PET117 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PET117
Entrez Gene ID	100303755
Full Name	PET117 homolog
Synonyms	CSRP2BP
General protein information	Preferred Names PET117 homolog Names protein PET117 homolog, mitochondrial alternative protein CSRP2BP
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p11.23
Disorder MIM:	614771

mRNA and Protein(s)

mRNA	Protein	Name
NM_001164811.1	NP_001158283.1	protein PET117 homolog, mitochondrial precursor
NM_001164811.2	NP_001158283.1	protein PET117 homolog, mitochondrial precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC100688040	XP_003433337.1
Mus musculus (house mouse)	Pet117	NP_001158285.1
Homo sapiens (human)	PET117	NP_001158283.1
	PET117	XP_001089476.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutated PET117 causes complex IV deficiency and is associated with neurodevelopmental regression and medulla oblongata lesions.
Renkema GH, Visser G, Baertling F, Wintjes LT, Wolters VM, van Montfrans J, de Kort GAP, Nikkels PGJ, van Hasselt PM, van der Crabben SN, Rodenburg RJT
Human genetics136(6)759-769(2017 Jun)

MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.
Vidoni S, Harbour ME, Guerrero-Castillo S, Signes A, Ding S, Fearnley IM, Taylor RW, Tiranti V, Arnold S, Fernandez-Vizarra E, Zeviani M
Cell reports18(7)1727-1738(2017 Feb)

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Szklarczyk R, Wanschers BF, Cuypers TD, Esseling JJ, Riemersma M, van den Brand MA, Gloerich J, Lasonder E, van den Heuvel LP, Nijtmans LG, Huynen MA
Genome biology13(2)R12(2012 Feb)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research13(10)2265-70(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

case presentation thus implicates mutations in PET117 as a novel cause of mitochondrial disease
Title: Mutated PET117 causes complex IV deficiency and is associated with neurodevelopmental regression and medulla oblongata lesions.

The short isoform of the myofibrillogenesis regulator 1 (MR-1S) as a new COX assembly factor, which works with the highly conserved PET100 and PET117 chaperones to assist COX biogenesis in higher eukaryotes.
Title: MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.

Ortholog of fungal COX assembly protein PET117
Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.

The following PET117 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PET117 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55805	NM_001164811.2 Latest version!	Homo sapiens PET117 cytochrome c oxidase chaperone (PET117), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55805	NM_001164811.1	Homo sapiens PET117 homolog (PET117), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PET117 ( NM_001164811.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001158283.1 Homo sapiens PET117 homolog (PET117), mRNA.

Price & Availability↑

CloneID	OHu55805
Clone ID Related Accession (Same CDS sequence)	NM_001164811.1 , NM_001164811.2
Accession Version	NM_001164811.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	protein PET117 homolog, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI601826.1, AY358666.1 and BM984163.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.393464.1, SRR1803615.450006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTAGGA GCTCGAAGGT GGTGCTGGGC CTCTCGGTGC TGCTGACGGC GGCCACAGTG 
GCCGGCGTAC ATGTGAAGCA GCAGTGGGAC CAGCAGAGGC TTCGTGACGG AGTTATCAGA 
GACATTGAGA GGCAAATTCG GAAAAAAGAA AACATTCGTC TTTTGGGAGA ACAGATTATT 
TTGACTGAGC AACTTGAAGC AGAAAGAGAG AAGATGTTAT TGGCAAAAGG ATCTCAAAAA 
TCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001158283.1
CDS	102..347
Translation	MSRSSKVVLGLSVLLTAATVAGVHVKQQWDQQRLRDGVIRDIERQIRKKENIRLLGEQIILTEQLEAEREKMLLAKGSQKS

Target ORF information:

RefSeq Version	NM_001164811.1
Organism	Homo sapiens(human)
Definition	Homo sapiens PET117 homolog (PET117), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164811.1

ORF Insert Sequence:

ATGTCTAGGA GCTCGAAGGT GGTGCTGGGC CTCTCGGTGC TGCTGACGGC GGCCACAGTG 
GCCGGCGTAC ATGTGAAGCA GCAGTGGGAC CAGCAGAGGC TTCGTGACGG AGTTATCAGA 
GACATTGAGA GGCAAATTCG GAAAAAAGAA AACATTCGTC TTTTGGGAGA ACAGATTATT 
TTGACTGAGC AACTTGAAGC AGAAAGAGAG AAGATGTTAT TGGCAAAAGG ATCTCAAAAA 
TCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PET117 ( NM_001164811.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001158283.1 Homo sapiens PET117 cytochrome c oxidase chaperone (PET117), mRNA.

Price & Availability↑

CloneID	OHu55805
Clone ID Related Accession (Same CDS sequence)	NM_001164811.1 , NM_001164811.2
Accession Version	NM_001164811.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	protein PET117 homolog, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI601826.1, AY358666.1 and BM984163.1. On Nov 23, 2018 this sequence version replaced NM_001164811.1. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.127921.1, SRR1803615.450006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000432901.4/ ENSP00000397881.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTAGGA GCTCGAAGGT GGTGCTGGGC CTCTCGGTGC TGCTGACGGC GGCCACAGTG 
GCCGGCGTAC ATGTGAAGCA GCAGTGGGAC CAGCAGAGGC TTCGTGACGG AGTTATCAGA 
GACATTGAGA GGCAAATTCG GAAAAAAGAA AACATTCGTC TTTTGGGAGA ACAGATTATT 
TTGACTGAGC AACTTGAAGC AGAAAGAGAG AAGATGTTAT TGGCAAAAGG ATCTCAAAAA 
TCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001158283.1
CDS	94..339
Translation	MSRSSKVVLGLSVLLTAATVAGVHVKQQWDQQRLRDGVIRDIERQIRKKENIRLLGEQIILTEQLEAEREKMLLAKGSQKS

Target ORF information:

RefSeq Version	NM_001164811.2
Organism	Homo sapiens(human)
Definition	Homo sapiens PET117 cytochrome c oxidase chaperone (PET117), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164811.2

ORF Insert Sequence:

ATGTCTAGGA GCTCGAAGGT GGTGCTGGGC CTCTCGGTGC TGCTGACGGC GGCCACAGTG 
GCCGGCGTAC ATGTGAAGCA GCAGTGGGAC CAGCAGAGGC TTCGTGACGG AGTTATCAGA 
GACATTGAGA GGCAAATTCG GAAAAAAGAA AACATTCGTC TTTTGGGAGA ACAGATTATT 
TTGACTGAGC AACTTGAAGC AGAAAGAGAG AAGATGTTAT TGGCAAAAGG ATCTCAAAAA 
TCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutated PET117 causes complex IV deficiency and is associated with neurodevelopmental regression and medulla oblongata lesions.
Human genetics136(6)759-769(2017 Jun)
Renkema GH,Visser G,Baertling F,Wintjes LT,Wolters VM,van Montfrans J,de Kort GAP,Nikkels PGJ,van Hasselt PM,van der Crabben SN,Rodenburg RJT

MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.
Cell reports18(7)1727-1738(2017 Feb)
Vidoni S,Harbour ME,Guerrero-Castillo S,Signes A,Ding S,Fearnley IM,Taylor RW,Tiranti V,Arnold S,Fernandez-Vizarra E,Zeviani M

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Genome biology13(2)R12(2012 Feb)
Szklarczyk R,Wanschers BF,Cuypers TD,Esseling JJ,Riemersma M,van den Brand MA,Gloerich J,Lasonder E,van den Heuvel LP,Nijtmans LG,Huynen MA

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome research13(10)2265-70(2003 Oct)
Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A

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PET117 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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