KLRC4-KLRK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KLRC4-KLRK1
Entrez Gene ID	100528032
Full Name	KLRC4-KLRK1 readthrough
General protein information	Preferred Names KLRC4-KLRK1 readthrough Names NKG2-D type II integral membrane protein NK cell receptor D NKG2-D-activating NK receptor killer cell lectin-like receptor subfamily K member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001199805.1	NP_001186734.1	NKG2-D type II integral membrane protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	KLRC4-KLRK1	NP_001186734.1
Homo sapiens (human)	KLRK1	NP_031386.2

Gene Ontology
Bibliography

Related articles in PubMed

A disease-linked
Zuo J, Willcox CR, Mohammed F, Davey M, Hunter S, Khan K, Antoun A, Katakia P, Croudace J, Inman C, Parry H, Briggs D, Malladi R, Willcox BE, Moss P
Science signaling10(481)(2017 May)

CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.
Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS
European journal of immunology43(9)2473-83(2013 Sep)

Genome-wide association analysis identifies new susceptibility loci for Beh?et's disease and epistasis between HLA-B*51 and ERAP1.
Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, G?l A, Remmers EF, Kastner DL
Nature genetics45(2)202-7(2013 Feb)

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
Serrano-Pertierra E, Cernuda-Moroll?n E, L?pez-Larrea C
European journal of immunology42(8)2142-51(2012 Aug)

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans.
Tsuboi S, Sutoh M, Hatakeyama S, Hiraoka N, Habuchi T, Horikawa Y, Hashimoto Y, Yoneyama T, Mori K, Koie T, Nakamura T, Saitoh H, Yamaya K, Funyu T, Fukuda M, Ohyama C
The EMBO journal30(15)3173-85(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KLRC4-KLRK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLRC4-KLRK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu07952	NM_001199805.1 Latest version!	Homo sapiens KLRC4-KLRK1 readthrough (KLRC4-KLRK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KLRC4-KLRK1 ( NM_001199805.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186734.1 Homo sapiens KLRC4-KLRK1 readthrough (KLRC4-KLRK1), mRNA.

Price & Availability↑

CloneID	OHu07952
Clone ID Related Accession (Same CDS sequence)	NM_001199805.1
Accession Version	NM_001199805.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	NKG2-D type II integral membrane protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF461811.1 and AC022075.29. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF461811.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 8302, 22914 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT 
TATAACTTGG ATCTGAAGAA GAGTGATTTT TCAACACGAT GGCAAAAGCA AAGATGTCCA 
GTAGTCAAAA GCAAATGTAG AGAAAATGCA TCTCCATTTT TTTTCTGCTG CTTCATCGCT 
GTAGCCATGG GAATCCGTTT CATTATTATG GTAACAATAT GGAGTGCTGT ATTCCTAAAC 
TCATTATTCA ACCAAGAAGT TCAAATTCCC TTGACCGAAA GTTACTGTGG CCCATGTCCT 
AAAAACTGGA TATGTTACAA AAATAACTGC TACCAATTTT TTGATGAGAG TAAAAACTGG 
TATGAGAGCC AGGCTTCTTG TATGTCTCAA AATGCCAGCC TTCTGAAAGT ATACAGCAAA 
GAGGACCAGG ATTTACTTAA ACTGGTGAAG TCATATCATT GGATGGGACT AGTACACATT 
CCAACAAATG GATCTTGGCA GTGGGAAGAT GGCTCCATTC TCTCACCCAA CCTACTAACA 
ATAATTGAAA TGCAGAAGGG AGACTGTGCA CTCTATGCCT CGAGCTTTAA AGGCTATATA 
GAAAACTGTT CAACTCCAAA TACGTACATC TGCATGCAAA GGACTGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186734.1
CDS	536..1186
Translation	MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

Target ORF information:

RefSeq Version	NM_001199805.1
Organism	Homo sapiens(human)
Definition	Homo sapiens KLRC4-KLRK1 readthrough (KLRC4-KLRK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199805.1

ORF Insert Sequence:

ATGGGGTGGA TTCGTGGTCG GAGGTCTCGA CACAGCTGGG AGATGAGTGA ATTTCATAAT 
TATAACTTGG ATCTGAAGAA GAGTGATTTT TCAACACGAT GGCAAAAGCA AAGATGTCCA 
GTAGTCAAAA GCAAATGTAG AGAAAATGCA TCTCCATTTT TTTTCTGCTG CTTCATCGCT 
GTAGCCATGG GAATCCGTTT CATTATTATG GTAACAATAT GGAGTGCTGT ATTCCTAAAC 
TCATTATTCA ACCAAGAAGT TCAAATTCCC TTGACCGAAA GTTACTGTGG CCCATGTCCT 
AAAAACTGGA TATGTTACAA AAATAACTGC TACCAATTTT TTGATGAGAG TAAAAACTGG 
TATGAGAGCC AGGCTTCTTG TATGTCTCAA AATGCCAGCC TTCTGAAAGT ATACAGCAAA 
GAGGACCAGG ATTTACTTAA ACTGGTGAAG TCATATCATT GGATGGGACT AGTACACATT 
CCAACAAATG GATCTTGGCA GTGGGAAGAT GGCTCCATTC TCTCACCCAA CCTACTAACA 
ATAATTGAAA TGCAGAAGGG AGACTGTGCA CTCTATGCCT CGAGCTTTAA AGGCTATATA 
GAAAACTGTT CAACTCCAAA TACGTACATC TGCATGCAAA GGACTGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A disease-linked
Science signaling10(481)(2017 May)
Zuo J,Willcox CR,Mohammed F,Davey M,Hunter S,Khan K,Antoun A,Katakia P,Croudace J,Inman C,Parry H,Briggs D,Malladi R,Willcox BE,Moss P

CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.
European journal of immunology43(9)2473-83(2013 Sep)
Hosomi S,Chen Z,Baker K,Chen L,Huang YH,Olszak T,Zeissig S,Wang JH,Mandelboim O,Beauchemin N,Lanier LL,Blumberg RS

Genome-wide association analysis identifies new susceptibility loci for Beh?et's disease and epistasis between HLA-B*51 and ERAP1.
Nature genetics45(2)202-7(2013 Feb)
Kirino Y,Bertsias G,Ishigatsubo Y,Mizuki N,Tugal-Tutkun I,Seyahi E,Ozyazgan Y,Sacli FS,Erer B,Inoko H,Emrence Z,Cakar A,Abaci N,Ustek D,Satorius C,Ueda A,Takeno M,Kim Y,Wood GM,Ombrello MJ,Meguro A,G?l A,Remmers EF,Kastner DL

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
European journal of immunology42(8)2142-51(2012 Aug)
Serrano-Pertierra E,Cernuda-Moroll?n E,L?pez-Larrea C

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans.
The EMBO journal30(15)3173-85(2011 Jun)
Tsuboi S,Sutoh M,Hatakeyama S,Hiraoka N,Habuchi T,Horikawa Y,Hashimoto Y,Yoneyama T,Mori K,Koie T,Nakamura T,Saitoh H,Yamaya K,Funyu T,Fukuda M,Ohyama C

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KLRC4-KLRK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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