IFNL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNL4
Entrez Gene ID	101180976
Full Name	interferon lambda 4 (gene/pseudogene)
Synonyms	IFNAN
General protein information	Preferred Names interferon lambda 4 (gene/pseudogene) Names interferon lambda-4 IFN-lambda-4 interferon, lambda 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017].
Disorder MIM:	615090

mRNA and Protein(s)

mRNA	Protein	Name
NM_001276254.2	NP_001263183.2	interferon lambda-4 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4).
Key FM, Peter B, Dennis MY, Huerta-S?nchez E, Tang W, Prokunina-Olsson L, Nielsen R, Andr?s AM
PLoS genetics10(10)e1004681(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The association between IFNL3/4 genotypes with elevated HCV VL observed in HCV g6-infected individuals may have implications for the progression of liver disease in Southeast Asian countries where this viral genotype predominates and therefore warrants further studies.
Title: Association of interferon lambda polymorphisms with elevated baseline viral loads in chronic hepatitis C virus genotype 6 infection.

rs368234815 TT/TT genotype associated with severity of fibrosis in nonalcoholic fatty liver disease patients of European ancestry
Title: Interferon lambda 4 rs368234815 TT>?G variant is associated with liver damage in patients with nonalcoholic fatty liver disease.

these results suggest unique functional properties of IFN-lambda4 that can be important in viral clearance and other clinical conditions
Title: IFN-?4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling.

Data show that the genotype distributions of IFNL3 and IFNL4 variants (rs4803217, rs368234815, rs117648444, and rs12979860) were in Hardy-Weinberg equilibrium.
Title: IFN-?3, not IFN-?4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.

Data show that interferon lambda 4 (IFNL4) genotypes determine hepatitis C virus (HCV) viral load through a mechanism dependent on a specific amino acid residue in the HCV NS5A protein.
Title: Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.

The following IFNL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27472	NM_001276254.2 Latest version!	Homo sapiens interferon lambda 4 (gene/pseudogene) (IFNL4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNL4 ( NM_001276254.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001263183.2 Homo sapiens interferon lambda 4 (gene/pseudogene) (IFNL4), transcript variant 1, mRNA.

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CloneID	OHu27472
Clone ID Related Accession (Same CDS sequence)	NM_001276254.2
Accession Version	NM_001276254.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	interferon lambda-4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JN806234.1. On Apr 23, 2013 this sequence version replaced NM_001276254.1. Transcript Variant: This variant (1) represents a protein coding transcript of this gene. Human populations are polymorphic for a frameshifting single nucleotide insertion in this transcript and thus transcripts with the alternate allele are non-coding. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JN806227.1, JN806234.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 25329461 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCGGCCGA GTGTCTGGGC CGCAGTGGCC GCGGGGCTGT GGGTCCTGTG CACGGTGATC 
GCAGCGGCCC CCCGGCGCTG CCTGCTCTCG CACTACCGCT CGCTGGAGCC CCGGACGCTG 
GCGGCTGCCA AGGCGCTGAG GGACCGCTAC GAGGAAGAGG CGCTGAGCTG GGGGCAGCGC 
AACTGCTCCT TCCGCCCCAG GAGGGATCCT CCGCGGCCAT CGTCCTGCGC TCGGCTCCGC 
CACGTGGCCC GGGGCATCGC GGACGCCCAG GCAGTGCTCA GCGGCCTGCA CCGCTCGGAG 
CTGCTCCCCG GCGCCGGCCC GATCCTGGAG CTGCTGGCGG CCGCGGGGAG GGATGTGGCG 
GCCTGCCTTG AGCTGGCACG GCCAGGCTCC TCCAGGAAGG TCCCCGGGGC CCAGAAGAGG 
CGTCACAAAC CCCGGAGAGC GGACTCGCCT CGGTGCCGCA AAGCCAGCGT GGTCTTCAAC 
CTCCTGCGCC TGCTCACGTG GGAGCTCCGG CTGGCTGCAC ACTCTGGGCC TTGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263183.2
CDS	278..817
Translation	MRPSVWAAVAAGLWVLCTVIAAAPRRCLLSHYRSLEPRTLAAAKALRDRYEEEALSWGQRNCSFRPRRDPPRPSSCARLRHVARGIADAQAVLSGLHRSELLPGAGPILELLAAAGRDVAACLELARPGSSRKVPGAQKRRHKPRRADSPRCRKASVVFNLLRLLTWELRLAAHSGPCL

Target ORF information:

RefSeq Version	NM_001276254.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon lambda 4 (gene/pseudogene) (IFNL4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276254.2

ORF Insert Sequence:

ATGCGGCCGA GTGTCTGGGC CGCAGTGGCC GCGGGGCTGT GGGTCCTGTG CACGGTGATC 
GCAGCGGCCC CCCGGCGCTG CCTGCTCTCG CACTACCGCT CGCTGGAGCC CCGGACGCTG 
GCGGCTGCCA AGGCGCTGAG GGACCGCTAC GAGGAAGAGG CGCTGAGCTG GGGGCAGCGC 
AACTGCTCCT TCCGCCCCAG GAGGGATCCT CCGCGGCCAT CGTCCTGCGC TCGGCTCCGC 
CACGTGGCCC GGGGCATCGC GGACGCCCAG GCAGTGCTCA GCGGCCTGCA CCGCTCGGAG 
CTGCTCCCCG GCGCCGGCCC GATCCTGGAG CTGCTGGCGG CCGCGGGGAG GGATGTGGCG 
GCCTGCCTTG AGCTGGCACG GCCAGGCTCC TCCAGGAAGG TCCCCGGGGC CCAGAAGAGG 
CGTCACAAAC CCCGGAGAGC GGACTCGCCT CGGTGCCGCA AAGCCAGCGT GGTCTTCAAC 
CTCCTGCGCC TGCTCACGTG GGAGCTCCGG CTGGCTGCAC ACTCTGGGCC TTGCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4).
PLoS genetics10(10)e1004681(2014 Oct)
Key FM,Peter B,Dennis MY,Huerta-S?nchez E,Tang W,Prokunina-Olsson L,Nielsen R,Andr?s AM

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IFNL4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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