HCN4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HCN4
Entrez Gene ID	10021
Full Name	hyperpolarization activated cyclic nucleotide gated potassium channel 4
Synonyms	SSS2
General protein information	Preferred Names hyperpolarization activated cyclic nucleotide gated potassium channel 4 Names potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 hyperpolarization activated cyclic nucleotide-gated cation channel 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q24.1
Summary	This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].
Disorder MIM:	605206
Disorder Html:	Sick sinus syndrome 2, 163800 (3); Brugada syndrome 8, 613123 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005477.3	NP_005468.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
NM_005477.2	NP_005468.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
XM_011521148.2	XP_011519450.1	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X1

Pathways from BioSystems

Homologies

	HCN4	XP_002804905.1
Mus musculus (house mouse)	Hcn4	NP_001074661.1
Danio rerio (zebrafish)	hcn4	XP_686078.4
Xenopus tropicalis (tropical clawed frog)	hcn4	XP_004916024.1
Pan troglodytes (chimpanzee)	HCN4	XP_003952750.1
Bos taurus (cattle)	HCN4	XP_002690539.1
Gallus gallus (chicken)	HCN4	XP_425050.3
Homo sapiens (human)	HCN4	NP_005468.1
Danio rerio (zebrafish)	hcn4l	XP_684730.5
Rattus norvegicus (Norway rat)	Hcn4	NP_067690.1

Gene Ontology

The following HCN4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HCN4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18158	NM_005477.3 Latest version!	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
OHu63614	XM_011521148.2 Latest version!	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu18158	NM_005477.2	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HCN4 ( NM_005477.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005468.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA.

Price & Availability↑

CloneID	OHu18158
Clone ID Related Accession (Same CDS sequence)	NM_005477.3 , NM_005477.2
Accession Version	NM_005477.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ238850.1, AJ132429.1, AC068397.6, BP291686.1 and BM979827.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005477.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ132429.1, AJ238850.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261917.4/ ENSP00000261917.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTCCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GACGCCGAGG AGGAGGGGGC CGGGGGCCGC 
CAAGACCCCA GCCGCAGGAG CATCCGGCTG CGGCCACTGC CCTCGCCCTC CCCCTCGGCG 
GCCGCGGGTG GCACGGAGTC CCGGAGCTCG GCCCTCGGGG CAGCGGACAG CGAAGGGCCG 
GCCCGCGGCG CGGGCAAGTC CAGCACGAAC GGCGACTGCA GGCGCTTCCG CGGGAGCCTG 
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGC GGCGGCACGG GGAGCGGCAG CAGTCACGGA 
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG AGGGCGACGC GTCCCCCGGC 
GAGGACAGGA CGCCCCCAGG CCTGGCGGCC GAGCCCGAGC GCCCCGGCGC CTCGGCGCAG 
CCCGCAGCCT CGCCGCCGCC GCCCCAGCAG CCACCGCAGC CGGCCTCCGC CTCCTGCGAG 
CAGCCCTCGG TGGACACCGC TATCAAAGTG GAGGGAGGCG CGGCTGCCGG CGACCAGATC 
CTCCCGGAGG CCGAGGTGCG CCTGGGCCAG GCCGGCTTCA TGCAGCGCCA GTTCGGGGCC 
ATGCTCCAAC CCGGGGTCAA CAAATTCTCC CTAAGGATGT TCGGCAGCCA GAAAGCCGTG 
GAGCGCGAAC AGGAGAGGGT CAAGTCGGCC GGATTTTGGA TTATCCACCC CTACAGTGAC 
TTCAGATTTT ACTGGGACCT GACCATGCTG CTGCTGATGG TGGGAAACCT GATTATCATT 
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACAC CCTGGATTGT CTTCAATGTG 
GTGTCAGACA CATTCTTCCT CATCGACTTG GTCCTCAACT TCCGCACAGG GATCGTGGTG 
GAGGACAACA CAGAGATCAT CCTGGACCCG CAGCGGATTA AAATGAAGTA CCTGAAAAGC 
TGGTTCATGG TAGATTTCAT TTCCTCCATC CCCGTGGACT ACATCTTCCT CATTGTGGAG 
ACACGCATCG ACTCGGAGGT CTACAAGACT GCCCGGGCCC TGCGCATTGT CCGCTTCACG 
AAGATCCTCA GCCTCTTACG CCTGTTACGC CTCTCCCGCC TCATTCGATA TATTCACCAG 
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGCG CCGTGGTGCG CATCGTGAAC 
CTCATCGGCA TGATGCTCCT GCTCTGCCAC TGGGACGGCT GCCTGCAGTT CCTGGTACCC 
ATGCTACAGG ACTTCCCTGA CGACTGCTGG GTGTCCATCA ACAACATGGT GAACAACTCC 
TGGGGGAAGC AGTACTCCTA CGCGCTCTTC AAGGCCATGA GCCACATGCT GTGCATCGGC 
TACGGGCGGC AGGCGCCCGT GGGCATGTCC GACGTCTGGC TCACCATGCT CAGCATGATC 
GTGGGTGCCA CCTGCTACGC CATGTTCATT GGCCACGCCA CTGCCCTCAT CCAGTCCCTG 
GACTCCTCCC GGCGCCAGTA CCAGGAAAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTT 
CACAAGCTCC CGCCCGACAC CCGGCAGCGC ATCCACGACT ACTACGAGCA CCGCTACCAG 
GGCAAGATGT TCGACGAGGA GAGCATCCTG GGCGAGCTAA GCGAGCCCCT GCGGGAGGAG 
ATCATCAACT TTAACTGTCG GAAGCTGGTG GCCTCCATGC CACTGTTTGC CAATGCGGAC 
CCCAACTTCG TGACGTCCAT GCTGACCAAG CTGCGTTTCG AGGTCTTCCA GCCTGGGGAC 
TACATCATCC GGGAAGGCAC CATTGGCAAG AAGATGTACT TCATCCAGCA TGGCGTGGTC 
AGCGTGCTCA CCAAGGGCAA CAAGGAGACC AAGCTGGCCG ACGGCTCCTA CTTTGGAGAG 
ATCTGCCTGC TGACCCGGGG CCGGCGCACA GCCAGCGTGA GGGCCGACAC CTACTGCCGC 
CTCTACTCGC TGAGCGTGGA CAACTTCAAT GAGGTGCTGG AGGAGTACCC CATGATGCGA 
AGGGCCTTCG AGACCGTGGC GCTGGACCGC CTGGACCGCA TTGGCAAGAA GAACTCCATC 
CTCCTCCACA AAGTCCAGCA CGACCTCAAC TCCGGCGTCT TCAACTACCA GGAGAATGAG 
ATCATCCAGC AGATTGTGCA GCATGACCGG GAGATGGCCC ACTGCGCGCA CCGCGTCCAG 
GCTGCTGCCT CTGCCACCCC AACCCCCACG CCCGTCATCT GGACCCCGCT GATCCAGGCA 
CCACTGCAGG CTGCCGCTGC CACCACTTCT GTGGCCATAG CCCTCACCCA CCACCCTCGC 
CTGCCTGCTG CCATCTTCCG CCCTCCCCCA GGATCTGGGC TGGGCAACCT CGGTGCCGGG 
CAGACGCCAA GGCACCTGAA ACGGCTGCAG TCCCTGATCC CTTCTGCGCT GGGCTCCGCC 
TCGCCCGCCA GCAGCCCGTC CCAGGTGGAC ACACCGTCTT CATCCTCCTT CCACATCCAA 
CAGCTGGCTG GATTCTCTGC CCCCGCTGGA CTGAGCCCAC TCCTGCCCTC ATCCAGCTCC 
TCCCCACCCC CCGGGGCCTG TGGCTCCCCC TCGGCTCCCA CACCATCAGC TGGCGTAGCC 
GCCACCACCA TAGCCGGGTT TGGCCACTTC CACAAGGCGC TGGGTGGCTC CCTGTCCTCC 
TCCGACTCTC CCCTGCTCAC CCCGCTGCAG CCAGGCGCCC GCTCCCCGCA GGCTGCCCAG 
CCATCTCCCG CGCCACCCGG GGCCCGGGGA GGCCTGGGAC TCCCGGAGCA CTTCCTGCCA 
CCCCCACCCT CATCCAGATC CCCGTCATCT AGCCCCGGGC AGCTGGGCCA GCCTCCCGGG 
GAGTTGTCCC TAGGTCTGGC CACTGGCCCA CTGAGCACGC CAGAGACACC CCCACGGCAG 
CCTGAGCCGC CGTCCCTTGT GGCAGGGGCC TCTGGGGGGG CTTCCCCTGT AGGCTTTACT 
CCCCGAGGAG GTCTCAGCCC CCCTGGCCAC AGCCCAGGCC CCCCAAGAAC CTTCCCGAGT 
GCCCCGCCCC GGGCCTCTGG CTCCCACGGA TCCTTGCTCC TGCCACCTGC ATCCAGCCCC 
CCACCACCCC AGGTCCCCCA GCGCCGGGGC ACACCCCCGC TCACCCCCGG CCGCCTCACC 
CAGGACCTCA AGCTCATCTC CGCGTCTCAG CCAGCCCTGC CTCAGGACGG GGCGCAGACT 
CTCCGCAGAG CCTCCCCGCA CTCCTCAGGG GAGTCCATGG CTGCCTTCCC GCTCTTCCCC 
AGGGCTGGGG GTGGCAGCGG GGGCAGTGGG AGCAGCGGGG GCCTCGGTCC CCCTGGGAGG 
CCCTATGGTG CCATCCCCGG CCAGCACGTC ACTCTGCCTC GGAAGACATC CTCAGGTTCT 
TTGCCACCCC CTCTGTCTTT GTTTGGGGCA AGAGCCACCT CTTCTGGGGG GCCCCCTCTG 
ACTGCTGGAC CCCAGAGGGA ACCTGGGGCC AGGCCTGAGC CAGTGCGCTC CAAACTGCCA 
TCCAATCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005468.1
CDS	689..4300
Translation	MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL

Target ORF information:

RefSeq Version	NM_005477.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005477.3

ORF Insert Sequence:

ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTCCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GACGCCGAGG AGGAGGGGGC CGGGGGCCGC 
CAAGACCCCA GCCGCAGGAG CATCCGGCTG CGGCCACTGC CCTCGCCCTC CCCCTCGGCG 
GCCGCGGGTG GCACGGAGTC CCGGAGCTCG GCCCTCGGGG CAGCGGACAG CGAAGGGCCG 
GCCCGCGGCG CGGGCAAGTC CAGCACGAAC GGCGACTGCA GGCGCTTCCG CGGGAGCCTG 
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGC GGCGGCACGG GGAGCGGCAG CAGTCACGGA 
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG AGGGCGACGC GTCCCCCGGC 
GAGGACAGGA CGCCCCCAGG CCTGGCGGCC GAGCCCGAGC GCCCCGGCGC CTCGGCGCAG 
CCCGCAGCCT CGCCGCCGCC GCCCCAGCAG CCACCGCAGC CGGCCTCCGC CTCCTGCGAG 
CAGCCCTCGG TGGACACCGC TATCAAAGTG GAGGGAGGCG CGGCTGCCGG CGACCAGATC 
CTCCCGGAGG CCGAGGTGCG CCTGGGCCAG GCCGGCTTCA TGCAGCGCCA GTTCGGGGCC 
ATGCTCCAAC CCGGGGTCAA CAAATTCTCC CTAAGGATGT TCGGCAGCCA GAAAGCCGTG 
GAGCGCGAAC AGGAGAGGGT CAAGTCGGCC GGATTTTGGA TTATCCACCC CTACAGTGAC 
TTCAGATTTT ACTGGGACCT GACCATGCTG CTGCTGATGG TGGGAAACCT GATTATCATT 
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACAC CCTGGATTGT CTTCAATGTG 
GTGTCAGACA CATTCTTCCT CATCGACTTG GTCCTCAACT TCCGCACAGG GATCGTGGTG 
GAGGACAACA CAGAGATCAT CCTGGACCCG CAGCGGATTA AAATGAAGTA CCTGAAAAGC 
TGGTTCATGG TAGATTTCAT TTCCTCCATC CCCGTGGACT ACATCTTCCT CATTGTGGAG 
ACACGCATCG ACTCGGAGGT CTACAAGACT GCCCGGGCCC TGCGCATTGT CCGCTTCACG 
AAGATCCTCA GCCTCTTACG CCTGTTACGC CTCTCCCGCC TCATTCGATA TATTCACCAG 
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGCG CCGTGGTGCG CATCGTGAAC 
CTCATCGGCA TGATGCTCCT GCTCTGCCAC TGGGACGGCT GCCTGCAGTT CCTGGTACCC 
ATGCTACAGG ACTTCCCTGA CGACTGCTGG GTGTCCATCA ACAACATGGT GAACAACTCC 
TGGGGGAAGC AGTACTCCTA CGCGCTCTTC AAGGCCATGA GCCACATGCT GTGCATCGGC 
TACGGGCGGC AGGCGCCCGT GGGCATGTCC GACGTCTGGC TCACCATGCT CAGCATGATC 
GTGGGTGCCA CCTGCTACGC CATGTTCATT GGCCACGCCA CTGCCCTCAT CCAGTCCCTG 
GACTCCTCCC GGCGCCAGTA CCAGGAAAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTT 
CACAAGCTCC CGCCCGACAC CCGGCAGCGC ATCCACGACT ACTACGAGCA CCGCTACCAG 
GGCAAGATGT TCGACGAGGA GAGCATCCTG GGCGAGCTAA GCGAGCCCCT GCGGGAGGAG 
ATCATCAACT TTAACTGTCG GAAGCTGGTG GCCTCCATGC CACTGTTTGC CAATGCGGAC 
CCCAACTTCG TGACGTCCAT GCTGACCAAG CTGCGTTTCG AGGTCTTCCA GCCTGGGGAC 
TACATCATCC GGGAAGGCAC CATTGGCAAG AAGATGTACT TCATCCAGCA TGGCGTGGTC 
AGCGTGCTCA CCAAGGGCAA CAAGGAGACC AAGCTGGCCG ACGGCTCCTA CTTTGGAGAG 
ATCTGCCTGC TGACCCGGGG CCGGCGCACA GCCAGCGTGA GGGCCGACAC CTACTGCCGC 
CTCTACTCGC TGAGCGTGGA CAACTTCAAT GAGGTGCTGG AGGAGTACCC CATGATGCGA 
AGGGCCTTCG AGACCGTGGC GCTGGACCGC CTGGACCGCA TTGGCAAGAA GAACTCCATC 
CTCCTCCACA AAGTCCAGCA CGACCTCAAC TCCGGCGTCT TCAACTACCA GGAGAATGAG 
ATCATCCAGC AGATTGTGCA GCATGACCGG GAGATGGCCC ACTGCGCGCA CCGCGTCCAG 
GCTGCTGCCT CTGCCACCCC AACCCCCACG CCCGTCATCT GGACCCCGCT GATCCAGGCA 
CCACTGCAGG CTGCCGCTGC CACCACTTCT GTGGCCATAG CCCTCACCCA CCACCCTCGC 
CTGCCTGCTG CCATCTTCCG CCCTCCCCCA GGATCTGGGC TGGGCAACCT CGGTGCCGGG 
CAGACGCCAA GGCACCTGAA ACGGCTGCAG TCCCTGATCC CTTCTGCGCT GGGCTCCGCC 
TCGCCCGCCA GCAGCCCGTC CCAGGTGGAC ACACCGTCTT CATCCTCCTT CCACATCCAA 
CAGCTGGCTG GATTCTCTGC CCCCGCTGGA CTGAGCCCAC TCCTGCCCTC ATCCAGCTCC 
TCCCCACCCC CCGGGGCCTG TGGCTCCCCC TCGGCTCCCA CACCATCAGC TGGCGTAGCC 
GCCACCACCA TAGCCGGGTT TGGCCACTTC CACAAGGCGC TGGGTGGCTC CCTGTCCTCC 
TCCGACTCTC CCCTGCTCAC CCCGCTGCAG CCAGGCGCCC GCTCCCCGCA GGCTGCCCAG 
CCATCTCCCG CGCCACCCGG GGCCCGGGGA GGCCTGGGAC TCCCGGAGCA CTTCCTGCCA 
CCCCCACCCT CATCCAGATC CCCGTCATCT AGCCCCGGGC AGCTGGGCCA GCCTCCCGGG 
GAGTTGTCCC TAGGTCTGGC CACTGGCCCA CTGAGCACGC CAGAGACACC CCCACGGCAG 
CCTGAGCCGC CGTCCCTTGT GGCAGGGGCC TCTGGGGGGG CTTCCCCTGT AGGCTTTACT 
CCCCGAGGAG GTCTCAGCCC CCCTGGCCAC AGCCCAGGCC CCCCAAGAAC CTTCCCGAGT 
GCCCCGCCCC GGGCCTCTGG CTCCCACGGA TCCTTGCTCC TGCCACCTGC ATCCAGCCCC 
CCACCACCCC AGGTCCCCCA GCGCCGGGGC ACACCCCCGC TCACCCCCGG CCGCCTCACC 
CAGGACCTCA AGCTCATCTC CGCGTCTCAG CCAGCCCTGC CTCAGGACGG GGCGCAGACT 
CTCCGCAGAG CCTCCCCGCA CTCCTCAGGG GAGTCCATGG CTGCCTTCCC GCTCTTCCCC 
AGGGCTGGGG GTGGCAGCGG GGGCAGTGGG AGCAGCGGGG GCCTCGGTCC CCCTGGGAGG 
CCCTATGGTG CCATCCCCGG CCAGCACGTC ACTCTGCCTC GGAAGACATC CTCAGGTTCT 
TTGCCACCCC CTCTGTCTTT GTTTGGGGCA AGAGCCACCT CTTCTGGGGG GCCCCCTCTG 
ACTGCTGGAC CCCAGAGGGA ACCTGGGGCC AGGCCTGAGC CAGTGCGCTC CAAACTGCCA 
TCCAATCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN4 ( NM_005477.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005468.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA.

Price & Availability↑

CloneID	OHu18158
Clone ID Related Accession (Same CDS sequence)	NM_005477.3 , NM_005477.2
Accession Version	NM_005477.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ238850.1, AJ132429.1, AC068397.6, BP291686.1 and BM979827.1. This sequence is a reference standard in the RefSeqGene project. On Oct 31, 2008 this sequence version replaced NM_005477.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ132429.1, AJ238850.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTCCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GACGCCGAGG AGGAGGGGGC CGGGGGCCGC 
CAAGACCCCA GCCGCAGGAG CATCCGGCTG CGGCCACTGC CCTCGCCCTC CCCCTCGGCG 
GCCGCGGGTG GCACGGAGTC CCGGAGCTCG GCCCTCGGGG CAGCGGACAG CGAAGGGCCG 
GCCCGCGGCG CGGGCAAGTC CAGCACGAAC GGCGACTGCA GGCGCTTCCG CGGGAGCCTG 
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGC GGCGGCACGG GGAGCGGCAG CAGTCACGGA 
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG AGGGCGACGC GTCCCCCGGC 
GAGGACAGGA CGCCCCCAGG CCTGGCGGCC GAGCCCGAGC GCCCCGGCGC CTCGGCGCAG 
CCCGCAGCCT CGCCGCCGCC GCCCCAGCAG CCACCGCAGC CGGCCTCCGC CTCCTGCGAG 
CAGCCCTCGG TGGACACCGC TATCAAAGTG GAGGGAGGCG CGGCTGCCGG CGACCAGATC 
CTCCCGGAGG CCGAGGTGCG CCTGGGCCAG GCCGGCTTCA TGCAGCGCCA GTTCGGGGCC 
ATGCTCCAAC CCGGGGTCAA CAAATTCTCC CTAAGGATGT TCGGCAGCCA GAAAGCCGTG 
GAGCGCGAAC AGGAGAGGGT CAAGTCGGCC GGATTTTGGA TTATCCACCC CTACAGTGAC 
TTCAGATTTT ACTGGGACCT GACCATGCTG CTGCTGATGG TGGGAAACCT GATTATCATT 
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACAC CCTGGATTGT CTTCAATGTG 
GTGTCAGACA CATTCTTCCT CATCGACTTG GTCCTCAACT TCCGCACAGG GATCGTGGTG 
GAGGACAACA CAGAGATCAT CCTGGACCCG CAGCGGATTA AAATGAAGTA CCTGAAAAGC 
TGGTTCATGG TAGATTTCAT TTCCTCCATC CCCGTGGACT ACATCTTCCT CATTGTGGAG 
ACACGCATCG ACTCGGAGGT CTACAAGACT GCCCGGGCCC TGCGCATTGT CCGCTTCACG 
AAGATCCTCA GCCTCTTACG CCTGTTACGC CTCTCCCGCC TCATTCGATA TATTCACCAG 
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGCG CCGTGGTGCG CATCGTGAAC 
CTCATCGGCA TGATGCTCCT GCTCTGCCAC TGGGACGGCT GCCTGCAGTT CCTGGTACCC 
ATGCTACAGG ACTTCCCTGA CGACTGCTGG GTGTCCATCA ACAACATGGT GAACAACTCC 
TGGGGGAAGC AGTACTCCTA CGCGCTCTTC AAGGCCATGA GCCACATGCT GTGCATCGGC 
TACGGGCGGC AGGCGCCCGT GGGCATGTCC GACGTCTGGC TCACCATGCT CAGCATGATC 
GTGGGTGCCA CCTGCTACGC CATGTTCATT GGCCACGCCA CTGCCCTCAT CCAGTCCCTG 
GACTCCTCCC GGCGCCAGTA CCAGGAAAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTT 
CACAAGCTCC CGCCCGACAC CCGGCAGCGC ATCCACGACT ACTACGAGCA CCGCTACCAG 
GGCAAGATGT TCGACGAGGA GAGCATCCTG GGCGAGCTAA GCGAGCCCCT GCGGGAGGAG 
ATCATCAACT TTAACTGTCG GAAGCTGGTG GCCTCCATGC CACTGTTTGC CAATGCGGAC 
CCCAACTTCG TGACGTCCAT GCTGACCAAG CTGCGTTTCG AGGTCTTCCA GCCTGGGGAC 
TACATCATCC GGGAAGGCAC CATTGGCAAG AAGATGTACT TCATCCAGCA TGGCGTGGTC 
AGCGTGCTCA CCAAGGGCAA CAAGGAGACC AAGCTGGCCG ACGGCTCCTA CTTTGGAGAG 
ATCTGCCTGC TGACCCGGGG CCGGCGCACA GCCAGCGTGA GGGCCGACAC CTACTGCCGC 
CTCTACTCGC TGAGCGTGGA CAACTTCAAT GAGGTGCTGG AGGAGTACCC CATGATGCGA 
AGGGCCTTCG AGACCGTGGC GCTGGACCGC CTGGACCGCA TTGGCAAGAA GAACTCCATC 
CTCCTCCACA AAGTCCAGCA CGACCTCAAC TCCGGCGTCT TCAACTACCA GGAGAATGAG 
ATCATCCAGC AGATTGTGCA GCATGACCGG GAGATGGCCC ACTGCGCGCA CCGCGTCCAG 
GCTGCTGCCT CTGCCACCCC AACCCCCACG CCCGTCATCT GGACCCCGCT GATCCAGGCA 
CCACTGCAGG CTGCCGCTGC CACCACTTCT GTGGCCATAG CCCTCACCCA CCACCCTCGC 
CTGCCTGCTG CCATCTTCCG CCCTCCCCCA GGATCTGGGC TGGGCAACCT CGGTGCCGGG 
CAGACGCCAA GGCACCTGAA ACGGCTGCAG TCCCTGATCC CTTCTGCGCT GGGCTCCGCC 
TCGCCCGCCA GCAGCCCGTC CCAGGTGGAC ACACCGTCTT CATCCTCCTT CCACATCCAA 
CAGCTGGCTG GATTCTCTGC CCCCGCTGGA CTGAGCCCAC TCCTGCCCTC ATCCAGCTCC 
TCCCCACCCC CCGGGGCCTG TGGCTCCCCC TCGGCTCCCA CACCATCAGC TGGCGTAGCC 
GCCACCACCA TAGCCGGGTT TGGCCACTTC CACAAGGCGC TGGGTGGCTC CCTGTCCTCC 
TCCGACTCTC CCCTGCTCAC CCCGCTGCAG CCAGGCGCCC GCTCCCCGCA GGCTGCCCAG 
CCATCTCCCG CGCCACCCGG GGCCCGGGGA GGCCTGGGAC TCCCGGAGCA CTTCCTGCCA 
CCCCCACCCT CATCCAGATC CCCGTCATCT AGCCCCGGGC AGCTGGGCCA GCCTCCCGGG 
GAGTTGTCCC TAGGTCTGGC CACTGGCCCA CTGAGCACGC CAGAGACACC CCCACGGCAG 
CCTGAGCCGC CGTCCCTTGT GGCAGGGGCC TCTGGGGGGG CTTCCCCTGT AGGCTTTACT 
CCCCGAGGAG GTCTCAGCCC CCCTGGCCAC AGCCCAGGCC CCCCAAGAAC CTTCCCGAGT 
GCCCCGCCCC GGGCCTCTGG CTCCCACGGA TCCTTGCTCC TGCCACCTGC ATCCAGCCCC 
CCACCACCCC AGGTCCCCCA GCGCCGGGGC ACACCCCCGC TCACCCCCGG CCGCCTCACC 
CAGGACCTCA AGCTCATCTC CGCGTCTCAG CCAGCCCTGC CTCAGGACGG GGCGCAGACT 
CTCCGCAGAG CCTCCCCGCA CTCCTCAGGG GAGTCCATGG CTGCCTTCCC GCTCTTCCCC 
AGGGCTGGGG GTGGCAGCGG GGGCAGTGGG AGCAGCGGGG GCCTCGGTCC CCCTGGGAGG 
CCCTATGGTG CCATCCCCGG CCAGCACGTC ACTCTGCCTC GGAAGACATC CTCAGGTTCT 
TTGCCACCCC CTCTGTCTTT GTTTGGGGCA AGAGCCACCT CTTCTGGGGG GCCCCCTCTG 
ACTGCTGGAC CCCAGAGGGA ACCTGGGGCC AGGCCTGAGC CAGTGCGCTC CAAACTGCCA 
TCCAATCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005468.1
CDS	995..4606
Translation	MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL

Target ORF information:

RefSeq Version	NM_005477.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005477.2

ORF Insert Sequence:

ATGGACAAGC TGCCGCCGTC CATGCGCAAG CGGCTCTACA GCCTCCCGCA GCAGGTGGGG 
GCCAAGGCGT GGATCATGGA CGAGGAAGAG GACGCCGAGG AGGAGGGGGC CGGGGGCCGC 
CAAGACCCCA GCCGCAGGAG CATCCGGCTG CGGCCACTGC CCTCGCCCTC CCCCTCGGCG 
GCCGCGGGTG GCACGGAGTC CCGGAGCTCG GCCCTCGGGG CAGCGGACAG CGAAGGGCCG 
GCCCGCGGCG CGGGCAAGTC CAGCACGAAC GGCGACTGCA GGCGCTTCCG CGGGAGCCTG 
GCCTCGCTGG GCAGCCGGGG CGGCGGCAGC GGCGGCACGG GGAGCGGCAG CAGTCACGGA 
CACCTGCATG ACTCCGCGGA GGAGCGGCGG CTCATCGCCG AGGGCGACGC GTCCCCCGGC 
GAGGACAGGA CGCCCCCAGG CCTGGCGGCC GAGCCCGAGC GCCCCGGCGC CTCGGCGCAG 
CCCGCAGCCT CGCCGCCGCC GCCCCAGCAG CCACCGCAGC CGGCCTCCGC CTCCTGCGAG 
CAGCCCTCGG TGGACACCGC TATCAAAGTG GAGGGAGGCG CGGCTGCCGG CGACCAGATC 
CTCCCGGAGG CCGAGGTGCG CCTGGGCCAG GCCGGCTTCA TGCAGCGCCA GTTCGGGGCC 
ATGCTCCAAC CCGGGGTCAA CAAATTCTCC CTAAGGATGT TCGGCAGCCA GAAAGCCGTG 
GAGCGCGAAC AGGAGAGGGT CAAGTCGGCC GGATTTTGGA TTATCCACCC CTACAGTGAC 
TTCAGATTTT ACTGGGACCT GACCATGCTG CTGCTGATGG TGGGAAACCT GATTATCATT 
CCTGTGGGCA TCACCTTCTT CAAGGATGAG AACACCACAC CCTGGATTGT CTTCAATGTG 
GTGTCAGACA CATTCTTCCT CATCGACTTG GTCCTCAACT TCCGCACAGG GATCGTGGTG 
GAGGACAACA CAGAGATCAT CCTGGACCCG CAGCGGATTA AAATGAAGTA CCTGAAAAGC 
TGGTTCATGG TAGATTTCAT TTCCTCCATC CCCGTGGACT ACATCTTCCT CATTGTGGAG 
ACACGCATCG ACTCGGAGGT CTACAAGACT GCCCGGGCCC TGCGCATTGT CCGCTTCACG 
AAGATCCTCA GCCTCTTACG CCTGTTACGC CTCTCCCGCC TCATTCGATA TATTCACCAG 
TGGGAAGAGA TCTTCCACAT GACCTACGAC CTGGCCAGCG CCGTGGTGCG CATCGTGAAC 
CTCATCGGCA TGATGCTCCT GCTCTGCCAC TGGGACGGCT GCCTGCAGTT CCTGGTACCC 
ATGCTACAGG ACTTCCCTGA CGACTGCTGG GTGTCCATCA ACAACATGGT GAACAACTCC 
TGGGGGAAGC AGTACTCCTA CGCGCTCTTC AAGGCCATGA GCCACATGCT GTGCATCGGC 
TACGGGCGGC AGGCGCCCGT GGGCATGTCC GACGTCTGGC TCACCATGCT CAGCATGATC 
GTGGGTGCCA CCTGCTACGC CATGTTCATT GGCCACGCCA CTGCCCTCAT CCAGTCCCTG 
GACTCCTCCC GGCGCCAGTA CCAGGAAAAG TACAAGCAGG TGGAGCAGTA CATGTCCTTT 
CACAAGCTCC CGCCCGACAC CCGGCAGCGC ATCCACGACT ACTACGAGCA CCGCTACCAG 
GGCAAGATGT TCGACGAGGA GAGCATCCTG GGCGAGCTAA GCGAGCCCCT GCGGGAGGAG 
ATCATCAACT TTAACTGTCG GAAGCTGGTG GCCTCCATGC CACTGTTTGC CAATGCGGAC 
CCCAACTTCG TGACGTCCAT GCTGACCAAG CTGCGTTTCG AGGTCTTCCA GCCTGGGGAC 
TACATCATCC GGGAAGGCAC CATTGGCAAG AAGATGTACT TCATCCAGCA TGGCGTGGTC 
AGCGTGCTCA CCAAGGGCAA CAAGGAGACC AAGCTGGCCG ACGGCTCCTA CTTTGGAGAG 
ATCTGCCTGC TGACCCGGGG CCGGCGCACA GCCAGCGTGA GGGCCGACAC CTACTGCCGC 
CTCTACTCGC TGAGCGTGGA CAACTTCAAT GAGGTGCTGG AGGAGTACCC CATGATGCGA 
AGGGCCTTCG AGACCGTGGC GCTGGACCGC CTGGACCGCA TTGGCAAGAA GAACTCCATC 
CTCCTCCACA AAGTCCAGCA CGACCTCAAC TCCGGCGTCT TCAACTACCA GGAGAATGAG 
ATCATCCAGC AGATTGTGCA GCATGACCGG GAGATGGCCC ACTGCGCGCA CCGCGTCCAG 
GCTGCTGCCT CTGCCACCCC AACCCCCACG CCCGTCATCT GGACCCCGCT GATCCAGGCA 
CCACTGCAGG CTGCCGCTGC CACCACTTCT GTGGCCATAG CCCTCACCCA CCACCCTCGC 
CTGCCTGCTG CCATCTTCCG CCCTCCCCCA GGATCTGGGC TGGGCAACCT CGGTGCCGGG 
CAGACGCCAA GGCACCTGAA ACGGCTGCAG TCCCTGATCC CTTCTGCGCT GGGCTCCGCC 
TCGCCCGCCA GCAGCCCGTC CCAGGTGGAC ACACCGTCTT CATCCTCCTT CCACATCCAA 
CAGCTGGCTG GATTCTCTGC CCCCGCTGGA CTGAGCCCAC TCCTGCCCTC ATCCAGCTCC 
TCCCCACCCC CCGGGGCCTG TGGCTCCCCC TCGGCTCCCA CACCATCAGC TGGCGTAGCC 
GCCACCACCA TAGCCGGGTT TGGCCACTTC CACAAGGCGC TGGGTGGCTC CCTGTCCTCC 
TCCGACTCTC CCCTGCTCAC CCCGCTGCAG CCAGGCGCCC GCTCCCCGCA GGCTGCCCAG 
CCATCTCCCG CGCCACCCGG GGCCCGGGGA GGCCTGGGAC TCCCGGAGCA CTTCCTGCCA 
CCCCCACCCT CATCCAGATC CCCGTCATCT AGCCCCGGGC AGCTGGGCCA GCCTCCCGGG 
GAGTTGTCCC TAGGTCTGGC CACTGGCCCA CTGAGCACGC CAGAGACACC CCCACGGCAG 
CCTGAGCCGC CGTCCCTTGT GGCAGGGGCC TCTGGGGGGG CTTCCCCTGT AGGCTTTACT 
CCCCGAGGAG GTCTCAGCCC CCCTGGCCAC AGCCCAGGCC CCCCAAGAAC CTTCCCGAGT 
GCCCCGCCCC GGGCCTCTGG CTCCCACGGA TCCTTGCTCC TGCCACCTGC ATCCAGCCCC 
CCACCACCCC AGGTCCCCCA GCGCCGGGGC ACACCCCCGC TCACCCCCGG CCGCCTCACC 
CAGGACCTCA AGCTCATCTC CGCGTCTCAG CCAGCCCTGC CTCAGGACGG GGCGCAGACT 
CTCCGCAGAG CCTCCCCGCA CTCCTCAGGG GAGTCCATGG CTGCCTTCCC GCTCTTCCCC 
AGGGCTGGGG GTGGCAGCGG GGGCAGTGGG AGCAGCGGGG GCCTCGGTCC CCCTGGGAGG 
CCCTATGGTG CCATCCCCGG CCAGCACGTC ACTCTGCCTC GGAAGACATC CTCAGGTTCT 
TTGCCACCCC CTCTGTCTTT GTTTGGGGCA AGAGCCACCT CTTCTGGGGG GCCCCCTCTG 
ACTGCTGGAC CCCAGAGGGA ACCTGGGGCC AGGCCTGAGC CAGTGCGCTC CAAACTGCCA 
TCCAATCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HCN4 ( XM_011521148.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519450.1 Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), transcript variant X1, mRNA.

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CloneID	OHu63614
Clone ID Related Accession (Same CDS sequence)	XM_011521148.2
Accession Version	XM_011521148.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2394bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011521148.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCTACG ACCTGGCCAG CGCCGTGGTG CGCATCGTGA ACCTCATCGG CATGATGCTC 
CTGCTCTGCC ACTGGGACGG CTGCCTGCAG TTCCTGGTAC CCATGCTACA GGACTTCCCT 
GACGACTGCT GGGTGTCCAT CAACAACATG GTGAACAACT CCTGGGGGAA GCAGTACTCC 
TACGCGCTCT TCAAGGCCAT GAGCCACATG CTGTGCATCG GCTACGGGCG GCAGGCGCCC 
GTGGGCATGT CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTGGGTGC CACCTGCTAC 
GCCATGTTCA TTGGCCACGC CACTGCCCTC ATCCAGTCCC TGGACTCCTC CCGGCGCCAG 
TACCAGGAAA AGTACAAGCA GGTGGAGCAG TACATGTCCT TTCACAAGCT CCCGCCCGAC 
ACCCGGCAGC GCATCCACGA CTACTACGAG CACCGCTACC AGGGCAAGAT GTTCGACGAG 
GAGAGCATCC TGGGCGAGCT AAGCGAGCCC CTGCGGGAGG AGATCATCAA CTTTAACTGT 
CGGAAGCTGG TGGCCTCCAT GCCACTGTTT GCCAATGCGG ACCCCAACTT CGTGACGTCC 
ATGCTGACCA AGCTGCGTTT CGAGGTCTTC CAGCCTGGGG ACTACATCAT CCGGGAAGGC 
ACCATTGGCA AGAAGATGTA CTTCATCCAG CATGGCGTGG TCAGCGTGCT CACCAAGGGC 
AACAAGGAGA CCAAGCTGGC CGACGGCTCC TACTTTGGAG AGATCTGCCT GCTGACCCGG 
GGCCGGCGCA CAGCCAGCGT GAGGGCCGAC ACCTACTGCC GCCTCTACTC GCTGAGCGTG 
GACAACTTCA ATGAGGTGCT GGAGGAGTAC CCCATGATGC GAAGGGCCTT CGAGACCGTG 
GCGCTGGACC GCCTGGACCG CATTGGCAAG AAGAACTCCA TCCTCCTCCA CAAAGTCCAG 
CACGACCTCA ACTCCGGCGT CTTCAACTAC CAGGAGAATG AGATCATCCA GCAGATTGTG 
CAGCATGACC GGGAGATGGC CCACTGCGCG CACCGCGTCC AGGCTGCTGC CTCTGCCACC 
CCAACCCCCA CGCCCGTCAT CTGGACCCCG CTGATCCAGG CACCACTGCA GGCTGCCGCT 
GCCACCACTT CTGTGGCCAT AGCCCTCACC CACCACCCTC GCCTGCCTGC TGCCATCTTC 
CGCCCTCCCC CAGGATCTGG GCTGGGCAAC CTCGGTGCCG GGCAGACGCC AAGGCACCTG 
AAACGGCTGC AGTCCCTGAT CCCTTCTGCG CTGGGCTCCG CCTCGCCCGC CAGCAGCCCG 
TCCCAGGTGG ACACACCGTC TTCATCCTCC TTCCACATCC AACAGCTGGC TGGATTCTCT 
GCCCCCGCTG GACTGAGCCC ACTCCTGCCC TCATCCAGCT CCTCCCCACC CCCCGGGGCC 
TGTGGCTCCC CCTCGGCTCC CACACCATCA GCTGGCGTAG CCGCCACCAC CATAGCCGGG 
TTTGGCCACT TCCACAAGGC GCTGGGTGGC TCCCTGTCCT CCTCCGACTC TCCCCTGCTC 
ACCCCGCTGC AGCCAGGCGC CCGCTCCCCG CAGGCTGCCC AGCCATCTCC CGCGCCACCC 
GGGGCCCGGG GAGGCCTGGG ACTCCCGGAG CACTTCCTGC CACCCCCACC CTCATCCAGA 
TCCCCGTCAT CTAGCCCCGG GCAGCTGGGC CAGCCTCCCG GGGAGTTGTC CCTAGGTCTG 
GCCACTGGCC CACTGAGCAC GCCAGAGACA CCCCCACGGC AGCCTGAGCC GCCGTCCCTT 
GTGGCAGGGG CCTCTGGGGG GGCTTCCCCT GTAGGCTTTA CTCCCCGAGG AGGTCTCAGC 
CCCCCTGGCC ACAGCCCAGG CCCCCCAAGA ACCTTCCCGA GTGCCCCGCC CCGGGCCTCT 
GGCTCCCACG GATCCTTGCT CCTGCCACCT GCATCCAGCC CCCCACCACC CCAGGTCCCC 
CAGCGCCGGG GCACACCCCC GCTCACCCCC GGCCGCCTCA CCCAGGACCT CAAGCTCATC 
TCCGCGTCTC AGCCAGCCCT GCCTCAGGAC GGGGCGCAGA CTCTCCGCAG AGCCTCCCCG 
CACTCCTCAG GGGAGTCCAT GGCTGCCTTC CCGCTCTTCC CCAGGGCTGG GGGTGGCAGC 
GGGGGCAGTG GGAGCAGCGG GGGCCTCGGT CCCCCTGGGA GGCCCTATGG TGCCATCCCC 
GGCCAGCACG TCACTCTGCC TCGGAAGACA TCCTCAGGTT CTTTGCCACC CCCTCTGTCT 
TTGTTTGGGG CAAGAGCCAC CTCTTCTGGG GGGCCCCCTC TGACTGCTGG ACCCCAGAGG 
GAACCTGGGG CCAGGCCTGA GCCAGTGCGC TCCAAACTGC CATCCAATCT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519450.1
CDS	56..2449
Translation	MTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL

Target ORF information:

RefSeq Version	XM_011521148.2
Organism	Homo sapiens(human)
Definition	Homo sapiens hyperpolarization activated cyclic nucleotide gated potassium channel 4 (HCN4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521148.2

ORF Insert Sequence:

ATGACCTACG ACCTGGCCAG CGCCGTGGTG CGCATCGTGA ACCTCATCGG CATGATGCTC 
CTGCTCTGCC ACTGGGACGG CTGCCTGCAG TTCCTGGTAC CCATGCTACA GGACTTCCCT 
GACGACTGCT GGGTGTCCAT CAACAACATG GTGAACAACT CCTGGGGGAA GCAGTACTCC 
TACGCGCTCT TCAAGGCCAT GAGCCACATG CTGTGCATCG GCTACGGGCG GCAGGCGCCC 
GTGGGCATGT CCGACGTCTG GCTCACCATG CTCAGCATGA TCGTGGGTGC CACCTGCTAC 
GCCATGTTCA TTGGCCACGC CACTGCCCTC ATCCAGTCCC TGGACTCCTC CCGGCGCCAG 
TACCAGGAAA AGTACAAGCA GGTGGAGCAG TACATGTCCT TTCACAAGCT CCCGCCCGAC 
ACCCGGCAGC GCATCCACGA CTACTACGAG CACCGCTACC AGGGCAAGAT GTTCGACGAG 
GAGAGCATCC TGGGCGAGCT AAGCGAGCCC CTGCGGGAGG AGATCATCAA CTTTAACTGT 
CGGAAGCTGG TGGCCTCCAT GCCACTGTTT GCCAATGCGG ACCCCAACTT CGTGACGTCC 
ATGCTGACCA AGCTGCGTTT CGAGGTCTTC CAGCCTGGGG ACTACATCAT CCGGGAAGGC 
ACCATTGGCA AGAAGATGTA CTTCATCCAG CATGGCGTGG TCAGCGTGCT CACCAAGGGC 
AACAAGGAGA CCAAGCTGGC CGACGGCTCC TACTTTGGAG AGATCTGCCT GCTGACCCGG 
GGCCGGCGCA CAGCCAGCGT GAGGGCCGAC ACCTACTGCC GCCTCTACTC GCTGAGCGTG 
GACAACTTCA ATGAGGTGCT GGAGGAGTAC CCCATGATGC GAAGGGCCTT CGAGACCGTG 
GCGCTGGACC GCCTGGACCG CATTGGCAAG AAGAACTCCA TCCTCCTCCA CAAAGTCCAG 
CACGACCTCA ACTCCGGCGT CTTCAACTAC CAGGAGAATG AGATCATCCA GCAGATTGTG 
CAGCATGACC GGGAGATGGC CCACTGCGCG CACCGCGTCC AGGCTGCTGC CTCTGCCACC 
CCAACCCCCA CGCCCGTCAT CTGGACCCCG CTGATCCAGG CACCACTGCA GGCTGCCGCT 
GCCACCACTT CTGTGGCCAT AGCCCTCACC CACCACCCTC GCCTGCCTGC TGCCATCTTC 
CGCCCTCCCC CAGGATCTGG GCTGGGCAAC CTCGGTGCCG GGCAGACGCC AAGGCACCTG 
AAACGGCTGC AGTCCCTGAT CCCTTCTGCG CTGGGCTCCG CCTCGCCCGC CAGCAGCCCG 
TCCCAGGTGG ACACACCGTC TTCATCCTCC TTCCACATCC AACAGCTGGC TGGATTCTCT 
GCCCCCGCTG GACTGAGCCC ACTCCTGCCC TCATCCAGCT CCTCCCCACC CCCCGGGGCC 
TGTGGCTCCC CCTCGGCTCC CACACCATCA GCTGGCGTAG CCGCCACCAC CATAGCCGGG 
TTTGGCCACT TCCACAAGGC GCTGGGTGGC TCCCTGTCCT CCTCCGACTC TCCCCTGCTC 
ACCCCGCTGC AGCCAGGCGC CCGCTCCCCG CAGGCTGCCC AGCCATCTCC CGCGCCACCC 
GGGGCCCGGG GAGGCCTGGG ACTCCCGGAG CACTTCCTGC CACCCCCACC CTCATCCAGA 
TCCCCGTCAT CTAGCCCCGG GCAGCTGGGC CAGCCTCCCG GGGAGTTGTC CCTAGGTCTG 
GCCACTGGCC CACTGAGCAC GCCAGAGACA CCCCCACGGC AGCCTGAGCC GCCGTCCCTT 
GTGGCAGGGG CCTCTGGGGG GGCTTCCCCT GTAGGCTTTA CTCCCCGAGG AGGTCTCAGC 
CCCCCTGGCC ACAGCCCAGG CCCCCCAAGA ACCTTCCCGA GTGCCCCGCC CCGGGCCTCT 
GGCTCCCACG GATCCTTGCT CCTGCCACCT GCATCCAGCC CCCCACCACC CCAGGTCCCC 
CAGCGCCGGG GCACACCCCC GCTCACCCCC GGCCGCCTCA CCCAGGACCT CAAGCTCATC 
TCCGCGTCTC AGCCAGCCCT GCCTCAGGAC GGGGCGCAGA CTCTCCGCAG AGCCTCCCCG 
CACTCCTCAG GGGAGTCCAT GGCTGCCTTC CCGCTCTTCC CCAGGGCTGG GGGTGGCAGC 
GGGGGCAGTG GGAGCAGCGG GGGCCTCGGT CCCCCTGGGA GGCCCTATGG TGCCATCCCC 
GGCCAGCACG TCACTCTGCC TCGGAAGACA TCCTCAGGTT CTTTGCCACC CCCTCTGTCT 
TTGTTTGGGG CAAGAGCCAC CTCTTCTGGG GGGCCCCCTC TGACTGCTGG ACCCCAGAGG 
GAACCTGGGG CCAGGCCTGA GCCAGTGCGC TCCAAACTGC CATCCAATCT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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HCN4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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