTCATCA AAATTGGATG GAAACTACAA AAATGAGAGT 
GATACCTTTT CAGACAGCCG ATCATCAGAC AGAGAGACAA AACACAAAAG GAGAAAAAGG 
AAGACCCGGA GCCTAAGTGT AGAGATAGTT TATGAAGGAA AAGCTACTGA TACAACTAAA 
CACCATAAAA AGAAAAAGAA GAAACATAAG AAGAAGCATA AGAAACACCA TGGAGATAAT 
GCTTCACGTT CCCCAGTTGT AATTACCATT GACAGTGACA GTGATAAGGA TTCTGAAGTA 
AAGGAGGATA CAGAATGTGA CAATAGTGGT CCTCAAGACC CTCTACAAAA TGAGTTTTTG 
GCTCCTTCCT TGGAACCATT TGAAACTAAA GATGTAGTTA CAATAGAAGC TGAATTTGGT 
GTGCTGGACA AGGAATGTGA TATTGCCACA CTTAGTAACA ACTTGAATAA TGCCAACAAA 
ACTGTAGATA ATATTCCACC TCTGGCAGCT TCAGTTGAAC AAACTCTCGA TGTAAGAGAA 
GAGAGCACCT TTGTTTCTGA TTTGGAGAAC CAGCCCAGTA ACATTGTGTC TCTTCAAACT 
GAGCCATCAA GGCAATTGCC ATCGCCACGG ACATCATTAA TGTCAGTATG TCTTGGTAGA 
GACTGTGATA TGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005793.2
CDS	151..3288
Translation	MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRDCDMS

Target ORF information:

RefSeq Version	NM_005802.5
Organism	Homo sapiens(human)
Definition	Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005802.5

ORF Insert Sequence:

ATGGGGTCGC AGCCGCCGCT GGGGTCTCCG CTGTCTCGCG AGGAGGGTGA AGCGCCCCCG 
CCTGCTCCCG CTTCGGAGGG TAGGCGGAGA AGTCGCCGGG TACGCCTTCG CGGATCCTGC 
CGACACCGAC CTAGCTTTCT GGGCTGCCGG GAGCTCGCGG CGAGCGCCCC AGCCAGGCCT 
GCGCCGGCAT CCTCCGAGAT AATGGCATCA GCTGCTAAGG AATTTAAAAT GGACAACTTT 
TCACCTAAAG CTGGCACTAG CAAATTGCAA CAGACAGTAC CAGCTGATGC ATCTCCTGAT 
TCTAAGTGTC CTATATGCTT GGATAGATTT GATAATGTGT CTTACTTAGA TCGCTGCTTA 
CATAAGTTCT GTTTTCGCTG TGTACAGGAG TGGTCAAAAA ACAAAGCTGA ATGCCCACTA 
TGTAAACAGC CCTTTGATTC TATTTTCCAT TCTGTGAGGG CAGAAGATGA CTTCAAGGAG 
TATGTCCTAA GGCCTTCGTA TAATGGTTCT TTTGTCACCC CTGATCGACG ATTTCGCTAC 
CGTACAACTC TGACAAGGGA ACGAAATGCT TCTGTGTATT CACCTAGTGG TCCTGTGAAC 
AGAAGAACAA CAACTCCACC GGATAGTGGA GTACTGTTTG AAGGGTTAGG CATTTCAACA 
AGACCTAGAG ATGTTGAAAT TCCTCAGTTT ATGAGACAGA TTGCAGTAAG GAGGCCAACT 
ACGGCAGATG AAAGATCTTT GCGGAAAATT CAAGAACAAG ATATTATTAA TTTTAGACGA 
ACTCTTTATC GTGCTGGTGC TCGAGTTAGA AATATTGAAG ATGGTGGCCG CTACAGGGAT 
ATTTCAGCTG AATTTTTCCG TAGAAATCCA GCTTGCCTTC ACAGATTAGT CCCCTGGTTA 
AAACGTGAAC TTACAGTTCT TTTTGGAGCT CATGGATCTT TAGTGAATAT TGTCCAGCAT 
ATTATCATGA GTAATGTTAC TCGCTATGAC TTGGAGAGTC AGGCATTTGT GTCTGATTTA 
AGACCATTTT TACTTAATCG AACTGAGCAT TTTATACATG AATTTATCAG TTTTGCCCGA 
TCTCCTTTTA ACATGGCAGC CTTTGACCAG CATGCCAATT ATGATTGCCC TGCTCCTTCA 
TACGAAGAAG GCAGCCATTC TGATTCTTCA GTCATAACAA TATCTCCAGA TGAGGCTGAG 
ACCCAAGAGC TGGATATTAA TGTAGCCACT GTTAGTCAGG CACCATGGGA TGATGAAACT 
CCAGGACCAT CTTACTCAAG CTCAGAGCAG GTACACGTTA CTATGTCTTC TCTTTTAAAT 
ACTTCTGACA GTTCAGATGA AGAACTTGTC ACAGGAGGAG CCACGTCTCA GATACAAGGA 
GTACAAACCA ATGACGACCT AAATAATGAC AGTGATGATT CTTCAGATAA TTGTGTCATT 
GTTGGGTTTG TTAAACCACT AGCTGAGAGG ACCCCAGAAC TTGTTGAACT GTCCTCTGAT 
TCTGAGGACT TAGGTTCTTA TGAGAAAATG GAGACAGTGA AGACACAAGA ACAGGAGCAA 
TCTTACAGTT CTGGTGATAG CGATGTTAGT AGATGCTCAT CTCCACACTC TGTCCTTGGA 
AAGGATGAAC AAATAAATAA AGGTCATTGT GATTCTAGTA CAAGAATCAA ATCAAAGAAG 
GAAGAGAAAC GATCTACATC ATTGTCATCT CCCAGAAACC TGAACTCATC TGTAAGAGGA 
GACAGAGTAT ATTCTCCATA TAACCATAGA CACAGAAAGA GGGGAAGATC AAGAAGTTCA 
GATTCACGTT CTCAGAGTAG AAGTGGGCAT GATCAGAAGA ATCATAGAAA GCATCATGGG 
AAGAAAAGAA TGAAAAGTAA ACGATCCAGA AGCAGGGAAA GTAGCAGACC TAGAGGGAGA 
AGAGACAAAA AGAGATCAAG AACTAGAGAT AGCAGTTGGT CCAGAAGAAG CCAAACTCTG 
TCTCTAAGTA GTGAAAGCAC AAGCAGATCA AGGTCTCGTA GCAGTGATCA TGGTAAAAGA 
AGATCACGGA GCAGAAATAG AGATCGTTAT TATTTAAGAA ATAATTATGG AAGCAGATAC 
AAATGGGAGT ATACTTATTA CAGTAGAAAC AAGGACAGGG ATGGGTACGA ATCATCTTAC 
AGGAGGAGGA CTCTGTCCAG AGCTCATTAT TCTAGACAGT CTTCAAGTCC AGAATTTAGA 
GTTCAGTCCT TTTCTGAAAG AACAAATGCT AGGAAAAAAA ATAATCACAG TGAGAGGAAG 
TATTACTACT ATGAAAGGCA CAGATCAAGG AGCCTGTCTA GTAACAGATC AAGGACTGCA 
TCTACCGGGA CTGACCGGGT GAGAAATGAA AAGCCTGGAG GGAAACGAAA ATACAAAACA 
CGGCATTTGG AGGGTACTAA CGAAGTGGCT CAGCCATCTC GTGAATTTGC TTCTAAAGCA 
AAGGACAGTC ATTACCAAAA ATCTTCATCA AAATTGGATG GAAACTACAA AAATGAGAGT 
GATACCTTTT CAGACAGCCG ATCATCAGAC AGAGAGACAA AACACAAAAG GAGAAAAAGG 
AAGACCCGGA GCCTAAGTGT AGAGATAGTT TATGAAGGAA AAGCTACTGA TACAACTAAA 
CACCATAAAA AGAAAAAGAA GAAACATAAG AAGAAGCATA AGAAACACCA TGGAGATAAT 
GCTTCACGTT CCCCAGTTGT AATTACCATT GACAGTGACA GTGATAAGGA TTCTGAAGTA 
AAGGAGGATA CAGAATGTGA CAATAGTGGT CCTCAAGACC CTCTACAAAA TGAGTTTTTG 
GCTCCTTCCT TGGAACCATT TGAAACTAAA GATGTAGTTA CAATAGAAGC TGAATTTGGT 
GTGCTGGACA AGGAATGTGA TATTGCCACA CTTAGTAACA ACTTGAATAA TGCCAACAAA 
ACTGTAGATA ATATTCCACC TCTGGCAGCT TCAGTTGAAC AAACTCTCGA TGTAAGAGAA 
GAGAGCACCT TTGTTTCTGA TTTGGAGAAC CAGCCCAGTA ACATTGTGTC TCTTCAAACT 
GAGCCATCAA GGCAATTGCC ATCGCCACGG ACATCATTAA TGTCAGTATG TCTTGGTAGA 
GACTGTGATA TGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOPORS ( NM_005802.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005793.2 Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 1, mRNA.

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CloneID	OHu18284
Clone ID Related Accession (Same CDS sequence)	NM_005802.5 , NM_005802.4
Accession Version	NM_005802.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3138bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	E3 ubiquitin-protein ligase Topors isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA238762.1, BC060884.1, U82939.1, BU674865.1, BJ993131.1 and BQ007035.1. This sequence is a reference standard in the RefSeqGene project. On Sep 21, 2010 this sequence version replaced NM_005802.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA238762.1, SRR1803614.20080.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTCGC AGCCGCCGCT GGGGTCTCCG CTGTCTCGCG AGGAGGGTGA AGCGCCCCCG 
CCTGCTCCCG CTTCGGAGGG TAGGCGGAGA AGTCGCCGGG TACGCCTTCG CGGATCCTGC 
CGACACCGAC CTAGCTTTCT GGGCTGCCGG GAGCTCGCGG CGAGCGCCCC AGCCAGGCCT 
GCGCCGGCAT CCTCCGAGAT AATGGCATCA GCTGCTAAGG AATTTAAAAT GGACAACTTT 
TCACCTAAAG CTGGCACTAG CAAATTGCAA CAGACAGTAC CAGCTGATGC ATCTCCTGAT 
TCTAAGTGTC CTATATGCTT GGATAGATTT GATAATGTGT CTTACTTAGA TCGCTGCTTA 
CATAAGTTCT GTTTTCGCTG TGTACAGGAG TGGTCAAAAA ACAAAGCTGA ATGCCCACTA 
TGTAAACAGC CCTTTGATTC TATTTTCCAT TCTGTGAGGG CAGAAGATGA CTTCAAGGAG 
TATGTCCTAA GGCCTTCGTA TAATGGTTCT TTTGTCACCC CTGATCGACG ATTTCGCTAC 
CGTACAACTC TGACAAGGGA ACGAAATGCT TCTGTGTATT CACCTAGTGG TCCTGTGAAC 
AGAAGAACAA CAACTCCACC GGATAGTGGA GTACTGTTTG AAGGGTTAGG CATTTCAACA 
AGACCTAGAG ATGTTGAAAT TCCTCAGTTT ATGAGACAGA TTGCAGTAAG GAGGCCAACT 
ACGGCAGATG AAAGATCTTT GCGGAAAATT CAAGAACAAG ATATTATTAA TTTTAGACGA 
ACTCTTTATC GTGCTGGTGC TCGAGTTAGA AATATTGAAG ATGGTGGCCG CTACAGGGAT 
ATTTCAGCTG AATTTTTCCG TAGAAATCCA GCTTGCCTTC ACAGATTAGT CCCCTGGTTA 
AAACGTGAAC TTACAGTTCT TTTTGGAGCT CATGGATCTT TAGTGAATAT TGTCCAGCAT 
ATTATCATGA GTAATGTTAC TCGCTATGAC TTGGAGAGTC AGGCATTTGT GTCTGATTTA 
AGACCATTTT TACTTAATCG AACTGAGCAT TTTATACATG AATTTATCAG TTTTGCCCGA 
TCTCCTTTTA ACATGGCAGC CTTTGACCAG CATGCCAATT ATGATTGCCC TGCTCCTTCA 
TACGAAGAAG GCAGCCATTC TGATTCTTCA GTCATAACAA TATCTCCAGA TGAGGCTGAG 
ACCCAAGAGC TGGATATTAA TGTAGCCACT GTTAGTCAGG CACCATGGGA TGATGAAACT 
CCAGGACCAT CTTACTCAAG CTCAGAGCAG GTACACGTTA CTATGTCTTC TCTTTTAAAT 
ACTTCTGACA GTTCAGATGA AGAACTTGTC ACAGGAGGAG CCACGTCTCA GATACAAGGA 
GTACAAACCA ATGACGACCT AAATAATGAC AGTGATGATT CTTCAGATAA TTGTGTCATT 
GTTGGGTTTG TTAAACCACT AGCTGAGAGG ACCCCAGAAC TTGTTGAACT GTCCTCTGAT 
TCTGAGGACT TAGGTTCTTA TGAGAAAATG GAGACAGTGA AGACACAAGA ACAGGAGCAA 
TCTTACAGTT CTGGTGATAG CGATGTTAGT AGATGCTCAT CTCCACACTC TGTCCTTGGA 
AAGGATGAAC AAATAAATAA AGGTCATTGT GATTCTAGTA CAAGAATCAA ATCAAAGAAG 
GAAGAGAAAC GATCTACATC ATTGTCATCT CCCAGAAACC TGAACTCATC TGTAAGAGGA 
GACAGAGTAT ATTCTCCATA TAACCATAGA CACAGAAAGA GGGGAAGATC AAGAAGTTCA 
GATTCACGTT CTCAGAGTAG AAGTGGGCAT GATCAGAAGA ATCATAGAAA GCATCATGGG 
AAGAAAAGAA TGAAAAGTAA ACGATCCAGA AGCAGGGAAA GTAGCAGACC TAGAGGGAGA 
AGAGACAAAA AGAGATCAAG AACTAGAGAT AGCAGTTGGT CCAGAAGAAG CCAAACTCTG 
TCTCTAAGTA GTGAAAGCAC AAGCAGATCA AGGTCTCGTA GCAGTGATCA TGGTAAAAGA 
AGATCACGGA GCAGAAATAG AGATCGTTAT TATTTAAGAA ATAATTATGG AAGCAGATAC 
AAATGGGAGT ATACTTATTA CAGTAGAAAC AAGGACAGGG ATGGGTACGA ATCATCTTAC 
AGGAGGAGGA CTCTGTCCAG AGCTCATTAT TCTAGACAGT CTTCAAGTCC AGAATTTAGA 
GTTCAGTCCT TTTCTGAAAG AACAAATGCT AGGAAAAAAA ATAATCACAG TGAGAGGAAG 
TATTACTACT ATGAAAGGCA CAGATCAAGG AGCCTGTCTA GTAACAGATC AAGGACTGCA 
TCTACCGGGA CTGACCGGGT GAGAAATGAA AAGCCTGGAG GGAAACGAAA ATACAAAACA 
CGGCATTTGG AGGGTACTAA CGAAGTGGCT CAGCCATCTC GTGAATTTGC TTCTAAAGCA 
AAGGACAGTC ATTACCAAAA ATCTTCATCA AAATTGGATG GAAACTACAA AAATGAGAGT 
GATACCTTTT CAGACAGCCG ATCATCAGAC AGAGAGACAA AACACAAAAG GAGAAAAAGG 
AAGACCCGGA GCCTAAGTGT AGAGATAGTT TATGAAGGAA AAGCTACTGA TACAACTAAA 
CACCATAAAA AGAAAAAGAA GAAACATAAG AAGAAGCATA AGAAACACCA TGGAGATAAT 
GCTTCACGTT CCCCAGTTGT AATTACCATT GACAGTGACA GTGATAAGGA TTCTGAAGTA 
AAGGAGGATA CAGAATGTGA CAATAGTGGT CCTCAAGACC CTCTACAAAA TGAGTTTTTG 
GCTCCTTCCT TGGAACCATT TGAAACTAAA GATGTAGTTA CAATAGAAGC TGAATTTGGT 
GTGCTGGACA AGGAATGTGA TATTGCCACA CTTAGTAACA ACTTGAATAA TGCCAACAAA 
ACTGTAGATA ATATTCCACC TCTGGCAGCT TCAGTTGAAC AAACTCTCGA TGTAAGAGAA 
GAGAGCACCT TTGTTTCTGA TTTGGAGAAC CAGCCCAGTA ACATTGTGTC TCTTCAAACT 
GAGCCATCAA GGCAATTGCC ATCGCCACGG ACATCATTAA TGTCAGTATG TCTTGGTAGA 
GACTGTGATA TGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005793.2
CDS	193..3330
Translation	MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRDCDMS

Target ORF information:

RefSeq Version	NM_005802.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005802.4

ORF Insert Sequence:

ATGGGGTCGC AGCCGCCGCT GGGGTCTCCG CTGTCTCGCG AGGAGGGTGA AGCGCCCCCG 
CCTGCTCCCG CTTCGGAGGG TAGGCGGAGA AGTCGCCGGG TACGCCTTCG CGGATCCTGC 
CGACACCGAC CTAGCTTTCT GGGCTGCCGG GAGCTCGCGG CGAGCGCCCC AGCCAGGCCT 
GCGCCGGCAT CCTCCGAGAT AATGGCATCA GCTGCTAAGG AATTTAAAAT GGACAACTTT 
TCACCTAAAG CTGGCACTAG CAAATTGCAA CAGACAGTAC CAGCTGATGC ATCTCCTGAT 
TCTAAGTGTC CTATATGCTT GGATAGATTT GATAATGTGT CTTACTTAGA TCGCTGCTTA 
CATAAGTTCT GTTTTCGCTG TGTACAGGAG TGGTCAAAAA ACAAAGCTGA ATGCCCACTA 
TGTAAACAGC CCTTTGATTC TATTTTCCAT TCTGTGAGGG CAGAAGATGA CTTCAAGGAG 
TATGTCCTAA GGCCTTCGTA TAATGGTTCT TTTGTCACCC CTGATCGACG ATTTCGCTAC 
CGTACAACTC TGACAAGGGA ACGAAATGCT TCTGTGTATT CACCTAGTGG TCCTGTGAAC 
AGAAGAACAA CAACTCCACC GGATAGTGGA GTACTGTTTG AAGGGTTAGG CATTTCAACA 
AGACCTAGAG ATGTTGAAAT TCCTCAGTTT ATGAGACAGA TTGCAGTAAG GAGGCCAACT 
ACGGCAGATG AAAGATCTTT GCGGAAAATT CAAGAACAAG ATATTATTAA TTTTAGACGA 
ACTCTTTATC GTGCTGGTGC TCGAGTTAGA AATATTGAAG ATGGTGGCCG CTACAGGGAT 
ATTTCAGCTG AATTTTTCCG TAGAAATCCA GCTTGCCTTC ACAGATTAGT CCCCTGGTTA 
AAACGTGAAC TTACAGTTCT TTTTGGAGCT CATGGATCTT TAGTGAATAT TGTCCAGCAT 
ATTATCATGA GTAATGTTAC TCGCTATGAC TTGGAGAGTC AGGCATTTGT GTCTGATTTA 
AGACCATTTT TACTTAATCG AACTGAGCAT TTTATACATG AATTTATCAG TTTTGCCCGA 
TCTCCTTTTA ACATGGCAGC CTTTGACCAG CATGCCAATT ATGATTGCCC TGCTCCTTCA 
TACGAAGAAG GCAGCCATTC TGATTCTTCA GTCATAACAA TATCTCCAGA TGAGGCTGAG 
ACCCAAGAGC TGGATATTAA TGTAGCCACT GTTAGTCAGG CACCATGGGA TGATGAAACT 
CCAGGACCAT CTTACTCAAG CTCAGAGCAG GTACACGTTA CTATGTCTTC TCTTTTAAAT 
ACTTCTGACA GTTCAGATGA AGAACTTGTC ACAGGAGGAG CCACGTCTCA GATACAAGGA 
GTACAAACCA ATGACGACCT AAATAATGAC AGTGATGATT CTTCAGATAA TTGTGTCATT 
GTTGGGTTTG TTAAACCACT AGCTGAGAGG ACCCCAGAAC TTGTTGAACT GTCCTCTGAT 
TCTGAGGACT TAGGTTCTTA TGAGAAAATG GAGACAGTGA AGACACAAGA ACAGGAGCAA 
TCTTACAGTT CTGGTGATAG CGATGTTAGT AGATGCTCAT CTCCACACTC TGTCCTTGGA 
AAGGATGAAC AAATAAATAA AGGTCATTGT GATTCTAGTA CAAGAATCAA ATCAAAGAAG 
GAAGAGAAAC GATCTACATC ATTGTCATCT CCCAGAAACC TGAACTCATC TGTAAGAGGA 
GACAGAGTAT ATTCTCCATA TAACCATAGA CACAGAAAGA GGGGAAGATC AAGAAGTTCA 
GATTCACGTT CTCAGAGTAG AAGTGGGCAT GATCAGAAGA ATCATAGAAA GCATCATGGG 
AAGAAAAGAA TGAAAAGTAA ACGATCCAGA AGCAGGGAAA GTAGCAGACC TAGAGGGAGA 
AGAGACAAAA AGAGATCAAG AACTAGAGAT AGCAGTTGGT CCAGAAGAAG CCAAACTCTG 
TCTCTAAGTA GTGAAAGCAC AAGCAGATCA AGGTCTCGTA GCAGTGATCA TGGTAAAAGA 
AGATCACGGA GCAGAAATAG AGATCGTTAT TATTTAAGAA ATAATTATGG AAGCAGATAC 
AAATGGGAGT ATACTTATTA CAGTAGAAAC AAGGACAGGG ATGGGTACGA ATCATCTTAC 
AGGAGGAGGA CTCTGTCCAG AGCTCATTAT TCTAGACAGT CTTCAAGTCC AGAATTTAGA 
GTTCAGTCCT TTTCTGAAAG AACAAATGCT AGGAAAAAAA ATAATCACAG TGAGAGGAAG 
TATTACTACT ATGAAAGGCA CAGATCAAGG AGCCTGTCTA GTAACAGATC AAGGACTGCA 
TCTACCGGGA CTGACCGGGT GAGAAATGAA AAGCCTGGAG GGAAACGAAA ATACAAAACA 
CGGCATTTGG AGGGTACTAA CGAAGTGGCT CAGCCATCTC GTGAATTTGC TTCTAAAGCA 
AAGGACAGTC ATTACCAAAA ATCTTCATCA AAATTGGATG GAAACTACAA AAATGAGAGT 
GATACCTTTT CAGACAGCCG ATCATCAGAC AGAGAGACAA AACACAAAAG GAGAAAAAGG 
AAGACCCGGA GCCTAAGTGT AGAGATAGTT TATGAAGGAA AAGCTACTGA TACAACTAAA 
CACCATAAAA AGAAAAAGAA GAAACATAAG AAGAAGCATA AGAAACACCA TGGAGATAAT 
GCTTCACGTT CCCCAGTTGT AATTACCATT GACAGTGACA GTGATAAGGA TTCTGAAGTA 
AAGGAGGATA CAGAATGTGA CAATAGTGGT CCTCAAGACC CTCTACAAAA TGAGTTTTTG 
GCTCCTTCCT TGGAACCATT TGAAACTAAA GATGTAGTTA CAATAGAAGC TGAATTTGGT 
GTGCTGGACA AGGAATGTGA TATTGCCACA CTTAGTAACA ACTTGAATAA TGCCAACAAA 
ACTGTAGATA ATATTCCACC TCTGGCAGCT TCAGTTGAAC AAACTCTCGA TGTAAGAGAA 
GAGAGCACCT TTGTTTCTGA TTTGGAGAAC CAGCCCAGTA ACATTGTGTC TCTTCAAACT 
GAGCCATCAA GGCAATTGCC ATCGCCACGG ACATCATTAA TGTCAGTATG TCTTGGTAGA 
GACTGTGATA TGTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel mutation in the dominantly inherited TOPORS gene supports haploinsufficiency as the mechanism of retinitis pigmentosa.
Ophthalmic genetics38(6)562-566(2017 Dec)
Latasiewicz M,Salvetti AP,MacLaren RE

TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.
PloS one11(2)e0148678(2016)
Czub B,Shah AZ,Alfano G,Kruczek PM,Chakarova CF,Bhattacharya SS

TOPORS modulates H2AX discriminating genotoxic stresses.
Journal of biochemical and molecular toxicology26(11)429-38(2012 Nov)
Seong KM,Nam SY,Kim JY,Yang KH,An S,Jin YW,Kim CS

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
Human genetics131(9)1403-21(2012 Sep)
Kennedy RB,Ovsyannikova IG,Pankratz VS,Haralambieva IH,Vierkant RA,Poland GA

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TOPORS cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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