ABCB6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ABCB6
Entrez Gene ID	10058
Full Name	ATP binding cassette subfamily B member 6 (Langereis blood group)
Synonyms	ABC,LAN,MTABC3,PRP,umat
General protein information	Preferred Names ATP binding cassette subfamily B member 6 (Langereis blood group) Names ATP-binding cassette sub-family B member 6, mitochondrial ATP-binding cassette half-transporter ATP-binding cassette sub-family B member 6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) P-glycoprotein-related protein mitochondrial ABC transporter 3 mt-ABC transporter 3 ubiquitously-expressed mammalian ABC half transporter
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Summary	This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. This protein is a member of the heavy metal importer subfamily and plays a role in porphyrin transport. This gene is the molecular basis of the Langereis (Lan) blood group antigen and mutations in this gene underlie familial pseudohyperkalemia and dyschromatosis universalis hereditaria. [provided by RefSeq, Mar 2017].
Disorder MIM:	605452
Disorder Html:	Microphthalmia, isolated, with coloboma 7, 614497 (3); [Blood group, Langereis system], 111600 (3); Dyschromatosis universalis hereditaria 3, 615402 (3); Pseudohyperkalemia, familial, 2, due to red cell leak, 609153 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005689.3	NP_005680.1	ATP-binding cassette sub-family B member 6, mitochondrial isoform 1
NM_001349828.1	NP_001336757.1	ATP-binding cassette sub-family B member 6, mitochondrial isoform 2
NM_001349828.2	NP_001336757.1	ATP-binding cassette sub-family B member 6, mitochondrial isoform 2
NM_005689.4	NP_005680.1	ATP-binding cassette sub-family B member 6, mitochondrial isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ABCB6	XP_001161097.1
	ABCB6	XP_002799099.1
Bos taurus (cattle)	ABCB6	NP_001091625.1
Schizosaccharomyces pombe (fission yeast)	hmt1	NP_588371.3
Magnaporthe oryzae (rice blast fungus)	MGG_05190	XP_003712732.1
Xenopus tropicalis (tropical clawed frog)	abcb6	NP_001072643.1
Homo sapiens (human)	ABCB6	NP_005680.1
Canis lupus familiaris (dog)	ABCB6	XP_005640740.1
Mus musculus (house mouse)	Abcb6	NP_076221.1
Danio rerio (zebrafish)	abcb6a	NP_001139165.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002278	XP_307900.5
Neurospora crassa	NCU00010	XP_956997.2
Rattus norvegicus (Norway rat)	Abcb6	NP_542149.1
Gallus gallus (chicken)	ABCB6	XP_423449.4
Drosophila melanogaster (fruit fly)	Hmt-1	NP_650503.1
Caenorhabditis elegans (roundworm)	hmt-1	NP_001022812.1

Gene Ontology
Bibliography

Related articles in PubMed

ATP-binding casette transporter expression in acute myeloid leukemia: association with in vitro cytotoxicity and prognostic markers.
Varatharajan S, Abraham A, Karathedath S, Ganesan S, Lakshmi KM, Arthur N, Srivastava VM, George B, Srivastava A, Mathews V, Balasubramanian P
Pharmacogenomics18(3)235-244(2017 Feb)

Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
Nakayama T, Otsuka S, Kobayashi T, Okajima H, Matsumoto K, Hagiya Y, Inoue K, Shuin T, Nakajima M, Tanaka T, Ogura SI
Scientific reports636478(2016 Nov)

New insights on hereditary erythrocyte membrane defects.
Andolfo I, Russo R, Gambale A, Iolascon A
Haematologica101(11)1284-1294(2016 11)

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.
Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, Trent RJ, Schuetz JD
Nature communications712353(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ABCB6 missense mutations in red blood cells from subjects with familial pseudohyperkalemia show elevated potassium ion efflux.
Title: Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia.

Data suggest N-terminal transmembrane domain of ABCB6 functions as independent folding unit and plays crucial role in lysosomal (rather than plasma membrane) targeting of ABCB6; this domain is dispensable for dimerization and ATP binding/hydrolysis.
Title: Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein.

These data indicate that the expression of ABCB6 in plasma membrane is important for porphyrin accumulation after ALA administration, including hypoxic conditions.
Title: Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: tumor cell response to hypoxia.

Identified two novel ABCB6 mutations in two Chinese families affected with dyschromatosis universalis hereditaria (DUH), underscoring the causative role of the ABCB6 mutations in the molecular pathogenesis of DUH.
Title: Novel missense mutations of ABCB6 in two chinese families with dyschromatosis universalis hereditaria.

genetic variants linked to lower or absent cell surface expression of ABCB6/Langereis may be more common than previously thought.
Title: Screening the expression of ABCB6 in erythrocytes reveals an unexpectedly high frequency of Lan mutations in healthy individuals.

The following ABCB6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ABCB6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22713	NM_005689.4 Latest version!	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu101128	NM_001349828.2 Latest version!	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu101128	NM_001349828.1	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OHu22713	NM_005689.3	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ABCB6 ( NM_005689.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005680.1 Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22713
Clone ID Related Accession (Same CDS sequence)	NM_005689.3 , NM_005689.4
Accession Version	NM_005689.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2529bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 6, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068946.4, AF308472.1 and AW664349.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005689.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.59569.1, SRR1803613.91997.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000265316.9/ ENSP00000265316.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCAGTTTAG CCTGTGGGTG CTGCGGTATG TGGTCTCTGG AGGGCTGTTT 
GTCCTGGGTC TCTGGGCCCC TGGACTTCGT CCCCAGTCCT ATACATTGCA GGTTCATGAA 
GAGGACCAAG ATGTGGAAAG GAGCCAGGTT CGGTCAGCAG CCCAACAGTC TACCTGGCGA 
GATTTTGGCA GGAAGCTCCG CCTCCTGAGT GGCTACCTGT GGCCTCGAGG GAGTCCAGCT 
CTGCAGCTGG TGGTGCTCAT CTGCCTGGGG CTCATGGGTT TGGAACGGGC ACTCAATGTG 
TTGGTGCCTA TATTCTATAG GAACATTGTG AACTTGCTGA CTGAGAAGGC ACCTTGGAAC 
TCTCTGGCCT GGACTGTTAC CAGTTACGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GCTTCGTGAG CAACCTGCGC ACCTTCCTGT GGATCCGGGT GCAGCAGTTC 
ACGTCTCGGC GGGTGGAGCT GCTCATCTTC TCCCACCTGC ACGAGCTCTC ACTGCGCTGG 
CACCTGGGGC GCCGCACAGG GGAGGTGCTG CGGATCGCGG ATCGGGGCAC ATCCAGTGTC 
ACAGGGCTGC TCAGCTACCT GGTGTTCAAT GTCATCCCCA CGCTGGCCGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAC GCCTGGTTTG GCCTCATTGT GTTCCTGTGC 
ATGAGTCTTT ACCTCACCCT GACCATTGTG GTCACTGAGT GGAGAACCAA GTTTCGTCGT 
GCTATGAACA CACAGGAGAA CGCTACCCGG GCACGAGCAG TGGACTCTCT GCTAAACTTC 
GAGACGGTGA AGTATTACAA CGCCGAGAGT TACGAAGTGG AACGCTATCG AGAGGCCATC 
ATCAAATATC AGGGTTTGGA GTGGAAGTCG AGCGCTTCAC TGGTTTTACT AAATCAGACC 
CAGAACCTGG TGATTGGGCT CGGGCTCCTC GCCGGCTCCC TGCTTTGCGC ATACTTTGTC 
ACTGAGCAGA AGCTACAGGT TGGGGACTAT GTGCTCTTTG GCACCTACAT TATCCAGCTG 
TACATGCCCC TCAATTGGTT TGGCACCTAC TACAGGATGA TCCAGACCAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGACCT TCCTGGAGCA 
GGGCCCCTTC GCTTTCAGAA GGGCCGTATT GAGTTTGAGA ACGTGCACTT CAGCTATGCC 
GATGGGCGGG AGACTCTGCA GGACGTGTCT TTCACTGTGA TGCCTGGACA GACACTTGCC 
CTGGTGGGCC CATCTGGGGC AGGGAAGAGC ACAATTTTGC GCCTGCTGTT TCGCTTCTAC 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGGCAGGACA TTTCACAGGT GACCCAGGCC 
TCTCTCCGGT CTCACATTGG AGTTGTGCCC CAAGACACTG TCCTCTTTAA TGACACCATC 
GCCGACAATA TCCGTTACGG CCGTGTCACA GCTGGGAATG ATGAGGTGGA GGCTGCTGCT 
CAGGCTGCAG GCATCCATGA TGCCATTATG GCTTTCCCTG AAGGGTACAG GACACAGGTG 
GGCGAGCGGG GACTGAAGCT GAGCGGCGGG GAGAAGCAGC GCGTCGCCAT TGCCCGCACC 
ATCCTCAAGG CTCCGGGCAT CATTCTGCTG GATGAGGCAA CGTCAGCGCT GGATACATCT 
AATGAGAGGG CCATCCAGGC TTCTCTGGCC AAAGTCTGTG CCAACCGCAC CACCATCGTA 
GTGGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TCCTCGTCAT CAAGGATGGC 
TGCATCGTGG AGAGGGGACG ACACGAGGCT CTGTTGTCCC GAGGTGGGGT GTATGCTGAC 
ATGTGGCAGC TGCAGCAGGG ACAGGAAGAA ACCTCTGAAG ACACTAAGCC TCAGACCATG 
GAACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005680.1
CDS	286..2814
Translation	MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER

Target ORF information:

RefSeq Version	NM_005689.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005689.4

ORF Insert Sequence:

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCAGTTTAG CCTGTGGGTG CTGCGGTATG TGGTCTCTGG AGGGCTGTTT 
GTCCTGGGTC TCTGGGCCCC TGGACTTCGT CCCCAGTCCT ATACATTGCA GGTTCATGAA 
GAGGACCAAG ATGTGGAAAG GAGCCAGGTT CGGTCAGCAG CCCAACAGTC TACCTGGCGA 
GATTTTGGCA GGAAGCTCCG CCTCCTGAGT GGCTACCTGT GGCCTCGAGG GAGTCCAGCT 
CTGCAGCTGG TGGTGCTCAT CTGCCTGGGG CTCATGGGTT TGGAACGGGC ACTCAATGTG 
TTGGTGCCTA TATTCTATAG GAACATTGTG AACTTGCTGA CTGAGAAGGC ACCTTGGAAC 
TCTCTGGCCT GGACTGTTAC CAGTTACGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GCTTCGTGAG CAACCTGCGC ACCTTCCTGT GGATCCGGGT GCAGCAGTTC 
ACGTCTCGGC GGGTGGAGCT GCTCATCTTC TCCCACCTGC ACGAGCTCTC ACTGCGCTGG 
CACCTGGGGC GCCGCACAGG GGAGGTGCTG CGGATCGCGG ATCGGGGCAC ATCCAGTGTC 
ACAGGGCTGC TCAGCTACCT GGTGTTCAAT GTCATCCCCA CGCTGGCCGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAC GCCTGGTTTG GCCTCATTGT GTTCCTGTGC 
ATGAGTCTTT ACCTCACCCT GACCATTGTG GTCACTGAGT GGAGAACCAA GTTTCGTCGT 
GCTATGAACA CACAGGAGAA CGCTACCCGG GCACGAGCAG TGGACTCTCT GCTAAACTTC 
GAGACGGTGA AGTATTACAA CGCCGAGAGT TACGAAGTGG AACGCTATCG AGAGGCCATC 
ATCAAATATC AGGGTTTGGA GTGGAAGTCG AGCGCTTCAC TGGTTTTACT AAATCAGACC 
CAGAACCTGG TGATTGGGCT CGGGCTCCTC GCCGGCTCCC TGCTTTGCGC ATACTTTGTC 
ACTGAGCAGA AGCTACAGGT TGGGGACTAT GTGCTCTTTG GCACCTACAT TATCCAGCTG 
TACATGCCCC TCAATTGGTT TGGCACCTAC TACAGGATGA TCCAGACCAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGACCT TCCTGGAGCA 
GGGCCCCTTC GCTTTCAGAA GGGCCGTATT GAGTTTGAGA ACGTGCACTT CAGCTATGCC 
GATGGGCGGG AGACTCTGCA GGACGTGTCT TTCACTGTGA TGCCTGGACA GACACTTGCC 
CTGGTGGGCC CATCTGGGGC AGGGAAGAGC ACAATTTTGC GCCTGCTGTT TCGCTTCTAC 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGGCAGGACA TTTCACAGGT GACCCAGGCC 
TCTCTCCGGT CTCACATTGG AGTTGTGCCC CAAGACACTG TCCTCTTTAA TGACACCATC 
GCCGACAATA TCCGTTACGG CCGTGTCACA GCTGGGAATG ATGAGGTGGA GGCTGCTGCT 
CAGGCTGCAG GCATCCATGA TGCCATTATG GCTTTCCCTG AAGGGTACAG GACACAGGTG 
GGCGAGCGGG GACTGAAGCT GAGCGGCGGG GAGAAGCAGC GCGTCGCCAT TGCCCGCACC 
ATCCTCAAGG CTCCGGGCAT CATTCTGCTG GATGAGGCAA CGTCAGCGCT GGATACATCT 
AATGAGAGGG CCATCCAGGC TTCTCTGGCC AAAGTCTGTG CCAACCGCAC CACCATCGTA 
GTGGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TCCTCGTCAT CAAGGATGGC 
TGCATCGTGG AGAGGGGACG ACACGAGGCT CTGTTGTCCC GAGGTGGGGT GTATGCTGAC 
ATGTGGCAGC TGCAGCAGGG ACAGGAAGAA ACCTCTGAAG ACACTAAGCC TCAGACCATG 
GAACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCB6 ( NM_001349828.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001336757.1 Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101128
Clone ID Related Accession (Same CDS sequence)	NM_001349828.1 , NM_001349828.2
Accession Version	NM_001349828.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-28
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 6, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068946.4. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.87361.1, SRR1660803.132181.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCGGTCAGC AGCCCAACAG TCTACCTGGC GAGATTTTGG CAGGAAGCTC 
CGCCTCCTGA GTGGCTACCT GTGGCCTCGA GGGAGTCCAG CTCTGCAGCT GGTGGTGCTC 
ATCTGCCTGG GGCTCATGGG TTTGGAACGG GCACTCAATG TGTTGGTGCC TATATTCTAT 
AGGAACATTG TGAACTTGCT GACTGAGAAG GCACCTTGGA ACTCTCTGGC CTGGACTGTT 
ACCAGTTACG TCTTCCTCAA GTTCCTCCAG GGGGGTGGCA CTGGCAGTAC AGGCTTCGTG 
AGCAACCTGC GCACCTTCCT GTGGATCCGG GTGCAGCAGT TCACGTCTCG GCGGGTGGAG 
CTGCTCATCT TCTCCCACCT GCACGAGCTC TCACTGCGCT GGCACCTGGG GCGCCGCACA 
GGGGAGGTGC TGCGGATCGC GGATCGGGGC ACATCCAGTG TCACAGGGCT GCTCAGCTAC 
CTGGTGTTCA ATGTCATCCC CACGCTGGCC GACATCATCA TTGGCATCAT CTACTTCAGC 
ATGTTCTTCA ACGCCTGGTT TGGCCTCATT GTGTTCCTGT GCATGAGTCT TTACCTCACC 
CTGACCATTG TGGTCACTGA GTGGAGAACC AAGTTTCGTC GTGCTATGAA CACACAGGAG 
AACGCTACCC GGGCACGAGC AGTGGACTCT CTGCTAAACT TCGAGACGGT GAAGTATTAC 
AACGCCGAGA GTTACGAAGT GGAACGCTAT CGAGAGGCCA TCATCAAATA TCAGGGTTTG 
GAGTGGAAGT CGAGCGCTTC ACTGGTTTTA CTAAATCAGA CCCAGAACCT GGTGATTGGG 
CTCGGGCTCC TCGCCGGCTC CCTGCTTTGC GCATACTTTG TCACTGAGCA GAAGCTACAG 
GTTGGGGACT ATGTGCTCTT TGGCACCTAC ATTATCCAGC TGTACATGCC CCTCAATTGG 
TTTGGCACCT ACTACAGGAT GATCCAGACC AACTTCATTG ACATGGAGAA CATGTTTGAC 
TTGCTGAAAG AGGAGACAGA AGTGAAGGAC CTTCCTGGAG CAGGGCCCCT TCGCTTTCAG 
AAGGGCCGTA TTGAGTTTGA GAACGTGCAC TTCAGCTATG CCGATGGGCG GGAGACTCTG 
CAGGACGTGT CTTTCACTGT GATGCCTGGA CAGACACTTG CCCTGGTGGG CCCATCTGGG 
GCAGGGAAGA GCACAATTTT GCGCCTGCTG TTTCGCTTCT ACGACATCAG CTCTGGCTGC 
ATCCGAATAG ATGGGCAGGA CATTTCACAG GTGACCCAGG CCTCTCTCCG GTCTCACATT 
GGAGTTGTGC CCCAAGACAC TGTCCTCTTT AATGACACCA TCGCCGACAA TATCCGTTAC 
GGCCGTGTCA CAGCTGGGAA TGATGAGGTG GAGGCTGCTG CTCAGGCTGC AGGCATCCAT 
GATGCCATTA TGGCTTTCCC TGAAGGGTAC AGGACACAGG TGGGCGAGCG GGGACTGAAG 
CTGAGCGGCG GGGAGAAGCA GCGCGTCGCC ATTGCCCGCA CCATCCTCAA GGCTCCGGGC 
ATCATTCTGC TGGATGAGGC AACGTCAGCG CTGGATACAT CTAATGAGAG GGCCATCCAG 
GCTTCTCTGG CCAAAGTCTG TGCCAACCGC ACCACCATCG TAGTGGCACA CAGGCTCTCA 
ACTGTGGTCA ATGCTGACCA GATCCTCGTC ATCAAGGATG GCTGCATCGT GGAGAGGGGA 
CGACACGAGG CTCTGTTGTC CCGAGGTGGG GTGTATGCTG ACATGTGGCA GCTGCAGCAG 
GGACAGGAAG AAACCTCTGA AGACACTAAG CCTCAGACCA TGGAACGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001336757.1
CDS	345..2735
Translation	MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER

Target ORF information:

RefSeq Version	NM_001349828.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001349828.1

ORF Insert Sequence:

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCGGTCAGC AGCCCAACAG TCTACCTGGC GAGATTTTGG CAGGAAGCTC 
CGCCTCCTGA GTGGCTACCT GTGGCCTCGA GGGAGTCCAG CTCTGCAGCT GGTGGTGCTC 
ATCTGCCTGG GGCTCATGGG TTTGGAACGG GCACTCAATG TGTTGGTGCC TATATTCTAT 
AGGAACATTG TGAACTTGCT GACTGAGAAG GCACCTTGGA ACTCTCTGGC CTGGACTGTT 
ACCAGTTACG TCTTCCTCAA GTTCCTCCAG GGGGGTGGCA CTGGCAGTAC AGGCTTCGTG 
AGCAACCTGC GCACCTTCCT GTGGATCCGG GTGCAGCAGT TCACGTCTCG GCGGGTGGAG 
CTGCTCATCT TCTCCCACCT GCACGAGCTC TCACTGCGCT GGCACCTGGG GCGCCGCACA 
GGGGAGGTGC TGCGGATCGC GGATCGGGGC ACATCCAGTG TCACAGGGCT GCTCAGCTAC 
CTGGTGTTCA ATGTCATCCC CACGCTGGCC GACATCATCA TTGGCATCAT CTACTTCAGC 
ATGTTCTTCA ACGCCTGGTT TGGCCTCATT GTGTTCCTGT GCATGAGTCT TTACCTCACC 
CTGACCATTG TGGTCACTGA GTGGAGAACC AAGTTTCGTC GTGCTATGAA CACACAGGAG 
AACGCTACCC GGGCACGAGC AGTGGACTCT CTGCTAAACT TCGAGACGGT GAAGTATTAC 
AACGCCGAGA GTTACGAAGT GGAACGCTAT CGAGAGGCCA TCATCAAATA TCAGGGTTTG 
GAGTGGAAGT CGAGCGCTTC ACTGGTTTTA CTAAATCAGA CCCAGAACCT GGTGATTGGG 
CTCGGGCTCC TCGCCGGCTC CCTGCTTTGC GCATACTTTG TCACTGAGCA GAAGCTACAG 
GTTGGGGACT ATGTGCTCTT TGGCACCTAC ATTATCCAGC TGTACATGCC CCTCAATTGG 
TTTGGCACCT ACTACAGGAT GATCCAGACC AACTTCATTG ACATGGAGAA CATGTTTGAC 
TTGCTGAAAG AGGAGACAGA AGTGAAGGAC CTTCCTGGAG CAGGGCCCCT TCGCTTTCAG 
AAGGGCCGTA TTGAGTTTGA GAACGTGCAC TTCAGCTATG CCGATGGGCG GGAGACTCTG 
CAGGACGTGT CTTTCACTGT GATGCCTGGA CAGACACTTG CCCTGGTGGG CCCATCTGGG 
GCAGGGAAGA GCACAATTTT GCGCCTGCTG TTTCGCTTCT ACGACATCAG CTCTGGCTGC 
ATCCGAATAG ATGGGCAGGA CATTTCACAG GTGACCCAGG CCTCTCTCCG GTCTCACATT 
GGAGTTGTGC CCCAAGACAC TGTCCTCTTT AATGACACCA TCGCCGACAA TATCCGTTAC 
GGCCGTGTCA CAGCTGGGAA TGATGAGGTG GAGGCTGCTG CTCAGGCTGC AGGCATCCAT 
GATGCCATTA TGGCTTTCCC TGAAGGGTAC AGGACACAGG TGGGCGAGCG GGGACTGAAG 
CTGAGCGGCG GGGAGAAGCA GCGCGTCGCC ATTGCCCGCA CCATCCTCAA GGCTCCGGGC 
ATCATTCTGC TGGATGAGGC AACGTCAGCG CTGGATACAT CTAATGAGAG GGCCATCCAG 
GCTTCTCTGG CCAAAGTCTG TGCCAACCGC ACCACCATCG TAGTGGCACA CAGGCTCTCA 
ACTGTGGTCA ATGCTGACCA GATCCTCGTC ATCAAGGATG GCTGCATCGT GGAGAGGGGA 
CGACACGAGG CTCTGTTGTC CCGAGGTGGG GTGTATGCTG ACATGTGGCA GCTGCAGCAG 
GGACAGGAAG AAACCTCTGA AGACACTAAG CCTCAGACCA TGGAACGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCB6 ( NM_001349828.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001336757.1 Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 2, mRNA.

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CloneID	OHu101128
Clone ID Related Accession (Same CDS sequence)	NM_001349828.1 , NM_001349828.2
Accession Version	NM_001349828.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 6, mitochondrial isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068946.4. On May 31, 2019 this sequence version replaced NM_001349828.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.87361.1, SRR1803613.280368.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCGGTCAGC AGCCCAACAG TCTACCTGGC GAGATTTTGG CAGGAAGCTC 
CGCCTCCTGA GTGGCTACCT GTGGCCTCGA GGGAGTCCAG CTCTGCAGCT GGTGGTGCTC 
ATCTGCCTGG GGCTCATGGG TTTGGAACGG GCACTCAATG TGTTGGTGCC TATATTCTAT 
AGGAACATTG TGAACTTGCT GACTGAGAAG GCACCTTGGA ACTCTCTGGC CTGGACTGTT 
ACCAGTTACG TCTTCCTCAA GTTCCTCCAG GGGGGTGGCA CTGGCAGTAC AGGCTTCGTG 
AGCAACCTGC GCACCTTCCT GTGGATCCGG GTGCAGCAGT TCACGTCTCG GCGGGTGGAG 
CTGCTCATCT TCTCCCACCT GCACGAGCTC TCACTGCGCT GGCACCTGGG GCGCCGCACA 
GGGGAGGTGC TGCGGATCGC GGATCGGGGC ACATCCAGTG TCACAGGGCT GCTCAGCTAC 
CTGGTGTTCA ATGTCATCCC CACGCTGGCC GACATCATCA TTGGCATCAT CTACTTCAGC 
ATGTTCTTCA ACGCCTGGTT TGGCCTCATT GTGTTCCTGT GCATGAGTCT TTACCTCACC 
CTGACCATTG TGGTCACTGA GTGGAGAACC AAGTTTCGTC GTGCTATGAA CACACAGGAG 
AACGCTACCC GGGCACGAGC AGTGGACTCT CTGCTAAACT TCGAGACGGT GAAGTATTAC 
AACGCCGAGA GTTACGAAGT GGAACGCTAT CGAGAGGCCA TCATCAAATA TCAGGGTTTG 
GAGTGGAAGT CGAGCGCTTC ACTGGTTTTA CTAAATCAGA CCCAGAACCT GGTGATTGGG 
CTCGGGCTCC TCGCCGGCTC CCTGCTTTGC GCATACTTTG TCACTGAGCA GAAGCTACAG 
GTTGGGGACT ATGTGCTCTT TGGCACCTAC ATTATCCAGC TGTACATGCC CCTCAATTGG 
TTTGGCACCT ACTACAGGAT GATCCAGACC AACTTCATTG ACATGGAGAA CATGTTTGAC 
TTGCTGAAAG AGGAGACAGA AGTGAAGGAC CTTCCTGGAG CAGGGCCCCT TCGCTTTCAG 
AAGGGCCGTA TTGAGTTTGA GAACGTGCAC TTCAGCTATG CCGATGGGCG GGAGACTCTG 
CAGGACGTGT CTTTCACTGT GATGCCTGGA CAGACACTTG CCCTGGTGGG CCCATCTGGG 
GCAGGGAAGA GCACAATTTT GCGCCTGCTG TTTCGCTTCT ACGACATCAG CTCTGGCTGC 
ATCCGAATAG ATGGGCAGGA CATTTCACAG GTGACCCAGG CCTCTCTCCG GTCTCACATT 
GGAGTTGTGC CCCAAGACAC TGTCCTCTTT AATGACACCA TCGCCGACAA TATCCGTTAC 
GGCCGTGTCA CAGCTGGGAA TGATGAGGTG GAGGCTGCTG CTCAGGCTGC AGGCATCCAT 
GATGCCATTA TGGCTTTCCC TGAAGGGTAC AGGACACAGG TGGGCGAGCG GGGACTGAAG 
CTGAGCGGCG GGGAGAAGCA GCGCGTCGCC ATTGCCCGCA CCATCCTCAA GGCTCCGGGC 
ATCATTCTGC TGGATGAGGC AACGTCAGCG CTGGATACAT CTAATGAGAG GGCCATCCAG 
GCTTCTCTGG CCAAAGTCTG TGCCAACCGC ACCACCATCG TAGTGGCACA CAGGCTCTCA 
ACTGTGGTCA ATGCTGACCA GATCCTCGTC ATCAAGGATG GCTGCATCGT GGAGAGGGGA 
CGACACGAGG CTCTGTTGTC CCGAGGTGGG GTGTATGCTG ACATGTGGCA GCTGCAGCAG 
GGACAGGAAG AAACCTCTGA AGACACTAAG CCTCAGACCA TGGAACGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001336757.1
CDS	286..2676
Translation	MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER

Target ORF information:

RefSeq Version	NM_001349828.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001349828.2

ORF Insert Sequence:

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCGGTCAGC AGCCCAACAG TCTACCTGGC GAGATTTTGG CAGGAAGCTC 
CGCCTCCTGA GTGGCTACCT GTGGCCTCGA GGGAGTCCAG CTCTGCAGCT GGTGGTGCTC 
ATCTGCCTGG GGCTCATGGG TTTGGAACGG GCACTCAATG TGTTGGTGCC TATATTCTAT 
AGGAACATTG TGAACTTGCT GACTGAGAAG GCACCTTGGA ACTCTCTGGC CTGGACTGTT 
ACCAGTTACG TCTTCCTCAA GTTCCTCCAG GGGGGTGGCA CTGGCAGTAC AGGCTTCGTG 
AGCAACCTGC GCACCTTCCT GTGGATCCGG GTGCAGCAGT TCACGTCTCG GCGGGTGGAG 
CTGCTCATCT TCTCCCACCT GCACGAGCTC TCACTGCGCT GGCACCTGGG GCGCCGCACA 
GGGGAGGTGC TGCGGATCGC GGATCGGGGC ACATCCAGTG TCACAGGGCT GCTCAGCTAC 
CTGGTGTTCA ATGTCATCCC CACGCTGGCC GACATCATCA TTGGCATCAT CTACTTCAGC 
ATGTTCTTCA ACGCCTGGTT TGGCCTCATT GTGTTCCTGT GCATGAGTCT TTACCTCACC 
CTGACCATTG TGGTCACTGA GTGGAGAACC AAGTTTCGTC GTGCTATGAA CACACAGGAG 
AACGCTACCC GGGCACGAGC AGTGGACTCT CTGCTAAACT TCGAGACGGT GAAGTATTAC 
AACGCCGAGA GTTACGAAGT GGAACGCTAT CGAGAGGCCA TCATCAAATA TCAGGGTTTG 
GAGTGGAAGT CGAGCGCTTC ACTGGTTTTA CTAAATCAGA CCCAGAACCT GGTGATTGGG 
CTCGGGCTCC TCGCCGGCTC CCTGCTTTGC GCATACTTTG TCACTGAGCA GAAGCTACAG 
GTTGGGGACT ATGTGCTCTT TGGCACCTAC ATTATCCAGC TGTACATGCC CCTCAATTGG 
TTTGGCACCT ACTACAGGAT GATCCAGACC AACTTCATTG ACATGGAGAA CATGTTTGAC 
TTGCTGAAAG AGGAGACAGA AGTGAAGGAC CTTCCTGGAG CAGGGCCCCT TCGCTTTCAG 
AAGGGCCGTA TTGAGTTTGA GAACGTGCAC TTCAGCTATG CCGATGGGCG GGAGACTCTG 
CAGGACGTGT CTTTCACTGT GATGCCTGGA CAGACACTTG CCCTGGTGGG CCCATCTGGG 
GCAGGGAAGA GCACAATTTT GCGCCTGCTG TTTCGCTTCT ACGACATCAG CTCTGGCTGC 
ATCCGAATAG ATGGGCAGGA CATTTCACAG GTGACCCAGG CCTCTCTCCG GTCTCACATT 
GGAGTTGTGC CCCAAGACAC TGTCCTCTTT AATGACACCA TCGCCGACAA TATCCGTTAC 
GGCCGTGTCA CAGCTGGGAA TGATGAGGTG GAGGCTGCTG CTCAGGCTGC AGGCATCCAT 
GATGCCATTA TGGCTTTCCC TGAAGGGTAC AGGACACAGG TGGGCGAGCG GGGACTGAAG 
CTGAGCGGCG GGGAGAAGCA GCGCGTCGCC ATTGCCCGCA CCATCCTCAA GGCTCCGGGC 
ATCATTCTGC TGGATGAGGC AACGTCAGCG CTGGATACAT CTAATGAGAG GGCCATCCAG 
GCTTCTCTGG CCAAAGTCTG TGCCAACCGC ACCACCATCG TAGTGGCACA CAGGCTCTCA 
ACTGTGGTCA ATGCTGACCA GATCCTCGTC ATCAAGGATG GCTGCATCGT GGAGAGGGGA 
CGACACGAGG CTCTGTTGTC CCGAGGTGGG GTGTATGCTG ACATGTGGCA GCTGCAGCAG 
GGACAGGAAG AAACCTCTGA AGACACTAAG CCTCAGACCA TGGAACGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCB6 ( NM_005689.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005680.1 Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA.

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CloneID	OHu22713
Clone ID Related Accession (Same CDS sequence)	NM_005689.3 , NM_005689.4
Accession Version	NM_005689.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2529bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-13
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family B member 6, mitochondrial isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC068946.4, AF308472.1 and AW664349.1. On Mar 28, 2017 this sequence version replaced NM_005689.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.237740.1, SRR1803613.91997.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCAGTTTAG CCTGTGGGTG CTGCGGTATG TGGTCTCTGG AGGGCTGTTT 
GTCCTGGGTC TCTGGGCCCC TGGACTTCGT CCCCAGTCCT ATACATTGCA GGTTCATGAA 
GAGGACCAAG ATGTGGAAAG GAGCCAGGTT CGGTCAGCAG CCCAACAGTC TACCTGGCGA 
GATTTTGGCA GGAAGCTCCG CCTCCTGAGT GGCTACCTGT GGCCTCGAGG GAGTCCAGCT 
CTGCAGCTGG TGGTGCTCAT CTGCCTGGGG CTCATGGGTT TGGAACGGGC ACTCAATGTG 
TTGGTGCCTA TATTCTATAG GAACATTGTG AACTTGCTGA CTGAGAAGGC ACCTTGGAAC 
TCTCTGGCCT GGACTGTTAC CAGTTACGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GCTTCGTGAG CAACCTGCGC ACCTTCCTGT GGATCCGGGT GCAGCAGTTC 
ACGTCTCGGC GGGTGGAGCT GCTCATCTTC TCCCACCTGC ACGAGCTCTC ACTGCGCTGG 
CACCTGGGGC GCCGCACAGG GGAGGTGCTG CGGATCGCGG ATCGGGGCAC ATCCAGTGTC 
ACAGGGCTGC TCAGCTACCT GGTGTTCAAT GTCATCCCCA CGCTGGCCGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAC GCCTGGTTTG GCCTCATTGT GTTCCTGTGC 
ATGAGTCTTT ACCTCACCCT GACCATTGTG GTCACTGAGT GGAGAACCAA GTTTCGTCGT 
GCTATGAACA CACAGGAGAA CGCTACCCGG GCACGAGCAG TGGACTCTCT GCTAAACTTC 
GAGACGGTGA AGTATTACAA CGCCGAGAGT TACGAAGTGG AACGCTATCG AGAGGCCATC 
ATCAAATATC AGGGTTTGGA GTGGAAGTCG AGCGCTTCAC TGGTTTTACT AAATCAGACC 
CAGAACCTGG TGATTGGGCT CGGGCTCCTC GCCGGCTCCC TGCTTTGCGC ATACTTTGTC 
ACTGAGCAGA AGCTACAGGT TGGGGACTAT GTGCTCTTTG GCACCTACAT TATCCAGCTG 
TACATGCCCC TCAATTGGTT TGGCACCTAC TACAGGATGA TCCAGACCAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGACCT TCCTGGAGCA 
GGGCCCCTTC GCTTTCAGAA GGGCCGTATT GAGTTTGAGA ACGTGCACTT CAGCTATGCC 
GATGGGCGGG AGACTCTGCA GGACGTGTCT TTCACTGTGA TGCCTGGACA GACACTTGCC 
CTGGTGGGCC CATCTGGGGC AGGGAAGAGC ACAATTTTGC GCCTGCTGTT TCGCTTCTAC 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGGCAGGACA TTTCACAGGT GACCCAGGCC 
TCTCTCCGGT CTCACATTGG AGTTGTGCCC CAAGACACTG TCCTCTTTAA TGACACCATC 
GCCGACAATA TCCGTTACGG CCGTGTCACA GCTGGGAATG ATGAGGTGGA GGCTGCTGCT 
CAGGCTGCAG GCATCCATGA TGCCATTATG GCTTTCCCTG AAGGGTACAG GACACAGGTG 
GGCGAGCGGG GACTGAAGCT GAGCGGCGGG GAGAAGCAGC GCGTCGCCAT TGCCCGCACC 
ATCCTCAAGG CTCCGGGCAT CATTCTGCTG GATGAGGCAA CGTCAGCGCT GGATACATCT 
AATGAGAGGG CCATCCAGGC TTCTCTGGCC AAAGTCTGTG CCAACCGCAC CACCATCGTA 
GTGGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TCCTCGTCAT CAAGGATGGC 
TGCATCGTGG AGAGGGGACG ACACGAGGCT CTGTTGTCCC GAGGTGGGGT GTATGCTGAC 
ATGTGGCAGC TGCAGCAGGG ACAGGAAGAA ACCTCTGAAG ACACTAAGCC TCAGACCATG 
GAACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005680.1
CDS	345..2873
Translation	MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGADSLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGACGLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTMER

Target ORF information:

RefSeq Version	NM_005689.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005689.3

ORF Insert Sequence:

ATGGTGACTG TGGGCAACTA CTGCGAGGCC GAAGGGCCCG TGGGTCCGGC CTGGATGCAG 
GATGGCCTGA GTCCCTGCTT CTTCTTCACG CTCGTGCCCT CGACGCGGAT GGCTCTGGGG 
ACTCTGGCCT TGGTGCTGGC TCTTCCCTGC AGACGCCGGG AGCGGCCCGC TGGTGCTGAT 
TCGCTGTCTT GGGGGGCCGG CCCTCGCATC TCTCCCTACG TGCTGCAGCT GCTTCTGGCC 
ACACTTCAGG CGGCGCTGCC CCTGGCCGGC CTGGCTGGCC GGGTGGGCAC TGCCCGGGGG 
GCCCCACTGC CAAGCTATCT ACTTCTGGCC TCCGTGCTGG AGAGTCTGGC CGGCGCCTGT 
GGCCTGTGGC TGCTTGTCGT GGAGCGGAGC CAGGCACGGC AGCGTCTGGC AATGGGCATC 
TGGATCAAGT TCAGGCACAG CCCTGGTCTC CTGCTCCTCT GGACTGTGGC GTTTGCAGCT 
GAGAACTTGG CCCTGGTGTC TTGGAACAGC CCACAGTGGT GGTGGGCAAG GGCAGACTTG 
GGCCAGCAGG TTCAGTTTAG CCTGTGGGTG CTGCGGTATG TGGTCTCTGG AGGGCTGTTT 
GTCCTGGGTC TCTGGGCCCC TGGACTTCGT CCCCAGTCCT ATACATTGCA GGTTCATGAA 
GAGGACCAAG ATGTGGAAAG GAGCCAGGTT CGGTCAGCAG CCCAACAGTC TACCTGGCGA 
GATTTTGGCA GGAAGCTCCG CCTCCTGAGT GGCTACCTGT GGCCTCGAGG GAGTCCAGCT 
CTGCAGCTGG TGGTGCTCAT CTGCCTGGGG CTCATGGGTT TGGAACGGGC ACTCAATGTG 
TTGGTGCCTA TATTCTATAG GAACATTGTG AACTTGCTGA CTGAGAAGGC ACCTTGGAAC 
TCTCTGGCCT GGACTGTTAC CAGTTACGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GCTTCGTGAG CAACCTGCGC ACCTTCCTGT GGATCCGGGT GCAGCAGTTC 
ACGTCTCGGC GGGTGGAGCT GCTCATCTTC TCCCACCTGC ACGAGCTCTC ACTGCGCTGG 
CACCTGGGGC GCCGCACAGG GGAGGTGCTG CGGATCGCGG ATCGGGGCAC ATCCAGTGTC 
ACAGGGCTGC TCAGCTACCT GGTGTTCAAT GTCATCCCCA CGCTGGCCGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAC GCCTGGTTTG GCCTCATTGT GTTCCTGTGC 
ATGAGTCTTT ACCTCACCCT GACCATTGTG GTCACTGAGT GGAGAACCAA GTTTCGTCGT 
GCTATGAACA CACAGGAGAA CGCTACCCGG GCACGAGCAG TGGACTCTCT GCTAAACTTC 
GAGACGGTGA AGTATTACAA CGCCGAGAGT TACGAAGTGG AACGCTATCG AGAGGCCATC 
ATCAAATATC AGGGTTTGGA GTGGAAGTCG AGCGCTTCAC TGGTTTTACT AAATCAGACC 
CAGAACCTGG TGATTGGGCT CGGGCTCCTC GCCGGCTCCC TGCTTTGCGC ATACTTTGTC 
ACTGAGCAGA AGCTACAGGT TGGGGACTAT GTGCTCTTTG GCACCTACAT TATCCAGCTG 
TACATGCCCC TCAATTGGTT TGGCACCTAC TACAGGATGA TCCAGACCAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGACCT TCCTGGAGCA 
GGGCCCCTTC GCTTTCAGAA GGGCCGTATT GAGTTTGAGA ACGTGCACTT CAGCTATGCC 
GATGGGCGGG AGACTCTGCA GGACGTGTCT TTCACTGTGA TGCCTGGACA GACACTTGCC 
CTGGTGGGCC CATCTGGGGC AGGGAAGAGC ACAATTTTGC GCCTGCTGTT TCGCTTCTAC 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGGCAGGACA TTTCACAGGT GACCCAGGCC 
TCTCTCCGGT CTCACATTGG AGTTGTGCCC CAAGACACTG TCCTCTTTAA TGACACCATC 
GCCGACAATA TCCGTTACGG CCGTGTCACA GCTGGGAATG ATGAGGTGGA GGCTGCTGCT 
CAGGCTGCAG GCATCCATGA TGCCATTATG GCTTTCCCTG AAGGGTACAG GACACAGGTG 
GGCGAGCGGG GACTGAAGCT GAGCGGCGGG GAGAAGCAGC GCGTCGCCAT TGCCCGCACC 
ATCCTCAAGG CTCCGGGCAT CATTCTGCTG GATGAGGCAA CGTCAGCGCT GGATACATCT 
AATGAGAGGG CCATCCAGGC TTCTCTGGCC AAAGTCTGTG CCAACCGCAC CACCATCGTA 
GTGGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TCCTCGTCAT CAAGGATGGC 
TGCATCGTGG AGAGGGGACG ACACGAGGCT CTGTTGTCCC GAGGTGGGGT GTATGCTGAC 
ATGTGGCAGC TGCAGCAGGG ACAGGAAGAA ACCTCTGAAG ACACTAAGCC TCAGACCATG 
GAACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ATP-binding casette transporter expression in acute myeloid leukemia: association with in vitro cytotoxicity and prognostic markers.
Pharmacogenomics18(3)235-244(2017 Feb)
Varatharajan S,Abraham A,Karathedath S,Ganesan S,Lakshmi KM,Arthur N,Srivastava VM,George B,Srivastava A,Mathews V,Balasubramanian P

Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
Scientific reports636478(2016 Nov)
Nakayama T,Otsuka S,Kobayashi T,Okajima H,Matsumoto K,Hagiya Y,Inoue K,Shuin T,Nakajima M,Tanaka T,Ogura SI

New insights on hereditary erythrocyte membrane defects.
Haematologica101(11)1284-1294(2016 11)
Andolfo I,Russo R,Gambale A,Iolascon A

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.
Nature communications712353(2016 Aug)
Fukuda Y,Cheong PL,Lynch J,Brighton C,Frase S,Kargas V,Rampersaud E,Wang Y,Sankaran VG,Yu B,Ney PA,Weiss MJ,Vogel P,Bond PJ,Ford RC,Trent RJ,Schuetz JD

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ABCB6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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